SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2bec'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A29_A_TFPA153_1
(CALMODULIN)		 2bec CALCINEURIN B
HOMOLOGOUS PROTEIN 2
(Homo
sapiens) 		4 / 8 ILE A 131
GLU A 163
ALA A 164
VAL A 172
 None
None
None
YT3  A1201 ( 4.8A)
 0.27A 1a29A-2becA:
6.2		 1a29A-2becA:
29.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FE2_A_LAXA700_1
(PROSTAGLANDIN
ENDOPEROXIDE H
SYNTHASE-1)		 2bec CALCINEURIN B
HOMOLOGOUS PROTEIN 2
(Homo
sapiens) 		5 / 10 ARG A  30
VAL A  78
VAL A  86
ILE A 194
LEU A  31
 None
 1.13A 1fe2A-2becA:
undetectable		 1fe2A-2becA:
15.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ODI_A_ADNA1237_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 2bec CALCINEURIN B
HOMOLOGOUS PROTEIN 2
SODIUM/HYDROGEN
EXCHANGER 1
(Homo
sapiens) 		5 / 11 ARG A 193
GLY B 533
GLU B 535
ASN A  60
ILE A  66
 None
 1.28A 1odiA-2becA:
undetectable		 1odiA-2becA:
21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V55_P_CHDP4271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE III
CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART)		 2bec CALCINEURIN B
HOMOLOGOUS PROTEIN 2
(Homo
sapiens) 		4 / 7 ARG A 112
LEU A 116
PHE A 120
LEU A 181
 None
 1.04A 1v55P-2becA:
undetectable
1v55W-2becA:
undetectable		 1v55P-2becA:
25.67
1v55W-2becA:
12.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIM_W_CHDW1271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 3)		 2bec CALCINEURIN B
HOMOLOGOUS PROTEIN 2
(Homo
sapiens) 		4 / 7 ARG A 112
LEU A 116
PHE A 120
LEU A 181
 None
 1.05A 2eimP-2becA:
undetectable
2eimW-2becA:
undetectable		 2eimP-2becA:
25.67
2eimW-2becA:
12.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIN_C_CHDC271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 3)		 2bec CALCINEURIN B
HOMOLOGOUS PROTEIN 2
(Homo
sapiens) 		4 / 7 ARG A 112
LEU A 116
PHE A 120
LEU A 181
 None
 1.04A 2einC-2becA:
undetectable
2einJ-2becA:
undetectable		 2einC-2becA:
25.67
2einJ-2becA:
12.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIN_P_CHDP1271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 3)		 2bec CALCINEURIN B
HOMOLOGOUS PROTEIN 2
(Homo
sapiens) 		4 / 6 ARG A 112
LEU A 116
PHE A 120
LEU A 181
 None
 0.96A 2einP-2becA:
undetectable
2einW-2becA:
undetectable		 2einP-2becA:
25.67
2einW-2becA:
12.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ASO_P_CHDP1271_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1)		 2bec CALCINEURIN B
HOMOLOGOUS PROTEIN 2
(Homo
sapiens) 		4 / 7 ARG A 112
LEU A 116
PHE A 120
LEU A 181
 None
 1.07A 3asoP-2becA:
undetectable
3asoW-2becA:
undetectable		 3asoP-2becA:
25.67
3asoW-2becA:
12.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UA5_A_06XA501_1
(CYTOCHROME P450 2B6)		 2bec CALCINEURIN B
HOMOLOGOUS PROTEIN 2
SODIUM/HYDROGEN
EXCHANGER 1
(Homo
sapiens) 		5 / 8 ILE B 534
PHE A  90
GLU A  68
LEU A  51
VAL A  78
 None
 1.11A 3ua5A-2becB:
undetectable		 3ua5A-2becB:
6.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WG7_P_CHDP306_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 2bec CALCINEURIN B
HOMOLOGOUS PROTEIN 2
(Homo
sapiens) 		4 / 6 ARG A 112
LEU A 116
PHE A 120
LEU A 181
 None
 1.02A 3wg7P-2becA:
undetectable
3wg7W-2becA:
undetectable		 3wg7P-2becA:
25.67
3wg7W-2becA:
12.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IY5_P_CHDP307_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 2bec CALCINEURIN B
HOMOLOGOUS PROTEIN 2
(Homo
sapiens) 		4 / 5 ARG A 112
LEU A 116
PHE A 120
LEU A 181
 None
 1.00A 5iy5P-2becA:
undetectable
5iy5W-2becA:
undetectable		 5iy5P-2becA:
25.10
5iy5W-2becA:
12.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ND2_B_TA1B601_1
(TUBULIN BETA-2B
CHAIN)		 2bec CALCINEURIN B
HOMOLOGOUS PROTEIN 2
(Homo
sapiens) 		5 / 12 ALA A  88
PHE A  23
ARG A  34
PRO A  92
LEU A 195
 None
 1.41A 5nd2B-2becA:
undetectable		 5nd2B-2becA:
19.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_A_PCFA1807_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 2bec CALCINEURIN B
HOMOLOGOUS PROTEIN 2
SODIUM/HYDROGEN
EXCHANGER 1
(Homo
sapiens;
Homo
sapiens) 		5 / 7 LEU B 530
LEU A 195
ILE A  66
GLY A  63
LEU A  57
 None
 1.08A 5vkqA-2becB:
undetectable
5vkqB-2becB:
undetectable		 5vkqA-2becB:
3.31
5vkqB-2becB:
3.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_B_PCFB1804_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 2bec CALCINEURIN B
HOMOLOGOUS PROTEIN 2
SODIUM/HYDROGEN
EXCHANGER 1
(Homo
sapiens;
Homo
sapiens) 		5 / 8 LEU B 530
LEU A 195
ILE A  66
GLY A  63
LEU A  57
 None
 1.09A 5vkqB-2becB:
undetectable
5vkqC-2becB:
undetectable		 5vkqB-2becB:
3.31
5vkqC-2becB:
3.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5W97_C_CHDC306_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 2bec CALCINEURIN B
HOMOLOGOUS PROTEIN 2
(Homo
sapiens) 		4 / 6 ARG A 112
LEU A 116
PHE A 120
LEU A 181
 None
 1.05A 5w97C-2becA:
undetectable
5w97J-2becA:
undetectable		 5w97C-2becA:
25.67
5w97J-2becA:
12.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X1B_P_CHDP305_0
(CYTOCHROME C OXIDASE
SUBUNIT 3)		 2bec CALCINEURIN B
HOMOLOGOUS PROTEIN 2
(Homo
sapiens) 		4 / 5 ARG A 112
LEU A 116
PHE A 120
LEU A 181
 None
 1.10A 5x1bP-2becA:
undetectable		 5x1bP-2becA:
25.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X1F_C_CHDC304_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 2bec CALCINEURIN B
HOMOLOGOUS PROTEIN 2
(Homo
sapiens) 		4 / 5 ARG A 112
LEU A 116
PHE A 120
LEU A 181
 None
 1.09A 5x1fC-2becA:
undetectable
5x1fJ-2becA:
undetectable		 5x1fC-2becA:
25.67
5x1fJ-2becA:
12.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XDX_C_CHDC308_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT VIIA-HEART)		 2bec CALCINEURIN B
HOMOLOGOUS PROTEIN 2
(Homo
sapiens) 		4 / 5 ARG A 112
LEU A 116
PHE A 120
LEU A 181
 None
 1.01A 5xdxC-2becA:
undetectable
5xdxJ-2becA:
undetectable		 5xdxC-2becA:
24.71
5xdxJ-2becA:
12.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XDX_P_CHDP306_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT VIIA-HEART)		 2bec CALCINEURIN B
HOMOLOGOUS PROTEIN 2
(Homo
sapiens) 		4 / 5 ARG A 112
LEU A 116
PHE A 120
LEU A 181
 None
 1.02A 5xdxP-2becA:
undetectable
5xdxW-2becA:
undetectable		 5xdxP-2becA:
24.71
5xdxW-2becA:
12.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NKN_W_CHDW101_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 2bec CALCINEURIN B
HOMOLOGOUS PROTEIN 2
(Homo
sapiens) 		3 / 3 ARG A 112
LEU A 116
PHE A 120
 None
 0.65A 6nknP-2becA:
undetectable		 6nknP-2becA:
25.67