SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2b9s'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FK6_A_LNLA1201_1
(NON-SPECIFIC LIPID
TRANSFER PROTEIN)		 2b9s DNA TOPOISOMERASE
I-LIKE PROTEIN
TOPOISOMERASE I-LIKE
PROTEIN
(Leishmania
donovani) 		5 / 12 VAL A 447
LEU A 450
ALA A 312
ALA A 273
ILE B 223
 None
 0.84A 1fk6A-2b9sA:
undetectable		 1fk6A-2b9sA:
15.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FSL_A_NIOA145_1
(LEGHEMOGLOBIN A)		 2b9s TOPOISOMERASE I-LIKE
PROTEIN
(Leishmania
donovani) 		4 / 8 PHE A 347
ILE A 337
PHE A 385
VAL A 345
 None
 0.91A 1fslA-2b9sA:
undetectable		 1fslA-2b9sA:
18.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FSL_B_NIOB145_1
(LEGHEMOGLOBIN A)		 2b9s TOPOISOMERASE I-LIKE
PROTEIN
(Leishmania
donovani) 		4 / 8 PHE A 347
ILE A 337
PHE A 385
VAL A 345
 None
 0.90A 1fslB-2b9sA:
undetectable		 1fslB-2b9sA:
18.36
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1K4T_D_TTCD990_1
(DNA TOPOISOMERASE I)		 2b9s DNA TOPOISOMERASE
I-LIKE PROTEIN
TOPOISOMERASE I-LIKE
PROTEIN
(Leishmania
donovani) 		4 / 5 GLU A 182
LYS A 352
ASP A 353
THR B 217
 None
VO4  B 301 ( 3.9A)
None
None
 1.24A 1k4tA-2b9sA:
32.6		 1k4tA-2b9sA:
48.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RG1_A_SPMA999_1
(TYROSYL-DNA
PHOSPHODIESTERASE 1)		 2b9s TOPOISOMERASE I-LIKE
PROTEIN
(Leishmania
donovani) 		3 / 3 TRP A 227
VAL A 220
PRO A 221
 None
 0.62A 1rg1A-2b9sA:
undetectable		 1rg1A-2b9sA:
18.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RH0_A_SPMA999_1
(TYROSYL-DNA
PHOSPHODIESTERASE 1)		 2b9s TOPOISOMERASE I-LIKE
PROTEIN
(Leishmania
donovani) 		3 / 3 TRP A 227
VAL A 220
PRO A 221
 None
 0.62A 1rh0A-2b9sA:
undetectable		 1rh0A-2b9sA:
18.92
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1RR8_A_TTCA100_1
(DNA TOPOISOMERASE I)		 2b9s DNA TOPOISOMERASE
I-LIKE PROTEIN
TOPOISOMERASE I-LIKE
PROTEIN
(Leishmania
donovani) 		4 / 5 GLU A 182
LYS A 352
ASP A 353
THR B 217
 None
VO4  B 301 ( 3.9A)
None
None
 1.24A 1rr8C-2b9sA:
36.4		 1rr8C-2b9sA:
50.56
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1RRJ_B_TTCB990_1
(DNA TOPOISOMERASE I)		 2b9s DNA TOPOISOMERASE
I-LIKE PROTEIN
TOPOISOMERASE I-LIKE
PROTEIN
(Leishmania
donovani) 		4 / 5 GLU A 182
LYS A 352
ASP A 353
THR B 217
 None
VO4  B 301 ( 3.9A)
None
None
 1.27A 1rrjA-2b9sA:
32.6		 1rrjA-2b9sA:
50.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RX3_A_MTXA161_2
(DIHYDROFOLATE
REDUCTASE)		 2b9s DNA TOPOISOMERASE
I-LIKE PROTEIN
TOPOISOMERASE I-LIKE
PROTEIN
(Leishmania
donovani) 		3 / 3 LYS B 211
ILE A 449
THR B 217
 None
 0.79A 1rx3A-2b9sB:
undetectable		 1rx3A-2b9sB:
18.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YRC_A_CAMA420_0
(CYTOCHROME P450-CAM)		 2b9s TOPOISOMERASE I-LIKE
PROTEIN
(Leishmania
donovani) 		4 / 7 THR A 375
LEU A 339
VAL A 345
VAL A 303
 None
 0.98A 1yrcA-2b9sA:
undetectable		 1yrcA-2b9sA:
20.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YRD_A_CAMA420_0
(CYTOCHROME P450-CAM)		 2b9s TOPOISOMERASE I-LIKE
PROTEIN
(Leishmania
donovani) 		4 / 7 THR A 375
LEU A 339
VAL A 345
VAL A 303
 None
 0.98A 1yrdA-2b9sA:
undetectable		 1yrdA-2b9sA:
20.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FEU_A_CAMA1420_0
(CYTOCHROME P450-CAM)		 2b9s TOPOISOMERASE I-LIKE
PROTEIN
(Leishmania
donovani) 		4 / 6 THR A 375
LEU A 339
VAL A 345
VAL A 303
 None
 1.00A 2feuA-2b9sA:
undetectable		 2feuA-2b9sA:
20.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FEU_B_CAMB1421_0
(CYTOCHROME P450-CAM)		 2b9s TOPOISOMERASE I-LIKE
PROTEIN
(Leishmania
donovani) 		4 / 7 THR A 375
LEU A 339
VAL A 345
VAL A 303
 None
 1.01A 2feuB-2b9sA:
undetectable		 2feuB-2b9sA:
20.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HRC_A_CHDA702_0
(FERROCHELATASE)		 2b9s TOPOISOMERASE I-LIKE
PROTEIN
(Leishmania
donovani) 		4 / 7 ARG A 116
LEU A 113
PRO A 184
VAL A  83
 None
 1.31A 2hrcA-2b9sA:
undetectable		 2hrcA-2b9sA:
20.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YGP_A_PCFA1213_0
(WNT INHIBITORY
FACTOR 1)		 2b9s TOPOISOMERASE I-LIKE
PROTEIN
(Leishmania
donovani) 		6 / 12 LEU A 311
ILE A 308
LEU A 393
VAL A 367
VAL A 363
PHE A 291
 None
 1.44A 2ygpA-2b9sA:
undetectable		 2ygpA-2b9sA:
17.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZUI_A_CAMA422_0
(CAMPHOR
5-MONOOXYGENASE)		 2b9s TOPOISOMERASE I-LIKE
PROTEIN
(Leishmania
donovani) 		4 / 6 THR A 375
LEU A 339
VAL A 345
VAL A 303
 None
 0.99A 2zuiA-2b9sA:
undetectable		 2zuiA-2b9sA:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZWT_A_CAMA422_0
(CAMPHOR
5-MONOOXYGENASE)		 2b9s TOPOISOMERASE I-LIKE
PROTEIN
(Leishmania
donovani) 		4 / 7 THR A 375
LEU A 339
VAL A 345
VAL A 303
 None
 0.98A 2zwtA-2b9sA:
undetectable		 2zwtA-2b9sA:
20.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZWU_A_CAMA422_0
(CAMPHOR
5-MONOOXYGENASE)		 2b9s TOPOISOMERASE I-LIKE
PROTEIN
(Leishmania
donovani) 		4 / 7 THR A 375
LEU A 339
VAL A 345
VAL A 303
 None
 0.98A 2zwuA-2b9sA:
undetectable		 2zwuA-2b9sA:
20.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FWF_A_CAMA420_0
(CAMPHOR
5-MONOOXYGENASE)		 2b9s TOPOISOMERASE I-LIKE
PROTEIN
(Leishmania
donovani) 		4 / 7 THR A 375
LEU A 339
VAL A 345
VAL A 303
 None
 1.00A 3fwfA-2b9sA:
undetectable		 3fwfA-2b9sA:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FWF_B_CAMB420_0
(CAMPHOR
5-MONOOXYGENASE)		 2b9s TOPOISOMERASE I-LIKE
PROTEIN
(Leishmania
donovani) 		4 / 7 THR A 375
LEU A 339
VAL A 345
VAL A 303
 None
 1.00A 3fwfB-2b9sA:
undetectable		 3fwfB-2b9sA:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FWJ_A_CAMA420_0
(CAMPHOR
5-MONOOXYGENASE)		 2b9s TOPOISOMERASE I-LIKE
PROTEIN
(Leishmania
donovani) 		4 / 7 THR A 375
LEU A 339
VAL A 345
VAL A 303
 None
 1.01A 3fwjA-2b9sA:
undetectable		 3fwjA-2b9sA:
20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K4V_B_ROCB201_2
(HIV-1 PROTEASE)		 2b9s TOPOISOMERASE I-LIKE
PROTEIN
(Leishmania
donovani) 		3 / 3 ARG A 310
VAL A 447
THR A 417
 None
 0.87A 3k4vA-2b9sA:
undetectable		 3k4vA-2b9sA:
13.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K4V_D_ROCD201_4
(HIV-1 PROTEASE)		 2b9s TOPOISOMERASE I-LIKE
PROTEIN
(Leishmania
donovani) 		3 / 3 ARG A 310
VAL A 447
THR A 417
 None
 0.83A 3k4vD-2b9sA:
undetectable		 3k4vD-2b9sA:
13.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3L63_A_CAMA440_0
(CAMPHOR
5-MONOOXYGENASE)		 2b9s TOPOISOMERASE I-LIKE
PROTEIN
(Leishmania
donovani) 		4 / 7 THR A 375
LEU A 339
VAL A 345
VAL A 303
 None
 1.02A 3l63A-2b9sA:
undetectable		 3l63A-2b9sA:
19.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NDU_D_ROCD100_3
(PROTEASE)		 2b9s TOPOISOMERASE I-LIKE
PROTEIN
(Leishmania
donovani) 		3 / 3 ARG A 310
VAL A 447
THR A 417
 None
 0.84A 3nduD-2b9sA:
undetectable		 3nduD-2b9sA:
13.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TL9_A_ROCA401_2
(PROTEASE)		 2b9s TOPOISOMERASE I-LIKE
PROTEIN
(Leishmania
donovani) 		3 / 3 ARG A 310
VAL A 447
THR A 417
 None
 0.85A 3tl9A-2b9sA:
undetectable		 3tl9A-2b9sA:
13.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WRH_A_CAMA503_0
(CAMPHOR
5-MONOOXYGENASE)		 2b9s TOPOISOMERASE I-LIKE
PROTEIN
(Leishmania
donovani) 		4 / 7 THR A 375
LEU A 339
VAL A 345
VAL A 303
 None
 1.00A 3wrhA-2b9sA:
undetectable		 3wrhA-2b9sA:
20.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WRJ_A_CAMA503_0
(CAMPHOR
5-MONOOXYGENASE)		 2b9s TOPOISOMERASE I-LIKE
PROTEIN
(Leishmania
donovani) 		4 / 7 THR A 375
LEU A 339
VAL A 345
VAL A 303
 None
 1.00A 3wrjA-2b9sA:
undetectable		 3wrjA-2b9sA:
20.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WRL_A_CAMA503_0
(CAMPHOR
5-MONOOXYGENASE)		 2b9s TOPOISOMERASE I-LIKE
PROTEIN
(Leishmania
donovani) 		4 / 7 THR A 375
LEU A 339
VAL A 345
VAL A 303
 None
 0.99A 3wrlA-2b9sA:
undetectable		 3wrlA-2b9sA:
20.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WRL_E_CAME503_0
(CAMPHOR
5-MONOOXYGENASE)		 2b9s TOPOISOMERASE I-LIKE
PROTEIN
(Leishmania
donovani) 		4 / 7 THR A 375
LEU A 339
VAL A 345
VAL A 303
 None
 1.03A 3wrlE-2b9sA:
undetectable		 3wrlE-2b9sA:
20.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WRM_A_CAMA503_0
(CAMPHOR
5-MONOOXYGENASE)		 2b9s TOPOISOMERASE I-LIKE
PROTEIN
(Leishmania
donovani) 		4 / 7 THR A 375
LEU A 339
VAL A 345
VAL A 303
 None
 0.99A 3wrmA-2b9sA:
undetectable		 3wrmA-2b9sA:
20.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WRM_F_CAMF503_0
(CAMPHOR
5-MONOOXYGENASE)		 2b9s TOPOISOMERASE I-LIKE
PROTEIN
(Leishmania
donovani) 		4 / 7 THR A 375
LEU A 339
VAL A 345
VAL A 303
 None
 1.01A 3wrmF-2b9sA:
undetectable		 3wrmF-2b9sA:
20.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GH8_A_MTXA201_2
(DIHYDROFOLATE
REDUCTASE)		 2b9s DNA TOPOISOMERASE
I-LIKE PROTEIN
TOPOISOMERASE I-LIKE
PROTEIN
(Leishmania
donovani) 		3 / 3 LYS B 211
ILE A 449
THR B 217
 None
 0.80A 4gh8A-2b9sB:
undetectable		 4gh8A-2b9sB:
22.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LB2_A_DM5A601_1
(SERUM ALBUMIN)		 2b9s TOPOISOMERASE I-LIKE
PROTEIN
(Leishmania
donovani) 		4 / 7 LEU A  55
VAL A 181
PRO A 183
GLU A 160
 None
 1.05A 4lb2A-2b9sA:
undetectable		 4lb2A-2b9sA:
22.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QZU_D_ACTD201_0
(RETINOL-BINDING
PROTEIN 2)		 2b9s TOPOISOMERASE I-LIKE
PROTEIN
(Leishmania
donovani) 		3 / 3 ASP A 114
HIS A 118
LYS A 115
 None
 0.87A 4qzuD-2b9sA:
undetectable		 4qzuD-2b9sA:
15.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UC1_B_486B801_1
(GLUCOCORTICOID
RECEPTOR)		 2b9s TOPOISOMERASE I-LIKE
PROTEIN
(Leishmania
donovani) 		3 / 3 TRP A 238
MET A 254
ASN A 178
 None
 1.25A 5uc1A-2b9sA:
undetectable		 5uc1A-2b9sA:
9.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VLM_B_CVIB301_0
(REGULATORY PROTEIN
TETR)		 2b9s TOPOISOMERASE I-LIKE
PROTEIN
(Leishmania
donovani) 		5 / 12 GLN A 372
ALA A 369
ILE A 384
VAL A 303
PHE A 307
 None
 1.20A 5vlmB-2b9sA:
undetectable		 5vlmB-2b9sA:
19.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WK9_A_CAMA503_0
(CAMPHOR
5-MONOOXYGENASE)		 2b9s TOPOISOMERASE I-LIKE
PROTEIN
(Leishmania
donovani) 		4 / 7 THR A 375
LEU A 339
VAL A 345
VAL A 303
 None
 1.02A 5wk9A-2b9sA:
undetectable		 5wk9A-2b9sA:
19.87