SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2bco'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
11GS_B_EAAB211_1
(GLUTATHIONE
S-TRANSFERASE)		 2bco SUCCINYLGLUTAMATE
DESUCCINYLASE
(Vibrio
parahaemolyticus) 		4 / 7 GLY A 160
ARG A 159
ILE A 158
GLY A 221
 None
 0.86A 11gsB-2bcoA:
undetectable		 11gsB-2bcoA:
20.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ERR_B_RALB600_1
(ESTROGEN RECEPTOR)		 2bco SUCCINYLGLUTAMATE
DESUCCINYLASE
(Vibrio
parahaemolyticus) 		5 / 12 ALA A  68
GLU A  71
LEU A  72
LEU A 231
LEU A 241
 None
 0.96A 1errB-2bcoA:
undetectable		 1errB-2bcoA:
22.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QHS_A_CLMA999_0
(PROTEIN
(CHLORAMPHENICOL
PHOSPHOTRANSFERASE))		 2bco SUCCINYLGLUTAMATE
DESUCCINYLASE
(Vibrio
parahaemolyticus) 		5 / 12 VAL A  87
ILE A 245
ILE A  76
PHE A  93
VAL A  32
 None
 1.03A 1qhsA-2bcoA:
undetectable		 1qhsA-2bcoA:
19.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1X70_B_715B801_2
(DIPEPTIDYL PEPTIDASE
IV)		 2bco SUCCINYLGLUTAMATE
DESUCCINYLASE
(Vibrio
parahaemolyticus) 		3 / 3 PHE A 203
TYR A 141
TYR A 211
 None
 0.94A 1x70B-2bcoA:
4.0		 1x70B-2bcoA:
18.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YAJ_G_BEZG3385_0
(CES1 PROTEIN)		 2bco SUCCINYLGLUTAMATE
DESUCCINYLASE
(Vibrio
parahaemolyticus) 		3 / 3 SER A 196
VAL A 311
LEU A 325
 None
 0.69A 1yajG-2bcoA:
4.9		 1yajG-2bcoA:
22.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BFP_C_H4BC1290_1
(PTERIDINE REDUCTASE
1)		 2bco SUCCINYLGLUTAMATE
DESUCCINYLASE
(Vibrio
parahaemolyticus) 		4 / 8 PHE A 116
ASP A 153
LEU A 112
LEU A 136
 None
 0.98A 2bfpC-2bcoA:
undetectable		 2bfpC-2bcoA:
22.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXC_A_P1ZA2001_1
(SERUM ALBUMIN)		 2bco SUCCINYLGLUTAMATE
DESUCCINYLASE
(Vibrio
parahaemolyticus) 		5 / 12 SER A 254
LEU A 152
ALA A 246
ILE A 245
ALA A 240
 None
 1.08A 2bxcA-2bcoA:
undetectable		 2bxcA-2bcoA:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FUM_D_MIXD3539_2
(PROBABLE
SERINE/THREONINE-PRO
TEIN KINASE PKNB)		 2bco SUCCINYLGLUTAMATE
DESUCCINYLASE
(Vibrio
parahaemolyticus) 		3 / 3 VAL A 281
VAL A 311
ASP A 296
 None
 0.71A 2fumD-2bcoA:
undetectable		 2fumD-2bcoA:
22.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VCV_K_ASDK1224_1
(GLUTATHIONE
S-TRANSFERASE A3)		 2bco SUCCINYLGLUTAMATE
DESUCCINYLASE
(Vibrio
parahaemolyticus) 		4 / 6 PHE A 184
LEU A 154
ALA A 167
ALA A 188
 None
 0.99A 2vcvK-2bcoA:
undetectable		 2vcvK-2bcoA:
19.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X45_B_HSMB1162_1
(ALLERGEN ARG R 1)		 2bco SUCCINYLGLUTAMATE
DESUCCINYLASE
(Vibrio
parahaemolyticus) 		3 / 3 GLU A 219
HIS A  63
GLU A  66
 ZN  A 501 ( 4.7A)
ZN  A 501 (-3.3A)
ZN  A 501 (-2.1A)
 0.75A 2x45B-2bcoA:
undetectable		 2x45B-2bcoA:
15.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X45_C_HSMC1162_1
(ALLERGEN ARG R 1)		 2bco SUCCINYLGLUTAMATE
DESUCCINYLASE
(Vibrio
parahaemolyticus) 		3 / 3 GLU A 219
HIS A  63
GLU A  66
 ZN  A 501 ( 4.7A)
ZN  A 501 (-3.3A)
ZN  A 501 (-2.1A)
 0.78A 2x45C-2bcoA:
undetectable		 2x45C-2bcoA:
15.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AOD_A_MIYA2001_1
(ACRIFLAVINE
RESISTANCE PROTEIN B)		 2bco SUCCINYLGLUTAMATE
DESUCCINYLASE
(Vibrio
parahaemolyticus) 		4 / 8 GLU A 110
ASN A 111
ILE A  62
ALA A  96
 None
 0.70A 3aodA-2bcoA:
undetectable		 3aodA-2bcoA:
16.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D90_B_NOGB2001_1
(PROGESTERONE
RECEPTOR)		 2bco SUCCINYLGLUTAMATE
DESUCCINYLASE
(Vibrio
parahaemolyticus) 		5 / 12 LEU A 244
LEU A 241
LEU A 220
LEU A 216
MET A 218
 None
 1.13A 3d90B-2bcoA:
undetectable		 3d90B-2bcoA:
20.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JAY_A_SAMA1102_1
(STRUCTURAL PROTEIN
VP3)		 2bco SUCCINYLGLUTAMATE
DESUCCINYLASE
(Vibrio
parahaemolyticus) 		3 / 3 ARG A 138
ASP A 143
ASP A 139
 None
 0.89A 3jayA-2bcoA:
undetectable		 3jayA-2bcoA:
16.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LB3_A_4CHA191_0
(DEHALOPEROXIDASE A)		 2bco SUCCINYLGLUTAMATE
DESUCCINYLASE
(Vibrio
parahaemolyticus) 		4 / 6 PHE A 273
PHE A 275
HIS A 316
VAL A 317
 None
 1.08A 3lb3A-2bcoA:
undetectable		 3lb3A-2bcoA:
18.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SI7_A_ACTA5_0
(CYSTIC FIBROSIS
TRANSMEMBRANE
CONDUCTANCE
REGULATOR)		 2bco SUCCINYLGLUTAMATE
DESUCCINYLASE
(Vibrio
parahaemolyticus) 		3 / 3 LYS A  54
SER A 178
GLN A 214
 None
 1.16A 3si7A-2bcoA:
undetectable		 3si7A-2bcoA:
23.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UA5_A_06XA501_1
(CYTOCHROME P450 2B6)		 2bco SUCCINYLGLUTAMATE
DESUCCINYLASE
(Vibrio
parahaemolyticus) 		4 / 8 ILE A  76
ILE A  58
PHE A  93
GLU A 247
 None
 0.83A 3ua5A-2bcoA:
undetectable		 3ua5A-2bcoA:
22.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FEV_E_KANE301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 2bco SUCCINYLGLUTAMATE
DESUCCINYLASE
(Vibrio
parahaemolyticus) 		5 / 11 SER A 100
HIS A  97
ASP A  65
ASN A 111
GLU A 126
 None
 1.49A 4fevE-2bcoA:
0.0		 4fevE-2bcoA:
23.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FP9_A_SAMA401_1
(METHYLTRANSFERASE
NSUN4)		 2bco SUCCINYLGLUTAMATE
DESUCCINYLASE
(Vibrio
parahaemolyticus) 		3 / 3 ASP A 274
ARG A 315
ASP A 296
 None
 0.85A 4fp9A-2bcoA:
undetectable		 4fp9A-2bcoA:
23.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M2X_A_TMQA202_2
(DIHYDROFOLATE
REDUCTASE)		 2bco SUCCINYLGLUTAMATE
DESUCCINYLASE
(Vibrio
parahaemolyticus) 		3 / 3 TRP A 205
GLN A 214
THR A 172
 None
 0.85A 4m2xA-2bcoA:
undetectable		 4m2xA-2bcoA:
18.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M83_A_ERYA1400_0
(OLEANDOMYCIN
GLYCOSYLTRANSFERASE)		 2bco SUCCINYLGLUTAMATE
DESUCCINYLASE
(Vibrio
parahaemolyticus) 		5 / 11 VAL A 137
PHE A 140
ILE A  56
LEU A 154
ALA A 213
 None
 1.48A 4m83A-2bcoA:
undetectable		 4m83A-2bcoA:
23.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O7G_A_ASCA303_0
(PROBABLE
TRANSMEMBRANE
ASCORBATE
FERRIREDUCTASE 2)		 2bco SUCCINYLGLUTAMATE
DESUCCINYLASE
(Vibrio
parahaemolyticus) 		4 / 7 PHE A 273
ILE A 266
PHE A 293
ARG A 264
 None
 1.38A 4o7gA-2bcoA:
undetectable
4o7gB-2bcoA:
undetectable		 4o7gA-2bcoA:
20.72
4o7gB-2bcoA:
20.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PD9_A_ADNA501_2
(NUPC FAMILY PROTEIN)		 2bco SUCCINYLGLUTAMATE
DESUCCINYLASE
(Vibrio
parahaemolyticus) 		3 / 3 THR A 101
ASN A 113
PHE A 203
 None
 0.68A 4pd9A-2bcoA:
undetectable		 4pd9A-2bcoA:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LSU_B_SAMB1304_1
(HISTONE-LYSINE
N-METHYLTRANSFERASE
NSD2)		 2bco SUCCINYLGLUTAMATE
DESUCCINYLASE
(Vibrio
parahaemolyticus) 		3 / 3 ASN A 197
TYR A 341
CYH A 328
 None
 1.06A 5lsuB-2bcoA:
undetectable		 5lsuB-2bcoA:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y7P_C_CHDC401_0
(BILE SALT HYDROLASE)		 2bco SUCCINYLGLUTAMATE
DESUCCINYLASE
(Vibrio
parahaemolyticus) 		4 / 8 LEU A 154
ILE A  56
ALA A 188
LEU A 185
 None
 0.87A 5y7pC-2bcoA:
undetectable		 5y7pC-2bcoA:
22.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BPL_B_PA1B605_1
(LIPID A EXPORT
ATP-BINDING/PERMEASE
PROTEIN MSBA)		 2bco SUCCINYLGLUTAMATE
DESUCCINYLASE
(Vibrio
parahaemolyticus) 		3 / 3 ARG A 106
ARG A 322
ARG A 159
 None
 1.01A 6bplA-2bcoA:
undetectable
6bplB-2bcoA:
undetectable		 6bplA-2bcoA:
15.22
6bplB-2bcoA:
15.22