SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2be1'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YAJ_J_BEZJ5041_0
(CES1 PROTEIN)		 2be1 SERINE/THREONINE-PRO
TEIN
KINASE/ENDORIBONUCLE
ASE IRE1
(Saccharomyces
cerevisiae) 		4 / 4 GLY A 323
SER A 320
ILE A 326
HIS A 375
 None
 1.38A 1yajJ-2be1A:
undetectable		 1yajJ-2be1A:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DZY_D_BRLD478_2
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 2be1 SERINE/THREONINE-PRO
TEIN
KINASE/ENDORIBONUCLE
ASE IRE1
(Saccharomyces
cerevisiae) 		4 / 4 ILE A 124
GLN A 306
ILE A 236
LEU A 313
 None
 1.30A 3dzyD-2be1A:
undetectable		 3dzyD-2be1A:
22.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ID5_B_SAMB301_0
(FIBRILLARIN-LIKE
RRNA/TRNA
2'-O-METHYLTRANSFERA
SE)		 2be1 SERINE/THREONINE-PRO
TEIN
KINASE/ENDORIBONUCLE
ASE IRE1
(Saccharomyces
cerevisiae) 		5 / 11 TYR A 301
GLY A 177
THR A 303
GLU A 172
ASP A 176
 None
 1.23A 3id5B-2be1A:
undetectable		 3id5B-2be1A:
22.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ID5_F_SAMF301_0
(FIBRILLARIN-LIKE
RRNA/TRNA
2'-O-METHYLTRANSFERA
SE)		 2be1 SERINE/THREONINE-PRO
TEIN
KINASE/ENDORIBONUCLE
ASE IRE1
(Saccharomyces
cerevisiae) 		5 / 11 TYR A 301
GLY A 177
THR A 303
GLU A 172
ASP A 176
 None
 1.22A 3id5F-2be1A:
undetectable		 3id5F-2be1A:
22.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L5F_Y_BO2Y301_1
(PROTEASOME SUBUNIT
BETA
TYPE-8,PROTEASOME
SUBUNIT BETA TYPE-5
PROTEASOME SUBUNIT
BETA
TYPE-6,PROTEASOME
SUBUNIT BETA
TYPE-1,PROTEASOME
SUBUNIT BETA
TYPE-6,PROTEASOME
SUBUNIT BETA
TYPE-1,PROTEASOME
SUBUNIT BETA TYPE-6)		 2be1 SERINE/THREONINE-PRO
TEIN
KINASE/ENDORIBONUCLE
ASE IRE1
(Saccharomyces
cerevisiae) 		4 / 8 THR A 165
ALA A 295
ASP A 221
SER A 291
 None
 0.94A 5l5fY-2be1A:
undetectable
5l5fZ-2be1A:
undetectable		 5l5fY-2be1A:
21.96
5l5fZ-2be1A:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NWV_A_ACAA18_1
(SCRFP-TAG,GP41)		 2be1 SERINE/THREONINE-PRO
TEIN
KINASE/ENDORIBONUCLE
ASE IRE1
(Saccharomyces
cerevisiae) 		5 / 12 GLY A 177
SER A 194
GLU A 286
LEU A 287
LEU A 198
 None
 1.19A 5nwvA-2be1A:
undetectable		 5nwvA-2be1A:
8.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NZY_A_CE3A1103_1
(DNA CROSS-LINK
REPAIR 1A PROTEIN)		 2be1 SERINE/THREONINE-PRO
TEIN
KINASE/ENDORIBONUCLE
ASE IRE1
(Saccharomyces
cerevisiae) 		4 / 8 THR A 283
GLN A 152
VAL A 356
GLY A 357
 None
 0.93A 5nzyA-2be1A:
undetectable		 5nzyA-2be1A:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ESM_A_PZEA307_1
(MATRIX
METALLOPROTEINASE-9,
MATRIX
METALLOPROTEINASE-9)		 2be1 SERINE/THREONINE-PRO
TEIN
KINASE/ENDORIBONUCLE
ASE IRE1
(Saccharomyces
cerevisiae) 		3 / 3 TYR A 420
HIS A 446
PHE A 182
 None
 0.79A 6esmA-2be1A:
undetectable		 6esmA-2be1A:
15.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F3M_D_ADND502_2
(-)		 2be1 SERINE/THREONINE-PRO
TEIN
KINASE/ENDORIBONUCLE
ASE IRE1
(Saccharomyces
cerevisiae) 		4 / 5 ILE A 155
GLN A 394
THR A 395
LEU A 169
 None
 1.05A 6f3mD-2be1A:
undetectable		 6f3mD-2be1A:
21.79