SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2b9e'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EIZ_A_SAMA301_1
(FTSJ)		 2b9e NOL1/NOP2/SUN DOMAIN
FAMILY, MEMBER 5
ISOFORM 2
(Homo
sapiens) 		3 / 3 ASP A 258
ASP A 285
ASP A 305
 SAM  A1201 (-2.6A)
SAM  A1201 (-3.6A)
SAM  A1201 (-3.7A)
 0.59A 1eizA-2b9eA:
11.9		 1eizA-2b9eA:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EJ0_A_SAMA301_1
(FTSJ)		 2b9e NOL1/NOP2/SUN DOMAIN
FAMILY, MEMBER 5
ISOFORM 2
(Homo
sapiens) 		3 / 3 ASP A 258
ASP A 285
ASP A 305
 SAM  A1201 (-2.6A)
SAM  A1201 (-3.6A)
SAM  A1201 (-3.7A)
 0.65A 1ej0A-2b9eA:
13.2		 1ej0A-2b9eA:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SQF_A_SAMA430_0
(SUN PROTEIN)		 2b9e NOL1/NOP2/SUN DOMAIN
FAMILY, MEMBER 5
ISOFORM 2
(Homo
sapiens) 		6 / 12 CYH A 234
ALA A 236
GLY A 238
LYS A 240
ASP A 260
ASP A 285
 SAM  A1201 (-3.8A)
SAM  A1201 (-4.1A)
SAM  A1201 (-3.9A)
SAM  A1201 (-3.1A)
None
SAM  A1201 (-3.6A)
 0.78A 1sqfA-2b9eA:
26.7		 1sqfA-2b9eA:
24.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SQF_A_SAMA430_1
(SUN PROTEIN)		 2b9e NOL1/NOP2/SUN DOMAIN
FAMILY, MEMBER 5
ISOFORM 2
(Homo
sapiens) 		3 / 3 PRO A 237
ASP A 258
ASP A 305
 SAM  A1201 (-3.7A)
SAM  A1201 (-2.6A)
SAM  A1201 (-3.7A)
 0.41A 1sqfA-2b9eA:
26.7		 1sqfA-2b9eA:
24.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XWF_D_ADND433_2
(ADENOSYLHOMOCYSTEINA
SE)		 2b9e NOL1/NOP2/SUN DOMAIN
FAMILY, MEMBER 5
ISOFORM 2
(Homo
sapiens) 		3 / 3 THR A 358
GLU A 367
HIS A 392
 None
 0.90A 1xwfD-2b9eA:
undetectable		 1xwfD-2b9eA:
17.93
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2B9E_A_SAMA1201_0
(NOL1/NOP2/SUN DOMAIN
FAMILY, MEMBER 5
ISOFORM 2)		 2b9e NOL1/NOP2/SUN DOMAIN
FAMILY, MEMBER 5
ISOFORM 2
(Homo
sapiens) 		12 / 12 CYH A 234
PRO A 237
GLY A 238
ASN A 239
LYS A 240
LEU A 259
ASP A 260
ARG A 263
ASP A 285
PHE A 286
SER A 307
PHE A 337
 SAM  A1201 (-3.8A)
SAM  A1201 (-3.7A)
SAM  A1201 (-3.9A)
SAM  A1201 (-4.4A)
SAM  A1201 (-3.1A)
SAM  A1201 (-4.5A)
None
SAM  A1201 (-3.9A)
SAM  A1201 (-3.6A)
None
SAM  A1201 (-3.6A)
SAM  A1201 (-4.2A)
 0.02A 2b9eA-2b9eA:
50.8		 2b9eA-2b9eA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXG_A_IBPA2002_1
(SERUM ALBUMIN)		 2b9e NOL1/NOP2/SUN DOMAIN
FAMILY, MEMBER 5
ISOFORM 2
(Homo
sapiens) 		4 / 8 ARG A 382
ALA A 386
LEU A 354
