SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2bbz'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_A_115A2_2
(HMG-COA REDUCTASE)		 2bbz VIRAL CASP8 AND
FADD-LIKE APOPTOSIS
REGULATOR
(Molluscum
contagiosum
virus) 		4 / 8 GLU A 132
LEU A 139
ALA A 142
LEU A 143
 None
 0.80A 1hwiB-2bbzA:
undetectable		 1hwiB-2bbzA:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_C_115C4_2
(HMG-COA REDUCTASE)		 2bbz VIRAL CASP8 AND
FADD-LIKE APOPTOSIS
REGULATOR
(Molluscum
contagiosum
virus) 		4 / 8 GLU A 132
LEU A 139
ALA A 142
LEU A 143
 None
 0.78A 1hwiD-2bbzA:
undetectable		 1hwiD-2bbzA:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_D_115D3_1
(HMG-COA REDUCTASE)		 2bbz VIRAL CASP8 AND
FADD-LIKE APOPTOSIS
REGULATOR
(Molluscum
contagiosum
virus) 		4 / 8 GLU A 132
LEU A 139
ALA A 142
LEU A 143
 None
 0.78A 1hwiC-2bbzA:
undetectable		 1hwiC-2bbzA:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2H21_A_SAMA801_0
(RIBULOSE-1,5
BISPHOSPHATE
CARBOXYLASE/OXYGENAS
E)		 2bbz VIRAL CASP8 AND
FADD-LIKE APOPTOSIS
REGULATOR
(Molluscum
contagiosum
virus) 		5 / 10 GLU A 105
GLY A 104
LEU A 107
SER A 134
ARG A 116
 None
 1.38A 2h21A-2bbzA:
undetectable		 2h21A-2bbzA:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2H21_B_SAMB802_0
(RIBULOSE-1,5
BISPHOSPHATE
CARBOXYLASE/OXYGENAS
E)		 2bbz VIRAL CASP8 AND
FADD-LIKE APOPTOSIS
REGULATOR
(Molluscum
contagiosum
virus) 		5 / 11 GLU A 105
GLY A 104
LEU A 107
SER A 134
ARG A 116
 None
 1.49A 2h21B-2bbzA:
undetectable		 2h21B-2bbzA:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KLR_B_CHDB503_0
(FERROCHELATASE,
MITOCHONDRIAL)		 2bbz VIRAL CASP8 AND
FADD-LIKE APOPTOSIS
REGULATOR
(Molluscum
contagiosum
virus) 		4 / 8 LEU A 130
SER A  26
VAL A 103
GLY A 104
 None
 0.91A 4klrB-2bbzA:
undetectable		 4klrB-2bbzA:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P65_K_IPHK101_0
(INSULIN)		 2bbz VIRAL CASP8 AND
FADD-LIKE APOPTOSIS
REGULATOR
(Molluscum
contagiosum
virus) 		5 / 12 LEU A 122
VAL A 149
LEU A 157
LEU A 126
ALA A 119
 None
 0.98A 4p65F-2bbzA:
undetectable
4p65H-2bbzA:
undetectable
4p65K-2bbzA:
undetectable
4p65L-2bbzA:
undetectable		 4p65F-2bbzA:
10.04
4p65H-2bbzA:
10.04
4p65K-2bbzA:
7.45
4p65L-2bbzA:
10.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZN7_B_DESB600_1
(ESTROGEN RECEPTOR)		 2bbz VIRAL CASP8 AND
FADD-LIKE APOPTOSIS
REGULATOR
(Molluscum
contagiosum
virus) 		5 / 11 LEU A  99
GLU A 106
LEU A 161
LEU A 169
LEU A 157
 None
 1.17A 4zn7B-2bbzA:
undetectable		 4zn7B-2bbzA:
24.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FPD_A_PZAA1385_0
(HEAT SHOCK-RELATED
70KDA PROTEIN 2)		 2bbz VIRAL CASP8 AND
FADD-LIKE APOPTOSIS
REGULATOR
(Molluscum
contagiosum
virus) 		4 / 7 VAL A 154
SER A 155
ALA A 158
VAL A 174
 None
 0.72A 5fpdA-2bbzA:
undetectable		 5fpdA-2bbzA:
18.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FPD_B_PZAB1385_0
(HEAT SHOCK-RELATED
70KDA PROTEIN 2)		 2bbz VIRAL CASP8 AND
FADD-LIKE APOPTOSIS
REGULATOR
(Molluscum
contagiosum
virus) 		4 / 7 VAL A 154
SER A 155
ALA A 158
VAL A 174
 None
 0.71A 5fpdB-2bbzA:
undetectable		 5fpdB-2bbzA:
18.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IEO_A_VDYA206_1
(CDL2.3A)		 2bbz VIRAL CASP8 AND
FADD-LIKE APOPTOSIS
REGULATOR
(Molluscum
contagiosum
virus) 		5 / 12 LEU A  73
LEU A  46
LEU A  13
PHE A  77
ALA A  59
 None
 1.32A 5ieoA-2bbzA:
undetectable		 5ieoA-2bbzA:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UXD_B_ZITB501_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E MPHH)		 2bbz VIRAL CASP8 AND
FADD-LIKE APOPTOSIS
REGULATOR
(Molluscum
contagiosum
virus) 		5 / 12 LEU A 141
LEU A  67
VAL A  66
ALA A  36
GLY A  38
 None
 1.03A 5uxdB-2bbzA:
undetectable		 5uxdB-2bbzA:
23.15