SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2bf4'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1BU5_A_RBFA301_1
(PROTEIN (FLAVODOXIN))		 2bf4 NADPH-CYTOCHROME
P450 REDUCTASE
(Saccharomyces
cerevisiae) 		4 / 7 THR A  69
THR A 117
GLY A 153
TYR A 157
 FMN  A 751 ( 3.3A)
FMN  A 751 (-3.9A)
FMN  A 751 (-3.2A)
FMN  A 751 (-3.5A)
 0.97A 1bu5A-2bf4A:
18.0		 1bu5A-2bf4A:
13.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1BU5_A_RBFA301_1
(PROTEIN (FLAVODOXIN))		 2bf4 NADPH-CYTOCHROME
P450 REDUCTASE
(Saccharomyces
cerevisiae) 		4 / 7 THR A  71
THR A 117
GLY A 153
TYR A 157
 FMN  A 751 (-3.5A)
FMN  A 751 (-3.9A)
FMN  A 751 (-3.2A)
FMN  A 751 (-3.5A)
 0.74A 1bu5A-2bf4A:
18.0		 1bu5A-2bf4A:
13.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1BU5_B_RBFB302_1
(PROTEIN (FLAVODOXIN))		 2bf4 NADPH-CYTOCHROME
P450 REDUCTASE
(Saccharomyces
cerevisiae) 		4 / 8 THR A  71
THR A 117
GLY A 153
TYR A 157
 FMN  A 751 (-3.5A)
FMN  A 751 (-3.9A)
FMN  A 751 (-3.2A)
FMN  A 751 (-3.5A)
 0.76A 1bu5B-2bf4A:
18.1		 1bu5B-2bf4A:
13.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQG_A_IBPA701_1
(PROSTAGLANDIN H2
SYNTHASE-1)		 2bf4 NADPH-CYTOCHROME
P450 REDUCTASE
(Saccharomyces
cerevisiae) 		5 / 9 VAL A 430
TYR A 226
LEU A 335
ILE A 352
ALA A 355
 None
 1.15A 1eqgA-2bf4A:
undetectable		 1eqgA-2bf4A:
20.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJQ_B_SAMB200_0
(METHIONINE REPRESSOR)		 2bf4 NADPH-CYTOCHROME
P450 REDUCTASE
(Saccharomyces
cerevisiae) 		5 / 11 GLU A 120
GLY A 121
GLU A 184
LEU A 182
GLU A 168
 None
 1.40A 1mjqA-2bf4A:
undetectable
1mjqB-2bf4A:
undetectable		 1mjqA-2bf4A:
10.63
1mjqB-2bf4A:
10.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XVA_B_ACTB294_0
(GLYCINE
N-METHYLTRANSFERASE)		 2bf4 NADPH-CYTOCHROME
P450 REDUCTASE
(Saccharomyces
cerevisiae) 		4 / 6 ALA A 164
TYR A 147
ILE A 113
LEU A 182
 None
 0.95A 1xvaA-2bf4A:
3.3
1xvaB-2bf4A:
3.5		 1xvaA-2bf4A:
17.93
1xvaB-2bf4A:
17.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZSB_A_AZMA264_1
(CARBONIC ANHYDRASE
II)		 2bf4 NADPH-CYTOCHROME
P450 REDUCTASE
(Saccharomyces
cerevisiae) 		5 / 12 VAL A 456
PHE A 292
LEU A 482
THR A 479
THR A 478
 None
None
None
FAD  A 750 (-3.1A)
FAD  A 750 (-3.4A)
 0.91A 1zsbA-2bf4A:
undetectable		 1zsbA-2bf4A:
18.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J9C_A_ACTA1121_0
(HYPOTHETICAL
NITROGEN REGULATORY
PII-LIKE PROTEIN
MJ0059)		 2bf4 NADPH-CYTOCHROME
P450 REDUCTASE
(Saccharomyces
cerevisiae) 		4 / 5 SER A 458
VAL A 456
VAL A 460
SER A 290
 None
 1.08A 2j9cA-2bf4A:
undetectable
2j9cB-2bf4A:
undetectable
2j9cC-2bf4A:
undetectable		 2j9cA-2bf4A:
11.88
2j9cB-2bf4A:
11.88
2j9cC-2bf4A:
11.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OPX_A_DXCA1001_0
(ALDEHYDE
