SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2bc0'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C6Y_B_MK1B524_2
(PROTEIN (PROTEASE))		 2bc0 NADH OXIDASE
(Streptococcus
pyogenes) 		5 / 12 GLY A 453
ALA A 454
ASP A 456
ILE A 387
ILE A 426
 None
 0.79A 1c6yB-2bc0A:
undetectable		 1c6yB-2bc0A:
12.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HSH_A_MK1A401_1
(HIV-II PROTEASE)		 2bc0 NADH OXIDASE
(Streptococcus
pyogenes) 		5 / 12 GLY A 453
ALA A 454
ASP A 456
ILE A 387
ILE A 426
 None
 0.83A 1hshA-2bc0A:
undetectable		 1hshA-2bc0A:
12.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HSH_C_MK1C402_1
(HIV-II PROTEASE)		 2bc0 NADH OXIDASE
(Streptococcus
pyogenes) 		5 / 12 GLY A 453
ALA A 454
ASP A 456
ILE A 387
ILE A 426
 None
 0.74A 1hshC-2bc0A:
undetectable		 1hshC-2bc0A:
12.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HXB_A_ROCA100_1
(HIV-1 PROTEASE)		 2bc0 NADH OXIDASE
(Streptococcus
pyogenes) 		5 / 12 GLY A 453
ALA A 454
ASP A 456
ILE A 387
ILE A 426
 None
 0.69A 1hxbA-2bc0A:
undetectable		 1hxbA-2bc0A:
12.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ICR_A_NIOA604_1
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 2bc0 NADH OXIDASE
(Streptococcus
pyogenes) 		4 / 5 SER A 283
THR A 282
PHE A 274
GLY A 262
 None
 1.33A 1icrA-2bc0A:
undetectable
1icrB-2bc0A:
undetectable		 1icrA-2bc0A:
18.71
1icrB-2bc0A:
18.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ICR_B_NIOB602_1
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 2bc0 NADH OXIDASE
(Streptococcus
pyogenes) 		4 / 5 GLY A 262
SER A 283
THR A 282
PHE A 274
 None
 1.31A 1icrA-2bc0A:
undetectable
1icrB-2bc0A:
undetectable		 1icrA-2bc0A:
18.71
1icrB-2bc0A:
18.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ICV_B_NIOB702_1
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 2bc0 NADH OXIDASE
(Streptococcus
pyogenes) 		4 / 5 GLY A 262
SER A 283
THR A 282
PHE A 274
 None
 1.34A 1icvA-2bc0A:
undetectable
1icvB-2bc0A:
undetectable		 1icvA-2bc0A:
18.71
1icvB-2bc0A:
18.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KQB_B_BEZB525_0
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 2bc0 NADH OXIDASE
(Streptococcus
pyogenes) 		4 / 5 GLY A 262
SER A 283
THR A 282
PHE A 274
 None
 1.32A 1kqbA-2bc0A:
undetectable
1kqbB-2bc0A:
undetectable		 1kqbA-2bc0A:
17.62
1kqbB-2bc0A:
17.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MUI_B_AB1B100_1
(PROTEASE)		 2bc0 NADH OXIDASE
(Streptococcus
pyogenes) 		5 / 10 GLY A 453
ALA A 454
ASP A 456
ILE A 387
ILE A 426
 None
 0.77A 1muiA-2bc0A:
undetectable		 1muiA-2bc0A:
12.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MUI_B_AB1B100_2
(PROTEASE)		 2bc0 NADH OXIDASE
(Streptococcus
pyogenes) 		5 / 12 GLY A 453
ALA A 454
ASP A 456
ILE A 387
ILE A 426
 None
 0.65A 1muiB-2bc0A:
undetectable		 1muiB-2bc0A:
12.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RL8_A_RITA9001_1
(PROTEASE RETROPEPSIN)		 2bc0 NADH OXIDASE
(Streptococcus
pyogenes) 		5 / 12 GLY A 453
ALA A 454
ASP A 456
ILE A 387
ILE A 426
 None
 0.70A 1rl8A-2bc0A:
undetectable		 1rl8A-2bc0A:
15.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RL8_A_RITA9001_2
(PROTEASE RETROPEPSIN)		 2bc0 NADH OXIDASE
(Streptococcus
pyogenes) 		5 / 12 GLY A 453
ALA A 454
ASP A 456
ILE A 387
ILE A 426
 None
 0.67A 1rl8B-2bc0A:
undetectable		 1rl8B-2bc0A:
15.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SDT_B_MK1B902_2
(PROTEASE RETROPEPSIN)		 2bc0 NADH OXIDASE
(Streptococcus
pyogenes) 		5 / 12 GLY A 453
ALA A 454
ASP A 456
ILE A 387
ILE A 426
 None
 0.66A 1sdtB-2bc0A:
undetectable		 1sdtB-2bc0A:
12.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SDU_B_MK1B902_2
