SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2b92'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

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	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1Z95_A_198A501_2 (ANDROGEN RECEPTOR)	2b92	INTERFERON-INDUCED GUANYLATE-BINDING PROTEIN 1 (Homo sapiens)	4 / 6	ASN A 302 LEU A 118 LEU A 296 ILE A 14	ASN A 302 ( 0.6A) LEU A 118 ( 0.5A) LEU A 296 ( 0.5A) ILE A 14 ( 0.6A)	0.96A	1z95A-2b92A: undetectable	1z95A-2b92A: 21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2BXK_A_IMNA2001_1 (SERUM ALBUMIN)	2b92	INTERFERON-INDUCED GUANYLATE-BINDING PROTEIN 1 (Homo sapiens)	4 / 8	SER A 305 ALA A 117 LEU A 148 ASP A 108	SER A 305 ( 0.0A) ALA A 117 ( 0.0A) LEU A 148 ( 0.6A) ASP A 108 ( 0.6A)	1.08A	2bxkA-2b92A: undetectable	2bxkA-2b92A: 20.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3DZG_B_NCAB302_0 (ADP-RIBOSYL CYCLASE 1)	2b92	INTERFERON-INDUCED GUANYLATE-BINDING PROTEIN 1 (Homo sapiens)	4 / 7	LEU A 67 GLU A 251 SER A 52 THR A 75	LEU A 67 (-0.6A) GLU A 251 ( 0.6A) SER A 52 ( 0.0A) THR A 75 ( 0.8A)	1.32A	3dzgB-2b92A: undetectable	3dzgB-2b92A: 21.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3I9J_B_NCAB302_0 (ADP-RIBOSYL CYCLASE)	2b92	INTERFERON-INDUCED GUANYLATE-BINDING PROTEIN 1 (Homo sapiens)	4 / 6	LEU A 67 GLU A 251 SER A 52 PHE A 65	LEU A 67 (-0.6A) GLU A 251 ( 0.6A) SER A 52 ( 0.0A) PHE A 65 ( 1.3A)	1.28A	3i9jB-2b92A: 3.2	3i9jB-2b92A: 21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3ROP_A_NCAA302_0 (ADP-RIBOSYL CYCLASE 1)	2b92	INTERFERON-INDUCED GUANYLATE-BINDING PROTEIN 1 (Homo sapiens)	4 / 6	LEU A 67 GLU A 251 SER A 52 THR A 75	LEU A 67 (-0.6A) GLU A 251 ( 0.6A) SER A 52 ( 0.0A) THR A 75 ( 0.8A)	1.40A	3ropA-2b92A: 4.0	3ropA-2b92A: 21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4C9N_A_CAMA1419_0 (CYTOCHROME P450)	2b92	INTERFERON-INDUCED GUANYLATE-BINDING PROTEIN 1 (Homo sapiens)	4 / 8	TYR A 128 LEU A 46 LEU A 101 GLY A 102	TYR A 128 ( 1.3A) LEU A 46 ( 0.5A) LEU A 101 ( 0.6A) GLY A 102 ( 0.0A)	0.82A	4c9nA-2b92A: undetectable	4c9nA-2b92A: 21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4MM4_B_8PRB603_2 (TRANSPORTER)	2b92	INTERFERON-INDUCED GUANYLATE-BINDING PROTEIN 1 (Homo sapiens)	3 / 3	SER A 52 MET A 55 ASP A 184	SER A 52 ( 0.0A) MET A 55 ( 0.0A) ASP A 184 (-0.6A)	0.96A	4mm4B-2b92A: 