SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2bb3'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4G_B_ZMRB466_2
(NEURAMINIDASE)		 2bb3 COBALAMIN
BIOSYNTHESIS
PRECORRIN-6Y
METHYLASE (CBIE)
(Archaeoglobus
fulgidus) 		3 / 3 ASP A  55
ARG A  58
ILE A  89
 None
 0.82A 1a4gB-2bb3A:
undetectable		 1a4gB-2bb3A:
17.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EPB_B_9CRB165_2
(EPIDIDYMAL RETINOIC
ACID-BINDING PROTEIN)		 2bb3 COBALAMIN
BIOSYNTHESIS
PRECORRIN-6Y
METHYLASE (CBIE)
(Archaeoglobus
fulgidus) 		4 / 8 PHE A 149
ALA A  80
VAL A  79
VAL A 120
 None
SAH  A 201 (-3.4A)
SAH  A 201 (-3.9A)
None
 0.87A 1epbB-2bb3A:
undetectable		 1epbB-2bb3A:
19.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GSE_A_EAAA224_1
(GLUTATHIONE
TRANSFERASE)		 2bb3 COBALAMIN
BIOSYNTHESIS
PRECORRIN-6Y
METHYLASE (CBIE)
(Archaeoglobus
fulgidus) 		5 / 12 ARG A 153
LEU A 132
LEU A 136
VAL A 191
ALA A 177
 None
 1.15A 1gseA-2bb3A:
undetectable		 1gseA-2bb3A:
24.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RL8_A_RITA9001_1
(PROTEASE RETROPEPSIN)		 2bb3 COBALAMIN
BIOSYNTHESIS
PRECORRIN-6Y
METHYLASE (CBIE)
(Archaeoglobus
fulgidus) 		5 / 12 GLY A  39
ALA A  38
GLY A  30
ALA A  25
ILE A  22
 None
 0.90A 1rl8A-2bb3A:
undetectable		 1rl8A-2bb3A:
17.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RL8_A_RITA9001_2
(PROTEASE RETROPEPSIN)		 2bb3 COBALAMIN
BIOSYNTHESIS
PRECORRIN-6Y
METHYLASE (CBIE)
(Archaeoglobus
fulgidus) 		5 / 12 GLY A  39
ALA A  38
GLY A  30
ALA A  25
ILE A  22
 None
 0.88A 1rl8B-2bb3A:
undetectable		 1rl8B-2bb3A:
17.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2B60_B_RITB100_1
(GAG-POL POLYPROTEIN)		 2bb3 COBALAMIN
BIOSYNTHESIS
PRECORRIN-6Y
METHYLASE (CBIE)
(Archaeoglobus
fulgidus) 		5 / 12 GLY A  39
ALA A  38
GLY A  30
ALA A  25
ILE A  22
 None
 0.83A 2b60A-2bb3A:
undetectable		 2b60A-2bb3A:
18.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2B60_B_RITB100_2
(GAG-POL POLYPROTEIN)		 2bb3 COBALAMIN
BIOSYNTHESIS
PRECORRIN-6Y
METHYLASE (CBIE)
(Archaeoglobus
fulgidus) 		5 / 11 GLY A  39
ALA A  38
GLY A  30
ALA A  25
ILE A  22
 None
 0.87A 2b60B-2bb3A:
undetectable		 2b60B-2bb3A:
18.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NMY_A_ROCA401_2
(PROTEASE)		 2bb3 COBALAMIN
BIOSYNTHESIS
PRECORRIN-6Y
METHYLASE (CBIE)
(Archaeoglobus
fulgidus) 		5 / 12 GLY A  39
ALA A  38
GLY A  30
ALA A  25
ILE A  22
 None
 0.94A 2nmyB-2bb3A:
undetectable		 2nmyB-2bb3A:
17.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q2H_B_ACTB501_0
(SECRETION CHAPERONE,
PHAGE-DISPLAY
DERIVED PEPTIDE)		 2bb3 COBALAMIN
BIOSYNTHESIS
PRECORRIN-6Y
METHYLASE (CBIE)
(Archaeoglobus
fulgidus) 		3 / 3 ARG A  33
SER A  31
TYR A 186
 None
 1.04A 2q2hA-2bb3A:
undetectable
2q2hB-2bb3A:
undetectable		 2q2hA-2bb3A:
23.66
2q2hB-2bb3A:
23.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RKF_A_AB1A501_1
(PROTEASE RETROPEPSIN)		 2bb3 COBALAMIN
BIOSYNTHESIS
PRECORRIN-6Y
METHYLASE (CBIE)
(Archaeoglobus
fulgidus) 		5 / 12 GLY A  39
ALA A  38
GLY A  30
ALA A  25
ILE A  22
 None
 0.89A 2rkfA-2bb3A:
undetectable		 2rkfA-2bb3A:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUF_B_SUEB1201_1
(NS3 PROTEASE, NS4A
PROTEIN)		 2bb3 COBALAMIN
BIOSYNTHESIS
PRECORRIN-6Y
METHYLASE (CBIE)
(Archaeoglobus
fulgidus) 		5 / 12 GLY A  81
ILE A  21
GLY A   6
SER A  73
ALA A  70
 None
None
None
SAH  A 201 ( 4.1A)
None
 1.02A 3sufB-2bb3A:
undetectable		 3sufB-2bb3A:
22.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AX8_A_SAMA1474_1
(WBDD)		 2bb3 COBALAMIN
BIOSYNTHESIS
PRECORRIN-6Y
METHYLASE (CBIE)
(Archaeoglobus
fulgidus) 		4 / 6 ARG A 173
ASP A 178
GLU A 194
LEU A 161
 None
 1.42A 4ax8A-2bb3A:
undetectable		 4ax8A-2bb3A:
19.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B89_B_NOVB403_1
(LIPOPOLYSACCHARIDE
EXPORT SYSTEM
ATP-BINDING PROTEIN
LPTB)		 2bb3 COBALAMIN
BIOSYNTHESIS
PRECORRIN-6Y
METHYLASE (CBIE)
(Archaeoglobus
fulgidus) 		4 / 7 ARG A 193
ARG A 139
LEU A 135
ALA A 130
 None
 1.20A 6b89A-2bb3A:
undetectable		 6b89A-2bb3A:
17.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6G9B_B_IXXB705_1
(ENVELOPE
GLYCOPROTEIN,ENVELOP
E GLYCOPROTEIN
ENVELOPE
GLYCOPROTEIN)		 2bb3 COBALAMIN
BIOSYNTHESIS
PRECORRIN-6Y
METHYLASE (CBIE)
(Archaeoglobus
fulgidus) 		4 / 5 ARG A 110
ALA A 107
GLN A  13
ILE A 101
 None
 1.36A 6g9bA-2bb3A:
undetectable
6g9bB-2bb3A:
undetectable		 6g9bA-2bb3A:
17.21
6g9bB-2bb3A:
15.31