VAL A 355
 None
 0.89A 2bxgA-2b9eA:
undetectable		 2bxgA-2b9eA:
20.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IGT_B_SAMB1002_1
(SAM DEPENDENT
METHYLTRANSFERASE)		 2b9e NOL1/NOP2/SUN DOMAIN
FAMILY, MEMBER 5
ISOFORM 2
(Homo
sapiens) 		3 / 3 ASP A 258
ASP A 285
ASP A 305
 SAM  A1201 (-2.6A)
SAM  A1201 (-3.6A)
SAM  A1201 (-3.7A)
 0.69A 2igtB-2b9eA:
15.0		 2igtB-2b9eA:
23.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NYU_A_SAMA201_1
(PUTATIVE RIBOSOMAL
RNA
METHYLTRANSFERASE 2)		 2b9e NOL1/NOP2/SUN DOMAIN
FAMILY, MEMBER 5
ISOFORM 2
(Homo
sapiens) 		4 / 4 PRO A 237
ASP A 258
ASP A 285
ASP A 232
 SAM  A1201 (-3.7A)
SAM  A1201 (-2.6A)
SAM  A1201 (-3.6A)
SAM  A1201 ( 4.4A)
 0.95A 2nyuA-2b9eA:
12.5		 2nyuA-2b9eA:
23.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NYU_A_SAMA201_1
(PUTATIVE RIBOSOMAL
RNA
METHYLTRANSFERASE 2)		 2b9e NOL1/NOP2/SUN DOMAIN
FAMILY, MEMBER 5
ISOFORM 2
(Homo
sapiens) 		4 / 4 PRO A 237
ASP A 258
ASP A 285
ASP A 305
 SAM  A1201 (-3.7A)
SAM  A1201 (-2.6A)
SAM  A1201 (-3.6A)
SAM  A1201 (-3.7A)
 0.45A 2nyuA-2b9eA:
12.5		 2nyuA-2b9eA:
23.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NYU_B_SAMB201_1
(PUTATIVE RIBOSOMAL
RNA
METHYLTRANSFERASE 2)		 2b9e NOL1/NOP2/SUN DOMAIN
FAMILY, MEMBER 5
ISOFORM 2
(Homo
sapiens) 		4 / 5 PRO A 237
ASP A 258
ASP A 285
ASP A 232
 SAM  A1201 (-3.7A)
SAM  A1201 (-2.6A)
SAM  A1201 (-3.6A)
SAM  A1201 ( 4.4A)
 1.02A 2nyuB-2b9eA:
11.8		 2nyuB-2b9eA:
23.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NYU_B_SAMB201_1
(PUTATIVE RIBOSOMAL
RNA
METHYLTRANSFERASE 2)		 2b9e NOL1/NOP2/SUN DOMAIN
FAMILY, MEMBER 5
ISOFORM 2
(Homo
sapiens) 		4 / 5 PRO A 237
ASP A 258
ASP A 285
ASP A 305
 SAM  A1201 (-3.7A)
SAM  A1201 (-2.6A)
SAM  A1201 (-3.6A)
SAM  A1201 (-3.7A)
 0.39A 2nyuB-2b9eA:
11.8		 2nyuB-2b9eA:
23.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DOU_A_SAMA1_1
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE J)		 2b9e NOL1/NOP2/SUN DOMAIN
FAMILY, MEMBER 5
ISOFORM 2
(Homo
sapiens) 		3 / 3 ASP A 258
ASP A 285
ASP A 305
 SAM  A1201 (-2.6A)
SAM  A1201 (-3.6A)
SAM  A1201 (-3.7A)
 0.51A 3douA-2b9eA:
11.0		 3douA-2b9eA:
19.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FI0_D_TRPD1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 2b9e NOL1/NOP2/SUN DOMAIN
FAMILY, MEMBER 5
ISOFORM 2
