SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2bbv'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A27_A_ESTA350_1
(17-BETA-HYDROXYSTERO
ID-DEHYDROGENASE)		 2bbv PROTEIN (BLACK
BEETLE VIRUS CAPSID
PROTEIN)
(Black
beetle
virus) 		5 / 12 VAL A 173
GLY A 174
LEU A 313
TYR A 176
VAL A 301
 None
 1.42A 1a27A-2bbvA:
undetectable		 1a27A-2bbvA:
22.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RV7_B_AB1B1001_1
(PROTEASE)		 2bbv PROTEIN (BLACK
BEETLE VIRUS CAPSID
PROTEIN)
(Black
beetle
virus) 		5 / 11 ALA A 107
ILE A 236
THR A 178
PRO A 177
ALA A 311
 None
 1.15A 1rv7A-2bbvA:
undetectable
1rv7B-2bbvA:
undetectable		 1rv7A-2bbvA:
15.28
1rv7B-2bbvA:
15.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VH3_A_DAHA2_1
(RANASMURFIN)		 2bbv PROTEIN (BLACK
BEETLE VIRUS CAPSID
PROTEIN)
(Black
beetle
virus) 		5 / 9 ALA A 169
PHE A 145
GLY A 120
SER A 170
ALA A 317
 None
 1.33A 2vh3A-2bbvA:
undetectable		 2vh3A-2bbvA:
15.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WA2_A_SAMA1248_0
(NON-STRUCTURAL
PROTEIN 5)		 2bbv PROTEIN (BLACK
BEETLE VIRUS CAPSID
PROTEIN)
(Black
beetle
virus) 		5 / 12 GLY A 186
GLY A 238
SER A 234
VAL A 173
THR A 315
 None
 1.09A 2wa2A-2bbvA:
undetectable		 2wa2A-2bbvA:
23.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DFR_A_MTXA164_1
(DIHYDROFOLATE
REDUCTASE)		 2bbv PROTEIN (BLACK
BEETLE VIRUS CAPSID
PROTEIN)
(Black
beetle
virus) 		5 / 12 LEU A 220
LEU A 114
PRO A 134
ALA A 279
THR A 118
 None
 1.03A 3dfrA-2bbvA:
undetectable		 3dfrA-2bbvA:
19.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_E_TFPE201_1
(PROTEIN S100-A4)		 2bbv PROTEIN (BLACK
BEETLE VIRUS CAPSID
PROTEIN)
(Black
beetle
virus) 		4 / 7 GLY A 174
PHE A 240
CYH A  69
PHE A  71
 None
 0.83A 3ko0D-2bbvA:
undetectable
3ko0E-2bbvA:
undetectable		 3ko0D-2bbvA:
12.11
3ko0E-2bbvA:
12.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_M_TFPM201_1
(PROTEIN S100-A4)		 2bbv PROTEIN (BLACK
BEETLE VIRUS CAPSID
PROTEIN)
(Black
beetle
virus) 		4 / 7 CYH A  69
PHE A  71
GLY A 174
PHE A 240
 None
 0.75A 3ko0M-2bbvA:
undetectable
3ko0P-2bbvA:
undetectable		 3ko0M-2bbvA:
12.11
3ko0P-2bbvA:
12.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_O_TFPO201_1
(PROTEIN S100-A4)		 2bbv PROTEIN (BLACK
BEETLE VIRUS CAPSID
PROTEIN)
(Black
beetle
virus) 		4 / 8 CYH A  69
PHE A  71
GLY A 174
PHE A 240
 None
 0.85A 3ko0O-2bbvA:
undetectable
3ko0Q-2bbvA:
undetectable		 3ko0O-2bbvA:
12.11
3ko0Q-2bbvA:
12.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_Q_TFPQ201_1
(PROTEIN S100-A4)		 2bbv PROTEIN (BLACK
BEETLE VIRUS CAPSID
PROTEIN)
(Black
beetle
virus) 		4 / 8 GLY A 174
PHE A 240
CYH A  69
PHE A  71
 None
 0.83A 3ko0O-2bbvA:
undetectable
3ko0Q-2bbvA:
undetectable		 3ko0O-2bbvA:
12.11
3ko0Q-2bbvA:
12.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NBQ_A_URFA400_1
(URIDINE
PHOSPHORYLASE 1)		 2bbv PROTEIN (BLACK
BEETLE VIRUS CAPSID
PROTEIN)
(Black
beetle
virus) 		5 / 9 THR A 315
GLY A 174
MET A 171
LEU A 313
ILE A 113
 None
 1.44A 3nbqA-2bbvA:
undetectable		 3nbqA-2bbvA:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NBQ_D_URFD400_1
(URIDINE
PHOSPHORYLASE 1)		 2bbv PROTEIN (BLACK
BEETLE VIRUS CAPSID
PROTEIN)
(Black
beetle
virus) 		5 / 9 THR A 315
GLY A 174
MET A 171
LEU A 313
ILE A 113
 None
 1.45A 3nbqD-2bbvA:
undetectable		 3nbqD-2bbvA:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NY4_A_SMXA310_1
(BETA-LACTAMASE)		 2bbv PROTEIN (BLACK
BEETLE VIRUS CAPSID
PROTEIN)
(Black
beetle
virus) 		5 / 8 LEU A 344
ARG A 348
ALA A 351
GLY A  83
