SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2b8e'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XDK_B_9CRB600_2
(RETINOIC ACID
RECEPTOR, BETA)		 2b8e CATION-TRANSPORTING
ATPASE
(Archaeoglobus
fulgidus) 		3 / 3 LEU A 429
PHE A 423
ARG A 652
 None
 0.88A 1xdkB-2b8eA:
undetectable		 1xdkB-2b8eA:
23.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BR4_E_SAME301_0
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 2b8e CATION-TRANSPORTING
ATPASE
(Archaeoglobus
fulgidus) 		5 / 12 LEU A 429
GLY A 617
ASP A 647
ASP A 424
ALA A 629
 None
 1.07A 2br4E-2b8eA:
2.6		 2br4E-2b8eA:
22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2O4L_A_TPVA403_1
(PROTEASE)		 2b8e CATION-TRANSPORTING
ATPASE
(Archaeoglobus
fulgidus) 		5 / 12 LEU A 631
ASP A 424
ILE A 571
GLY A 569
VAL A 568
 None
 1.21A 2o4lA-2b8eA:
undetectable		 2o4lA-2b8eA:
15.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OXT_B_SAMB300_0
(NUCLEOSIDE-2'-O-METH
YLTRANSFERASE)		 2b8e CATION-TRANSPORTING
ATPASE
(Archaeoglobus
fulgidus) 		6 / 12 GLY A 646
GLY A 617
GLY A 619
THR A 428
LEU A 429
VAL A 658
 None
 1.00A 2oxtB-2b8eA:
undetectable		 2oxtB-2b8eA:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3C6G_A_VD3A701_2
(CYTOCHROME P450 2R1)		 2b8e CATION-TRANSPORTING
ATPASE
(Archaeoglobus
fulgidus) 		3 / 3 MET A 506
VAL A 532
GLU A 491
 None
 0.86A 3c6gA-2b8eA:
undetectable		 3c6gA-2b8eA:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DH0_A_SAMA220_0
(SAM DEPENDENT
METHYLTRANSFERASE)		 2b8e CATION-TRANSPORTING
ATPASE
(Archaeoglobus
fulgidus) 		5 / 12 VAL A 616
GLY A 617
GLY A 619
THR A 428
LEU A 655
 None
 0.91A 3dh0A-2b8eA:
3.5		 3dh0A-2b8eA:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EQM_A_ASDA601_1
(CYTOCHROME P450 19A1)		 2b8e CATION-TRANSPORTING
ATPASE
(Archaeoglobus
fulgidus) 		5 / 10 ILE A 571
ASP A 424
THR A 428
VAL A 635
LEU A 626
 None
 1.28A 3eqmA-2b8eA:
0.0		 3eqmA-2b8eA:
19.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JW3_B_TOPB208_1
(DIHYDROFOLATE
REDUCTASE)		 2b8e CATION-TRANSPORTING
ATPASE
(Archaeoglobus
fulgidus) 		5 / 9 ALA A 557
VAL A 421
ILE A 648
LEU A 631
ILE A 662
 None
 1.12A 3jw3B-2b8eA:
undetectable		 3jw3B-2b8eA:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S79_A_ASDA601_1
(CYTOCHROME P450 19A1)		 2b8e CATION-TRANSPORTING
ATPASE
(Archaeoglobus
fulgidus) 		5 / 12 ILE A 571
ASP A 424
THR A 428
VAL A 635
LEU A 626
 None
 1.28A 3s79A-2b8eA:
undetectable		 3s79A-2b8eA:
19.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GH8_A_MTXA201_2
(DIHYDROFOLATE
REDUCTASE)		 2b8e CATION-TRANSPORTING
ATPASE
(Archaeoglobus
fulgidus) 		3 / 3 LYS A 529
ILE A 464
THR A 572
 None
 0.88A 4gh8A-2b8eA:
undetectable		 4gh8A-2b8eA:
20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IIZ_A_LURA201_1
(TRANSTHYRETIN)		 2b8e CATION-TRANSPORTING
ATPASE
(Archaeoglobus
fulgidus) 		3 / 3 LYS A 567
LEU A 590
ALA A 420
 None
 0.60A 4iizA-2b8eA:
undetectable		 4iizA-2b8eA:
18.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IK6_A_LURA201_1
(TRANSTHYRETIN)		 2b8e CATION-TRANSPORTING
ATPASE
(Archaeoglobus
fulgidus) 		4 / 4 LYS A 567
LEU A 590
ALA A 420
VAL A 612
 None
 1.23A 4ik6A-2b8eA:
0.0		 4ik6A-2b8eA:
18.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JEC_B_478B401_3
(HIV-1 PROTEASE)		 2b8e CATION-TRANSPORTING
ATPASE
(Archaeoglobus
fulgidus) 		3 / 3 ASP A 496
LEU A 452
VAL A 469
 None
 0.69A 4jecB-2b8eA:
undetectable		 4jecB-2b8eA:
15.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KQ8_A_ASDA602_1
(CYTOCHROME P450 19A1)		 2b8e CATION-TRANSPORTING
ATPASE
(Archaeoglobus
fulgidus) 		5 / 10 ILE A 571
ASP A 424
THR A 428
VAL A 635
LEU A 626
 None
 1.36A 4kq8A-2b8eA:
0.0		 4kq8A-2b8eA:
20.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LL3_A_017A201_1
(PROTEASE)		 2b8e CATION-TRANSPORTING
ATPASE
(Archaeoglobus
fulgidus) 		5 / 8 ALA A 531
ASP A 438
VAL A 440
VAL A 517
ILE A 543
 None
 1.35A 4ll3A-2b8eA:
undetectable		 4ll3A-2b8eA:
14.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M11_D_MXMD606_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 2b8e CATION-TRANSPORTING
ATPASE
(Archaeoglobus
fulgidus) 		5 / 12 VAL A 658
ILE A 566
VAL A 568
LEU A 588
LEU A 561
 None
 1.47A 4m11D-2b8eA:
undetectable		 4m11D-2b8eA:
16.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P65_C_IPHC101_0
(INSULIN)		 2b8e CATION-TRANSPORTING
ATPASE
(Archaeoglobus
fulgidus) 		5 / 11 LEU A 429
LEU A 655
ALA A 554
LEU A 586
VAL A 421
 None
 1.12A 4p65C-2b8eA:
undetectable
4p65D-2b8eA:
undetectable
4p65J-2b8eA:
undetectable
4p65L-2b8eA:
undetectable		 4p65C-2b8eA:
8.70
4p65D-2b8eA:
8.13
4p65J-2b8eA:
8.13
4p65L-2b8eA:
8.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P65_C_IPHC101_0
(INSULIN)		 2b8e CATION-TRANSPORTING
ATPASE
(Archaeoglobus
fulgidus) 		5 / 11 LEU A 655
ALA A 554
LEU A 586
VAL A 421
LEU A 561
 None
 0.96A 4p65C-2b8eA:
undetectable
4p65D-2b8eA:
undetectable
4p65J-2b8eA:
undetectable
4p65L-2b8eA:
undetectable		 4p65C-2b8eA:
8.70
4p65D-2b8eA:
8.13
4p65J-2b8eA:
8.13
4p65L-2b8eA:
8.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P65_G_IPHG101_0
(INSULIN)		 2b8e CATION-TRANSPORTING
ATPASE
(Archaeoglobus
fulgidus) 		5 / 11 LEU A 586
LEU A 561
LEU A 429
LEU A 655
ALA A 554
 None
 1.16A 4p65B-2b8eA:
undetectable
4p65D-2b8eA:
undetectable
4p65G-2b8eA:
undetectable
4p65H-2b8eA:
undetectable		 4p65B-2b8eA:
8.13
4p65D-2b8eA:
8.13
4p65G-2b8eA:
8.70
4p65H-2b8eA:
8.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P65_G_IPHG101_0