(PROTEASE RETROPEPSIN)		 2bc0 NADH OXIDASE
(Streptococcus
pyogenes) 		5 / 12 GLY A 453
ALA A 454
ASP A 456
ILE A 387
ILE A 426
 None
 0.79A 1sduB-2bc0A:
undetectable		 1sduB-2bc0A:
13.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SDV_B_MK1B902_2
(PROTEASE RETROPEPSIN)		 2bc0 NADH OXIDASE
(Streptococcus
pyogenes) 		5 / 11 GLY A 453
ALA A 454
ASP A 456
ILE A 387
ILE A 426
 None
 0.62A 1sdvB-2bc0A:
undetectable		 1sdvB-2bc0A:
12.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YAJ_F_BEZF5023_0
(CES1 PROTEIN)		 2bc0 NADH OXIDASE
(Streptococcus
pyogenes) 		4 / 6 LEU A 188
GLY A 172
LEU A 196
ILE A 342
 None
 0.96A 1yajF-2bc0A:
undetectable		 1yajF-2bc0A:
22.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YAJ_K_BEZK4387_0
(CES1 PROTEIN)		 2bc0 NADH OXIDASE
(Streptococcus
pyogenes) 		3 / 3 TRP A  49
LEU A 155
LYS A 182
 None
 1.45A 1yajK-2bc0A:
undetectable		 1yajK-2bc0A:
22.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AVV_A_MK1A901_1
(POL POLYPROTEIN)		 2bc0 NADH OXIDASE
(Streptococcus
pyogenes) 		5 / 12 GLY A 453
ALA A 454
ASP A 456
ILE A 387
ILE A 426
 None
 0.63A 2avvA-2bc0A:
undetectable		 2avvA-2bc0A:
12.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AVV_A_MK1A901_3
(POL POLYPROTEIN)		 2bc0 NADH OXIDASE
(Streptococcus
pyogenes) 		5 / 12 GLY A 453
ALA A 454
ASP A 456
ILE A 387
ILE A 426
 None
 0.57A 2avvB-2bc0A:
undetectable		 2avvB-2bc0A:
12.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AVV_E_MK1E902_3
(POL POLYPROTEIN)		 2bc0 NADH OXIDASE
(Streptococcus
pyogenes) 		5 / 12 GLY A 453
ALA A 454
ASP A 456
ILE A 387
ILE A 426
 None
 0.64A 2avvE-2bc0A:
undetectable		 2avvE-2bc0A:
12.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F81_A_017A302_1
(POL POLYPROTEIN)		 2bc0 NADH OXIDASE
(Streptococcus
pyogenes) 		5 / 12 GLY A 453
ALA A 454
ASP A 456
ILE A 387
ILE A 426
 None
 0.65A 2f81A-2bc0A:
undetectable		 2f81A-2bc0A:
13.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2GJ5_A_VD3A163_1
(BETA-LACTOGLOBULIN)		 2bc0 NADH OXIDASE
(Streptococcus
pyogenes) 		5 / 12 VAL A 348
ILE A 387
ILE A 447
ALA A 451
MET A 415
 None
 1.12A 2gj5A-2bc0A:
undetectable		 2gj5A-2bc0A:
16.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HS1_A_017A201_1
(HIV-1 PROTEASE)		 2bc0 NADH OXIDASE
(Streptococcus
pyogenes) 		5 / 12 GLY A 453
ALA A 454
ASP A 456
ILE A 387
ILE A 426
 None
 0.65A 2hs1A-2bc0A:
undetectable		 2hs1A-2bc0A:
12.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HS2_A_017A201_2
(PROTEASE)		 2bc0 NADH OXIDASE
(Streptococcus
pyogenes) 		5 / 12 GLY A 453
ALA A 454
ASP A 456
ILE A 387
ILE A 426
 None
 0.48A 2hs2B-2bc0A:
undetectable		 2hs2B-2bc0A:
13.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IEN_B_017B402_1
(PROTEASE)		 2bc0 NADH OXIDASE
(Streptococcus
pyogenes) 		5 / 12 GLY A 453
ALA A 454
ASP A 456
ILE A 387
ILE A 426
 None
 0.63A 2ienA-2bc0A:
undetectable		 2ienA-2bc0A:
12.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NMY_A_ROCA401_1
(PROTEASE)		 2bc0 NADH OXIDASE
(Streptococcus
pyogenes) 		5 / 12 GLY A 453
ALA A 454
ASP A 456
ILE A 387
ILE A 426
 None
 0.77A 2nmyA-2bc0A:
undetectable		 2nmyA-2bc0A:
12.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NMY_A_ROCA401_2
(PROTEASE)		 2bc0 NADH OXIDASE
(Streptococcus
pyogenes) 		5 / 12 GLY A 453
ALA A 454
ASP A 456
ILE A 387
ILE A 426
 None
 0.64A 2nmyB-2bc0A:
undetectable		 2nmyB-2bc0A:
12.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NMZ_B_ROCB401_1
(PROTEASE)		 2bc0 NADH OXIDASE
(Streptococcus
pyogenes) 		5 / 12 GLY A 453
ALA A 454
ASP A 456
ILE A 387
ILE A 426
 None
 0.71A 2nmzA-2bc0A:
undetectable		 2nmzA-2bc0A:
12.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2O4N_A_TPVA300_2
(PROTEASE)		 2bc0 NADH OXIDASE
(Streptococcus
pyogenes) 		5 / 8 LEU A  48
ALA A 178
ILE A 342
GLY A 172
ILE A 171
 None
None
None
None
FAD  A 601 (-4.0A)
 1.41A 2o4nB-2bc0A:
undetectable		 2o4nB-2bc0A:
13.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2O4S_A_AB1A400_2
(PROTEASE)		 2bc0 NADH OXIDASE
(Streptococcus
pyogenes) 		5 / 12 GLY A 453
ALA A 454
ASP A 456
ILE A 387
ILE A 426
 None
 0.64A 2o4sB-2bc0A:
undetectable		 2o4sB-2bc0A:
13.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QHC_B_AB1B9001_2
(PROTEASE RETROPEPSIN)		 2bc0 NADH OXIDASE
(Streptococcus
pyogenes) 		5 / 12 GLY A 453
ALA A 454
ASP A 456
ILE A 387
ILE A 426
 None
 0.67A 2qhcB-2bc0A:
undetectable		 2qhcB-2bc0A:
12.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2R5P_D_MK1D902_2
(PROTEASE)		 2bc0 NADH OXIDASE
(Streptococcus
pyogenes) 		5 / 12 GLY A 453
ALA A 454
ASP A 456
ILE A 387
ILE A 426
 None
 0.66A 2r5pD-2bc0A:
undetectable		 2r5pD-2bc0A:
12.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2R5Q_B_1UNB900_2
(PROTEASE)		 2bc0 NADH OXIDASE
(Streptococcus
pyogenes) 		5 / 11 GLY A 453
ALA A 454
ASP A 456
ILE A 387
ILE A 426
 None
 0.80A 2r5qB-2bc0A:
undetectable		 2r5qB-2bc0A:
12.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2R5Q_D_1UND900_2
(PROTEASE)		 2bc0 NADH OXIDASE
(Streptococcus
pyogenes) 		5 / 10 GLY A 453
ALA A 454
ASP A 456
ILE A 387
ILE A 426
 None
 0.80A 2r5qD-2bc0A:
undetectable		 2r5qD-2bc0A:
12.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RKF_A_AB1A501_1
(PROTEASE RETROPEPSIN)		 2bc0 NADH OXIDASE
(Streptococcus
pyogenes) 		5 / 12 GLY A 453
ALA A 454
ASP A 456
ILE A 387
ILE A 426
 None
 0.60A 2rkfA-2bc0A:
undetectable		 2rkfA-2bc0A:
12.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RKF_A_AB1A501_2
(PROTEASE RETROPEPSIN)		 2bc0 NADH OXIDASE
(Streptococcus
pyogenes) 		5 / 12 GLY A 453
ALA A 454
ASP A 456
ILE A 387
ILE A 426
 None
 0.68A 2rkfB-2bc0A:
undetectable		 2rkfB-2bc0A:
12.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RKG_B_AB1B501_1
(PROTEASE RETROPEPSIN)		 2bc0 NADH OXIDASE
(Streptococcus
pyogenes) 		5 / 12 GLY A 453
ALA A 454
ASP A 456
ILE A 387
ILE A 426
 None
 0.66A 2rkgA-2bc0A:
undetectable		 2rkgA-2bc0A:
12.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RKG_B_AB1B501_2
(PROTEASE RETROPEPSIN)		 2bc0 NADH OXIDASE
(Streptococcus
pyogenes) 		5 / 12 GLY A 453
ALA A 454
ASP A 456
ILE A 387
ILE A 426
 None
 0.66A 2rkgB-2bc0A:
undetectable		 2rkgB-2bc0A:
12.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W1B_A_DXCA2034_0
(ACRIFLAVIN
RESISTANCE PROTEIN B)		 2bc0 NADH OXIDASE
(Streptococcus
pyogenes) 		3 / 3 PHE A  61
SER A 148
LEU A 144
 None
 0.55A 2w1bA-2bc0A:
undetectable		 2w1bA-2bc0A:
20.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WEK_A_DIFA1373_1
(ZINC-BINDING ALCOHOL
DEHYDROGENASE
DOMAIN-CONTAINING
PROTEIN 2)		 2bc0 NADH OXIDASE
(Streptococcus
pyogenes) 		4 / 8 ASN A 147
SER A 148
PHE A  61
ASN A  38
 None
 1.05A 2wekA-2bc0A:
3.6		 2wekA-2bc0A:
22.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7H_C_SAMC530_0
(TYPE I RESTRICTION
ENZYME ECOKI M
PROTEIN)		 2bc0 NADH OXIDASE
(Streptococcus
pyogenes) 		6 / 12 ALA A  15
GLY A 317
THR A 316
GLY A 291
LEU A  71
THR A  22
 None
None
None
FAD  A 601 (-3.2A)
None
None
 1.26A 2y7hC-2bc0A:
undetectable		 2y7hC-2bc0A:
22.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Z54_A_AB1A200_1
(HIV-1 PROTEASE)		 2bc0 NADH OXIDASE
(Streptococcus
pyogenes) 		5 / 12 GLY A 453
ALA A 454
ASP A 456
ILE A 387
ILE A 426
 None
 0.68A 2z54A-2bc0A:
undetectable		 2z54A-2bc0A:
