SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2bbk'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTI_A_CCSA47_0
(GLUTATHIONE
S-TRANSFERASE)		 2bbk METHYLAMINE
DEHYDROGENASE (HEAVY
SUBUNIT)
(Paracoccus
denitrificans) 		4 / 7 LEU H 138
THR H 129
GLY H 150
LEU H 114
 None
 0.95A 1gtiA-2bbkH:
undetectable		 1gtiA-2bbkH:
20.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TV8_B_SAMB2501_0
(MOLYBDENUM COFACTOR
BIOSYNTHESIS PROTEIN
A)		 2bbk METHYLAMINE
DEHYDROGENASE (HEAVY
SUBUNIT)
(Paracoccus
denitrificans) 		4 / 7 TYR H 141
THR H 174
THR H 178
VAL H 165
 None
 1.18A 1tv8B-2bbkH:
undetectable		 1tv8B-2bbkH:
22.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EJT_A_SAMA501_1
(N(2),N(2)-DIMETHYLGU
ANOSINE TRNA
METHYLTRANSFERASE)		 2bbk METHYLAMINE
DEHYDROGENASE (HEAVY
SUBUNIT)
(Paracoccus
denitrificans) 		3 / 3 ARG H  33
ASP H  75
ASP H 134
 None
 0.74A 2ejtA-2bbkH:
undetectable		 2ejtA-2bbkH:
22.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FXD_A_DR7A102_2
(POL PROTEIN)		 2bbk METHYLAMINE
DEHYDROGENASE (HEAVY
SUBUNIT)
(Paracoccus
denitrificans) 		4 / 7 ALA H 370
ASP H 371
ILE H 367
PRO H  70
 None
 0.72A 2fxdB-2bbkH:
undetectable		 2fxdB-2bbkH:
13.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HDN_H_TACH4888_1
(ELONGATION FACTOR
EF-TU)		 2bbk METHYLAMINE
DEHYDROGENASE (HEAVY
SUBUNIT)
(Paracoccus
denitrificans) 		4 / 7 LEU H  67
THR H 338
SER H 322
ASP H 321
 None
 0.95A 2hdnF-2bbkH:
undetectable
2hdnG-2bbkH:
undetectable
2hdnH-2bbkH:
undetectable		 2hdnF-2bbkH:
23.10
2hdnG-2bbkH:
8.93
2hdnH-2bbkH:
23.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J9D_A_ACTA1117_0
(HYPOTHETICAL
NITROGEN REGULATORY
PII-LIKE PROTEIN
MJ0059)		 2bbk METHYLAMINE
DEHYDROGENASE (HEAVY
SUBUNIT)
(Paracoccus
denitrificans) 		3 / 3 ASP H 289
ARG H 288
ARG H 265
 None
 1.03A 2j9dA-2bbkH:
undetectable
2j9dC-2bbkH:
undetectable		 2j9dA-2bbkH:
16.43
2j9dC-2bbkH:
16.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J9D_A_ACTA1117_0
(HYPOTHETICAL
NITROGEN REGULATORY
PII-LIKE PROTEIN
MJ0059)		 2bbk METHYLAMINE
DEHYDROGENASE (HEAVY
SUBUNIT)
(Paracoccus
denitrificans) 		3 / 3 ASP H 289
ARG H 288
ARG H 292
 None
 1.10A 2j9dA-2bbkH:
undetectable
2j9dC-2bbkH:
undetectable		 2j9dA-2bbkH:
16.43
2j9dC-2bbkH:
16.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZXW_C_CHDC271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 2bbk METHYLAMINE
DEHYDROGENASE (HEAVY
SUBUNIT)
(Paracoccus
denitrificans) 		4 / 7 ARG H 119
GLN H 142
PHE H 143
PHE H  66
 None
 0.89A 2zxwC-2bbkH:
undetectable
2zxwJ-2bbkH:
undetectable		 2zxwC-2bbkH:
20.44