(Homo
sapiens) 		5 / 9 GLY A 238
GLN A 211
ASP A 232
ILE A 254
VAL A 276
 SAM  A1201 (-3.9A)
None
SAM  A1201 ( 4.4A)
None
None
 1.32A 3fi0D-2b9eA:
undetectable		 3fi0D-2b9eA:
22.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FI0_J_TRPJ1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 2b9e NOL1/NOP2/SUN DOMAIN
FAMILY, MEMBER 5
ISOFORM 2
(Homo
sapiens) 		5 / 9 GLY A 238
GLN A 211
ASP A 232
ILE A 254
VAL A 276
 SAM  A1201 (-3.9A)
None
SAM  A1201 ( 4.4A)
None
None
 1.35A 3fi0J-2b9eA:
undetectable		 3fi0J-2b9eA:
22.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FI0_R_TRPR1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 2b9e NOL1/NOP2/SUN DOMAIN
FAMILY, MEMBER 5
ISOFORM 2
(Homo
sapiens) 		5 / 9 GLY A 238
GLN A 211
ASP A 232
ILE A 254
VAL A 276
 SAM  A1201 (-3.9A)
None
SAM  A1201 ( 4.4A)
None
None
 1.36A 3fi0R-2b9eA:
undetectable		 3fi0R-2b9eA:
22.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3M6V_A_SAMA465_0
(RRNA METHYLASE)		 2b9e NOL1/NOP2/SUN DOMAIN
FAMILY, MEMBER 5
ISOFORM 2
(Homo
sapiens) 		5 / 12 GLY A 238
LYS A 240
ASP A 260
ARG A 263
ASP A 305
 SAM  A1201 (-3.9A)
SAM  A1201 (-3.1A)
None
SAM  A1201 (-3.9A)
SAM  A1201 (-3.7A)
 1.02A 3m6vA-2b9eA:
29.7		 3m6vA-2b9eA:
26.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3M6V_B_SAMB465_0
(RRNA METHYLASE)		 2b9e NOL1/NOP2/SUN DOMAIN
FAMILY, MEMBER 5
ISOFORM 2
(Homo
sapiens) 		5 / 12 GLY A 238
LYS A 240
ASP A 260
ARG A 263
ASP A 305
 SAM  A1201 (-3.9A)
SAM  A1201 (-3.1A)
None
SAM  A1201 (-3.9A)
SAM  A1201 (-3.7A)
 0.99A 3m6vB-2b9eA:
29.6		 3m6vB-2b9eA:
26.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4B17_A_SAMA1358_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE M)		 2b9e NOL1/NOP2/SUN DOMAIN
FAMILY, MEMBER 5
ISOFORM 2
(Homo
sapiens) 		5 / 12 PRO A 237
GLY A 238
ASP A 258
ASP A 285
ASP A 305
 SAM  A1201 (-3.7A)
SAM  A1201 (-3.9A)
SAM  A1201 (-2.6A)
SAM  A1201 (-3.6A)
SAM  A1201 (-3.7A)
 0.75A 4b17A-2b9eA:
12.6		 4b17A-2b9eA:
21.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FP9_A_SAMA401_0
(METHYLTRANSFERASE
NSUN4)		 2b9e NOL1/NOP2/SUN DOMAIN
FAMILY, MEMBER 5
ISOFORM 2
(Homo
sapiens) 		6 / 12 CYH A 234
PRO A 237
GLY A 238
LYS A 240
LEU A 259
ASP A 305
 SAM  A1201 (-3.8A)
SAM  A1201 (-3.7A)
SAM  A1201 (-3.9A)
SAM  A1201 (-3.1A)
SAM  A1201 (-4.5A)