12.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Z54_A_AB1A200_2
(HIV-1 PROTEASE)		 2bc0 NADH OXIDASE
(Streptococcus
pyogenes) 		5 / 12 GLY A 453
ALA A 454
ASP A 456
ILE A 387
ILE A 426
 None
 0.65A 2z54B-2bc0A:
undetectable		 2z54B-2bc0A:
12.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BVB_B_017B401_2
(PROTEASE
(RETROPEPSIN))		 2bc0 NADH OXIDASE
(Streptococcus
pyogenes) 		5 / 12 GLY A 453
ALA A 454
ASP A 456
ILE A 387
ILE A 426
 None
 0.65A 3bvbB-2bc0A:
undetectable		 3bvbB-2bc0A:
12.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CYW_A_017A201_2
(HIV-1 PROTEASE)		 2bc0 NADH OXIDASE
(Streptococcus
pyogenes) 		5 / 12 GLY A 453
ALA A 454
ASP A 456
ILE A 387
ILE A 426
 None
 0.60A 3cywB-2bc0A:
undetectable		 3cywB-2bc0A:
12.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D20_A_017A201_1
(HIV-1 PROTEASE)		 2bc0 NADH OXIDASE
(Streptococcus
pyogenes) 		5 / 12 GLY A 453
ALA A 454
ASP A 456
ILE A 387
ILE A 426
 None
 0.62A 3d20A-2bc0A:
undetectable		 3d20A-2bc0A:
12.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D20_A_017A201_2
(HIV-1 PROTEASE)		 2bc0 NADH OXIDASE
(Streptococcus
pyogenes) 		5 / 12 GLY A 453
ALA A 454
ASP A 456
ILE A 387
ILE A 426
 None
 0.59A 3d20B-2bc0A:
undetectable		 3d20B-2bc0A:
12.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EKP_C_478C200_2
(PROTEASE)		 2bc0 NADH OXIDASE
(Streptococcus
pyogenes) 		5 / 10 GLY A 453
ALA A 454
ASP A 456
ILE A 387
ILE A 426
 None
 0.60A 3ekpD-2bc0A:
undetectable		 3ekpD-2bc0A:
12.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EKQ_A_ROCA100_1
(PROTEASE)		 2bc0 NADH OXIDASE
(Streptococcus
pyogenes) 		5 / 12 GLY A 453
ALA A 454
ASP A 456
ILE A 387
ILE A 426
 None
 0.81A 3ekqA-2bc0A:
undetectable		 3ekqA-2bc0A:
12.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EKT_D_017D200_1
(PROTEASE)		 2bc0 NADH OXIDASE
(Streptococcus
pyogenes) 		5 / 11 GLY A 453
ALA A 454
ASP A 456
ILE A 387
ILE A 426
 None
 0.55A 3ektC-2bc0A:
undetectable		 3ektC-2bc0A:
12.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EKT_D_017D200_2
(PROTEASE)		 2bc0 NADH OXIDASE
(Streptococcus
pyogenes) 		5 / 11 GLY A 453
ALA A 454
ASP A 456
ILE A 387
ILE A 426
 None
 0.59A 3ektD-2bc0A:
undetectable		 3ektD-2bc0A:
12.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EKV_A_478A200_1
(PROTEASE)		 2bc0 NADH OXIDASE
(Streptococcus
pyogenes) 		5 / 10 GLY A 453
ALA A 454
ASP A 456
ILE A 387
ILE A 426
 None
 0.67A 3ekvA-2bc0A:
undetectable		 3ekvA-2bc0A:
12.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EL0_A_1UNA201_1
(PROTEASE)		 2bc0 NADH OXIDASE
(Streptococcus
pyogenes) 		4 / 8 GLY A 453
ALA A 454
ASP A 456
ILE A 426
 None
 0.60A 3el0A-2bc0A:
undetectable		 3el0A-2bc0A:
12.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JW2_A_017A401_1
(GAG-POL POLYPROTEIN)		 2bc0 NADH OXIDASE
(Streptococcus
pyogenes) 		5 / 12 GLY A 453
ALA A 454
ASP A 456
ILE A 387
ILE A 426
 None
 0.82A 3jw2A-2bc0A:
undetectable		 3jw2A-2bc0A:
12.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JW2_A_017A401_2
(GAG-POL POLYPROTEIN)		 2bc0 NADH OXIDASE
(Streptococcus
pyogenes) 		5 / 12 GLY A 453
ALA A 454
ASP A 456
ILE A 387
ILE A 426
 None
 0.64A 3jw2B-2bc0A:
undetectable		 3jw2B-2bc0A:
12.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K4V_B_ROCB201_1
(HIV-1 PROTEASE)		 2bc0 NADH OXIDASE
(Streptococcus
pyogenes) 		5 / 12 GLY A 453
ALA A 454
ASP A 456
ILE A 387
ILE A 426
 None
 0.82A 3k4vA-2bc0A:
undetectable		 3k4vA-2bc0A:
12.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K4V_B_ROCB201_3
(HIV-1 PROTEASE)		 2bc0 NADH OXIDASE
(Streptococcus
pyogenes) 		5 / 12 GLY A 453
ALA A 454
ASP A 456
ILE A 387
ILE A 426
 None
 0.81A 3k4vB-2bc0A:
undetectable		 3k4vB-2bc0A:
12.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LZS_A_017A200_1
(HIV-1 PROTEASE)		 2bc0 NADH OXIDASE
(Streptococcus
pyogenes) 		5 / 12 GLY A 453
ALA A 454
ASP A 456
ILE A 387
ILE A 426
 None
 0.61A 3lzsA-2bc0A:
undetectable		 3lzsA-2bc0A:
12.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LZS_A_017A200_2
(HIV-1 PROTEASE)		 2bc0 NADH OXIDASE
(Streptococcus
pyogenes) 		5 / 12 GLY A 453
ALA A 454
ASP A 456
ILE A 387
ILE A 426
 None
 0.65A 3lzsB-2bc0A:
undetectable		 3lzsB-2bc0A:
12.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LZU_A_017A200_1
(HIV-1 PROTEASE)		 2bc0 NADH OXIDASE
(Streptococcus
pyogenes) 		5 / 12 GLY A 453
ALA A 454
ASP A 456
ILE A 387
ILE A 426
 None
 0.61A 3lzuA-2bc0A:
undetectable		 3lzuA-2bc0A:
13.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MBG_A_ACTA207_0
(FAD-LINKED
SULFHYDRYL OXIDASE
ALR)		 2bc0 NADH OXIDASE
(Streptococcus
pyogenes) 		4 / 7 GLU A 177
LEU A  48
ARG A 181
ALA A  47
 None
 1.25A 3mbgA-2bc0A:
undetectable
3mbgB-2bc0A:
undetectable		 3mbgA-2bc0A:
15.71
3mbgB-2bc0A:
15.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MDR_A_GJZA506_1
(CHOLESTEROL
24-HYDROXYLASE)		 2bc0 NADH OXIDASE
(Streptococcus
pyogenes) 		4 / 6 LEU A 251
PHE A 141
ILE A 125
ALA A 134
 None
 0.96A 3mdrA-2bc0A:
undetectable		 3mdrA-2bc0A:
21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NDT_A_ROCA101_1
(PROTEASE)		 2bc0 NADH OXIDASE
(Streptococcus
pyogenes) 		5 / 12 GLY A 453
ALA A 454
ASP A 456
ILE A 387
ILE A 426
 None
 0.81A 3ndtA-2bc0A:
undetectable		 3ndtA-2bc0A:
12.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NDT_A_ROCA101_3
(PROTEASE)		 2bc0 NADH OXIDASE
(Streptococcus
pyogenes) 		5 / 12 GLY A 453
ALA A 454
ASP A 456
ILE A 387
ILE A 426
 None
 0.85A 3ndtB-2bc0A:
undetectable		 3ndtB-2bc0A:
12.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NDW_A_RITA100_1
(PROTEASE)		 2bc0 NADH OXIDASE
(Streptococcus
pyogenes) 		5 / 12 GLY A 453
ALA A 454
ASP A 456
ILE A 387
ILE A 426
 None
 0.62A 3ndwA-2bc0A:
undetectable		 3ndwA-2bc0A:
12.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NDX_A_RITA100_1
(PROTEASE)		 2bc0 NADH OXIDASE
(Streptococcus
pyogenes) 		5 / 12 GLY A 453
ALA A 454
ASP A 456
ILE A 387
ILE A 426
 None
 0.64A 3ndxA-2bc0A:
undetectable		 3ndxA-2bc0A:
12.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NDX_A_RITA100_2
(PROTEASE)		 2bc0 NADH OXIDASE
(Streptococcus
pyogenes) 		5 / 11 GLY A 453
ALA A 454
ASP A 456
ILE A 387
ILE A 426
 None
 0.87A 3ndxB-2bc0A:
undetectable		 3ndxB-2bc0A:
12.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NU3_B_478B401_2
(PROTEASE)		 2bc0 NADH OXIDASE
(Streptococcus
pyogenes) 		5 / 11 GLY A 453
ALA A 454
ASP A 456
ILE A 387
ILE A 426
 None
 0.67A 3nu3B-2bc0A:
undetectable		 3nu3B-2bc0A:
12.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NU4_B_478B401_2
(PROTEASE)		 2bc0 NADH OXIDASE
(Streptococcus
pyogenes) 		5 / 9 GLY A 453
ALA A 454
ASP A 456
ILE A 387
ILE A 426
 None
 0.64A 3nu4B-2bc0A:
undetectable		 3nu4B-2bc0A:
12.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NU6_B_478B401_2
(PROTEASE)		 2bc0 NADH OXIDASE
(Streptococcus
pyogenes) 		5 / 10 GLY A 453
ALA A 454
ASP A 456
ILE A 387
ILE A 426
 None
 0.62A 3nu6B-2bc0A:
undetectable		 3nu6B-2bc0A:
12.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NUJ_B_478B401_2
(PROTEASE)		 2bc0 NADH OXIDASE
(Streptococcus
pyogenes) 		5 / 9 GLY A 453
ALA A 454
ASP A 456
ILE A 387
ILE A 426
 None
 0.61A 3nujB-2bc0A:
undetectable		 3nujB-2bc0A:
12.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NUO_B_478B478_2
(PROTEASE)		 2bc0 NADH OXIDASE
(Streptococcus
