SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2b7u'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O1Z_B_MXMB807_1
(PROSTAGLANDIN G/H
SYNTHASE 1)		 2b7u CHARYBDIN
(Drimia
maritima) 		5 / 12 LEU A  78
VAL A  12
LEU A  60
SER A  34
LEU A  35
 None
 1.11A 4o1zB-2b7uA:
undetectable		 4o1zB-2b7uA:
19.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V1F_B_BQ1B1087_0
(F0F1 ATP SYNTHASE
SUBUNIT C)		 2b7u CHARYBDIN
(Drimia
maritima) 		5 / 8 ALA A 175
ALA A 168
ILE A 174
PHE A 239
LEU A 198
 None
None
None
MES  A 258 (-3.9A)
None
 1.48A 4v1fA-2b7uA:
undetectable
4v1fB-2b7uA:
undetectable		 4v1fA-2b7uA:
16.67
4v1fB-2b7uA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5D0Y_A_FOLA201_0
(CONSERVED
HYPOTHETICAL
MEMBRANE PROTEIN)		 2b7u CHARYBDIN
(Drimia
maritima) 		5 / 12 LEU A  35
GLY A 241
PHE A  27
THR A  23
VAL A  12
 None
 1.23A 5d0yA-2b7uA:
undetectable		 5d0yA-2b7uA:
22.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NWV_A_ACAA18_1
(SCRFP-TAG,GP41)		 2b7u CHARYBDIN
(Drimia
maritima) 		5 / 12 GLY A 107
GLU A  95
LEU A 111
GLU A 109
LEU A  92
 None
 1.30A 5nwvA-2b7uA:
undetectable		 5nwvA-2b7uA:
11.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6C2M_C_SUEC1203_1
(NS3 PROTEASE)		 2b7u CHARYBDIN
(Drimia
maritima) 		5 / 9 HIS A  41
GLY A  42
ILE A  28
LEU A  31
LYS A  29
 None
 1.21A 6c2mC-2b7uA:
undetectable		 6c2mC-2b7uA:
15.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FGC_A_ACTA811_0
(GEPHYRIN)		 2b7u CHARYBDIN
(Drimia
maritima) 		3 / 3 LEU A 158
LEU A 111
ARG A 154
 None
 0.62A 6fgcA-2b7uA:
undetectable		 6fgcA-2b7uA:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FGD_A_ACTA810_0
(GEPHYRIN)		 2b7u CHARYBDIN
(Drimia
maritima) 		3 / 3 LEU A 158
LEU A 111
ARG A 154
 None
 0.67A 6fgdA-2b7uA:
undetectable		 6fgdA-2b7uA:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NMP_P_CHDP307_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 2b7u CHARYBDIN
(Drimia
maritima) 		4 / 5 ARG A  18
LEU A  19
GLN A 139
PHE A  27
 None
 1.47A 6nmpP-2b7uA:
undetectable
6nmpW-2b7uA:
undetectable		 6nmpP-2b7uA:
20.93
6nmpW-2b7uA:
14.00