SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2bex'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C4D_A_DVAA8_0
(GRAMICIDIN A)		 2bex RIBONUCLEASE
INHIBITOR
(Homo
sapiens) 		3 / 3 VAL A 319
TRP A 263
TRP A 261
 None
 1.47A 1c4dA-2bexA:
undetectable
1c4dB-2bexA:
undetectable		 1c4dA-2bexA:
3.42
1c4dB-2bexA:
3.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CQP_A_803A311_1
(ANTIGEN CD11A (P180))		 2bex RIBONUCLEASE
INHIBITOR
(Homo
sapiens) 		5 / 10 LEU A 233
ILE A 262
LEU A 285
LEU A 257
VAL A 222
 None
 1.20A 1cqpA-2bexA:
undetectable
1cqpB-2bexA:
undetectable		 1cqpA-2bexA:
15.37
1cqpB-2bexA:
15.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DYI_A_FOLA161_0
(DIHYDROFOLATE
REDUCTASE)		 2bex RIBONUCLEASE
INHIBITOR
(Homo
sapiens) 		5 / 12 ILE A 181
ALA A 156
ASP A 126
LEU A 129
LEU A 174
 None
 1.00A 1dyiA-2bexA:
undetectable		 1dyiA-2bexA:
16.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DYI_B_FOLB161_0
(DIHYDROFOLATE
REDUCTASE)		 2bex RIBONUCLEASE
INHIBITOR
(Homo
sapiens) 		5 / 12 ILE A 181
ALA A 156
ASP A 126
LEU A 129
LEU A 174
 None
 1.02A 1dyiB-2bexA:
undetectable		 1dyiB-2bexA:
16.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MZ9_A_VDYA1002_1
(CARTILAGE OLIGOMERIC
MATRIX PROTEIN)		 2bex RIBONUCLEASE
INHIBITOR
(Homo
sapiens) 		4 / 4 ILE A 262
LEU A 233
VAL A 210
ALA A 184
 None
 0.97A 1mz9A-2bexA:
undetectable		 1mz9A-2bexA:
7.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MZ9_A_VDYA1002_3
(CARTILAGE OLIGOMERIC
MATRIX PROTEIN)		 2bex RIBONUCLEASE
INHIBITOR
(Homo
sapiens) 		4 / 5 ILE A 262
LEU A 233
VAL A 210
ALA A 184
 None
 0.94A 1mz9C-2bexA:
undetectable		 1mz9C-2bexA:
7.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PTH_A_SALA710_1
(PROSTAGLANDIN H2
SYNTHASE-1)		 2bex RIBONUCLEASE
INHIBITOR
(Homo
sapiens) 		4 / 7 VAL A  75
VAL A  32
LEU A   7
LEU A  51
 None
 0.66A 1pthA-2bexA:
undetectable		 1pthA-2bexA:
21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PTH_B_SALB711_1
(PROSTAGLANDIN H2
SYNTHASE-1)		 2bex RIBONUCLEASE
INHIBITOR
(Homo
sapiens) 		4 / 7 VAL A  75
VAL A  32
LEU A   7
LEU A  51
 None
 0.65A 1pthB-2bexA:
undetectable		 1pthB-2bexA:
21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RA2_A_FOLA161_0
(DIHYDROFOLATE
REDUCTASE)		 2bex RIBONUCLEASE
INHIBITOR
(Homo
sapiens) 		5 / 12 ILE A 181
ALA A 156
ASP A 126
LEU A 129
LEU A 174
 None
 0.94A 1ra2A-2bexA:
undetectable		 1ra2A-2bexA:
16.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RA3_A_MTXA161_1
(DIHYDROFOLATE
REDUCTASE)		 2bex RIBONUCLEASE
INHIBITOR
(Homo
sapiens) 		5 / 12 ILE A 181
ALA A 156
ASP A 126
LEU A 129
LEU A 174
 None
 1.07A 1ra3A-2bexA:
undetectable		 1ra3A-2bexA:
16.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RB2_B_FOLB161_0