PRO A  85
 None
 1.31A 3ny4A-2bbvA:
undetectable		 3ny4A-2bbvA:
21.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V3O_A_T1CA404_1
(TETX2 PROTEIN)		 2bbv PROTEIN (BLACK
BEETLE VIRUS CAPSID
PROTEIN)
(Black
beetle
virus) 		5 / 12 THR A 189
ASN A 230
ALA A 360
GLY A 238
ASN A 363
 None
 1.22A 3v3oA-2bbvA:
undetectable		 3v3oA-2bbvA:
22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JLT_A_8PRA505_1
(CYTOCHROME P450 2B4)		 2bbv PROTEIN (BLACK
BEETLE VIRUS CAPSID
PROTEIN)
(Black
beetle
virus) 		4 / 8 ILE A 113
ILE A 175
ALA A 311
VAL A 301
 None
 0.82A 4jltA-2bbvA:
undetectable		 4jltA-2bbvA:
20.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OLB_A_TRPA901_0
(PROTEIN ARGONAUTE-2)		 2bbv PROTEIN (BLACK
BEETLE VIRUS CAPSID
PROTEIN)
(Black
beetle
virus) 		3 / 3 VAL A 285
ALA A 280
PHE A 148
 None
 0.85A 4olbA-2bbvA:
undetectable		 4olbA-2bbvA:
17.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OTW_A_DB8A1101_2
(RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-3)		 2bbv PROTEIN (BLACK
BEETLE VIRUS CAPSID
PROTEIN)
(Black
beetle
virus) 		3 / 3 LEU A 256
LEU A 319
ASN A 293
 None
 0.66A 4otwA-2bbvA:
undetectable		 4otwA-2bbvA:
19.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PCU_A_SAMA603_0
(CYSTATHIONINE
BETA-SYNTHASE)		 2bbv PROTEIN (BLACK
BEETLE VIRUS CAPSID
PROTEIN)
(Black
beetle
virus) 		4 / 7 PHE A 140
PRO A 275
THR A 296
ILE A 115
 None
 0.98A 4pcuA-2bbvA:
undetectable		 4pcuA-2bbvA:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UCK_A_SAMA2409_1
(RNA-DIRECTED RNA
POLYMERASE L)		 2bbv PROTEIN (BLACK
BEETLE VIRUS CAPSID
PROTEIN)
(Black
beetle
virus) 		3 / 3 SER A 272
ASP A 295
ASP A 221
 None
None
CA  A 364 (-3.1A)
 0.70A 4uckA-2bbvA:
undetectable		 4uckA-2bbvA:
21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4W5N_A_IPHA901_0
(PROTEIN ARGONAUTE-2)		 2bbv PROTEIN (BLACK
BEETLE VIRUS CAPSID
PROTEIN)
(Black
beetle
virus) 		3 / 3 VAL A 285
ALA A 280
PHE A 148
 None
 0.93A 4w5nA-2bbvA:
undetectable		 4w5nA-2bbvA:
17.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NFJ_A_SAMA501_0
(MITOCHONDRIAL
RIBONUCLEASE P
PROTEIN 1)		 2bbv PROTEIN (BLACK
BEETLE VIRUS CAPSID
PROTEIN)
(Black
beetle
virus) 		5 / 12 ILE A 259
LEU A 217
LEU A 220
ASN A 277
LEU A 278
 None
 0.94A 5nfjA-2bbvA:
undetectable		 5nfjA-2bbvA:
19.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NFJ_B_SAMB501_0
(MITOCHONDRIAL
RIBONUCLEASE P
PROTEIN 1)		 2bbv PROTEIN (BLACK
BEETLE VIRUS CAPSID
PROTEIN)
(Black
beetle
virus) 		5 / 12 ILE A 259
LEU A 217
LEU A 220
ASN A 277
LEU A 278
 None
 0.94A 5nfjB-2bbvA:
undetectable		 5nfjB-2bbvA:
19.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NFJ_C_SAMC501_0
(MITOCHONDRIAL
RIBONUCLEASE P
PROTEIN 1)		 2bbv PROTEIN (BLACK
BEETLE VIRUS CAPSID
PROTEIN)
(Black
beetle
virus) 		5 / 12 ILE A 259
LEU A 217
LEU A 220
ASN A 277
LEU A 278
 None
 0.93A 5nfjC-2bbvA:
undetectable		 5nfjC-2bbvA:
19.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ELI_A_T27A701_1
(REVERSE
TRANSCRIPTASE)		 2bbv PROTEIN (BLACK
BEETLE VIRUS CAPSID
PROTEIN)
(Black
beetle
virus) 		5 / 12 LEU A 217
VAL A 223
PRO A 134
PHE A 140
TRP A 124
 None
 1.44A 6eliA-2bbvA:
undetectable		 6eliA-2bbvA:
11.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HLO_A_GBQA1501_1
(SUBSTANCE-P
RECEPTOR,GLGA
GLYCOGEN
SYNTHASE,SUBSTANCE-P
RECEPTOR)		 2bbv PROTEIN (BLACK
BEETLE VIRUS CAPSID
PROTEIN)
(Black
beetle
virus) 		5 / 9 ILE A 299
ILE A 115
GLU A 233
VAL A 190
ILE A 297
 None
 1.31A 6hloA-2bbvA:
undetectable		 6hloA-2bbvA:
21.25