pyogenes) 		5 / 9 GLY A 453
ALA A 454
ASP A 456
ILE A 387
ILE A 426
 None
 0.64A 3nuoB-2bc0A:
undetectable		 3nuoB-2bc0A:
13.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OXC_A_ROCA401_1
(PROTEASE)		 2bc0 NADH OXIDASE
(Streptococcus
pyogenes) 		5 / 12 GLY A 453
ALA A 454
ASP A 456
ILE A 387
ILE A 426
 None
 0.71A 3oxcA-2bc0A:
undetectable		 3oxcA-2bc0A:
12.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OZW_B_KKKB413_1
(FLAVOHEMOGLOBIN)		 2bc0 NADH OXIDASE
(Streptococcus
pyogenes) 		5 / 12 ILE A  54
ALA A  47
LEU A  48
HIS A  11
ILE A 250
 None
None
None
FAD  A 601 (-4.4A)
None
 1.05A 3ozwB-2bc0A:
4.6		 3ozwB-2bc0A:
22.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PWM_B_017B402_1
(PROTEASE)		 2bc0 NADH OXIDASE
(Streptococcus
pyogenes) 		5 / 12 GLY A 453
ALA A 454
ASP A 456
ILE A 387
ILE A 426
 None
 0.68A 3pwmA-2bc0A:
undetectable		 3pwmA-2bc0A:
12.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S54_B_017B201_1
(PROTEASE)		 2bc0 NADH OXIDASE
(Streptococcus
pyogenes) 		5 / 12 GLY A 453
ALA A 454
ASP A 456
ILE A 387
ILE A 426
 None
 0.66A 3s54A-2bc0A:
undetectable		 3s54A-2bc0A:
12.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S54_B_017B201_1
(PROTEASE)		 2bc0 NADH OXIDASE
(Streptococcus
pyogenes) 		6 / 12 LEU A 429
GLY A 453
ALA A 454
ASP A 456
ILE A 398
ILE A 426
 None
 1.29A 3s54A-2bc0A:
undetectable		 3s54A-2bc0A:
12.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S54_B_017B201_2
(PROTEASE)		 2bc0 NADH OXIDASE
(Streptococcus
pyogenes) 		5 / 12 GLY A 453
ALA A 454
ASP A 456
ILE A 387
ILE A 426
 None
 0.67A 3s54B-2bc0A:
undetectable		 3s54B-2bc0A:
12.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S54_B_017B201_2
(PROTEASE)		 2bc0 NADH OXIDASE
(Streptococcus
pyogenes) 		6 / 12 LEU A 429
GLY A 453
ALA A 454
ASP A 456
ILE A 398
ILE A 426
 None
 1.26A 3s54B-2bc0A:
undetectable		 3s54B-2bc0A:
12.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TKW_B_017B401_1
(PROTEASE)		 2bc0 NADH OXIDASE
(Streptococcus
pyogenes) 		5 / 12 GLY A 453
ALA A 454
ASP A 456
ILE A 387
ILE A 426
 None
 0.56A 3tkwA-2bc0A:
undetectable		 3tkwA-2bc0A:
13.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TKW_B_017B401_2
(PROTEASE)		 2bc0 NADH OXIDASE
(Streptococcus
pyogenes) 		5 / 12 GLY A 453
ALA A 454
ASP A 456
ILE A 387
ILE A 426
 None
 0.58A 3tkwB-2bc0A:
undetectable		 3tkwB-2bc0A:
13.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TL9_A_ROCA401_1
(PROTEASE)		 2bc0 NADH OXIDASE
(Streptococcus
pyogenes) 		5 / 12 GLY A 453
ALA A 454
ASP A 456
ILE A 387
ILE A 426
 None
 0.80A 3tl9A-2bc0A:
undetectable		 3tl9A-2bc0A:
13.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TNE_A_RITA401_2
(SECRETED ASPARTIC
PROTEASE)		 2bc0 NADH OXIDASE
(Streptococcus
pyogenes) 		4 / 6 TYR A  86
VAL A 287
THR A  90
THR A 103
 None
 1.07A 3tneA-2bc0A:
undetectable		 3tneA-2bc0A:
23.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TTP_A_017A201_1
(HIV-1 PROTEASE)		 2bc0 NADH OXIDASE
(Streptococcus
pyogenes) 		5 / 10 GLY A 453
ALA A 454
ASP A 456
ILE A 387
ILE A 426
 None
 0.59A 3ttpA-2bc0A:
undetectable		 3ttpA-2bc0A:
12.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TTP_A_017A201_2
(HIV-1 PROTEASE)		 2bc0 NADH OXIDASE
(Streptococcus
pyogenes) 		5 / 10 GLY A 453
ALA A 454
ASP A 456
ILE A 387
ILE A 426
 None
 0.59A 3ttpB-2bc0A:
undetectable		 3ttpB-2bc0A:
12.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A3P_A_ACTA1223_0
(UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE 15)		 2bc0 NADH OXIDASE
(Streptococcus
pyogenes) 		4 / 5 ASP A 201
THR A 205
LEU A 204
LYS A 388
 None
 1.17A 4a3pA-2bc0A:
undetectable		 4a3pA-2bc0A:
19.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DU2_A_LDPA501_1
(CYTOCHROME P450 BM3
VARIANT B7)		 2bc0 NADH OXIDASE
(Streptococcus
pyogenes) 		4 / 7 ALA A  15
ALA A 110
ALA A 313
THR A 316
 None
None
FAD  A 601 ( 3.7A)
None
 0.94A 4du2A-2bc0A:
undetectable		 4du2A-2bc0A:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DU2_B_LDPB501_1
(CYTOCHROME P450 BM3
VARIANT B7)		 2bc0 NADH OXIDASE
(Streptococcus
pyogenes) 		4 / 7 ALA A  15
ALA A 110
ALA A 313
THR A 316
 None
None
FAD  A 601 ( 3.7A)
None
 0.90A 4du2B-2bc0A:
undetectable		 4du2B-2bc0A:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F8H_A_RKEA401_1
(PROTON-GATED ION
CHANNEL)		 2bc0 NADH OXIDASE
(Streptococcus
pyogenes) 		4 / 8 ASP A 206
VAL A 173
PHE A 221
LEU A 219
 None
 0.90A 4f8hA-2bc0A:
undetectable
4f8hB-2bc0A:
undetectable		 4f8hA-2bc0A:
21.05
4f8hB-2bc0A:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F8H_B_RKEB401_1
(PROTON-GATED ION
CHANNEL)		 2bc0 NADH OXIDASE
(Streptococcus
pyogenes) 		4 / 8 ASP A 206
VAL A 173
PHE A 221
LEU A 219
 None
 0.97A 4f8hB-2bc0A:
undetectable
4f8hC-2bc0A:
undetectable		 4f8hB-2bc0A:
21.05
4f8hC-2bc0A:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F8H_C_RKEC401_1
(PROTON-GATED ION
CHANNEL)		 2bc0 NADH OXIDASE
(Streptococcus
pyogenes) 		4 / 8 ASP A 206
VAL A 173
PHE A 221
LEU A 219
 None
 0.93A 4f8hC-2bc0A:
undetectable
4f8hD-2bc0A:
undetectable		 4f8hC-2bc0A:
21.05
4f8hD-2bc0A:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F8H_D_RKED401_1
(PROTON-GATED ION
CHANNEL)		 2bc0 NADH OXIDASE
(Streptococcus
pyogenes) 		4 / 8 ASP A 206
VAL A 173
PHE A 221
LEU A 219
 None
 0.91A 4f8hD-2bc0A:
undetectable
4f8hE-2bc0A:
undetectable		 4f8hD-2bc0A:
21.05
4f8hE-2bc0A:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F8H_E_RKEE401_1
(PROTON-GATED ION
CHANNEL)		 2bc0 NADH OXIDASE
(Streptococcus
pyogenes) 		4 / 8 VAL A 173
PHE A 221
LEU A 219
ASP A 206
 None
 0.93A 4f8hA-2bc0A:
undetectable
4f8hE-2bc0A:
undetectable		 4f8hA-2bc0A:
21.05
4f8hE-2bc0A:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HLA_A_017A200_1
(PROTEASE)		 2bc0 NADH OXIDASE
(Streptococcus
pyogenes) 		5 / 12 GLY A 453
ALA A 454
ASP A 456
ILE A 387
ILE A 426
 None
 0.62A 4hlaA-2bc0A:
undetectable		 4hlaA-2bc0A:
12.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HLA_A_017A200_2
(PROTEASE)		 2bc0 NADH OXIDASE
(Streptococcus
pyogenes) 		5 / 11 GLY A 453
ALA A 454
ASP A 456
ILE A 387
ILE A 426
 None
 0.62A 4hlaB-2bc0A:
undetectable		 4hlaB-2bc0A:
12.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JEC_B_478B401_1
(HIV-1 PROTEASE)		 2bc0 NADH OXIDASE
(Streptococcus
pyogenes) 		5 / 12 GLY A 453
ALA A 454
ASP A 456
ILE A 387
ILE A 426
 None
 0.58A 4jecA-2bc0A:
undetectable		 4jecA-2bc0A:
12.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LL3_A_017A201_2
(PROTEASE)		 2bc0 NADH OXIDASE
(Streptococcus
pyogenes) 		5 / 10 GLY A 453
ALA A 454
ASP A 456
ILE A 387
ILE A 426
 None
 0.57A 4ll3B-2bc0A:
undetectable		 4ll3B-2bc0A:
12.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LL3_A_017A202_1
(PROTEASE)		 2bc0 NADH OXIDASE
(Streptococcus
pyogenes) 		5 / 10 GLY A 453
ALA A 454
ASP A 456
ILE A 387
ILE A 426
 None
 0.54A 4ll3A-2bc0A:
undetectable		 4ll3A-2bc0A:
12.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O0W_A_ADNA501_1
(AURORA KINASE A)		 2bc0 NADH OXIDASE
(Streptococcus
pyogenes) 		4 / 6 LEU A 399
GLY A 400
VAL A 390
ALA A 364
 None
 0.23A 4o0wA-2bc0A:
undetectable		 4o0wA-2bc0A:
20.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RVJ_B_478B101_2
(HIV-1 PROTEASE)		 2bc0 NADH OXIDASE
(Streptococcus
pyogenes) 		5 / 9 GLY A 453
ALA A 454
ASP A 456
ILE A 387
ILE A 426
