SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2bb6'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HK2_A_T44A3002_1
(SERUM ALBUMIN)		 2bb6 TRANSCOBALAMIN II
(Bos
taurus) 		4 / 8 LEU A  27
LEU A  58
TYR A  62
LEU A 363
 None
None
None
B12  A   0 (-3.7A)
 1.22A 1hk2A-2bb6A:
undetectable		 1hk2A-2bb6A:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P93_D_DEXD4999_2
(GLUCOCORTICOID
RECEPTOR)		 2bb6 TRANSCOBALAMIN II
(Bos
taurus) 		4 / 5 LEU A 281
MET A 239
LEU A 235
GLN A 260
 None
 1.20A 1p93D-2bb6A:
undetectable		 1p93D-2bb6A:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RX3_A_MTXA161_2
(DIHYDROFOLATE
REDUCTASE)		 2bb6 TRANSCOBALAMIN II
(Bos
taurus) 		3 / 3 LYS A 160
ILE A 143
THR A 180
 None
 0.85A 1rx3A-2bb6A:
undetectable		 1rx3A-2bb6A:
18.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SV9_A_DIFA701_1
(PHOSPHOLIPASE A2)		 2bb6 TRANSCOBALAMIN II
(Bos
taurus) 		4 / 8 LEU A 161
ALA A 207
ILE A 204
GLY A 185
 None
 0.81A 1sv9A-2bb6A:
undetectable		 1sv9A-2bb6A:
19.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JN3_A_JN3A130_2
(FATTY ACID-BINDING
PROTEIN, LIVER)		 2bb6 TRANSCOBALAMIN II
(Bos
taurus) 		4 / 7 LEU A  55
PRO A 292
ARG A 298
ARG A  95
 None
 0.93A 2jn3A-2bb6A:
undetectable		 2jn3A-2bb6A:
13.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IJX_H_HCZH800_1
(GLUTAMATE RECEPTOR 2)		 2bb6 TRANSCOBALAMIN II
(Bos
taurus) 		4 / 5 PRO A 232
SER A 230
LEU A 263
SER A 262
 None
B12  A   0 (-3.2A)
None
None
 1.35A 3ijxH-2bb6A:
undetectable		 3ijxH-2bb6A:
22.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A3P_A_ACTA1223_0
(UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE 15)		 2bb6 TRANSCOBALAMIN II
(Bos
taurus) 		4 / 5 ASP A 389
THR A 390
LEU A 385
GLU A 408
 None
 1.46A 4a3pA-2bb6A:
5.4		 4a3pA-2bb6A:
19.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A9K_B_TYLB2198_1
(CREB-BINDING PROTEIN)		 2bb6 TRANSCOBALAMIN II
(Bos
taurus) 		4 / 5 VAL A 384
LEU A 342
ILE A 396
VAL A 371
 B12  A   0 (-4.3A)
None
None
None
 0.96A 4a9kB-2bb6A:
undetectable		 4a9kB-2bb6A:
15.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4I41_A_MIXA500_2
(SERINE/THREONINE-PRO
TEIN KINASE PIM-1)		 2bb6 TRANSCOBALAMIN II
(Bos
taurus) 		4 / 4 LEU A  20
LEU A 277
GLN A  46
GLU A  14
 None
 1.11A 4i41A-2bb6A:
undetectable		 4i41A-2bb6A:
19.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M11_B_MXMB606_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 2bb6 TRANSCOBALAMIN II
(Bos
taurus) 		5 / 12 ILE A 290
VAL A 287
ALA A 187
SER A 189
LEU A 193
 None
 1.03A 4m11B-2bb6A:
0.2		 4m11B-2bb6A:
22.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O1Z_A_MXMA807_1
(PROSTAGLANDIN G/H
SYNTHASE 1)		 2bb6 TRANSCOBALAMIN II
(Bos
taurus) 		6 / 12 ILE A 290
VAL A 287
GLY A 185
ALA A 187
SER A 189
LEU A 193
 None
 1.05A 4o1zA-2bb6A:
undetectable		 4o1zA-2bb6A:
22.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4USW_A_ACTA1470_0
(ADENYLATE CYCLASE
TYPE 10)		 2bb6 TRANSCOBALAMIN II
(Bos
taurus) 		4 / 6 LEU A 372
LEU A 409
VAL A 323
PHE A 357
 None
 1.11A 4uswA-2bb6A:
undetectable		 4uswA-2bb6A:
22.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XT8_A_TMQA302_1
(RV2671)		 2bb6 TRANSCOBALAMIN II
(Bos
taurus) 		5 / 12 ILE A 317
SER A 340
GLY A 339
ALA A 338
PHE A 316
 None
 1.28A 4xt8A-2bb6A:
undetectable		 4xt8A-2bb6A:
22.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Y8W_C_STRC603_1
(CYTOCHROME P450
21-HYDROXYLASE)		 2bb6 TRANSCOBALAMIN II
(Bos
taurus) 		5 / 12 VAL A 158
ILE A 204
ILE A 143
GLY A 142
VAL A 110
 None
 0.98A 4y8wC-2bb6A:
undetectable		 4y8wC-2bb6A:
22.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ESG_A_1YNA701_2
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 2bb6 TRANSCOBALAMIN II
(Bos
taurus) 		4 / 4 LEU A 278
TYR A 229
PRO A 271
ILE A  36
 None
B12  A   0 ( 3.4A)
None
None
 1.17A 5esgA-2bb6A:
undetectable		 5esgA-2bb6A:
22.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5K50_A_ACTA1403_0
(L-THREONINE
3-DEHYDROGENASE)		 2bb6 TRANSCOBALAMIN II
(Bos
taurus) 		4 / 5 SER A 177
VAL A 178
GLY A 226
ALA A 218
 None
 0.90A 5k50A-2bb6A:
undetectable		 5k50A-2bb6A:
21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KC0_A_RBFA303_2
(RIBOFLAVIN
TRANSPORTER RIBU)		 2bb6 TRANSCOBALAMIN II
(Bos
taurus) 		3 / 3 LYS A  50
LEU A  58
ILE A  36
 None
 0.75A 5kc0A-2bb6A:
2.1		 5kc0A-2bb6A:
18.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_A_PCFA1808_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 2bb6 TRANSCOBALAMIN II
(Bos
taurus) 		4 / 5 LEU A 144
ALA A  88
LEU A  89
LEU A 113
 None
 0.82A 5vkqA-2bb6A:
2.1
5vkqD-2bb6A:
2.0		 5vkqA-2bb6A:
13.87
5vkqD-2bb6A:
13.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_B_PCFB1805_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 2bb6 TRANSCOBALAMIN II
(Bos
taurus) 		4 / 5 LEU A 113
LEU A 144
ALA A  88
LEU A  89
 None
 0.82A 5vkqA-2bb6A:
2.1
5vkqB-2bb6A:
2.0		 5vkqA-2bb6A:
13.87
5vkqB-2bb6A:
13.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_C_PCFC1806_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 2bb6 TRANSCOBALAMIN II
(Bos
taurus) 		4 / 5 LEU A 113
LEU A 144
ALA A  88
LEU A  89
 None
 0.79A 5vkqB-2bb6A:
2.0
5vkqC-2bb6A:
2.1		 5vkqB-2bb6A:
13.87
5vkqC-2bb6A:
13.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_D_PCFD1806_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 2bb6 TRANSCOBALAMIN II
(Bos
taurus) 		4 / 5 LEU A 113
LEU A 144
ALA A  88
LEU A  89
 None
 0.86A 5vkqC-2bb6A:
2.0
5vkqD-2bb6A:
2.0		 5vkqC-2bb6A:
13.87
5vkqD-2bb6A:
13.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AG0_C_ACRC608_1
(ALPHA-AMYLASE)		 2bb6 TRANSCOBALAMIN II
(Bos
taurus) 		3 / 3 TYR A 139
ALA A 145
LEU A 146
 None
 0.50A 6ag0C-2bb6A:
undetectable		 6ag0C-2bb6A:
14.05