SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2bap'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ERE_E_ESTE600_1
(ESTROGEN RECEPTOR)		 2bap DIAPHANOUS PROTEIN
HOMOLOG 1
(Mus
musculus) 		4 / 8 MET B 266
ALA B 273
GLU B 276
LEU B 233
 None
 0.98A 1ereE-2bapB:
undetectable		 1ereE-2bapB:
23.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ERE_F_ESTF600_1
(ESTROGEN RECEPTOR)		 2bap DIAPHANOUS PROTEIN
HOMOLOG 1
(Mus
musculus) 		4 / 8 MET B 266
ALA B 273
GLU B 276
LEU B 233
 None
 0.95A 1ereF-2bapB:
undetectable		 1ereF-2bapB:
23.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LIN_A_TFPA154_1
(CALMODULIN)		 2bap DIAPHANOUS PROTEIN
HOMOLOG 1
(Mus
musculus) 		4 / 7 GLU B 230
LEU B 233
GLU B 276
MET B 280
 None
 1.11A 1linA-2bapB:
undetectable		 1linA-2bapB:
19.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V54_J_CHDJ3060_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE I
CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART)		 2bap DIAPHANOUS PROTEIN
HOMOLOG 1
(Mus
musculus) 		4 / 6 LEU B 234
MET B 225
THR B 224
LEU B 179
 None
 1.04A 1v54A-2bapB:
0.0
1v54J-2bapB:
undetectable		 1v54A-2bapB:
19.02
1v54J-2bapB:
10.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WRL_D_TFPD207_1
(TROPONIN C, SLOW
SKELETAL AND CARDIAC
MUSCLES)		 2bap DIAPHANOUS PROTEIN
HOMOLOG 1
(Mus
musculus) 		4 / 8 LEU B 159
PHE B 174
PHE B 220
PHE B 215
 None
 1.04A 1wrlC-2bapB:
undetectable
1wrlD-2bapB:
undetectable		 1wrlC-2bapB:
15.87
1wrlD-2bapB:
15.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DYR_J_CHDJ60_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 1)		 2bap DIAPHANOUS PROTEIN
HOMOLOG 1
(Mus
musculus) 		4 / 6 LEU B 234
MET B 225
THR B 224
LEU B 179
 None
 1.03A 2dyrA-2bapB:
0.0
2dyrJ-2bapB:
undetectable		 2dyrA-2bapB:
19.02
2dyrJ-2bapB:
10.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DYS_J_CHDJ101_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 1)		 2bap DIAPHANOUS PROTEIN
HOMOLOG 1
(Mus
musculus) 		4 / 6 LEU B 234
MET B 225
THR B 224
LEU B 179
 None
 1.03A 2dysA-2bapB:
0.0
2dysJ-2bapB:
undetectable		 2dysA-2bapB:
19.02
2dysJ-2bapB:
10.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DYS_W_CHDW101_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 1)		 2bap DIAPHANOUS PROTEIN
HOMOLOG 1
(Mus
musculus) 		4 / 6 LEU B 234
MET B 225
THR B 224
LEU B 179
 None
 1.02A 2dysN-2bapB:
0.0
2dysW-2bapB:
undetectable		 2dysN-2bapB:
19.02
2dysW-2bapB:
10.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIJ_J_CHDJ60_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 1)		 2bap DIAPHANOUS PROTEIN
HOMOLOG 1
(Mus
musculus) 		4 / 6 LEU B 234
MET B 225
THR B 224
LEU B 179
 None
 1.05A 2eijA-2bapB:
0.0
2eijJ-2bapB:
undetectable		 2eijA-2bapB:
19.02
2eijJ-2bapB:
10.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIL_J_CHDJ60_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 1)		 2bap DIAPHANOUS PROTEIN
HOMOLOG 1
(Mus
musculus) 		4 / 6 LEU B 234
MET B 225
THR B 224
LEU B 179
 None
 1.04A 2eilA-2bapB:
0.0
2eilJ-2bapB:
undetectable		 2eilA-2bapB:
19.02
2eilJ-2bapB:
10.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NXE_A_SAMA302_1
(RIBOSOMAL PROTEIN
L11
METHYLTRANSFERASE)		 2bap DIAPHANOUS PROTEIN
HOMOLOG 1
(Mus
musculus) 		3 / 3 THR B 297
ASP B 240
SER B 202
 None
 0.72A 2nxeA-2bapB:
undetectable		 2nxeA-2bapB:
21.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NXE_B_SAMB303_1
(RIBOSOMAL PROTEIN
L11
METHYLTRANSFERASE)		 2bap DIAPHANOUS PROTEIN
HOMOLOG 1
(Mus
musculus) 		3 / 3 THR B 297
ASP B 240
SER B 202
 None
 0.76A 2nxeB-2bapB:
undetectable		 2nxeB-2bapB:
21.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OIP_A_MTXA605_1
(CHAIN A, CRYSTAL
STRUCTURE OF DHFR)		 2bap DIAPHANOUS PROTEIN
HOMOLOG 1
(Mus
musculus) 		5 / 12 ALA B 238
LEU B 234
LEU B 212
ILE B 185
LEU B 156
 None
 1.10A 2oipA-2bapB:
undetectable		 2oipA-2bapB:
19.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OIP_D_MTXD617_1
(CHAIN A, CRYSTAL
STRUCTURE OF DHFR)		 2bap DIAPHANOUS PROTEIN
HOMOLOG 1
(Mus
musculus) 		5 / 12 ALA B 238
LEU B 234
LEU B 212
ILE B 185
LEU B 156
 None
 1.06A 2oipD-2bapB:
undetectable		 2oipD-2bapB:
19.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OUZ_A_C3DA999_0
(ESTROGEN RECEPTOR)		 2bap DIAPHANOUS PROTEIN
HOMOLOG 1
(Mus
musculus) 		5 / 12 LEU B 179
LEU B 159
LEU B 163
ILE B 208
LEU B 143
 None
 1.00A 2ouzA-2bapB:
undetectable		 2ouzA-2bapB:
23.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ABM_J_CHDJ60_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 1)		 2bap DIAPHANOUS PROTEIN
HOMOLOG 1
(Mus
musculus) 		4 / 6 LEU B 234
MET B 225
THR B 224
LEU B 179
 None
 1.03A 3abmA-2bapB:
0.0
3abmJ-2bapB:
undetectable		 3abmA-2bapB:
19.02
3abmJ-2bapB:
10.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ASN_J_CHDJ60_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1)		 2bap DIAPHANOUS PROTEIN
HOMOLOG 1
(Mus
musculus) 		4 / 6 LEU B 234
MET B 225
THR B 224
LEU B 179
 None
 1.03A 3asnA-2bapB:
0.0
3asnJ-2bapB:
undetectable		 3asnA-2bapB:
19.02
3asnJ-2bapB:
10.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ASO_J_CHDJ60_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1)		 2bap DIAPHANOUS PROTEIN
HOMOLOG 1
(Mus
musculus) 		4 / 6 LEU B 234
MET B 225
THR B 224
LEU B 179
 None
 1.02A 3asoA-2bapB:
0.0
3asoJ-2bapB:
undetectable		 3asoA-2bapB:
19.02
3asoJ-2bapB:
10.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CL9_A_MTXA602_1
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE (DHFR-TS))		 2bap DIAPHANOUS PROTEIN
HOMOLOG 1
(Mus
musculus) 		5 / 12 ALA B 251
ILE B 248
THR B 297
SER B 298
LEU B 341
 None
 1.31A 3cl9A-2bapB:
undetectable		 3cl9A-2bapB:
20.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HJ3_B_MTXB609_1
(CHAIN A, CRYSTAL
STRUCTURE OF DHFR)		 2bap DIAPHANOUS PROTEIN
HOMOLOG 1
(Mus
musculus) 		5 / 12 ALA B 238
LEU B 234
LEU B 212
ILE B 185
LEU B 156
 None
 1.12A 3hj3B-2bapB:
undetectable		 3hj3B-2bapB:
19.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HM1_A_J3ZA2_1
(ESTROGEN RECEPTOR)		 2bap DIAPHANOUS PROTEIN
HOMOLOG 1
(Mus
musculus) 		5 / 12 MET B 266
ALA B 273
GLU B 276
LEU B 233
LEU B 254
 None
 1.12A 3hm1A-2bapB:
undetectable		 3hm1A-2bapB:
23.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KK6_A_CELA701_2
(PROSTAGLANDIN G/H
SYNTHASE 1)		 2bap DIAPHANOUS PROTEIN
HOMOLOG 1
(Mus
musculus) 		4 / 6 VAL B 270
LEU B 293
ILE B 248
LEU B 312
 None
 0.98A 3kk6A-2bapB:
undetectable		 3kk6A-2bapB:
20.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KY8_B_MTXB603_1
(BIFUNCTIONAL
THYMIDYLATE
SYNTHASE-DIHYDROFOLA
TE REDUCTASE)		 2bap DIAPHANOUS PROTEIN
HOMOLOG 1
(Mus
musculus) 		5 / 12 ALA B 238
LEU B 234
LEU B 212
ILE B 185
LEU B 156
 None
 1.07A 4ky8B-2bapB:
undetectable		 4ky8B-2bapB:
19.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KY8_D_MTXD603_1
(BIFUNCTIONAL
THYMIDYLATE
SYNTHASE-DIHYDROFOLA
TE REDUCTASE)		 2bap DIAPHANOUS PROTEIN
HOMOLOG 1
(Mus
musculus) 		5 / 12 ALA B 238
LEU B 234
LEU B 212
ILE B 185
LEU B 156
 None
 1.10A 4ky8D-2bapB:
undetectable		 4ky8D-2bapB:
19.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KY8_E_MTXE603_1
(BIFUNCTIONAL
THYMIDYLATE
SYNTHASE-DIHYDROFOLA
TE REDUCTASE)		 2bap DIAPHANOUS PROTEIN
HOMOLOG 1
(Mus
musculus) 		5 / 12 ALA B 238
LEU B 234
LEU B 212
ILE B 185
LEU B 156
 None
 1.07A 4ky8E-2bapB:
undetectable		 4ky8E-2bapB:
19.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q0D_A_MTXA604_1
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 2bap DIAPHANOUS PROTEIN
HOMOLOG 1
(Mus
musculus) 		5 / 12 ALA B 238
LEU B 234
LEU B 212
ILE B 185
LEU B 156
 None
 1.07A 4q0dA-2bapB:
undetectable		 4q0dA-2bapB:
19.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q0D_B_MTXB604_1
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 2bap DIAPHANOUS PROTEIN
HOMOLOG 1
(Mus
musculus) 		5 / 12 ALA B 238
LEU B 234
LEU B 212
ILE B 185
LEU B 156
 None
 1.07A 4q0dB-2bapB:
undetectable		 4q0dB-2bapB:
19.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q0D_E_MTXE604_1
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 2bap DIAPHANOUS PROTEIN
HOMOLOG 1
(Mus
musculus) 		5 / 12 ALA B 238
LEU B 234
LEU B 212
ILE B 185
LEU B 156
 None
 1.07A 4q0dE-2bapB:
undetectable		 4q0dE-2bapB:
19.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZME_B_ADNB902_1
(MYOSIN HEAVY CHAIN
KINASE A)		 2bap DIAPHANOUS PROTEIN
HOMOLOG 1
(Mus
musculus) 		5 / 10 ALA B 278
VAL B 236
LEU B 308
LEU B 289
PHE B 286
 None
 1.23A 4zmeB-2bapB:
undetectable		 4zmeB-2bapB:
20.64