SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2bde'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1D4F_A_ADNA601_1
(S-ADENOSYLHOMOCYSTEI
NE HYDROLASE)		 2bde CYTOSOLIC IMP-GMP
SPECIFIC
5'-NUCLEOTIDASE
(Legionella
pneumophila) 		5 / 12 LEU A  28
LEU A 437
LEU A 438
GLY A 194
PHE A 238
 None
 1.35A 1d4fA-2bdeA:
undetectable		 1d4fA-2bdeA:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PNL_B_PACB559_0
(PENICILLIN
AMIDOHYDROLASE)		 2bde CYTOSOLIC IMP-GMP
SPECIFIC
5'-NUCLEOTIDASE
(Legionella
pneumophila) 		4 / 8 PHE A 251
ALA A 245
ILE A 242
ASN A 210
 None
 1.17A 1pnlA-2bdeA:
undetectable
1pnlB-2bdeA:
3.2		 1pnlA-2bdeA:
19.44
1pnlB-2bdeA:
20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1S1X_A_NVPA999_1
(REVERSE
TRANSCRIPTASE)		 2bde CYTOSOLIC IMP-GMP
SPECIFIC
5'-NUCLEOTIDASE
(Legionella
pneumophila) 		4 / 8 LEU A  84
TYR A 109
LEU A 116
TYR A 418
 None
 1.01A 1s1xA-2bdeA:
undetectable		 1s1xA-2bdeA:
22.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Z95_A_198A501_2
(ANDROGEN RECEPTOR)		 2bde CYTOSOLIC IMP-GMP
SPECIFIC
5'-NUCLEOTIDASE
(Legionella
pneumophila) 		4 / 6 LEU A 299
LEU A 195
MET A 431
ILE A 199
 None
 0.81A 1z95A-2bdeA:
undetectable		 1z95A-2bdeA:
19.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FN1_A_SALA506_1
(SALICYLATE
SYNTHETASE, IRP9)		 2bde CYTOSOLIC IMP-GMP
SPECIFIC
5'-NUCLEOTIDASE
(Legionella
pneumophila) 		5 / 11 ILE A  20
GLY A 302
THR A  27
LEU A 438
GLY A  21
 None
 1.23A 2fn1A-2bdeA:
undetectable		 2fn1A-2bdeA:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2I_A_QPSA1050_1
(ALPHA-1,4-GLUCAN
LYASE ISOZYME 1)		 2bde CYTOSOLIC IMP-GMP
SPECIFIC
5'-NUCLEOTIDASE
(Legionella
pneumophila) 		5 / 12 LEU A 244
GLN A 280
TYR A 215
ASP A  25
HIS A 168
 None
 1.23A 2x2iA-2bdeA:
undetectable		 2x2iA-2bdeA:
18.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X45_B_HSMB1161_1
(ALLERGEN ARG R 1)		 2bde CYTOSOLIC IMP-GMP
SPECIFIC
5'-NUCLEOTIDASE
(Legionella
pneumophila) 		4 / 4 VAL A 324
TYR A 430
VAL A 423
SER A 417
 None
 1.40A 2x45B-2bdeA:
undetectable		 2x45B-2bdeA:
13.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KL3_A_DHIA403_0
(GLUCURONOXYLANASE
XYNC)		 2bde CYTOSOLIC IMP-GMP
SPECIFIC
5'-NUCLEOTIDASE
(Legionella
pneumophila) 		4 / 4 GLY A  21
TYR A 300
GLY A 302
ASP A  23
 None
 0.85A 3kl3A-2bdeA:
undetectable		 3kl3A-2bdeA:
21.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LS4_H_TCIH220_2
(HEAVY CHAIN OF
ANTIBODY FAB
FRAGMENT
LIGHT CHAIN OF
ANTIBODY FAB
FRAGMENT)		 2bde CYTOSOLIC IMP-GMP
SPECIFIC
5'-NUCLEOTIDASE
(Legionella
pneumophila) 		4 / 5 TYR A 402
GLN A 398
ILE A 391
LEU A 395
 None
 1.14A 3ls4L-2bdeA:
undetectable		 3ls4L-2bdeA:
17.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3M0W_F_P77F203_1
(PROTEIN S100-A4)		 2bde CYTOSOLIC IMP-GMP
SPECIFIC
5'-NUCLEOTIDASE
(Legionella
pneumophila) 		5 / 9 LEU A 434
ASP A 436
ILE A 301
PHE A   7
PHE A 446
 None
 1.43A 3m0wC-2bdeA:
undetectable
3m0wD-2bdeA:
undetectable
3m0wE-2bdeA:
1.2
3m0wF-2bdeA:
undetectable		 3m0wC-2bdeA:
12.32
3m0wD-2bdeA:
12.32
3m0wE-2bdeA:
12.32
3m0wF-2bdeA:
12.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VRJ_A_1KXA301_1
(HLA CLASS I
HISTOCOMPATIBILITY
ANTIGEN, B-57 ALPHA
CHAIN
10-MER PEPTIDE)		 2bde CYTOSOLIC IMP-GMP
SPECIFIC
5'-NUCLEOTIDASE
(Legionella