2zxwJ-2bbkH:
10.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZXW_P_CHDP1271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 2bbk METHYLAMINE
DEHYDROGENASE (HEAVY
SUBUNIT)
(Paracoccus
denitrificans) 		4 / 6 ARG H 119
GLN H 142
PHE H 143
PHE H  66
 None
 0.85A 2zxwP-2bbkH:
undetectable
2zxwW-2bbkH:
undetectable		 2zxwP-2bbkH:
20.44
2zxwW-2bbkH:
10.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ABL_C_CHDC271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 2bbk METHYLAMINE
DEHYDROGENASE (HEAVY
SUBUNIT)
(Paracoccus
denitrificans) 		4 / 5 ARG H 119
GLN H 142
PHE H 143
PHE H  66
 None
 0.86A 3ablC-2bbkH:
undetectable
3ablJ-2bbkH:
undetectable		 3ablC-2bbkH:
20.44
3ablJ-2bbkH:
10.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ABL_P_CHDP1271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 2bbk METHYLAMINE
DEHYDROGENASE (HEAVY
SUBUNIT)
(Paracoccus
denitrificans) 		4 / 6 ARG H 119
GLN H 142
PHE H 143
PHE H  66
 None
 0.97A 3ablP-2bbkH:
undetectable
3ablW-2bbkH:
undetectable		 3ablP-2bbkH:
20.44
3ablW-2bbkH:
10.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG1_C_CHDC271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 2bbk METHYLAMINE
DEHYDROGENASE (HEAVY
SUBUNIT)
(Paracoccus
denitrificans) 		4 / 6 ARG H 119
GLN H 142
PHE H 143
PHE H  66
 None
 0.82A 3ag1C-2bbkH:
undetectable
3ag1J-2bbkH:
undetectable		 3ag1C-2bbkH:
20.44
3ag1J-2bbkH:
10.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJ8_C_SPMC500_1
(DIAMINE
ACETYLTRANSFERASE 1)		 2bbk METHYLAMINE
DEHYDROGENASE (HEAVY
SUBUNIT)
(Paracoccus
denitrificans) 		4 / 6 ASP H 245
LEU H 188
ASP H 240
LEU H 249
 None
 1.22A 3bj8C-2bbkH:
undetectable
3bj8D-2bbkH:
undetectable		 3bj8C-2bbkH:
19.29
3bj8D-2bbkH:
19.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EL9_A_DR7A100_1
(PROTEASE)		 2bbk METHYLAMINE
DEHYDROGENASE (HEAVY
SUBUNIT)
(Paracoccus
denitrificans) 		4 / 8 ALA H 370
ASP H 371
ILE H 367
PRO H  70
 None
 0.82A 3el9A-2bbkH:
undetectable		 3el9A-2bbkH:
13.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K9F_F_LFXF0_1
(DNA TOPOISOMERASE 4
SUBUNIT A
DNA TOPOISOMERASE 4
SUBUNIT B)		 2bbk METHYLAMINE
DEHYDROGENASE (HEAVY
SUBUNIT)
(Paracoccus
denitrificans) 		4 / 5 SER H 297
ARG H 260
GLY H 234
GLU H 253
 None
 1.17A 3k9fA-2bbkH:
undetectable
3k9fB-2bbkH:
undetectable
3k9fC-2bbkH:
undetectable		 3k9fA-2bbkH:
23.11
3k9fB-2bbkH:
23.11
3k9fC-2bbkH:
18.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K9F_H_LFXH0_1
(DNA TOPOISOMERASE 4
SUBUNIT A
DNA TOPOISOMERASE 4
SUBUNIT B)		 2bbk METHYLAMINE
DEHYDROGENASE (HEAVY
SUBUNIT)
(Paracoccus