(DIHYDROFOLATE
REDUCTASE)		 2bex RIBONUCLEASE
INHIBITOR
(Homo
sapiens) 		5 / 12 ILE A 181
ALA A 156
ASP A 126
LEU A 129
LEU A 174
 None
 0.98A 1rb2B-2bexA:
undetectable		 1rb2B-2bexA:
16.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RD7_B_FOLB361_0
(DIHYDROFOLATE
REDUCTASE)		 2bex RIBONUCLEASE
INHIBITOR
(Homo
sapiens) 		5 / 12 ILE A 181
ALA A 156
ASP A 126
LEU A 129
LEU A 174
 None
 1.02A 1rd7B-2bexA:
undetectable		 1rd7B-2bexA:
16.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RQP_B_SAMB500_1
(5'-FLUORO-5'-DEOXYAD
ENOSINE SYNTHASE)		 2bex RIBONUCLEASE
INHIBITOR
(Homo
sapiens) 		4 / 8 ASP A 435
ASN A 406
SER A 460
ALA A 377
 None
 1.02A 1rqpC-2bexA:
undetectable		 1rqpC-2bexA:
19.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RQP_C_SAMC500_0
(5'-FLUORO-5'-DEOXYAD
ENOSINE SYNTHASE)		 2bex RIBONUCLEASE
INHIBITOR
(Homo
sapiens) 		4 / 8 ASP A 435
ASN A 406
SER A 460
ALA A 377
 None
 1.03A 1rqpA-2bexA:
undetectable		 1rqpA-2bexA:
19.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZUC_B_T98B202_1
(PROGESTERONE
RECEPTOR)		 2bex RIBONUCLEASE
INHIBITOR
(Homo
sapiens) 		5 / 12 LEU A 108
LEU A 136
LEU A 137
LEU A 161
LEU A 119
 None
 1.16A 1zucB-2bexA:
undetectable		 1zucB-2bexA:
20.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AB2_A_SNLA502_2
(MINERALOCORTICOID
RECEPTOR)		 2bex RIBONUCLEASE
INHIBITOR
(Homo
sapiens) 		4 / 6 LEU A 285
LEU A 314
LEU A 275
LEU A 251
 None
 0.98A 2ab2A-2bexA:
undetectable		 2ab2A-2bexA:
21.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PLW_A_SAMA203_1
(RIBOSOMAL RNA
METHYLTRANSFERASE,
PUTATIVE)		 2bex RIBONUCLEASE
INHIBITOR
(Homo
sapiens) 		3 / 3 SER A 460
ASP A 403
ASP A 435
 None
 0.79A 2plwA-2bexA:
undetectable		 2plwA-2bexA:
15.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V7U_A_SAMA1299_0
(5'-FLUORO-5'-DEOXY
ADENOSINE SYNTHETASE)		 2bex RIBONUCLEASE
INHIBITOR
(Homo
sapiens) 		4 / 8 ASP A 435
ASN A 406
SER A 460
ALA A 377
 None
 1.02A 2v7uA-2bexA:
undetectable		 2v7uA-2bexA:
19.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AIA_B_SAMB206_0
(UPF0217 PROTEIN
MJ1640)		 2bex RIBONUCLEASE
INHIBITOR
(Homo
sapiens) 		4 / 5 LEU A 205
GLY A 234
GLU A 149
CYH A 208
 None
 1.20A 3aiaA-2bexA:
undetectable
3aiaB-2bexA:
undetectable		 3aiaA-2bexA:
16.27
3aiaB-2bexA:
16.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KP6_B_SALB3003_1
(TRANSCRIPTIONAL
REGULATOR TCAR)		 2bex RIBONUCLEASE
INHIBITOR
(Homo
sapiens) 		4 / 6 ILE A 181
VAL A 176
LEU A 148
LEU A 129
 None
 0.87A 3kp6A-2bexA:
undetectable
3kp6B-2bexA:
undetectable		 3kp6A-2bexA:
15.32
3kp6B-2bexA:
15.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NDV_A_AICA375_1
(BETA-PEPTIDYL
AMINOPEPTIDASE)		 2bex RIBONUCLEASE
