SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2bej'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I9G_A_SAMA301_0
(HYPOTHETICAL PROTEIN
RV2118C)		 2bej SEGREGATION PROTEIN
(Thermus
thermophilus) 		5 / 12 GLY A  19
ALA A 213
LEU A 212
LEU A  11
VAL A 138
 ADP  A 500 (-3.1A)
ADP  A 500 (-3.6A)
ADP  A 500 (-4.1A)
None
None
 1.02A 1i9gA-2bejA:
undetectable		 1i9gA-2bejA:
25.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TW4_A_CHDA130_1
(FATTY ACID-BINDING
PROTEIN)		 2bej SEGREGATION PROTEIN
(Thermus
thermophilus) 		3 / 3 TYR A 235
ARG A 208
GLN A 142
 None
ADP  A 500 (-4.3A)
None
 0.95A 1tw4A-2bejA:
undetectable		 1tw4A-2bejA:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YI4_A_ADNA306_1
(PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE PIM-1)		 2bej SEGREGATION PROTEIN
(Thermus
thermophilus) 		5 / 10 LEU A 131
ALA A  12
LEU A  11
PRO A 120
LEU A  43
 None
 1.11A 1yi4A-2bejA:
undetectable		 1yi4A-2bejA:
21.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AB2_B_SNLB503_2
(MINERALOCORTICOID
RECEPTOR)		 2bej SEGREGATION PROTEIN
(Thermus
thermophilus) 		4 / 5 LEU A  43
LEU A 117
LEU A  40
LEU A  83
 None
 1.00A 2ab2B-2bejA:
undetectable		 2ab2B-2bejA:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2E7F_B_C2FB4000_0
(5-METHYLTETRAHYDROFO
LATE CORRINOID/IRON
SULFUR PROTEIN
METHYLTRANSFERASE)		 2bej SEGREGATION PROTEIN
(Thermus
thermophilus) 		5 / 12 GLU A 241
ILE A   9
LEU A  11
GLY A 173
ARG A 194
 None
 1.22A 2e7fB-2bejA:
3.0		 2e7fB-2bejA:
23.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OGY_A_C2FA3000_0
(5-METHYLTETRAHYDROFO
LATE CORRINOID/IRON
SULFUR PROTEIN
METHYLTRANSFERASE)		 2bej SEGREGATION PROTEIN
(Thermus
thermophilus) 		5 / 12 GLU A 241
ILE A   9
LEU A  11
GLY A 173
ARG A 194
 None
 1.25A 2ogyA-2bejA:
2.8		 2ogyA-2bejA:
24.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OGY_B_C2FB4000_0
(5-METHYLTETRAHYDROFO
LATE CORRINOID/IRON
SULFUR PROTEIN
METHYLTRANSFERASE)		 2bej SEGREGATION PROTEIN
(Thermus
thermophilus) 		5 / 12 GLU A 241
ILE A   9
LEU A  11
GLY A 173
ARG A 194
 None
 1.25A 2ogyB-2bejA:
undetectable		 2ogyB-2bejA:
24.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YY8_B_SAMB500_0
(UPF0106 PROTEIN
PH0461)		 2bej SEGREGATION PROTEIN
(Thermus
thermophilus) 		5 / 11 LEU A 171
VAL A 137
GLY A 136
LYS A   5
VAL A   6
 None
 1.18A 2yy8A-2bejA:
undetectable
2yy8B-2bejA:
undetectable		 2yy8A-2bejA:
22.88
2yy8B-2bejA:
22.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KP6_A_SALA3002_1
(TRANSCRIPTIONAL
REGULATOR TCAR)		 2bej SEGREGATION PROTEIN
(Thermus
thermophilus) 		5 / 8 VAL A 242
LEU A 238
ILE A   9
VAL A 138
LEU A 175
 None
 1.40A 3kp6A-2bejA:
undetectable
3kp6B-2bejA:
undetectable		 3kp6A-2bejA:
21.71
3kp6B-2bejA:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ME6_D_CGED501_1
(CYTOCHROME P450 2B4)		 2bej SEGREGATION PROTEIN
(Thermus
thermophilus) 		5 / 9 VAL A 151
ILE A 174
ALA A 195
VAL A 189
VAL A 176
 None
 1.15A 3me6D-2bejA:
undetectable		 3me6D-2bejA:
20.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SI7_B_ACTB4_0
(CYSTIC FIBROSIS
TRANSMEMBRANE
CONDUCTANCE
REGULATOR)		 2bej SEGREGATION PROTEIN
(Thermus
thermophilus) 		3 / 3 GLY A  17
GLY A  19
THR A  21
