SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2b81'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KGL_A_RTLA175_1
(CELLULAR
RETINOL-BINDING
PROTEIN TYPE I)		 2b81 LUCIFERASE-LIKE
MONOOXYGENASE
(Bacillus
cereus) 		4 / 7 LEU A 279
ILE A 247
MET A 215
TRP A  59
 None
 1.26A 1kglA-2b81A:
undetectable		 1kglA-2b81A:
18.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OLT_A_SAMA501_0
(OXYGEN-INDEPENDENT
COPROPORPHYRINOGEN
III OXIDASE)		 2b81 LUCIFERASE-LIKE
MONOOXYGENASE
(Bacillus
cereus) 		5 / 12 THR A 197
GLY A 134
ASP A 135
PHE A  70
ALA A  74
 None
 1.24A 1oltA-2b81A:
3.9		 1oltA-2b81A:
23.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VE3_A_SAMA302_1
(HYPOTHETICAL PROTEIN
PH0226)		 2b81 LUCIFERASE-LIKE
MONOOXYGENASE
(Bacillus
cereus) 		4 / 4 TYR A 216
ARG A 219
ASP A 135
ASP A  67
 SO4  A2448 (-4.5A)
SO4  A2448 (-3.5A)
None
None
 1.28A 1ve3A-2b81A:
0.1		 1ve3A-2b81A:
22.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VE3_B_SAMB301_1
(HYPOTHETICAL PROTEIN
PH0226)		 2b81 LUCIFERASE-LIKE
MONOOXYGENASE
(Bacillus
cereus) 		4 / 4 TYR A 216
ARG A 219
ASP A 135
ASP A  67
 SO4  A2448 (-4.5A)
SO4  A2448 (-3.5A)
None
None
 1.29A 1ve3B-2b81A:
0.4		 1ve3B-2b81A:
22.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IGT_C_SAMC1003_1
(SAM DEPENDENT
METHYLTRANSFERASE)		 2b81 LUCIFERASE-LIKE
MONOOXYGENASE
(Bacillus
cereus) 		4 / 4 ASP A 135
ASP A  62
ASP A  67
GLY A  76
 None
 1.19A 2igtC-2b81A:
undetectable		 2igtC-2b81A:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B6H_A_MXDA551_1
(PROSTACYCLIN
SYNTHASE)		 2b81 LUCIFERASE-LIKE
MONOOXYGENASE
(Bacillus
cereus) 		4 / 6 TYR A 166
LEU A 165
ALA A 117
THR A 118
 None
 0.86A 3b6hA-2b81A:
undetectable		 3b6hA-2b81A:
23.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B6H_B_MXDB551_1
(PROSTACYCLIN
SYNTHASE)		 2b81 LUCIFERASE-LIKE
MONOOXYGENASE
(Bacillus
cereus) 		4 / 6 TYR A 166
LEU A 165
ALA A 117
THR A 118
 None
 0.87A 3b6hB-2b81A:
undetectable		 3b6hB-2b81A:
23.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_G_SVRG506_3
(PHOSPHOLIPASE A2)		 2b81 LUCIFERASE-LIKE
MONOOXYGENASE
(Bacillus
cereus) 		3 / 3 PRO A 188
PHE A   7
LYS A 190
 None
 1.18A 3bjwG-2b81A:
undetectable		 3bjwG-2b81A:
15.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S56_B_ROCB203_1
(PROTEASE)		 2b81 LUCIFERASE-LIKE
MONOOXYGENASE
(Bacillus
cereus) 		4 / 7 LEU A 252
LEU A 276
GLU A 260
PRO A 258
 None
 0.96A 3s56B-2b81A:
undetectable		 3s56B-2b81A:
15.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SP9_B_IL2B901_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR DELTA)		 2b81 LUCIFERASE-LIKE
MONOOXYGENASE
(Bacillus
cereus) 		5 / 12 LEU A 306
VAL A  26
PHE A 292
LEU A  88
VAL A  47
 None
 1.29A 3sp9B-2b81A:
undetectable		 3sp9B-2b81A:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUE_B_SUEB1201_2
(NS3 PROTEASE, NS4A
PROTEIN)		 2b81 LUCIFERASE-LIKE
MONOOXYGENASE
(Bacillus
cereus) 		3 / 3 PHE A 123
TYR A  87
LEU A 129
 None
MES  A2403 (-4.7A)
None
 0.74A 3sueB-2b81A:
undetectable		 3sueB-2b81A:
18.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QC6_B_KANB201_2
(BIFUNCTIONAL AAC/APH)		 2b81 LUCIFERASE-LIKE
MONOOXYGENASE
(Bacillus
cereus) 		3 / 3 LEU A 234
ASP A 237
TYR A 238
 None
 0.67A 4qc6B-2b81A:
undetectable		 4qc6B-2b81A:
19.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BTA_G_MFXG101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
DNA SUBSTRATE 24-MER
TTACGTGCATAGTCATTCAT
GACC)		 2b81 LUCIFERASE-LIKE
MONOOXYGENASE
(Bacillus
cereus) 		4 / 7 ASP A 253
ARG A 270
GLY A 272
GLU A 260
 None
 0.98A 5btaA-2b81A:
undetectable
5btaC-2b81A:
undetectable
5btaD-2b81A:
undetectable		 5btaA-2b81A:
22.44
5btaC-2b81A:
22.44
5btaD-2b81A:
20.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5GS4_A_ESTA603_1
(ESTROGEN RECEPTOR)		 2b81 LUCIFERASE-LIKE
MONOOXYGENASE
(Bacillus
cereus) 		5 / 12 MET A  82
THR A  86
LEU A  88
ALA A  89
LEU A 119
 None
 1.14A 5gs4A-2b81A:
undetectable		 5gs4A-2b81A:
22.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L5F_Y_BO2Y301_1
(PROTEASOME SUBUNIT
BETA
TYPE-8,PROTEASOME
SUBUNIT BETA TYPE-5
PROTEASOME SUBUNIT
BETA
TYPE-6,PROTEASOME
SUBUNIT BETA
TYPE-1,PROTEASOME
SUBUNIT BETA
TYPE-6,PROTEASOME
SUBUNIT BETA
TYPE-1,PROTEASOME
SUBUNIT BETA TYPE-6)		 2b81 LUCIFERASE-LIKE
MONOOXYGENASE
(Bacillus
cereus) 		4 / 8 THR A 197
SER A 133
SER A 105
ASP A 139
 None
SO4  A2429 ( 4.7A)
None
None
 0.88A 5l5fY-2b81A:
undetectable
5l5fZ-2b81A:
undetectable		 5l5fY-2b81A:
21.32
5l5fZ-2b81A:
20.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LJC_A_RTLA201_1
(RETINOL-BINDING
PROTEIN 1)		 2b81 LUCIFERASE-LIKE
MONOOXYGENASE
(Bacillus
cereus) 		4 / 7 LEU A 295
ILE A 247
MET A 215
TRP A  59
 None
 1.39A 5ljcA-2b81A:
undetectable		 5ljcA-2b81A:
18.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LJE_A_RTLA201_1
(RETINOL-BINDING
PROTEIN 1)		 2b81 LUCIFERASE-LIKE
MONOOXYGENASE
(Bacillus
cereus) 		4 / 6 LEU A 279
ILE A 247
MET A 215
TRP A  59
 None
 1.09A 5ljeA-2b81A:
undetectable		 5ljeA-2b81A:
18.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ND7_B_TA1B601_2
(TUBULIN BETA-2B
CHAIN)		 2b81 LUCIFERASE-LIKE
MONOOXYGENASE
(Bacillus
cereus) 		3 / 3 THR A 271
PRO A 221
ARG A 219
 None
SO4  A2447 (-3.5A)
SO4  A2448 (-3.5A)
 0.83A 5nd7B-2b81A:
undetectable		 5nd7B-2b81A:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UUN_B_ACTB307_0
(GLUTATHIONE
S-TRANSFERASE-LIKE
PROTEIN)		 2b81 LUCIFERASE-LIKE
MONOOXYGENASE
(Bacillus
cereus) 		3 / 3 LEU A 276
ALA A 275
LEU A 252
 None
 0.52A 5uunB-2b81A:
undetectable		 5uunB-2b81A:
23.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ECE_C_DVAC3010_0
(VLM2
DODECADEPSIPEPTIDE)		 2b81 LUCIFERASE-LIKE
MONOOXYGENASE
(Bacillus
cereus) 		3 / 3 ALA A 227
PHE A 246
GLN A 248
 None
 0.68A 6eceA-2b81A:
undetectable		 6eceA-2b81A:
23.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MDQ_A_TESA605_0
(SERUM ALBUMIN)		 2b81 LUCIFERASE-LIKE
MONOOXYGENASE
(Bacillus
cereus) 		4 / 8 GLY A  54
LEU A 309
GLY A 310
LEU A 314
 None
 0.79A 6mdqA-2b81A:
undetectable		 6mdqA-2b81A:
12.29