INHIBITOR
(Homo
sapiens) 		5 / 11 GLY A 365
LEU A 336
SER A 369
LEU A 399
LEU A 360
 None
 1.05A 3ndvA-2bexA:
undetectable
3ndvB-2bexA:
undetectable		 3ndvA-2bexA:
22.85
3ndvB-2bexA:
22.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NDV_A_AICA375_1
(BETA-PEPTIDYL
AMINOPEPTIDASE)		 2bex RIBONUCLEASE
INHIBITOR
(Homo
sapiens) 		5 / 11 GLY A 365
LEU A 399
ARG A 372
SER A 369
LEU A 393
 None
 1.30A 3ndvA-2bexA:
undetectable
3ndvB-2bexA:
undetectable		 3ndvA-2bexA:
22.85
3ndvB-2bexA:
22.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NDV_B_AICB376_1
(BETA-PEPTIDYL
AMINOPEPTIDASE)		 2bex RIBONUCLEASE
INHIBITOR
(Homo
sapiens) 		5 / 11 LEU A 360
GLY A 365
LEU A 336
SER A 369
LEU A 399
 None
 1.05A 3ndvA-2bexA:
undetectable
3ndvB-2bexA:
undetectable		 3ndvA-2bexA:
22.85
3ndvB-2bexA:
22.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NDV_B_AICB376_1
(BETA-PEPTIDYL
AMINOPEPTIDASE)		 2bex RIBONUCLEASE
INHIBITOR
(Homo
sapiens) 		5 / 11 LEU A 393
GLY A 365
LEU A 399
ARG A 372
SER A 369
 None
 1.31A 3ndvA-2bexA:
undetectable
3ndvB-2bexA:
undetectable		 3ndvA-2bexA:
22.85
3ndvB-2bexA:
22.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NDV_C_AICC375_1
(BETA-PEPTIDYL
AMINOPEPTIDASE)		 2bex RIBONUCLEASE
INHIBITOR
(Homo
sapiens) 		5 / 11 GLY A 365
LEU A 336
SER A 369
LEU A 399
LEU A 360
 None
 1.04A 3ndvC-2bexA:
undetectable
3ndvD-2bexA:
0.0		 3ndvC-2bexA:
22.85
3ndvD-2bexA:
22.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NDV_C_AICC375_1
(BETA-PEPTIDYL
AMINOPEPTIDASE)		 2bex RIBONUCLEASE
INHIBITOR
(Homo
sapiens) 		5 / 11 GLY A 365
LEU A 399
ARG A 372
SER A 369
LEU A 393
 None
 1.30A 3ndvC-2bexA:
undetectable
3ndvD-2bexA:
0.0		 3ndvC-2bexA:
22.85
3ndvD-2bexA:
22.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NDV_D_AICD374_1
(BETA-PEPTIDYL
AMINOPEPTIDASE)		 2bex RIBONUCLEASE
INHIBITOR
(Homo
sapiens) 		5 / 11 LEU A 360
GLY A 365
LEU A 336
SER A 369
LEU A 399
 None
 1.03A 3ndvC-2bexA:
undetectable
3ndvD-2bexA:
undetectable		 3ndvC-2bexA:
22.85
3ndvD-2bexA:
22.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NDV_D_AICD374_1
(BETA-PEPTIDYL
AMINOPEPTIDASE)		 2bex RIBONUCLEASE
INHIBITOR
(Homo
sapiens) 		5 / 11 LEU A 393
GLY A 365
LEU A 399
ARG A 372
SER A 369
 None
 1.30A 3ndvC-2bexA:
undetectable
3ndvD-2bexA:
undetectable		 3ndvC-2bexA:
22.85
3ndvD-2bexA:
22.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PGH_C_FLPC701_1
(CYCLOOXYGENASE-2)		 2bex RIBONUCLEASE
INHIBITOR
(Homo
sapiens) 		6 / 12 VAL A  75
VAL A  32
LEU A   7
LEU A  62
ALA A  50
LEU A  51
 None
 1.29A 3pghC-2bexA:
undetectable		 3pghC-2bexA:
19.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V4T_H_ACTH504_0
(UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE)		 2bex RIBONUCLEASE
