SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2be3'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MT1_A_AG2A7005_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE BETA
CHAIN
PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE ALPHA
CHAIN)		 2be3 GTP
PYROPHOSPHOKINASE
(Streptococcus
pneumoniae) 		4 / 6 LEU A 145
LEU A 183
GLU A  40
ARG A 117
 None
 1.04A 1mt1A-2be3A:
undetectable
1mt1F-2be3A:
undetectable		 1mt1A-2be3A:
12.95
1mt1F-2be3A:
16.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MT1_B_AG2B7001_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE ALPHA
CHAIN
PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE BETA
CHAIN)		 2be3 GTP
PYROPHOSPHOKINASE
(Streptococcus
pneumoniae) 		4 / 6 GLU A  40
ARG A 117
LEU A 145
LEU A 183
 None
 0.98A 1mt1B-2be3A:
undetectable
1mt1C-2be3A:
undetectable		 1mt1B-2be3A:
16.81
1mt1C-2be3A:
12.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QQD_A_AG2A671_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE (EC
4.1.1.19) (PVLARGDC))		 2be3 GTP
PYROPHOSPHOKINASE
(Streptococcus
pneumoniae) 		4 / 7 LEU A 145
LEU A 183
GLU A  40
ARG A 117
 None
 1.03A 2qqdA-2be3A:
undetectable
2qqdE-2be3A:
undetectable		 2qqdA-2be3A:
12.50
2qqdE-2be3A:
16.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XCT_H_CPFH1020_1
(DNA GYRASE SUBUNIT
B, DNA GYRASE
SUBUNIT A)		 2be3 GTP
PYROPHOSPHOKINASE
(Streptococcus
pneumoniae) 		3 / 3 ARG A  58
GLU A  54
SER A 114
 None
 0.70A 2xctD-2be3A:
undetectable		 2xctD-2be3A:
15.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G0V_A_MIXA1301_1
(DNA TOPOISOMERASE
2-BETA)		 2be3 GTP
PYROPHOSPHOKINASE
(Streptococcus
pneumoniae) 		4 / 7 ARG A  45
GLY A  44
ASN A 148
MET A  99
 None
 1.12A 4g0vA-2be3A:
undetectable		 4g0vA-2be3A:
15.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G0V_D_MIXD101_1
(DNA TOPOISOMERASE
2-BETA)		 2be3 GTP
PYROPHOSPHOKINASE
(Streptococcus
pneumoniae) 		4 / 6 ARG A  45
GLY A  44
ASN A 148
MET A  99
 None
 1.22A 4g0vB-2be3A:
undetectable		 4g0vB-2be3A:
15.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KHP_A_PARA1606_1
(16S RIBOSOMAL RNA
30S RIBOSOMAL
PROTEIN S9
30S RIBOSOMAL
PROTEIN S10)		 2be3 GTP
PYROPHOSPHOKINASE
(Streptococcus
pneumoniae) 		3 / 3 TYR A 116
ARG A 143
SER A 118
 None
 1.03A 4khpI-2be3A:
undetectable
4khpJ-2be3A:
undetectable		 4khpI-2be3A:
20.45
4khpJ-2be3A:
20.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R38_B_RBFB201_2
(BLUE-LIGHT-ACTIVATED
HISTIDINE KINASE 2)		 2be3 GTP
PYROPHOSPHOKINASE
(Streptococcus
pneumoniae) 		4 / 8 ILE A 142
LEU A 137
VAL A  16
LEU A  19
 None
 0.83A 4r38B-2be3A:
undetectable		 4r38B-2be3A:
20.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OM2_B_DXTB501_1
(ALPHA-1-ANTICHYMOTRY
PSIN)		 2be3 GTP
PYROPHOSPHOKINASE
(Streptococcus
pneumoniae) 		5 / 9 VAL A 121
LEU A  93
ASP A  98
VAL A  78
ILE A 142
 None
 1.20A 5om2A-2be3A:
undetectable
5om2B-2be3A:
undetectable		 5om2A-2be3A:
16.97
5om2B-2be3A:
10.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TZO_B_7V7B201_1
(ENDO-1,4-BETA-XYLANA
SE A)		 2be3 GTP
PYROPHOSPHOKINASE
(Streptococcus
pneumoniae) 		5 / 12 LEU A   9
VAL A  46
ALA A 138
ALA A  74
GLY A  75
 None
 1.13A 5tzoB-2be3A:
undetectable		 5tzoB-2be3A:
19.57