 ADP  A 500 (-3.3A)
ADP  A 500 (-3.1A)
MG  A 501 ( 3.1A)
 0.45A 3si7B-2bejA:
undetectable		 3si7B-2bejA:
20.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUF_C_SUEC1201_1
(NS3 PROTEASE, NS4A
PROTEIN)		 2bej SEGREGATION PROTEIN
(Thermus
thermophilus) 		5 / 11 TYR A 112
ASP A 109
GLY A 136
ALA A 133
ALA A 132
 None
 1.17A 3sufC-2bejA:
undetectable		 3sufC-2bejA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZOS_A_0LIA1004_1
(EPITHELIAL DISCOIDIN
DOMAIN-CONTAINING
RECEPTOR 1)		 2bej SEGREGATION PROTEIN
(Thermus
thermophilus) 		5 / 11 ALA A  92
LEU A  96
LEU A 123
VAL A  61
LEU A  89
 None
 1.18A 3zosA-2bejA:
undetectable
3zosB-2bejA:
undetectable		 3zosA-2bejA:
26.14
3zosB-2bejA:
26.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZBR_A_NPSA602_1
(SERUM ALBUMIN)		 2bej SEGREGATION PROTEIN
(Thermus
thermophilus) 		5 / 12 LEU A 116
PHE A 202
LEU A 238
TYR A 235
GLY A 173
 None
 1.40A 4zbrA-2bejA:
undetectable		 4zbrA-2bejA:
19.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZBR_A_NPSA602_1
(SERUM ALBUMIN)		 2bej SEGREGATION PROTEIN
(Thermus
thermophilus) 		5 / 12 PHE A 202
LEU A 238
TYR A 235
GLY A 173
LEU A  11
 None
 1.44A 4zbrA-2bejA:
undetectable		 4zbrA-2bejA:
19.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QGG_A_ACTA301_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 2bej SEGREGATION PROTEIN
(Thermus
thermophilus) 		4 / 4 VAL A 205
VAL A 176
TYR A 179
GLN A 142
 None
 1.40A 5qggA-2bejA:
undetectable		 5qggA-2bejA:
23.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QGO_A_ACTA302_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 2bej SEGREGATION PROTEIN
(Thermus
thermophilus) 		4 / 4 VAL A 205
VAL A 176
TYR A 179
GLN A 142
 None
 1.37A 5qgoA-2bejA:
undetectable		 5qgoA-2bejA:
23.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QGP_A_ACTA301_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 2bej SEGREGATION PROTEIN
(Thermus
thermophilus) 		4 / 4 VAL A 205
VAL A 176
TYR A 179
GLN A 142
 None
 1.35A 5qgpA-2bejA:
undetectable		 5qgpA-2bejA:
23.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QGQ_A_ACTA301_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 2bej SEGREGATION PROTEIN
(Thermus
thermophilus) 		4 / 4 VAL A 205
VAL A 176
TYR A 179
GLN A 142
 None
 1.32A 5qgqA-2bejA:
undetectable		 5qgqA-2bejA:
23.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QHB_A_ACTA301_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 2bej SEGREGATION PROTEIN
(Thermus
thermophilus) 		4 / 4 VAL A 205
VAL A 176
TYR A 179
GLN A 142
 None
 1.37A 5qhbA-2bejA:
undetectable		 5qhbA-2bejA:
23.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UMD_A_YMZA3801_1
(60S RIBOSOMAL
PROTEIN L28
28S RIBOSOMAL RNA
60S RIBOSOMAL
PROTEIN L4)		 2bej SEGREGATION PROTEIN
(Thermus
thermophilus) 		4 / 6 ASN A  48
ALA A  49
PRO A 216
ASP A  44
 None
None
ADP  A 500 ( 4.9A)
None
 1.22A 5umd2-2bejA:
undetectable
5umdF-2bejA:
undetectable		 5umd2-2bejA:
14.73
5umdF-2bejA:
14.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V5Z_A_1YNA602_2
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 2bej SEGREGATION PROTEIN
(Thermus
thermophilus) 		3 / 3 GLY A 164
THR A  93
PRO A 100
 None
 0.55A 5v5zA-2bejA:
undetectable		 5v5zA-2bejA:
19.74