SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2bdw'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RA8_A_FOLA161_0
(DIHYDROFOLATE
REDUCTASE)		 2bdw HYPOTHETICAL PROTEIN
K11E8.1D
(Caenorhabditis
elegans) 		6 / 12 ILE A 205
PHE A  98
ILE A 119
LEU A 141
ILE A 202
THR A 286
 None
 1.45A 1ra8A-2bdwA:
undetectable		 1ra8A-2bdwA:
18.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1S8F_A_BEZA1501_0
(RAS-RELATED PROTEIN
RAB-9A)		 2bdw HYPOTHETICAL PROTEIN
K11E8.1D
(Caenorhabditis
elegans) 		4 / 5 ILE A 248
TRP A 237
LEU A 252
PRO A 212
 None
 1.18A 1s8fA-2bdwA:
undetectable
1s8fB-2bdwA:
0.0		 1s8fA-2bdwA:
20.97
1s8fB-2bdwA:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TYR_B_9CRB130_1
(TRANSTHYRETIN)		 2bdw HYPOTHETICAL PROTEIN
K11E8.1D
(Caenorhabditis
elegans) 		4 / 7 THR A 305
ALA A 309
LEU A 313
SER A 314
 None
 0.96A 1tyrB-2bdwA:
undetectable		 1tyrB-2bdwA:
15.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XKK_A_FMMA91_2
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 2bdw HYPOTHETICAL PROTEIN
K11E8.1D
(Caenorhabditis
elegans) 		6 / 9 LEU A  19
VAL A  27
LYS A  42
LEU A  75
LEU A  87
LEU A  91
 None
 0.83A 1xkkA-2bdwA:
20.9		 1xkkA-2bdwA:
23.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FK8_A_SAMA302_1
(METHOXY MYCOLIC ACID
SYNTHASE 4)		 2bdw HYPOTHETICAL PROTEIN
K11E8.1D
(Caenorhabditis
elegans) 		3 / 3 SER A  10
THR A  46
GLN A  80
 None
 0.82A 2fk8A-2bdwA:
undetectable		 2fk8A-2bdwA:
20.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CS9_A_NILA600_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 2bdw HYPOTHETICAL PROTEIN
K11E8.1D
(Caenorhabditis
elegans) 		5 / 10 LEU A  19
VAL A  27
LYS A  42
VAL A  73
ASP A 156
 None
 0.92A 3cs9A-2bdwA:
21.5		 3cs9A-2bdwA:
23.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CS9_D_NILD600_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 2bdw HYPOTHETICAL PROTEIN
K11E8.1D
(Caenorhabditis
elegans) 		4 / 6 LEU A  19
VAL A  27
LYS A  42
ASP A 156
 None
 0.66A 3cs9D-2bdwA:
20.8		 3cs9D-2bdwA:
23.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3H5G_A_LEIA16_0
(COIL SER L16D-PEN)		 2bdw HYPOTHETICAL PROTEIN
K11E8.1D
(Caenorhabditis
elegans) 		4 / 6 GLN A 118
LEU A 120
GLU A 121
LEU A 266
 None
 0.72A 3h5gA-2bdwA:
undetectable
3h5gC-2bdwA:
undetectable		 3h5gA-2bdwA:
6.96
3h5gC-2bdwA:
6.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HEC_A_STIA1_1
(MITOGEN-ACTIVATED
PROTEIN KINASE 14)		 2bdw HYPOTHETICAL PROTEIN
K11E8.1D
(Caenorhabditis
elegans) 		5 / 12 ALA A  40
LYS A  42
GLU A  60
LEU A  91
ASP A 156
 None
 0.71A 3hecA-2bdwA:
21.9		 3hecA-2bdwA:
29.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JB2_A_SAMA1101_1
(STRUCTURAL PROTEIN
VP3)		 2bdw HYPOTHETICAL PROTEIN
K11E8.1D
(Caenorhabditis
elegans) 		3 / 3 GLU A 236
ASP A 238
ASP A 231
 None
 0.69A 3jb2A-2bdwA:
undetectable		 3jb2A-2bdwA:
16.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KK6_B_CELB1701_2
(PROSTAGLANDIN G/H
SYNTHASE 1)		 2bdw HYPOTHETICAL PROTEIN
K11E8.1D
(Caenorhabditis
elegans) 		5 / 6 SER A 128
LEU A 136
ILE A 131
ALA A 262
LEU A 266
 None
 1.26A 3kk6B-2bdwA:
undetectable		 3kk6B-2bdwA:
20.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LFA_A_1N1A361_1
(MITOGEN-ACTIVATED
PROTEIN KINASE 14)		 2bdw HYPOTHETICAL PROTEIN
K11E8.1D
(Caenorhabditis
elegans) 		5 / 8 ALA A  40
LYS A  42
GLU A  60
LEU A  87
LEU A  91
 None
 0.39A 3lfaA-2bdwA:
22.0		 3lfaA-2bdwA:
29.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OHT_A_1N1A1000_2
(P38A)		 2bdw HYPOTHETICAL PROTEIN
K11E8.1D
(Caenorhabditis
elegans) 		3 / 3 GLU A  60
LEU A  87
LEU A  91
 None
 0.42A 3ohtA-2bdwA:
5.5		 3ohtA-2bdwA:
28.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OHT_B_1N1B1000_2
(P38A)		 2bdw HYPOTHETICAL PROTEIN
K11E8.1D
(Caenorhabditis
elegans) 		3 / 3 GLU A  60
LEU A  87
LEU A  91
 None
 0.44A 3ohtB-2bdwA:
5.5		 3ohtB-2bdwA:
28.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RAE_F_LFXF101_1
(DNA TOPOISOMERASE 4
SUBUNIT A
DNA TOPOISOMERASE 4
SUBUNIT B)		 2bdw HYPOTHETICAL PROTEIN
K11E8.1D
(Caenorhabditis
elegans) 		3 / 4 SER A  25
GLY A 158
GLU A 162
 None
 0.56A 3raeA-2bdwA:
1.8
3raeC-2bdwA:
undetectable		 3raeA-2bdwA:
20.90
3raeC-2bdwA:
24.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U5K_D_08JD4_1
(BROMODOMAIN-CONTAINI
NG PROTEIN 4)		 2bdw HYPOTHETICAL PROTEIN
K11E8.1D
(Caenorhabditis
elegans) 		4 / 8 VAL A 152
LEU A  97
LEU A 141
ILE A 116
 None
 0.93A 3u5kD-2bdwA:
undetectable		 3u5kD-2bdwA:
16.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A9J_B_TYLB1187_1
(BROMODOMAIN
CONTAINING 2)		 2bdw HYPOTHETICAL PROTEIN
K11E8.1D
(Caenorhabditis
elegans) 		4 / 5 VAL A 152
LEU A  97
LEU A 141
ILE A 116
 None
 0.94A 4a9jB-2bdwA:
undetectable		 4a9jB-2bdwA:
18.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AQL_A_TXCA1452_2
(GUANINE DEAMINASE)		 2bdw HYPOTHETICAL PROTEIN
K11E8.1D
(Caenorhabditis
elegans) 		4 / 5 HIS A 127
LEU A 252
LEU A 203
ASP A 249
 None
 1.26A 4aqlA-2bdwA:
undetectable		 4aqlA-2bdwA:
21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JUO_F_LFXF101_1
(DNA TOPOISOMERASE 4
SUBUNIT A
DNA TOPOISOMERASE 4
SUBUNIT B
E-SITE DNA)		 2bdw HYPOTHETICAL PROTEIN
K11E8.1D
(Caenorhabditis
elegans) 		3 / 4 SER A  25
GLY A 158
GLU A 162
 None
 0.61A 4juoA-2bdwA:
2.6
4juoC-2bdwA:
undetectable		 4juoA-2bdwA:
20.90
4juoC-2bdwA:
20.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L6V_1_PQN12001_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1
FUSION PROTEIN OF
PHOTOSYSTEM I
SUBUNIT III AND
SUBUNIT IX)		 2bdw HYPOTHETICAL PROTEIN
K11E8.1D
(Caenorhabditis
elegans) 		5 / 11 SER A  25
ARG A  28
LEU A  19
GLY A  20
ALA A 147
 None
 1.23A 4l6v1-2bdwA:
undetectable
4l6v6-2bdwA:
0.0		 4l6v1-2bdwA:
18.31
4l6v6-2bdwA:
15.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M51_A_BEZA501_0
(AMIDOHYDROLASE
FAMILY PROTEIN)		 2bdw HYPOTHETICAL PROTEIN
K11E8.1D
(Caenorhabditis
elegans) 		4 / 6 ILE A 196
ILE A 119
SER A 122
LEU A 266
 None
 0.97A 4m51A-2bdwA:
undetectable		 4m51A-2bdwA:
22.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PWJ_B_30ZB201_1
(TRANSTHYRETIN)		 2bdw HYPOTHETICAL PROTEIN
K11E8.1D
(Caenorhabditis
elegans) 		4 / 7 THR A 305
ALA A 309
LEU A 313
SER A 314
 None
 1.03A 4pwjB-2bdwA:
undetectable		 4pwjB-2bdwA:
17.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QRC_A_0LIA802_2
(FIBROBLAST GROWTH
FACTOR RECEPTOR 4)		 2bdw HYPOTHETICAL PROTEIN
K11E8.1D
(Caenorhabditis
elegans) 		4 / 8 VAL A 152
ILE A 116
ALA A 112
LEU A 206
 None
 0.81A 4qrcA-2bdwA:
7.7		 4qrcA-2bdwA:
22.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WKQ_A_IREA1101_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 2bdw HYPOTHETICAL PROTEIN
K11E8.1D
(Caenorhabditis
elegans) 		6 / 12 LEU A  19
ALA A  40
LYS A  42
GLU A  60
LEU A  87
LEU A  91
 None
 0.53A 4wkqA-2bdwA:
23.8		 4wkqA-2bdwA:
23.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X5I_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 2bdw HYPOTHETICAL PROTEIN
K11E8.1D
(Caenorhabditis
elegans) 		6 / 12 ILE A 205
PHE A  98
ILE A 119
LEU A 141
ILE A 202
THR A 286
 None
 1.42A 4x5iA-2bdwA:
undetectable		 4x5iA-2bdwA:
18.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZAU_A_YY3A1101_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 2bdw HYPOTHETICAL PROTEIN
K11E8.1D
(Caenorhabditis
elegans) 		5 / 8 LEU A  19
GLY A  20
VAL A  27
ALA A  40
LEU A  91
 None
 0.54A 4zauA-2bdwA:
24.1		 4zauA-2bdwA:
23.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AJQ_B_DB8B800_1
(SERINE/THREONINE-PRO
TEIN KINASE 10)		 2bdw HYPOTHETICAL PROTEIN
K11E8.1D
(Caenorhabditis
elegans) 		4 / 10 GLY A  95
LEU A 142
ALA A 155
ASP A 156
 None
 0.35A 5ajqB-2bdwA:
22.8		 5ajqB-2bdwA:
27.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BOJ_B_4TXB201_1
(TRANSTHYRETIN)		 2bdw HYPOTHETICAL PROTEIN
K11E8.1D
(Caenorhabditis
elegans) 		4 / 7 THR A 305
ALA A 309
LEU A 313
SER A 314
 None
 1.03A 5bojB-2bdwA:
undetectable		 5bojB-2bdwA:
15.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EAJ_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 2bdw HYPOTHETICAL PROTEIN
K11E8.1D
(Caenorhabditis
elegans) 		6 / 12 ILE A 205
PHE A  98
ILE A 119
LEU A 141
ILE A 202
THR A 286
 None
 1.50A 5eajA-2bdwA:
undetectable		 5eajA-2bdwA:
18.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VCV_A_1N1A404_1
(MEMBRANE-ASSOCIATED
TYROSINE- AND
THREONINE-SPECIFIC
CDC2-INHIBITORY
KINASE)		 2bdw HYPOTHETICAL PROTEIN
K11E8.1D
(Caenorhabditis
elegans) 		6 / 12 LEU A  19
ALA A  40
LYS A  42
GLU A  60
VAL A  73
LEU A  87
 None
 0.72A 5vcvA-2bdwA:
24.3		 5vcvA-2bdwA:
25.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VCY_A_DB8A401_1
(MEMBRANE-ASSOCIATED
TYROSINE- AND
THREONINE-SPECIFIC
CDC2-INHIBITORY
KINASE)		 2bdw HYPOTHETICAL PROTEIN
K11E8.1D
(Caenorhabditis
elegans) 		6 / 12 LEU A  19
VAL A  27
ALA A  40
LYS A  42
GLU A  60
LEU A  87
 None
 0.74A 5vcyA-2bdwA:
23.6		 5vcyA-2bdwA:
25.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XV7_A_EMHA705_1
(SERINE-ARGININE (SR)
PROTEIN KINASE 1)		 2bdw HYPOTHETICAL PROTEIN
K11E8.1D
(Caenorhabditis
elegans) 		5 / 12 LEU A  19
GLY A  20
VAL A  27
ALA A  40
PHE A  89
 None
 0.32A 5xv7A-2bdwA:
25.3		 5xv7A-2bdwA:
12.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YU9_A_1E8A1101_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 2bdw HYPOTHETICAL PROTEIN
K11E8.1D
(Caenorhabditis
elegans) 		6 / 12 LEU A  19
GLY A  20
VAL A  27
ALA A  40
LYS A  42
LEU A  87
 None
 0.67A 5yu9A-2bdwA:
20.5		 5yu9A-2bdwA:
13.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z6J_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 2bdw HYPOTHETICAL PROTEIN
K11E8.1D
(Caenorhabditis
elegans) 		6 / 12 ILE A 205
PHE A  98
ILE A 119
LEU A 141
ILE A 202
THR A 286
 None
 1.45A 5z6jA-2bdwA:
undetectable		 5z6jA-2bdwA:
18.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EXI_A_ADNA502_1
(ADENOSYLHOMOCYSTEINA
SE)		 2bdw HYPOTHETICAL PROTEIN
K11E8.1D
(Caenorhabditis
elegans) 		3 / 3 LEU A 206
ASN A  71
LEU A 136
 None
 0.69A 6exiA-2bdwA:
undetectable		 6exiA-2bdwA:
12.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
7DFR_A_FOLA161_0
(DIHYDROFOLATE
REDUCTASE)		 2bdw HYPOTHETICAL PROTEIN
K11E8.1D
(Caenorhabditis
elegans) 		6 / 12 ILE A 205
PHE A  98
ILE A 119
LEU A 141
ILE A 202
THR A 286
 None
 1.47A 7dfrA-2bdwA:
undetectable		 7dfrA-2bdwA:
18.21