SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2b7n'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N2X_A_SAMA401_0
(S-ADENOSYL-METHYLTRA
NSFERASE MRAW)		 2b7n PROBABLE
NICOTINATE-NUCLEOTID
E PYROPHOSPHORYLASE
(Helicobacter
pylori) 		6 / 12 HIS A  99
GLY A 102
ASP A 123
VAL A 139
ASN A 237
ARG A 128
 None
None
None
None
SO4  A2003 (-3.8A)
None
 1.37A 1n2xA-2b7nA:
undetectable		 1n2xA-2b7nA:
23.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HDN_F_TACF3888_1
(ELONGATION FACTOR
EF-TU)		 2b7n PROBABLE
NICOTINATE-NUCLEOTID
E PYROPHOSPHORYLASE
(Helicobacter
pylori) 		4 / 7 SER A 100
SER A  44
VAL A  42
LEU A 121
 None
 1.05A 2hdnE-2b7nA:
undetectable
2hdnF-2b7nA:
2.6
2hdnH-2b7nA:
3.0		 2hdnE-2b7nA:
13.37
2hdnF-2b7nA:
21.84
2hdnH-2b7nA:
21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HDN_H_TACH4888_1
(ELONGATION FACTOR
EF-TU)		 2b7n PROBABLE
NICOTINATE-NUCLEOTID
E PYROPHOSPHORYLASE
(Helicobacter
pylori) 		4 / 7 SER A  44
VAL A  42
LEU A 121
SER A 100
 None
 1.00A 2hdnF-2b7nA:
2.6
2hdnG-2b7nA:
undetectable
2hdnH-2b7nA:
3.0		 2hdnF-2b7nA:
21.84
2hdnG-2b7nA:
13.37
2hdnH-2b7nA:
21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YQZ_A_SAMA301_0
(HYPOTHETICAL PROTEIN
TTHA0223)		 2b7n PROBABLE
NICOTINATE-NUCLEOTID
E PYROPHOSPHORYLASE
(Helicobacter
pylori) 		5 / 12 GLY A  45
ILE A 103
ALA A  49
LEU A  97
LEU A  76
 None
 0.98A 2yqzA-2b7nA:
2.1		 2yqzA-2b7nA:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YQZ_B_SAMB401_0
(HYPOTHETICAL PROTEIN
TTHA0223)		 2b7n PROBABLE
NICOTINATE-NUCLEOTID
E PYROPHOSPHORYLASE
(Helicobacter
pylori) 		6 / 12 GLY A  45
ILE A 103
ALA A  49
LEU A  97
LEU A  76
VAL A  35
 None
 1.14A 2yqzB-2b7nA:
undetectable		 2yqzB-2b7nA:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B9M_A_SALA1100_1
(SERUM ALBUMIN)		 2b7n PROBABLE
NICOTINATE-NUCLEOTID
E PYROPHOSPHORYLASE
(Helicobacter
pylori) 		4 / 4 LEU A 162
ARG A 176
LEU A 155
ALA A 203
 None
 1.06A 3b9mA-2b7nA:
undetectable		 3b9mA-2b7nA:
19.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DEU_A_SALA305_1
(TRANSCRIPTIONAL
REGULATOR SLYA)		 2b7n PROBABLE
NICOTINATE-NUCLEOTID
E PYROPHOSPHORYLASE
(Helicobacter
pylori) 		4 / 7 VAL A 251
ILE A 254
ILE A 238
SER A 242
 None
 0.81A 3deuA-2b7nA:
undetectable		 3deuA-2b7nA:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G1U_A_ADNA438_1
(ADENOSYLHOMOCYSTEINA
SE)		 2b7n PROBABLE
NICOTINATE-NUCLEOTID
E PYROPHOSPHORYLASE
(Helicobacter
pylori) 		5 / 12 LEU A  50
GLU A  46
ASN A 141
LEU A  96
LEU A  97
 None
 1.37A 3g1uA-2b7nA:
undetectable		 3g1uA-2b7nA:
19.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IX9_A_MTXA200_1
(DIHYDROFOLATE
REDUCTASE)		 2b7n PROBABLE
NICOTINATE-NUCLEOTID
E PYROPHOSPHORYLASE
(Helicobacter
pylori) 		5 / 12 ILE A 205
ALA A 203
LEU A 172
LEU A 157
ARG A 148
 None
None
None
None
NTM  A1001 (-3.6A)
 1.13A 3ix9A-2b7nA:
undetectable		 3ix9A-2b7nA:
21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O2B_B_LOCB503_2
(TUBULIN BETA-2B
CHAIN)		 2b7n PROBABLE
NICOTINATE-NUCLEOTID
E PYROPHOSPHORYLASE
(Helicobacter
pylori) 		5 / 12 LEU A 168
ASN A 200
ALA A 203
ILE A 185
ILE A 187
 None
 1.01A 4o2bB-2b7nA:
undetectable		 4o2bB-2b7nA:
20.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVL_V_BO2V301_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-3)		 2b7n PROBABLE
NICOTINATE-NUCLEOTID
E PYROPHOSPHORYLASE
(Helicobacter
pylori) 		5 / 10 SER A 100
ALA A 263
THR A 105
ALA A 104
THR A 107
 None
 1.31A 4qvlV-2b7nA:
0.0
4qvlW-2b7nA:
0.0		 4qvlV-2b7nA:
23.71
4qvlW-2b7nA:
22.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVW_H_BO2H301_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-3)		 2b7n PROBABLE
NICOTINATE-NUCLEOTID
E PYROPHOSPHORYLASE
(Helicobacter
pylori) 		5 / 10 SER A 100
ALA A 263
THR A 105
ALA A 104
THR A 107
 None
 1.32A 4qvwH-2b7nA:
undetectable
4qvwI-2b7nA:
undetectable		 4qvwH-2b7nA:
23.71
4qvwI-2b7nA:
22.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVW_V_BO2V301_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-3)		 2b7n PROBABLE
NICOTINATE-NUCLEOTID
E PYROPHOSPHORYLASE
(Helicobacter
pylori) 		5 / 10 SER A 100
ALA A 263
THR A 105
ALA A 104
THR A 107
 None
 1.31A 4qvwV-2b7nA:
undetectable
4qvwW-2b7nA:
undetectable		 4qvwV-2b7nA:
23.71
4qvwW-2b7nA:
22.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QW3_H_BO2H301_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-3)		 2b7n PROBABLE
NICOTINATE-NUCLEOTID
E PYROPHOSPHORYLASE
(Helicobacter
pylori) 		5 / 10 SER A 100
ALA A 263
THR A 105
ALA A 104
THR A 107
 None
 1.34A 4qw3H-2b7nA:
0.0
4qw3I-2b7nA:
0.0		 4qw3H-2b7nA:
23.71
4qw3I-2b7nA:
22.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QW3_V_BO2V301_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-3)		 2b7n PROBABLE
NICOTINATE-NUCLEOTID
E PYROPHOSPHORYLASE
(Helicobacter
pylori) 		5 / 11 SER A 100
ALA A 263
THR A 105
ALA A 104
THR A 107
 None
 1.33A 4qw3V-2b7nA:
undetectable
4qw3W-2b7nA:
0.0		 4qw3V-2b7nA:
23.71
4qw3W-2b7nA:
22.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5GSN_A_MMZA503_1
(FLAVIN-CONTAINING
MONOOXYGENASE)		 2b7n PROBABLE
NICOTINATE-NUCLEOTID
E PYROPHOSPHORYLASE
(Helicobacter
pylori) 		3 / 3 ASN A 141
SER A 100
SER A 101
 None
 0.78A 5gsnA-2b7nA:
undetectable		 5gsnA-2b7nA:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L66_V_BO2V301_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-3)		 2b7n PROBABLE
NICOTINATE-NUCLEOTID
E PYROPHOSPHORYLASE
(Helicobacter
pylori) 		5 / 12 SER A 100
ALA A 263
THR A 105
ALA A 104
THR A 107
 None
 1.29A 5l66V-2b7nA:
undetectable
5l66W-2b7nA:
undetectable		 5l66V-2b7nA:
23.71
5l66W-2b7nA:
22.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TJY_A_BEZA304_0
(4-HYDROXY-TETRAHYDRO
DIPICOLINATE
REDUCTASE)		 2b7n PROBABLE
NICOTINATE-NUCLEOTID
E PYROPHOSPHORYLASE
(Helicobacter
pylori) 		3 / 3 MET A  55
GLU A   2
ARG A   4
 None
 0.76A 5tjyA-2b7nA:
4.7		 5tjyA-2b7nA:
22.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TJZ_A_BEZA302_0
(4-HYDROXY-TETRAHYDRO
DIPICOLINATE
REDUCTASE)		 2b7n PROBABLE
NICOTINATE-NUCLEOTID
E PYROPHOSPHORYLASE
(Helicobacter
pylori) 		3 / 3 MET A  55
GLU A   2
ARG A   4
 None
 0.72A 5tjzA-2b7nA:
4.8		 5tjzA-2b7nA:
22.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6G2P_A_TRPA502_0
(FLAVIN-DEPENDENT
L-TRYPTOPHAN OXIDASE
VIOA)		 2b7n PROBABLE
NICOTINATE-NUCLEOTID
E PYROPHOSPHORYLASE
(Helicobacter
pylori) 		4 / 7 TYR A 222
LEU A 232
TYR A 227
VAL A 206
 None
 1.32A 6g2pA-2b7nA:
undetectable		 6g2pA-2b7nA:
20.83