SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2bbh'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MX1_A_THAA1_1
(LIVER
CARBOXYLESTERASE I)		 2bbh DIVALENT CATION
TRANSPORT-RELATED
PROTEIN
(Thermotoga
maritima) 		5 / 11 LEU A  87
GLY A  77
VAL A  50
LEU A  51
LEU A 137
 None
 0.83A 1mx1A-2bbhA:
undetectable		 1mx1A-2bbhA:
19.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MX1_D_THAD4_1
(LIVER
CARBOXYLESTERASE I)		 2bbh DIVALENT CATION
TRANSPORT-RELATED
PROTEIN
(Thermotoga
maritima) 		5 / 12 LEU A  87
GLY A  77
VAL A  50
LEU A  51
LEU A 137
 None
 0.94A 1mx1D-2bbhA:
undetectable		 1mx1D-2bbhA:
19.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TI1_A_B49A299_1
(CYCLIN-DEPENDENT
KINASE 2)		 2bbh DIVALENT CATION
TRANSPORT-RELATED
PROTEIN
(Thermotoga
maritima) 		5 / 9 ILE A 225
VAL A 146
PHE A 113
LEU A 177
ASP A 179
 None
None
DMU  A 402 (-4.3A)
DMU  A 402 ( 4.7A)
DMU  A 404 (-4.6A)
 1.26A 3ti1A-2bbhA:
undetectable		 3ti1A-2bbhA:
23.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKV_D_AERD601_2
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 2bbh DIVALENT CATION
TRANSPORT-RELATED
PROTEIN
(Thermotoga
maritima) 		4 / 5 GLY A 144
ASP A 145
GLU A 141
VAL A 109
 NA  A 301 (-4.1A)
None
None
None
 1.16A 4nkvD-2bbhA:
undetectable		 4nkvD-2bbhA:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKX_C_STRC601_2
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 2bbh DIVALENT CATION
TRANSPORT-RELATED
PROTEIN
(Thermotoga
maritima) 		4 / 5 ILE A  67
ASP A 145
GLU A 141
VAL A 109
 None
 1.06A 4nkxC-2bbhA:
undetectable		 4nkxC-2bbhA:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKX_D_STRD601_2
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 2bbh DIVALENT CATION
TRANSPORT-RELATED
PROTEIN
(Thermotoga
maritima) 		4 / 5 ILE A  67
ASP A 145
GLU A 141
VAL A 109
 None
 1.06A 4nkxD-2bbhA:
undetectable		 4nkxD-2bbhA:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_C_PCFC1801_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 2bbh DIVALENT CATION
TRANSPORT-RELATED
PROTEIN
(Thermotoga
maritima) 		4 / 9 LYS A 187
ILE A 188
ILE A 192
LEU A 195
 None
 0.69A 5vkqB-2bbhA:
4.0
5vkqC-2bbhA:
4.0		 5vkqB-2bbhA:
10.78
5vkqC-2bbhA:
10.78