0.0	4mm4B-2b92A: 21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4U15_A_0HKA2001_2 (MUSCARINIC ACETYLCHOLINE RECEPTOR M3,LYSOZYME,MUSCARIN IC ACETYLCHOLINE RECEPTOR M3)	2b92	INTERFERON-INDUCED GUANYLATE-BINDING PROTEIN 1 (Homo sapiens)	3 / 3	ASN A 111 PHE A 116 TYR A 144	ASN A 111 ( 0.6A) PHE A 116 ( 1.3A) TYR A 144 ( 1.3A)	0.58A	4u15A-2b92A: undetectable	4u15A-2b92A: 21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5NM5_B_LOCB502_2 (TUBULIN BETA-2B CHAIN)	2b92	INTERFERON-INDUCED GUANYLATE-BINDING PROTEIN 1 (Homo sapiens)	5 / 12	LEU A 13 MET A 38 ILE A 30 ALA A 27 ILE A 34	LEU A 13 ( 0.6A) MET A 38 ( 0.0A) ILE A 30 ( 0.6A) ALA A 27 ( 0.0A) ILE A 34 ( 0.6A)	1.33A	5nm5B-2b92A: undetectable	5nm5B-2b92A: 20.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5NWU_A_ACAA18_1 (WTFP-TAG,GP41)	2b92	INTERFERON-INDUCED GUANYLATE-BINDING PROTEIN 1 (Homo sapiens)	5 / 12	ALA A 59 GLY A 60 GLN A 254 GLU A 257 GLU A 256	ALA A 59 ( 0.0A) GLY A 60 ( 0.0A) GLN A 254 ( 0.6A) GLU A 257 ( 0.6A) GLU A 256 ( 0.6A)	1.13A	5nwuA-2b92A: undetectable	5nwuA-2b92A: 7.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5UC3_A_486A801_2 (GLUCOCORTICOID RECEPTOR)	2b92	INTERFERON-INDUCED GUANYLATE-BINDING PROTEIN 1 (Homo sapiens)	4 / 5	LEU A 208 LEU A 224 MET A 139 TYR A 204	LEU A 208 ( 0.6A) LEU A 224 ( 0.6A) MET A 139 ( 0.0A) TYR A 204 ( 1.3A)	1.44A	5uc3A-2b92A: undetectable	5uc3A-2b92A: 13.03

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["1Z95_A_198A501_2","ANDROGEN RECEPTOR","2b92","INTERFERON-INDUCED GUANYLATE-BINDING PROTEIN 1","Homo sapiens",4,"ASN A 302;LEU A 118;LEU A 296;ILE A  14","ASN A 302 ( 0.6A);LEU A 118 ( 0.5A);LEU A 296 ( 0.5A);ILE A  14 ( 0.6A)","0.96A","1z95A-2b92A:undetectable","1z95A-2b92A:21.43"],["2BXK_A_IMNA2001_1","SERUM ALBUMIN","2b92","INTERFERON-INDUCED GUANYLATE-BINDING PROTEIN 1","Homo sapiens",4,"SER A 305;ALA A 117;LEU A 148;ASP A 108","SER A 305 ( 0.0A);ALA A 117 ( 0.0A);LEU A 148 ( 0.6A);ASP A 108 ( 0.6A)","1.08A","2bxkA-2b92A:undetectable","2bxkA-2b92A:20.78"],["3DZG_B_NCAB302_0","ADP-RIBOSYL CYCLASE 1","2b92","INTERFERON-INDUCED GUANYLATE-BINDING PROTEIN 1","Homo sapiens",4,"LEU A  67;GLU A 251;SER A  52;THR A  75","LEU A  67 (-0.6A);GLU A 251 ( 0.6A);SER A  52 ( 0.0A);THR A  75 ( 0.8A)","1.32A","3dzgB-2b92A:undetectable","3dzgB-2b92A:21.53"],["3I9J_B_NCAB302_0","ADP-RIBOSYL