SAM  A1201 (-3.7A)
 0.47A 4fp9A-2b9eA:
23.3		 4fp9A-2b9eA:
25.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FP9_A_SAMA401_1
(METHYLTRANSFERASE
NSUN4)		 2b9e NOL1/NOP2/SUN DOMAIN
FAMILY, MEMBER 5
ISOFORM 2
(Homo
sapiens) 		3 / 3 ASP A 258
ARG A 263
ASP A 285
 SAM  A1201 (-2.6A)
SAM  A1201 (-3.9A)
SAM  A1201 (-3.6A)
 0.71A 4fp9A-2b9eA:
23.4		 4fp9A-2b9eA:
25.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FP9_C_SAMC401_0
(METHYLTRANSFERASE
NSUN4)		 2b9e NOL1/NOP2/SUN DOMAIN
FAMILY, MEMBER 5
ISOFORM 2
(Homo
sapiens) 		6 / 12 CYH A 234
PRO A 237
GLY A 238
LYS A 240
LEU A 259
ASP A 305
 SAM  A1201 (-3.8A)
SAM  A1201 (-3.7A)
SAM  A1201 (-3.9A)
SAM  A1201 (-3.1A)
SAM  A1201 (-4.5A)
SAM  A1201 (-3.7A)
 0.49A 4fp9C-2b9eA:
23.2		 4fp9C-2b9eA:
25.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FP9_C_SAMC401_1
(METHYLTRANSFERASE
NSUN4)		 2b9e NOL1/NOP2/SUN DOMAIN
FAMILY, MEMBER 5
ISOFORM 2
(Homo
sapiens) 		3 / 3 ASP A 258
ARG A 263
ASP A 285
 SAM  A1201 (-2.6A)
SAM  A1201 (-3.9A)
SAM  A1201 (-3.6A)
 0.52A 4fp9C-2b9eA:
23.3		 4fp9C-2b9eA:
25.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FP9_D_SAMD401_0
(METHYLTRANSFERASE
NSUN4)		 2b9e NOL1/NOP2/SUN DOMAIN
FAMILY, MEMBER 5
ISOFORM 2
(Homo
sapiens) 		6 / 12 CYH A 234
PRO A 237
GLY A 238
LYS A 240
LEU A 259
ASP A 285
 SAM  A1201 (-3.8A)
SAM  A1201 (-3.7A)
SAM  A1201 (-3.9A)
SAM  A1201 (-3.1A)
SAM  A1201 (-4.5A)
SAM  A1201 (-3.6A)
 0.51A 4fp9D-2b9eA:
23.5		 4fp9D-2b9eA:
25.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FP9_D_SAMD401_1
(METHYLTRANSFERASE
NSUN4)		 2b9e NOL1/NOP2/SUN DOMAIN
FAMILY, MEMBER 5
ISOFORM 2
(Homo
sapiens) 		3 / 3 ASP A 258
ARG A 263
ASP A 305
 SAM  A1201 (-2.6A)
SAM  A1201 (-3.9A)
SAM  A1201 (-3.7A)
 0.52A 4fp9D-2b9eA:
23.5		 4fp9D-2b9eA:
25.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FP9_F_SAMF401_0
(METHYLTRANSFERASE
NSUN4)		 2b9e NOL1/NOP2/SUN DOMAIN
FAMILY, MEMBER 5
ISOFORM 2
(Homo
sapiens) 		6 / 12 CYH A 234
PRO A 237
GLY A 238
LYS A 240
LEU A 259
ASP A 305
 SAM  A1201 (-3.8A)
SAM  A1201 (-3.7A)
SAM  A1201 (-3.9A)
SAM  A1201 (-3.1A)
SAM  A1201 (-4.5A)
SAM  A1201 (-3.7A)
 0.48A 4fp9F-2b9eA:
23.3		 4fp9F-2b9eA:
25.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FP9_F_SAMF401_1
(METHYLTRANSFERASE
NSUN4)		 2b9e NOL1/NOP2/SUN DOMAIN
FAMILY, MEMBER 5
ISOFORM 2