INHIBITOR
(Homo
sapiens) 		3 / 3 LYS A 204
GLU A 230
TRP A 261
 None
 0.83A 3v4tH-2bexA:
1.3		 3v4tH-2bexA:
24.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4I1N_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 2bex RIBONUCLEASE
INHIBITOR
(Homo
sapiens) 		5 / 11 ILE A 181
ALA A 156
ASP A 126
LEU A 129
LEU A 174
 None
 1.00A 4i1nA-2bexA:
undetectable		 4i1nA-2bexA:
16.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LMN_A_EUIA503_1
(DUAL SPECIFICITY
MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE 1)		 2bex RIBONUCLEASE
INHIBITOR
(Homo
sapiens) 		5 / 12 LEU A  62
LEU A  67
ILE A  47
GLY A  38
LEU A  34
 None
 0.86A 4lmnA-2bexA:
undetectable		 4lmnA-2bexA:
22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M11_D_MXMD606_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 2bex RIBONUCLEASE
INHIBITOR
(Homo
sapiens) 		5 / 12 VAL A  75
VAL A  32
LEU A   7
LEU A  60
ALA A  50
 None
 1.43A 4m11D-2bexA:
undetectable		 4m11D-2bexA:
22.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4N09_D_ADND401_2
(ADENOSINE KINASE)		 2bex RIBONUCLEASE
INHIBITOR
(Homo
sapiens) 		4 / 5 CYH A 304
LEU A 342
LEU A 374
LEU A 317
 None
 1.24A 4n09D-2bexA:
undetectable		 4n09D-2bexA:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QLE_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 2bex RIBONUCLEASE
INHIBITOR
(Homo
sapiens) 		5 / 12 ILE A 181
ALA A 156
ASP A 126
LEU A 129
LEU A 174
 None
 1.02A 4qleA-2bexA:
undetectable		 4qleA-2bexA:
14.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QLE_B_FOLB201_0
(DIHYDROFOLATE
REDUCTASE)		 2bex RIBONUCLEASE
INHIBITOR
(Homo
sapiens) 		5 / 11 ILE A 181
ALA A 156
ASP A 126
LEU A 129
LEU A 174
 None
 1.05A 4qleB-2bexA:
undetectable		 4qleB-2bexA:
14.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QLG_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 2bex RIBONUCLEASE
INHIBITOR
(Homo
sapiens) 		5 / 12 ILE A 181
ALA A 156
ASP A 126
LEU A 129
LEU A 174
 None
 1.00A 4qlgA-2bexA:
undetectable		 4qlgA-2bexA:
16.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QLG_B_FOLB201_0
(DIHYDROFOLATE
REDUCTASE)		 2bex RIBONUCLEASE
INHIBITOR
(Homo
sapiens) 		5 / 12 ILE A 181
ALA A 156
ASP A 126
LEU A 129
LEU A 174
 None
 1.03A 4qlgB-2bexA:
undetectable		 4qlgB-2bexA:
16.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RGC_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 2bex RIBONUCLEASE
INHIBITOR
(Homo
sapiens) 		5 / 12 ILE A 181
ALA A 156
ASP A 126
LEU A 129
LEU A 174
 None
 0.94A 4rgcA-2bexA:
undetectable		 4rgcA-2bexA:
16.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WG0_E_CHDE104_0
(NUCLEAR RECEPTOR
COACTIVATOR 2)		 2bex RIBONUCLEASE
INHIBITOR
(Homo
