SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2b8n'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HK1_A_T44A3004_1
(SERUM ALBUMIN)		 2b8n GLYCERATE KINASE,
PUTATIVE
(Thermotoga
maritima) 		4 / 6 PHE A 267
LEU A 307
VAL A 294
MET A 291
 None
 0.97A 1hk1A-2b8nA:
undetectable		 1hk1A-2b8nA:
23.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HK3_A_T44A3004_1
(SERUM ALBUMIN)		 2b8n GLYCERATE KINASE,
PUTATIVE
(Thermotoga
maritima) 		4 / 7 PHE A 267
LEU A 307
VAL A 294
MET A 291
 None
 1.02A 1hk3A-2b8nA:
undetectable		 1hk3A-2b8nA:
23.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MZ9_D_VDYD1001_5
(CARTILAGE OLIGOMERIC
MATRIX PROTEIN)		 2b8n GLYCERATE KINASE,
PUTATIVE
(Thermotoga
maritima) 		3 / 3 THR A 101
LEU A 105
VAL A 108
 None
 0.61A 1mz9E-2b8nA:
undetectable		 1mz9E-2b8nA:
8.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA3_A_STRA1001_1
(MINERALOCORTICOID
RECEPTOR)		 2b8n GLYCERATE KINASE,
PUTATIVE
(Thermotoga
maritima) 		5 / 12 LEU A 329
ASN A 326
LEU A 399
ALA A 360
THR A 313
 None
 1.30A 1ya3A-2b8nA:
undetectable		 1ya3A-2b8nA:
20.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AA5_B_STRB302_1
(MINERALOCORTICOID
RECEPTOR)		 2b8n GLYCERATE KINASE,
PUTATIVE
(Thermotoga
maritima) 		5 / 12 LEU A 329
ASN A 326
LEU A 399
ALA A 360
THR A 313
 None
 1.31A 2aa5B-2b8nA:
undetectable		 2aa5B-2b8nA:
20.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2H77_A_T3A1_1
(THRA PROTEIN)		 2b8n GLYCERATE KINASE,
PUTATIVE
(Thermotoga
maritima) 		5 / 12 ALA A 397
ALA A 369
SER A 395
LEU A 383
ILE A 335
 None
 1.16A 2h77A-2b8nA:
undetectable		 2h77A-2b8nA:
21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HRE_D_CHDD702_0
(FERROCHELATASE)		 2b8n GLYCERATE KINASE,
PUTATIVE
(Thermotoga
maritima) 		3 / 3 ARG A 325
GLY A 355
PRO A 356
 None
 0.74A 2hreD-2b8nA:
undetectable		 2hreD-2b8nA:
20.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VCV_F_ASDF1224_1
(GLUTATHIONE
S-TRANSFERASE A3)		 2b8n GLYCERATE KINASE,
PUTATIVE
(Thermotoga
maritima) 		4 / 8 LEU A 383
PRO A 379
ALA A 369
ALA A 397
 None
 0.90A 2vcvF-2b8nA:
undetectable		 2vcvF-2b8nA:
19.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A50_C_VD3C2001_1
(VITAMIN D
HYDROXYLASE)		 2b8n GLYCERATE KINASE,
PUTATIVE
(Thermotoga
maritima) 		5 / 11 LEU A 399
LEU A 345
ILE A 363
THR A 368
LEU A 392
 None
 1.24A 3a50C-2b8nA:
undetectable		 3a50C-2b8nA:
23.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A50_E_VD3E2001_1
(VITAMIN D
HYDROXYLASE)		 2b8n GLYCERATE KINASE,
PUTATIVE
(Thermotoga
maritima) 		5 / 12 LEU A 399
LEU A 345
ILE A 363
THR A 368
LEU A 392
 None
 1.21A 3a50E-2b8nA:
undetectable		 3a50E-2b8nA:
23.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EEY_A_SAMA300_0
(PUTATIVE RRNA
METHYLASE)		 2b8n GLYCERATE KINASE,
PUTATIVE
(Thermotoga
maritima) 		5 / 12 GLY A 362
ILE A 400
GLY A 402
LEU A 392
THR A 357
 None
 1.09A 3eeyA-2b8nA:
4.0		 3eeyA-2b8nA:
17.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EEY_B_SAMB300_0
(PUTATIVE RRNA
METHYLASE)		 2b8n GLYCERATE KINASE,
PUTATIVE
(Thermotoga
maritima) 		5 / 12 GLY A 362
ILE A 400
GLY A 402
LEU A 392
THR A 357
 None
 1.09A 3eeyB-2b8nA:
4.0		 3eeyB-2b8nA:
17.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EEY_C_SAMC300_0
(PUTATIVE RRNA
METHYLASE)		 2b8n GLYCERATE KINASE,
PUTATIVE
(Thermotoga
maritima) 		5 / 12 GLY A 362
ILE A 400
GLY A 402
LEU A 392
THR A 357
 None
 1.12A 3eeyC-2b8nA:
4.1		 3eeyC-2b8nA:
17.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EEY_E_SAME300_0
(PUTATIVE RRNA
METHYLASE)		 2b8n GLYCERATE KINASE,
PUTATIVE
(Thermotoga
maritima) 		5 / 12 GLY A 362
ILE A 400
GLY A 402
LEU A 392
THR A 357
 None
 0.96A 3eeyE-2b8nA:
3.9		 3eeyE-2b8nA:
17.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EEY_F_SAMF300_0
(PUTATIVE RRNA
METHYLASE)		 2b8n GLYCERATE KINASE,
PUTATIVE
(Thermotoga
maritima) 		5 / 12 GLY A 362
ILE A 400
GLY A 402
LEU A 392
THR A 357
 None
 0.86A 3eeyF-2b8nA:
4.0		 3eeyF-2b8nA:
17.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EEY_H_SAMH300_0
(PUTATIVE RRNA
METHYLASE)		 2b8n GLYCERATE KINASE,
PUTATIVE
(Thermotoga
maritima) 		5 / 12 GLY A 362
ILE A 400
GLY A 402
LEU A 392
THR A 357
 None
 1.19A 3eeyH-2b8nA:
4.0		 3eeyH-2b8nA:
17.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EEY_I_SAMI300_0
(PUTATIVE RRNA
METHYLASE)		 2b8n GLYCERATE KINASE,
PUTATIVE
(Thermotoga
maritima) 		5 / 12 GLY A 362
ILE A 400
GLY A 402
LEU A 392
THR A 357
 None
 1.11A 3eeyI-2b8nA:
3.5		 3eeyI-2b8nA:
17.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EEY_J_SAMJ300_0
(PUTATIVE RRNA
METHYLASE)		 2b8n GLYCERATE KINASE,
PUTATIVE
(Thermotoga
maritima) 		5 / 12 GLY A 362
ILE A 400
GLY A 402
LEU A 392
THR A 357
 None
 1.01A 3eeyJ-2b8nA:
3.2		 3eeyJ-2b8nA:
17.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BBO_C_ACTC1113_0
(BLR5658 PROTEIN)		 2b8n GLYCERATE KINASE,
PUTATIVE
(Thermotoga
maritima) 		4 / 4 ASN A 326
ALA A 348
GLY A 349
THR A 350
 None
 1.21A 4bboC-2b8nA:
undetectable		 4bboC-2b8nA:
13.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IAQ_A_2GMA2001_1
(CHIMERA PROTEIN OF
HUMAN
5-HYDROXYTRYPTAMINE
RECEPTOR 1B AND E.
COLI SOLUBLE
CYTOCHROME B562)		 2b8n GLYCERATE KINASE,
PUTATIVE
(Thermotoga
maritima) 		5 / 12 LEU A  42
ALA A 180
PHE A 173
LEU A 128
PHE A 129
 None
 1.18A 4iaqA-2b8nA:
undetectable		 4iaqA-2b8nA:
21.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LNX_A_T3A502_1
(THYROID HORMONE
RECEPTOR ALPHA)		 2b8n GLYCERATE KINASE,
PUTATIVE
(Thermotoga
maritima) 		5 / 12 ALA A 397
ALA A 369
SER A 395
LEU A 383
ILE A 335
 None
 1.15A 4lnxA-2b8nA:
undetectable		 4lnxA-2b8nA:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OKW_A_198A1001_1
(ANDROGEN RECEPTOR)		 2b8n GLYCERATE KINASE,
PUTATIVE
(Thermotoga
maritima) 		5 / 12 LEU A 276
GLY A 310
THR A 350
ILE A  19
VAL A  22
 None
 1.29A 4okwA-2b8nA:
undetectable		 4okwA-2b8nA:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PST_A_FOLA201_1
(DIHYDROFOLATE
REDUCTASE)		 2b8n GLYCERATE KINASE,
PUTATIVE
(Thermotoga
maritima) 		3 / 3 ILE A 335
ASP A 378
ARG A 281
 None
 0.60A 4pstA-2b8nA:
undetectable		 4pstA-2b8nA:
14.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R20_B_AERB602_1
(CYTOCHROME P450
FAMILY 17
POLYPEPTIDE 2)		 2b8n GLYCERATE KINASE,
PUTATIVE
(Thermotoga
maritima) 		5 / 9 ASN A 326
ILE A 412
GLY A 349
THR A 401
VAL A  15
 None
 1.27A 4r20B-2b8nA:
undetectable		 4r20B-2b8nA:
21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XO7_A_ASDA402_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C2)		 2b8n GLYCERATE KINASE,
PUTATIVE
(Thermotoga
maritima) 		4 / 7 VAL A 177
HIS A 246
LEU A  35
LEU A  37
 None
 1.02A 4xo7A-2b8nA:
undetectable		 4xo7A-2b8nA:
24.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZBR_A_NPSA603_1
(SERUM ALBUMIN)		 2b8n GLYCERATE KINASE,
PUTATIVE
(Thermotoga
maritima) 		5 / 10 ALA A  27
LEU A  32
ALA A  55
SER A 122
ALA A  48
 None
 1.21A 4zbrA-2b8nA:
undetectable		 4zbrA-2b8nA:
22.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HWA_A_GCSA303_1
(CHITOSANASE)		 2b8n GLYCERATE KINASE,
PUTATIVE
(Thermotoga
maritima) 		4 / 5 HIS A 239
VAL A 243
GLY A 171
ALA A 174
 None
 1.04A 5hwaA-2b8nA:
undetectable		 5hwaA-2b8nA:
21.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XXI_A_LSNA501_1
(CYTOCHROME P450 2C9)		 2b8n GLYCERATE KINASE,
PUTATIVE
(Thermotoga
maritima) 		5 / 12 VAL A  15
ASN A 409
GLY A 349
ALA A 348
LEU A 345
 None
 1.07A 5xxiA-2b8nA:
undetectable		 5xxiA-2b8nA:
22.29