SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2b7k'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OZ7_A_CA4A1_1
(ANDROGEN RECEPTOR)		 2b7k SCO1 PROTEIN
(Saccharomyces
cerevisiae) 		5 / 12 LEU A 177
LEU A 203
GLY A 204
ALA A 215
PHE A 143
 None
 1.14A 2oz7A-2b7kA:
undetectable		 2oz7A-2b7kA:
20.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K2H_A_LYAA513_1
(DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE)		 2b7k SCO1 PROTEIN
(Saccharomyces
cerevisiae) 		5 / 12 ALA A 215
ILE A 141
GLY A 144
PHE A 143
TYR A 194
 None
 1.09A 3k2hA-2b7kA:
undetectable		 3k2hA-2b7kA:
17.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K2H_B_LYAB513_1
(DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE)		 2b7k SCO1 PROTEIN
(Saccharomyces
cerevisiae) 		5 / 12 ALA A 215
ILE A 141
GLY A 144
PHE A 143
TYR A 194
 None
 1.11A 3k2hB-2b7kA:
undetectable		 3k2hB-2b7kA:
17.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NRR_A_D16A530_1
(DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 2b7k SCO1 PROTEIN
(Saccharomyces
cerevisiae) 		5 / 12 ALA A 215
ILE A 141
GLY A 144
PHE A 143
TYR A 194
 None
 1.05A 3nrrA-2b7kA:
undetectable		 3nrrA-2b7kA:
17.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NRR_B_D16B530_1
(DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 2b7k SCO1 PROTEIN
(Saccharomyces
cerevisiae) 		5 / 12 ALA A 215
ILE A 141
GLY A 144
PHE A 143
TYR A 194
 None
 1.04A 3nrrB-2b7kA:
undetectable		 3nrrB-2b7kA:
17.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PO7_A_ZONA601_1
(AMINE OXIDASE
[FLAVIN-CONTAINING]
B)		 2b7k SCO1 PROTEIN
(Saccharomyces
cerevisiae) 		4 / 8 LEU A 156
TYR A 142
PHE A 178
TYR A 194
 None
 1.21A 3po7A-2b7kA:
undetectable		 3po7A-2b7kA:
17.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_A_PCFA1801_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 2b7k SCO1 PROTEIN
(Saccharomyces
cerevisiae) 		4 / 6 ILE A 172
LEU A 159
HIS A 199
PHE A 143
 None
 1.07A 5vkqA-2b7kA:
undetectable
5vkqB-2b7kA:
undetectable		 5vkqA-2b7kA:
7.75
5vkqB-2b7kA:
7.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_D_PCFD1807_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 2b7k SCO1 PROTEIN
(Saccharomyces
cerevisiae) 		4 / 6 PHE A 143
ILE A 172
LEU A 159
HIS A 199
 None
 1.06A 5vkqA-2b7kA:
undetectable
5vkqD-2b7kA:
undetectable		 5vkqA-2b7kA:
7.75
5vkqD-2b7kA:
7.75