sapiens) 		6 / 11 ALA A 202
LEU A 203
GLU A 149
LEU A 205
LEU A 233
LEU A 218
 None
 1.29A 4wg0C-2bexA:
undetectable
4wg0D-2bexA:
undetectable
4wg0E-2bexA:
undetectable		 4wg0C-2bexA:
2.65
4wg0D-2bexA:
2.65
4wg0E-2bexA:
2.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WG0_G_CHDG103_0
(NUCLEAR RECEPTOR
COACTIVATOR 2)		 2bex RIBONUCLEASE
INHIBITOR
(Homo
sapiens) 		6 / 11 ALA A 202
LEU A 203
GLU A 149
LEU A 205
LEU A 233
LEU A 218
 None
 1.32A 4wg0E-2bexA:
undetectable
4wg0F-2bexA:
undetectable
4wg0G-2bexA:
undetectable		 4wg0E-2bexA:
2.65
4wg0F-2bexA:
2.65
4wg0G-2bexA:
2.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X5G_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 2bex RIBONUCLEASE
INHIBITOR
(Homo
sapiens) 		5 / 12 ILE A 181
ALA A 156
ASP A 126
LEU A 129
LEU A 174
 None
 0.96A 4x5gA-2bexA:
undetectable		 4x5gA-2bexA:
16.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XUM_A_IMNA501_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 2bex RIBONUCLEASE
INHIBITOR
(Homo
sapiens) 		5 / 12 CYH A 247
ILE A 267
LEU A 279
LEU A 285
LEU A 260
 None
 1.22A 4xumA-2bexA:
undetectable		 4xumA-2bexA:
22.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZAU_A_YY3A1101_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 2bex RIBONUCLEASE
INHIBITOR
(Homo
sapiens) 		5 / 8 LEU A 189
GLY A 185
VAL A 188
ALA A 162
LEU A 165
 None
 1.23A 4zauA-2bexA:
undetectable		 4zauA-2bexA:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZOW_A_CLMA500_0
(MULTIDRUG
TRANSPORTER MDFA)		 2bex RIBONUCLEASE
INHIBITOR
(Homo
sapiens) 		6 / 11 LEU A 336
LEU A 360
LEU A 290
LEU A 314
LEU A 342
LEU A 288
 None
 1.20A 4zowA-2bexA:
undetectable		 4zowA-2bexA:
23.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HI6_B_MTXB201_1
(DIHYDROFOLATE
REDUCTASE)		 2bex RIBONUCLEASE
INHIBITOR
(Homo
sapiens) 		5 / 12 ILE A 181
ALA A 156
ASP A 126
LEU A 129
SER A 163
 None
 1.10A 5hi6B-2bexA:
undetectable		 5hi6B-2bexA:
15.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HI6_B_MTXB201_1
(DIHYDROFOLATE
REDUCTASE)		 2bex RIBONUCLEASE
INHIBITOR
(Homo
sapiens) 		5 / 12 ILE A 181
ALA A 156
LEU A 129
SER A 163
LEU A 174
 None
 1.04A 5hi6B-2bexA:
undetectable		 5hi6B-2bexA:
15.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IEP_A_VDYA201_1
(CDL2.3B)		 2bex RIBONUCLEASE
INHIBITOR
(Homo
sapiens) 		5 / 12 LEU A 129
LEU A 148
PHE A 171
ALA A 162
LEU A 189
 None
 1.19A 5iepA-2bexA:
undetectable		 5iepA-2bexA:
14.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KB5_A_ADNA401_2
(ADENOSINE KINASE)		 2bex RIBONUCLEASE
INHIBITOR
(Homo
sapiens) 		4 / 4 ASN A 407
LEU A 409
SER A 405
LEU A 431
 None
 1.34A 5kb5A-2bexA:
undetectable		 5kb5A-2bexA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M5K_B_ADNB502_2