 None
 0.70A 4rvjB-2bc0A:
undetectable		 4rvjB-2bc0A:
12.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RVJ_D_478D101_2
(HIV-1 PROTEASE)		 2bc0 NADH OXIDASE
(Streptococcus
pyogenes) 		5 / 9 GLY A 453
ALA A 454
ASP A 456
ILE A 387
ILE A 426
 None
 0.69A 4rvjD-2bc0A:
undetectable		 4rvjD-2bc0A:
12.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E5J_A_017A201_1
(PROTEASE)		 2bc0 NADH OXIDASE
(Streptococcus
pyogenes) 		5 / 12 GLY A 453
ALA A 454
ASP A 456
ILE A 387
ILE A 426
 None
 0.61A 5e5jA-2bc0A:
undetectable		 5e5jA-2bc0A:
12.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E5K_B_017B201_1
(HIV-1 PROTEASE)		 2bc0 NADH OXIDASE
(Streptococcus
pyogenes) 		5 / 12 GLY A 453
ALA A 454
ASP A 456
ILE A 387
ILE A 426
 None
 0.68A 5e5kA-2bc0A:
undetectable		 5e5kA-2bc0A:
12.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LSU_B_SAMB1304_1
(HISTONE-LYSINE
N-METHYLTRANSFERASE
NSD2)		 2bc0 NADH OXIDASE
(Streptococcus
pyogenes) 		3 / 3 ASN A  10
TYR A  62
CYH A  44
 FAD  A 601 (-3.5A)
None
FAD  A 601 (-3.5A)
 1.10A 5lsuB-2bc0A:
undetectable		 5lsuB-2bc0A:
21.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NZ0_A_ZLDA301_0
(HTH-TYPE
TRANSCRIPTIONAL
REGULATOR ETHR)		 2bc0 NADH OXIDASE
(Streptococcus
pyogenes) 		5 / 12 GLY A 412
ILE A 413
PHE A 416
TYR A 446
VAL A 385
 None
 0.87A 5nz0A-2bc0A:
0.0		 5nz0A-2bc0A:
18.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QH8_A_ACTA302_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 2bc0 NADH OXIDASE
(Streptococcus
pyogenes) 		3 / 3 CYH A 325
MET A  20
ASN A  23
 None
 0.99A 5qh8A-2bc0A:
undetectable		 5qh8A-2bc0A:
19.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5T2Z_B_017B201_1
(PROTEASE)		 2bc0 NADH OXIDASE
(Streptococcus
pyogenes) 		5 / 12 GLY A 453
ALA A 454
ASP A 456
ILE A 387
ILE A 426
 None
 0.57A 5t2zA-2bc0A:
undetectable		 5t2zA-2bc0A:
13.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5T2Z_B_017B201_2
(PROTEASE)		 2bc0 NADH OXIDASE
(Streptococcus
pyogenes) 		5 / 12 GLY A 453
ALA A 454
ASP A 456
ILE A 387
ILE A 426
 None
 0.60A 5t2zB-2bc0A:
undetectable		 5t2zB-2bc0A:
13.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5T8H_B_478B401_1
(PROTEASE)		 2bc0 NADH OXIDASE
(Streptococcus
pyogenes) 		5 / 12 GLY A 453
ALA A 454
ASP A 456
ILE A 387
ILE A 426
 None
 0.61A 5t8hA-2bc0A:
undetectable		 5t8hA-2bc0A:
12.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y80_A_IREA402_0
(CYCLIN-G-ASSOCIATED
KINASE)		 2bc0 NADH OXIDASE
(Streptococcus
pyogenes) 		5 / 11 ALA A  73
ASP A  34
VAL A 287
THR A 111
ILE A  84
 None
FAD  A 601 (-2.9A)
None
FAD  A 601 (-4.1A)
None
 1.25A 5y80A-2bc0A:
undetectable		 5y80A-2bc0A:
10.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AGO_A_SAMA2301_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
ASH1L)		 2bc0 NADH OXIDASE
(Streptococcus
pyogenes) 		5 / 11 GLY A 331
ASN A 323
TYR A 288
CYH A  16
ILE A 108
 None
 1.39A 6agoA-2bc0A:
undetectable		 6agoA-2bc0A:
17.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EXI_C_ADNC503_0
(ADENOSYLHOMOCYSTEINA
SE)		 2bc0 NADH OXIDASE
(Streptococcus
pyogenes) 		5 / 12 GLY A   8
GLY A  13
THR A 111
ASN A 258
GLN A 114
 FAD  A 601 (-3.1A)
None
FAD  A 601 (-4.1A)
FAD  A 601 ( 4.9A)
None
 1.16A 6exiC-2bc0A:
2.7
6exiD-2bc0A:
2.9		 6exiC-2bc0A:
9.83
6exiD-2bc0A:
9.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EXI_D_ADND503_0
(ADENOSYLHOMOCYSTEINA
SE)		 2bc0 NADH OXIDASE
(Streptococcus
pyogenes) 		5 / 12 GLN A 114
GLY A   8
GLY A  13
THR A 111
ASN A 258
 None
FAD  A 601 (-3.1A)
None
FAD  A 601 (-4.1A)
FAD  A 601 ( 4.9A)
 1.19A 6exiC-2bc0A:
2.7
6exiD-2bc0A:
2.8		 6exiC-2bc0A:
9.83
6exiD-2bc0A:
9.83