pneumophila) 		5 / 12 TYR A 300
ILE A 298
ILE A  12
THR A  27
ILE A  17
 None
 1.31A 3vrjA-2bdeA:
undetectable
3vrjC-2bdeA:
undetectable		 3vrjA-2bdeA:
20.56
3vrjC-2bdeA:
3.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W1W_A_CHDA1503_0
(FERROCHELATASE,
MITOCHONDRIAL)		 2bde CYTOSOLIC IMP-GMP
SPECIFIC
5'-NUCLEOTIDASE
(Legionella
pneumophila) 		4 / 8 MET A  14
ILE A 301
LEU A  22
GLY A 194
 None
 0.87A 3w1wA-2bdeA:
undetectable		 3w1wA-2bdeA:
23.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G0V_D_MIXD101_1
(DNA TOPOISOMERASE
2-BETA)		 2bde CYTOSOLIC IMP-GMP
SPECIFIC
5'-NUCLEOTIDASE
(Legionella
pneumophila) 		4 / 6 ARG A 411
GLY A 413
ASN A 399
GLU A 407
 None
 1.25A 4g0vB-2bdeA:
5.3		 4g0vB-2bdeA:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4N49_A_SAMA601_0
(CAP-SPECIFIC MRNA
(NUCLEOSIDE-2'-O-)-M
ETHYLTRANSFERASE 1)		 2bde CYTOSOLIC IMP-GMP
SPECIFIC
5'-NUCLEOTIDASE
(Legionella
pneumophila) 		5 / 12 ALA A 427
GLY A 302
THR A  27
LEU A  28
LEU A 438
 None
 0.99A 4n49A-2bdeA:
undetectable		 4n49A-2bdeA:
20.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NC3_A_ERMA1202_1
(CHIMERA PROTEIN OF
HUMAN
5-HYDROXYTRYPTAMINE
RECEPTOR 2B AND E.
COLI SOLUBLE
CYTOCHROME B562)		 2bde CYTOSOLIC IMP-GMP
SPECIFIC
5'-NUCLEOTIDASE
(Legionella
pneumophila) 		5 / 12 LEU A 438
VAL A 191
ALA A 223
PHE A 238
LEU A 208
 None
 1.29A 4nc3A-2bdeA:
3.4		 4nc3A-2bdeA:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKV_C_AERC601_1
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 2bde CYTOSOLIC IMP-GMP
SPECIFIC
5'-NUCLEOTIDASE
(Legionella
pneumophila) 		5 / 12 LEU A  43
ASN A 175
ILE A 176
ILE A 177
GLY A 171
 None
 1.04A 4nkvC-2bdeA:
undetectable		 4nkvC-2bdeA:
23.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O1E_B_C2FB4000_1
(DIHYDROPTEROATE
SYNTHASE DHPS)		 2bde CYTOSOLIC IMP-GMP
SPECIFIC
5'-NUCLEOTIDASE
(Legionella
pneumophila) 		4 / 4 LYS A 286
ASN A 317
ASP A 296
ASP A 290
 None
 1.38A 4o1eB-2bdeA:
undetectable		 4o1eB-2bdeA:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OKW_A_198A1001_2
(ANDROGEN RECEPTOR)		 2bde CYTOSOLIC IMP-GMP
SPECIFIC
5'-NUCLEOTIDASE
(Legionella
pneumophila) 		4 / 7 LEU A 299
LEU A 195
MET A 431
ILE A 199
 None
 0.71A 4okwA-2bdeA:
undetectable		 4okwA-2bdeA:
19.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A06_D_SORD1341_0
(ALDOSE-ALDOSE
OXIDOREDUCTASE)		 2bde CYTOSOLIC IMP-GMP
SPECIFIC
5'-NUCLEOTIDASE
(Legionella
pneumophila) 		4 / 6 CYH A 316
GLY A 294
GLY A 295
ASP A 296
 None
 0.98A 5a06D-2bdeA:
undetectable		 5a06D-2bdeA:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A7M_A_ACTA1923_0
(BETA-XYLOSIDASE)		 2bde CYTOSOLIC IMP-GMP
SPECIFIC
5'-NUCLEOTIDASE
(Legionella
pneumophila) 		3 / 3 ASP A 253
ARG A 249
TYR A 252
 None
 1.00A 5a7mA-2bdeA:
3.0		 5a7mA-2bdeA:
19.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A7M_B_ACTB1924_0
(BETA-XYLOSIDASE)		 2bde CYTOSOLIC IMP-GMP
SPECIFIC
5'-NUCLEOTIDASE
(Legionella
pneumophila) 		3 / 3 ASP A 253
ARG A 249
TYR A 252
 None
 0.95A 5a7mB-2bdeA:
2.9		 5a7mB-2bdeA:
19.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TDZ_A_ADNA905_1
(ATP-CITRATE SYNTHASE)		 2bde CYTOSOLIC IMP-GMP
SPECIFIC
5'-NUCLEOTIDASE
(Legionella
pneumophila) 		4 / 6 ASP A 308
ARG A 311
LEU A 312
ASP A 315
 None
 1.20A 5tdzA-2bdeA:
undetectable		 5tdzA-2bdeA:
22.70