(ADENOSYLHOMOCYSTEINA
SE)		 2bex RIBONUCLEASE
INHIBITOR
(Homo
sapiens) 		4 / 4 GLN A  87
THR A 113
LEU A  51
LEU A  57
 None
 1.28A 5m5kB-2bexA:
undetectable		 5m5kB-2bexA:
21.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5SXT_B_NIZB808_1
(CATALASE-PEROXIDASE)		 2bex RIBONUCLEASE
INHIBITOR
(Homo
sapiens) 		4 / 8 VAL A 103
GLY A  78
LEU A  79
THR A  81
 None
 1.00A 5sxtB-2bexA:
undetectable		 5sxtB-2bexA:
20.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z6M_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 2bex RIBONUCLEASE
INHIBITOR
(Homo
sapiens) 		5 / 11 ILE A 181
ALA A 156
ASP A 126
LEU A 129
LEU A 174
 None
 0.90A 5z6mA-2bexA:
undetectable		 5z6mA-2bexA:
16.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZNI_A_YMZA302_0
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 2bex RIBONUCLEASE
INHIBITOR
(Homo
sapiens) 		5 / 9 VAL A 335
GLY A 299
GLU A 305
ASP A 297
GLY A 296
 None
 1.27A 5zniA-2bexA:
undetectable		 5zniA-2bexA:
11.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BP4_A_SAMA505_1
(HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-9 SPECIFIC)		 2bex RIBONUCLEASE
INHIBITOR
(Homo
sapiens) 		3 / 3 ILE A 181
ASN A 236
CYH A 215
 None
 0.77A 6bp4A-2bexA:
undetectable		 6bp4A-2bexA:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CI6_A_NBOA607_1
(SERUM ALBUMIN)		 2bex RIBONUCLEASE
INHIBITOR
(Homo
sapiens) 		4 / 7 ALA A  58
LYS A  88
GLU A 116
LEU A 111
 None
 0.89A 6ci6A-2bexA:
undetectable		 6ci6A-2bexA:
11.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CZM_B_HISB402_0
(ATP
PHOSPHORIBOSYLTRANSF
ERASE CATALYTIC
SUBUNIT)		 2bex RIBONUCLEASE
INHIBITOR
(Homo
sapiens) 		5 / 9 VAL A 103
LEU A  89
GLY A  78
LEU A  79
VAL A  72
 None
 1.22A 6czmA-2bexA:
undetectable
6czmB-2bexA:
undetectable		 6czmA-2bexA:
23.44
6czmB-2bexA:
23.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EXI_C_ADNC502_1
(ADENOSYLHOMOCYSTEINA
SE)		 2bex RIBONUCLEASE
INHIBITOR
(Homo
sapiens) 		3 / 3 LEU A 104
GLY A 135
PHE A 171
 None
GOL  A1461 ( 4.1A)
None
 0.51A 6exiC-2bexA:
undetectable		 6exiC-2bexA:
10.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6G9B_A_IXXA609_1
(ENVELOPE
GLYCOPROTEIN,ENVELOP
E GLYCOPROTEIN
ENVELOPE
GLYCOPROTEIN)		 2bex RIBONUCLEASE
INHIBITOR
(Homo
sapiens) 		4 / 7 LEU A 360
VAL A 319
LEU A 345
LEU A 342
 None
 0.62A 6g9bA-2bexA:
undetectable
6g9bB-2bexA:
undetectable		 6g9bA-2bexA:
12.09
6g9bB-2bexA:
11.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MD4_A_BRLA501_0
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 2bex RIBONUCLEASE
INHIBITOR
(Homo
sapiens) 		5 / 12 GLY A 363
GLN A 366
SER A 369
HIS A 397
LEU A 399
 None
 1.35A 6md4A-2bexA:
undetectable		 6md4A-2bexA:
9.13