SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2b8t'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RG7_A_MTXA161_2
(DIHYDROFOLATE
REDUCTASE)		 2b8t THYMIDINE KINASE
(Ureaplasma
parvum) 		3 / 3 ILE A 121
ILE A  14
THR A  18
 None
 0.59A 1rg7A-2b8tA:
undetectable		 1rg7A-2b8tA:
23.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W9S_C_TOPC1160_1
(DIHYDROFOLATE
REDUCTASE TYPE 1
FROM TN4003)		 2b8t THYMIDINE KINASE
(Ureaplasma
parvum) 		5 / 10 ILE A  77
ALA A 109
LEU A 139
ILE A  95
PHE A 101
 None
 1.17A 2w9sC-2b8tA:
undetectable		 2w9sC-2b8tA:
19.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FPJ_B_SAMB301_0
(PUTATIVE
UNCHARACTERIZED
PROTEIN)		 2b8t THYMIDINE KINASE
(Ureaplasma
parvum) 		5 / 12 PHE A 117
VAL A 118
ILE A  95
LEU A  44
VAL A  41
 None
 1.25A 3fpjB-2b8tA:
3.1		 3fpjB-2b8tA:
21.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S56_A_ROCA201_1
(PROTEASE)		 2b8t THYMIDINE KINASE
(Ureaplasma
parvum) 		5 / 12 ALA A 143
ASP A 144
ILE A  95
THR A  18
ILE A 136
 None
 1.05A 3s56A-2b8tA:
undetectable		 3s56A-2b8tA:
19.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EYR_B_RITB301_1
(HIV-1 PROTEASE)		 2b8t THYMIDINE KINASE
(Ureaplasma
parvum) 		4 / 7 ALA A 143
ASP A 144
ILE A  93
THR A  18
 None
 0.77A 4eyrA-2b8tA:
undetectable		 4eyrA-2b8tA:
18.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UIL_H_QI9H1223_0
(FAB 314.1)		 2b8t THYMIDINE KINASE
(Ureaplasma
parvum) 		5 / 12 ALA A  74
GLY A  94
GLN A  99
GLY A 123
LEU A 139
 None
 1.28A 4uilH-2b8tA:
undetectable
4uilL-2b8tA:
undetectable		 4uilH-2b8tA:
20.91
4uilL-2b8tA:
19.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DWD_D_GLYD713_0
(DEOXYNUCLEOSIDE
TRIPHOSPHATE
TRIPHOSPHOHYDROLASE
SAMHD1)		 2b8t THYMIDINE KINASE
(Ureaplasma
parvum) 		3 / 3 ARG A 192
HIS A 195
ARG A 200
 None
 1.19A 6dwdD-2b8tA:
undetectable		 6dwdD-2b8tA:
18.80