denitrificans) 		4 / 6 SER H 297
ARG H 260
GLY H 234
GLU H 253
 None
 1.17A 3k9fA-2bbkH:
undetectable
3k9fB-2bbkH:
undetectable
3k9fD-2bbkH:
undetectable		 3k9fA-2bbkH:
23.11
3k9fB-2bbkH:
23.11
3k9fD-2bbkH:
18.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V4T_E_ACTE503_0
(UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE)		 2bbk METHYLAMINE
DEHYDROGENASE (HEAVY
SUBUNIT)
(Paracoccus
denitrificans) 		3 / 3 GLN H  48
THR H  46
ASN H  37
 None
 0.89A 3v4tE-2bbkH:
undetectable		 3v4tE-2bbkH:
24.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R38_D_RBFD201_2
(BLUE-LIGHT-ACTIVATED
HISTIDINE KINASE 2)		 2bbk METHYLAMINE
DEHYDROGENASE (HEAVY
SUBUNIT)
(Paracoccus
denitrificans) 		5 / 8 ILE H 215
LEU H 336
VAL H 300
LEU H 284
ILE H 320
 None
 1.39A 4r38D-2bbkH:
2.1		 4r38D-2bbkH:
17.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X1F_A_3WFA501_1
(NUCLEAR RECEPTOR
SUBFAMILY 1 GROUP I
MEMBER 2)		 2bbk METHYLAMINE
DEHYDROGENASE (HEAVY
SUBUNIT)
(Paracoccus
denitrificans) 		5 / 12 ASP H 240
LEU H 241
SER H 243
LEU H 188
ILE H 239
 None
 1.04A 4x1fA-2bbkH:
undetectable		 4x1fA-2bbkH:
21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X1G_A_3WFA501_1
(NUCLEAR RECEPTOR
SUBFAMILY 1 GROUP I
MEMBER 2)		 2bbk METHYLAMINE
DEHYDROGENASE (HEAVY
SUBUNIT)
(Paracoccus
denitrificans) 		5 / 12 ASP H 240
LEU H 241
SER H 243
LEU H 188
ILE H 239
 None
 1.03A 4x1gA-2bbkH:
undetectable		 4x1gA-2bbkH:
21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XUM_B_IMNB501_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 2bbk METHYLAMINE
DEHYDROGENASE (HEAVY
SUBUNIT)
(Paracoccus
denitrificans) 		5 / 11 ALA H 246
ILE H 239
LEU H 227
ILE H 171
MET H 128
 None
 1.16A 4xumB-2bbkH:
undetectable		 4xumB-2bbkH:
23.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z3O_F_MFXF101_1
(DNA TOPOISOMERASE 4
SUBUNIT
B,PARE30-PARC55
FUSED TOPO IV FROM
S. PNEUMONIAE
E-SITE DNA)		 2bbk METHYLAMINE
DEHYDROGENASE (HEAVY
SUBUNIT)
(Paracoccus
denitrificans) 		4 / 5 ARG H 288
GLY H 234
GLU H 253
SER H 297
 None
 1.09A 4z3oA-2bbkH:
undetectable
4z3oB-2bbkH:
undetectable		 4z3oA-2bbkH:
19.24
4z3oB-2bbkH:
19.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CDQ_E_MFXE2101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT
B,DNA GYRASE SUBUNIT
B)		 2bbk METHYLAMINE
DEHYDROGENASE (HEAVY
SUBUNIT)
(Paracoccus
denitrificans) 		4 / 5 SER H 297
ARG H 260
GLY H 234
GLU H 253
 None
 1.01A 5cdqA-2bbkH:
undetectable
5cdqB-2bbkH:
undetectable
5cdqC-2bbkH:
undetectable		 5cdqA-2bbkH:
22.09
5cdqB-2bbkH:
18.16
5cdqC-2bbkH:
22.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CDQ_V_MFXV2101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT
B,DNA GYRASE SUBUNIT
B)		 2bbk METHYLAMINE
DEHYDROGENASE (HEAVY
SUBUNIT)
(Paracoccus
denitrificans) 		4 / 5 SER H 297
ARG H 260
GLY H 234
GLU H 253
 None
 1.01A 5cdqR-2bbkH:
undetectable
5cdqS-2bbkH:
undetectable
5cdqT-2bbkH:
undetectable		 5cdqR-2bbkH:
22.09
5cdqS-2bbkH:
18.16
5cdqT-2bbkH:
22.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L66_K_BO2K301_1
(PROTEASOME SUBUNIT
BETA
TYPE-8,PROTEASOME
SUBUNIT BETA TYPE-5
PROTEASOME SUBUNIT
BETA
TYPE-6,PROTEASOME
SUBUNIT BETA
TYPE-1,PROTEASOME
SUBUNIT BETA
TYPE-6,PROTEASOME
SUBUNIT BETA
TYPE-1,PROTEASOME
SUBUNIT BETA TYPE-6)		 2bbk METHYLAMINE
DEHYDROGENASE (HEAVY
SUBUNIT)
(Paracoccus
denitrificans) 		5 / 10 THR H 368
ALA H 370
ALA H  73
ASP H  75
SER H  77
 None
 1.31A 5l66K-2bbkH:
undetectable
5l66L-2bbkH:
undetectable		 5l66K-2bbkH:
19.61
5l66L-2bbkH:
23.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L66_Y_BO2Y301_1
(PROTEASOME SUBUNIT
BETA
TYPE-8,PROTEASOME
SUBUNIT BETA TYPE-5
PROTEASOME SUBUNIT
BETA
TYPE-6,PROTEASOME
SUBUNIT BETA
TYPE-1,PROTEASOME
SUBUNIT BETA
TYPE-6,PROTEASOME
SUBUNIT BETA
TYPE-1,PROTEASOME
SUBUNIT BETA TYPE-6)		 2bbk METHYLAMINE
DEHYDROGENASE (HEAVY
SUBUNIT)
(Paracoccus
denitrificans) 		5 / 10 THR H 368
ALA H 370
ALA H  73
ASP H  75
SER H  77
 None
 1.32A 5l66Y-2bbkH:
undetectable
5l66Z-2bbkH:
undetectable		 5l66Y-2bbkH:
19.61
5l66Z-2bbkH:
23.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UC1_A_486A801_2
(GLUCOCORTICOID
RECEPTOR)		 2bbk METHYLAMINE
DEHYDROGENASE (HEAVY
SUBUNIT)
(Paracoccus
denitrificans) 		3 / 3 TRP H 127
MET H 128
ASN H  69
 None
 1.03A 5uc1B-2bbkH:
undetectable		 5uc1B-2bbkH:
13.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UC1_B_486B801_1
(GLUCOCORTICOID
RECEPTOR)		 2bbk METHYLAMINE
DEHYDROGENASE (HEAVY
SUBUNIT)
(Paracoccus
denitrificans) 		3 / 3 TRP H 127
MET H 128
ASN H  69
 None
 0.95A 5uc1A-2bbkH:
undetectable		 5uc1A-2bbkH:
13.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X6Y_A_SAMA902_0
(MRNA CAPPING ENZYME
P5)		 2bbk METHYLAMINE
DEHYDROGENASE (HEAVY
SUBUNIT)
(Paracoccus
denitrificans) 		5 / 12 GLY H  64
PRO H  39
ALA H  40
HIS H 362
PHE H 101
 None
 1.23A 5x6yA-2bbkH:
undetectable		 5x6yA-2bbkH:
18.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NKN_J_CHDJ101_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 2bbk METHYLAMINE
DEHYDROGENASE (HEAVY
SUBUNIT)
(Paracoccus
denitrificans) 		3 / 3 ARG H 119
PHE H 143
PHE H  66
 None
 0.91A 6nknC-2bbkH:
undetectable
6nknJ-2bbkH:
undetectable		 6nknC-2bbkH:
20.44
6nknJ-2bbkH:
10.76