(INSULIN)		 2b8e CATION-TRANSPORTING
ATPASE
(Archaeoglobus
fulgidus) 		5 / 11 LEU A 586
VAL A 421
LEU A 561
LEU A 429
ALA A 554
 None
 1.00A 4p65B-2b8eA:
undetectable
4p65D-2b8eA:
undetectable
4p65G-2b8eA:
undetectable
4p65H-2b8eA:
undetectable		 4p65B-2b8eA:
8.13
4p65D-2b8eA:
8.13
4p65G-2b8eA:
8.70
4p65H-2b8eA:
8.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P65_I_IPHI101_0
(INSULIN)		 2b8e CATION-TRANSPORTING
ATPASE
(Archaeoglobus
fulgidus) 		5 / 12 VAL A 421
LEU A 561
LEU A 586
LEU A 429
ALA A 554
 None
 0.94A 4p65B-2b8eA:
undetectable
4p65D-2b8eA:
undetectable
4p65I-2b8eA:
undetectable
4p65J-2b8eA:
undetectable		 4p65B-2b8eA:
8.13
4p65D-2b8eA:
8.13
4p65I-2b8eA:
8.70
4p65J-2b8eA:
8.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P65_K_IPHK101_0
(INSULIN)		 2b8e CATION-TRANSPORTING
ATPASE
(Archaeoglobus
fulgidus) 		5 / 12 LEU A 586
VAL A 421
LEU A 561
LEU A 429
ALA A 554
 None
 1.00A 4p65F-2b8eA:
undetectable
4p65H-2b8eA:
undetectable
4p65K-2b8eA:
undetectable
4p65L-2b8eA:
undetectable		 4p65F-2b8eA:
8.13
4p65H-2b8eA:
8.13
4p65K-2b8eA:
8.70
4p65L-2b8eA:
8.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V1F_B_BQ1B1087_0
(F0F1 ATP SYNTHASE
SUBUNIT C)		 2b8e CATION-TRANSPORTING
ATPASE
(Archaeoglobus
fulgidus) 		5 / 8 ALA A 531
ALA A 545
ILE A 543
ALA A 454
LEU A 449
 None
 1.44A 4v1fA-2b8eA:
undetectable
4v1fB-2b8eA:
undetectable		 4v1fA-2b8eA:
16.91
4v1fB-2b8eA:
16.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JL7_A_ASDA601_1
(AROMATASE)		 2b8e CATION-TRANSPORTING
ATPASE
(Archaeoglobus
fulgidus) 		5 / 10 ILE A 571
ASP A 424
THR A 428
VAL A 635
LEU A 626
 None
 1.35A 5jl7A-2b8eA:
0.0		 5jl7A-2b8eA:
19.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JL9_A_ASDA601_1
(AROMATASE)		 2b8e CATION-TRANSPORTING
ATPASE
(Archaeoglobus
fulgidus) 		5 / 9 ILE A 571
ASP A 424
THR A 428
VAL A 635
LEU A 626
 None
 1.35A 5jl9A-2b8eA:
0.0		 5jl9A-2b8eA:
19.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MB5_A_NMYA301_0
(AAC(3)-IIIB PROTEIN)		 2b8e CATION-TRANSPORTING
ATPASE
(Archaeoglobus
fulgidus) 		5 / 11 ASP A 622
ASP A 574
THR A 572
THR A 428
GLY A 427
 None
 1.34A 6mb5A-2b8eA:
undetectable		 6mb5A-2b8eA:
16.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MB9_C_NMYC302_0
(AAC(3)-IIIB PROTEIN)		 2b8e CATION-TRANSPORTING
ATPASE
(Archaeoglobus
fulgidus) 		5 / 10 ASP A 622
ASP A 574
THR A 572
THR A 428
GLY A 427
 None
 1.34A 6mb9C-2b8eA:
0.0		 6mb9C-2b8eA:
16.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MB9_D_NMYD302_0
(AAC(3)-IIIB PROTEIN)		 2b8e CATION-TRANSPORTING
ATPASE
(Archaeoglobus
fulgidus) 		5 / 10 ASP A 622
ASP A 574
THR A 572
THR A 428
GLY A 427
 None
 1.35A 6mb9D-2b8eA:
undetectable		 6mb9D-2b8eA:
16.47