(Homo
sapiens) 		3 / 3 ASP A 258
ARG A 263
ASP A 285
 SAM  A1201 (-2.6A)
SAM  A1201 (-3.9A)
SAM  A1201 (-3.6A)
 0.50A 4fp9F-2b9eA:
23.3		 4fp9F-2b9eA:
25.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FZV_A_SAMA401_0
(PUTATIVE
METHYLTRANSFERASE
NSUN4)		 2b9e NOL1/NOP2/SUN DOMAIN
FAMILY, MEMBER 5
ISOFORM 2
(Homo
sapiens) 		6 / 12 CYH A 234
PRO A 237
GLY A 238
LYS A 240
LEU A 259
ASP A 285
 SAM  A1201 (-3.8A)
SAM  A1201 (-3.7A)
SAM  A1201 (-3.9A)
SAM  A1201 (-3.1A)
SAM  A1201 (-4.5A)
SAM  A1201 (-3.6A)
 0.48A 4fzvA-2b9eA:
23.3		 4fzvA-2b9eA:
25.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FZV_A_SAMA401_1
(PUTATIVE
METHYLTRANSFERASE
NSUN4)		 2b9e NOL1/NOP2/SUN DOMAIN
FAMILY, MEMBER 5
ISOFORM 2
(Homo
sapiens) 		3 / 3 ASP A 258
ARG A 263
ASP A 305
 SAM  A1201 (-2.6A)
SAM  A1201 (-3.9A)
SAM  A1201 (-3.7A)
 0.80A 4fzvA-2b9eA:
23.2		 4fzvA-2b9eA:
25.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NQA_A_9CRA501_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 2b9e NOL1/NOP2/SUN DOMAIN
FAMILY, MEMBER 5
ISOFORM 2
(Homo
sapiens) 		5 / 11 ILE A 422
LEU A 346
ALA A 345
CYH A 404
HIS A 403
 None
 1.18A 4nqaA-2b9eA:
undetectable		 4nqaA-2b9eA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OR0_A_NPSA603_1
(SERUM ALBUMIN)		 2b9e NOL1/NOP2/SUN DOMAIN
FAMILY, MEMBER 5
ISOFORM 2
(Homo
sapiens) 		5 / 11 ARG A 330
LEU A 331
SER A 360
LEU A 361
LEU A 334
 None
 1.39A 4or0A-2b9eA:
undetectable		 4or0A-2b9eA:
20.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IEO_A_VDYA206_1
(CDL2.3A)		 2b9e NOL1/NOP2/SUN DOMAIN
FAMILY, MEMBER 5
ISOFORM 2
(Homo
sapiens) 		5 / 12 LEU A 287
PHE A 286
LEU A 354
LEU A 351
ALA A 373
 None
 1.24A 5ieoA-2b9eA:
undetectable		 5ieoA-2b9eA:
18.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LSU_B_SAMB1304_1
(HISTONE-LYSINE
N-METHYLTRANSFERASE
NSD2)		 2b9e NOL1/NOP2/SUN DOMAIN
FAMILY, MEMBER 5
ISOFORM 2
(Homo
sapiens) 		3 / 3 ASN A 366
TYR A 356
CYH A 404
 None
 0.80A 5lsuB-2b9eA:
undetectable		 5lsuB-2b9eA:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UUN_B_ACTB307_0
(GLUTATHIONE
S-TRANSFERASE-LIKE
PROTEIN)		 2b9e NOL1/NOP2/SUN DOMAIN
FAMILY, MEMBER 5
ISOFORM 2
(Homo
sapiens) 		3 / 3 LEU A 383
ALA A 384
LEU A 374
 None
 0.51A 5uunB-2b9eA:
undetectable		 5uunB-2b9eA:
22.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VLM_H_CVIH301_0