CYCLASE","2b92","INTERFERON-INDUCED GUANYLATE-BINDING PROTEIN 1","Homo sapiens",4,"LEU A  67;GLU A 251;SER A  52;PHE A  65","LEU A  67 (-0.6A);GLU A 251 ( 0.6A);SER A  52 ( 0.0A);PHE A  65 ( 1.3A)","1.28A","3i9jB-2b92A:3.2","3i9jB-2b92A:21.66"],["3ROP_A_NCAA302_0","ADP-RIBOSYL CYCLASE 1","2b92","INTERFERON-INDUCED GUANYLATE-BINDING PROTEIN 1","Homo sapiens",4,"LEU A  67;GLU A 251;SER A  52;THR A  75","LEU A  67 (-0.6A);GLU A 251 ( 0.6A);SER A  52 ( 0.0A);THR A  75 ( 0.8A)","1.40A","3ropA-2b92A:4.0","3ropA-2b92A:21.07"],["4C9N_A_CAMA1419_0","CYTOCHROME P450","2b92","INTERFERON-INDUCED GUANYLATE-BINDING PROTEIN 1","Homo sapiens",4,"TYR A 128;LEU A  46;LEU A 101;GLY A 102","TYR A 128 ( 1.3A);LEU A  46 ( 0.5A);LEU A 101 ( 0.6A);GLY A 102 ( 0.0A)","0.82A","4c9nA-2b92A:undetectable","4c9nA-2b92A:21.65"],["4MM4_B_8PRB603_2","TRANSPORTER","2b92","INTERFERON-INDUCED GUANYLATE-BINDING PROTEIN 1","Homo sapiens",3,"SER A  52;MET A  55;ASP A 184","SER A  52 ( 0.0A);MET A  55 ( 0.0A);ASP A 184 (-0.6A)","0.96A","4mm4B-2b92A:0.0","4mm4B-2b92A:21.31"],["4U15_A_0HKA2001_2","MUSCARINIC ACETYLCHOLINE RECEPTOR M3,LYSOZYME,MUSCARINIC ACETYLCHOLINE RECEPTOR M3","2b92","INTERFERON-INDUCED GUANYLATE-BINDING PROTEIN 1","Homo sapiens",3,"ASN A 111;PHE A 116;TYR A 144","ASN A 111 ( 0.6A);PHE A 116 ( 1.3A);TYR A 144 ( 1.3A)","0.58A","4u15A-2b92A:undetectable","4u15A-2b92A:21.11"],["5NM5_B_LOCB502_2","TUBULIN BETA-2B CHAIN","2b92","INTERFERON-INDUCED GUANYLATE-BINDING PROTEIN 1","Homo sapiens",5,"LEU A  13;MET A  38;ILE A  30;ALA A  27;ILE A  34","LEU A  13 ( 0.6A);MET A  38 ( 0.0A);ILE A  30 ( 0.6A);ALA A  27 ( 0.0A);ILE A  34 ( 0.6A)","1.33A","5nm5B-2b92A:undetectable","5nm5B-2b92A:20.76"],["5NWU_A_ACAA18_1","WTFP-TAG,GP41","2b92","INTERFERON-INDUCED GUANYLATE-BINDING PROTEIN 1","Homo sapiens",5,"ALA A  59;GLY A  60;GLN A 254;GLU A 257;GLU A 256","ALA A  59 ( 0.0A);GLY A  60 ( 0.0A);GLN A 254 ( 0.6A);GLU A 257 ( 0.6A);GLU A 256 ( 0.6A)","1.13A","5nwuA-2b92A:undetectable","5nwuA-2b92A:7.59"],["5UC3_A_486A801_2","GLUCOCORTICOID RECEPTOR","2b92","INTERFERON-INDUCED GUANYLATE-BINDING PROTEIN 1","Homo sapiens",4,"LEU A 208;LEU A 224;MET A 139;TYR A 204","LEU A 208 ( 0.6A);LEU A 224 ( 0.6A);MET A 139 ( 0.0A);TYR A 204 ( 1.3A)","1.44A","5uc3A-2b92A:undetectable","5uc3A-2b92A:13.03"]]