(REGULATORY PROTEIN
TETR)		 2b9e NOL1/NOP2/SUN DOMAIN
FAMILY, MEMBER 5
ISOFORM 2
(Homo
sapiens) 		5 / 12 ALA A 384
GLU A 402
LEU A 405
VAL A 370
PHE A 398
 None
 1.45A 5vlmH-2b9eA:
undetectable		 5vlmH-2b9eA:
21.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WWS_A_SAMA501_0
(PUTATIVE
METHYLTRANSFERASE
NSUN6)		 2b9e NOL1/NOP2/SUN DOMAIN
FAMILY, MEMBER 5
ISOFORM 2
(Homo
sapiens) 		6 / 12 CYH A 234
ALA A 236
PRO A 237
ASP A 258
ASP A 285
ASP A 305
 SAM  A1201 (-3.8A)
SAM  A1201 (-4.1A)
SAM  A1201 (-3.7A)
SAM  A1201 (-2.6A)
SAM  A1201 (-3.6A)
SAM  A1201 (-3.7A)
 0.40A 5wwsA-2b9eA:
28.8		 5wwsA-2b9eA:
26.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WWS_B_SAMB501_0
(PUTATIVE
METHYLTRANSFERASE
NSUN6)		 2b9e NOL1/NOP2/SUN DOMAIN
FAMILY, MEMBER 5
ISOFORM 2
(Homo
sapiens) 		7 / 12 CYH A 234
ALA A 236
PRO A 237
LYS A 240
ASP A 258
ASP A 285
ASP A 305
 SAM  A1201 (-3.8A)
SAM  A1201 (-4.1A)
SAM  A1201 (-3.7A)
SAM  A1201 (-3.1A)
SAM  A1201 (-2.6A)
SAM  A1201 (-3.6A)
SAM  A1201 (-3.7A)
 0.40A 5wwsB-2b9eA:
28.9		 5wwsB-2b9eA:
26.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZVG_A_SAMA401_1
(389AA LONG
HYPOTHETICAL
NUCLEOLAR PROTEIN)		 2b9e NOL1/NOP2/SUN DOMAIN
FAMILY, MEMBER 5
ISOFORM 2
(Homo
sapiens) 		3 / 3 ASP A 258
ARG A 263
ASP A 305
 SAM  A1201 (-2.6A)
SAM  A1201 (-3.9A)
SAM  A1201 (-3.7A)
 0.78A 5zvgA-2b9eA:
30.6		 5zvgA-2b9eA:
26.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZVG_B_SAMB401_1
(389AA LONG
HYPOTHETICAL
NUCLEOLAR PROTEIN)		 2b9e NOL1/NOP2/SUN DOMAIN
FAMILY, MEMBER 5
ISOFORM 2
(Homo
sapiens) 		3 / 3 ASP A 258
ARG A 263
ASP A 305
 SAM  A1201 (-2.6A)
SAM  A1201 (-3.9A)
SAM  A1201 (-3.7A)
 0.71A 5zvgB-2b9eA:
30.7		 5zvgB-2b9eA:
26.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B54_A_OAQA302_0
(SULFOTRANSFERASE)		 2b9e NOL1/NOP2/SUN DOMAIN
FAMILY, MEMBER 5
ISOFORM 2
(Homo
sapiens) 		5 / 12 LEU A 259
LEU A 342
PHE A 337
THR A 347
LEU A 346
 SAM  A1201 (-4.5A)
None
SAM  A1201 (-4.2A)
None
None
 1.12A 6b54A-2b9eA:
undetectable		 6b54A-2b9eA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6D8F_A_ACTA803_0
(UNCHARACTERIZED
PROTEIN)		 2b9e NOL1/NOP2/SUN DOMAIN
FAMILY, MEMBER 5
ISOFORM 2
(Homo
sapiens) 		3 / 3 GLU A 199
LEU A 197
ARG A 136
 None
 0.77A 6d8fA-2b9eA:
undetectable		 6d8fA-2b9eA:
18.38