DEHYDROGENASE A)		 2bf4 NADPH-CYTOCHROME
P450 REDUCTASE
(Saccharomyces
cerevisiae) 		4 / 7 LEU A 412
PHE A 377
PHE A 325
ILE A 408
 None
 0.70A 2opxA-2bf4A:
3.8		 2opxA-2bf4A:
22.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2POU_A_I7AA1000_1
(CARBONIC ANHYDRASE 2)		 2bf4 NADPH-CYTOCHROME
P450 REDUCTASE
(Saccharomyces
cerevisiae) 		5 / 12 VAL A 456
PHE A 292
LEU A 482
THR A 479
THR A 478
 None
None
None
FAD  A 750 (-3.1A)
FAD  A 750 (-3.4A)
 0.95A 2pouA-2bf4A:
undetectable		 2pouA-2bf4A:
18.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AOC_C_ERYC3402_0
(ACRIFLAVINE
RESISTANCE PROTEIN B)		 2bf4 NADPH-CYTOCHROME
P450 REDUCTASE
(Saccharomyces
cerevisiae) 		5 / 12 PHE A 333
ILE A 352
PHE A 321
ASP A  74
GLU A  73
 None
None
None
FMN  A 752 (-3.5A)
None
 1.44A 3aocC-2bf4A:
undetectable		 3aocC-2bf4A:
22.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B9L_A_AZZA1009_1
(SERUM ALBUMIN)		 2bf4 NADPH-CYTOCHROME
P450 REDUCTASE
(Saccharomyces
cerevisiae) 		4 / 8 GLU A 431
SER A 222
VAL A  63
CYH A  93
 None
 1.24A 3b9lA-2bf4A:
undetectable		 3b9lA-2bf4A:
22.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_C_SVRC505_2
(PHOSPHOLIPASE A2)		 2bf4 NADPH-CYTOCHROME
P450 REDUCTASE
(Saccharomyces
cerevisiae) 		4 / 5 VAL A  96
GLN A  68
PHE A 114
ARG A 522
 None
 1.28A 3bjwH-2bf4A:
undetectable		 3bjwH-2bf4A:
9.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_G_SVRG506_2
(PHOSPHOLIPASE A2)		 2bf4 NADPH-CYTOCHROME
P450 REDUCTASE
(Saccharomyces
cerevisiae) 		4 / 5 VAL A  96
GLN A  68
PHE A 114
ARG A 522
 None
 1.37A 3bjwB-2bf4A:
1.7		 3bjwB-2bf4A:
9.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CAJ_A_EZLA265_1
(CARBONIC ANHYDRASE 2)		 2bf4 NADPH-CYTOCHROME
P450 REDUCTASE
(Saccharomyces
cerevisiae) 		5 / 10 VAL A 456
PHE A 292
LEU A 482
THR A 479
THR A 478
 None
None
None
FAD  A 750 (-3.1A)
FAD  A 750 (-3.4A)
 0.90A 3cajA-2bf4A:
undetectable		 3cajA-2bf4A:
18.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DAZ_A_MZMA263_1
(CARBONIC ANHYDRASE 2)		 2bf4 NADPH-CYTOCHROME
P450 REDUCTASE
(Saccharomyces
cerevisiae) 		5 / 10 VAL A 456
PHE A 292
LEU A 482
THR A 479
THR A 478
 None
None
None
FAD  A 750 (-3.1A)
FAD  A 750 (-3.4A)
 0.94A 3dazA-2bf4A:
undetectable		 3dazA-2bf4A:
18.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DC3_A_AZMA263_1
(CARBONIC ANHYDRASE 2)		 2bf4 NADPH-CYTOCHROME
P450 REDUCTASE
(Saccharomyces
cerevisiae) 		5 / 12 VAL A 456
PHE A 292
LEU A 482
THR A 479
THR A 478
 None
None
None
FAD  A 750 (-3.1A)
FAD  A 750 (-3.4A)
 0.91A 3dc3A-2bf4A:
undetectable		 3dc3A-2bf4A:
16.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DCS_A_MZMA263_1
(CARBONIC ANHYDRASE 2)		 2bf4 NADPH-CYTOCHROME
P450 REDUCTASE
(Saccharomyces
cerevisiae) 		5 / 10 VAL A 456
PHE A 292
LEU A 482
THR A 479
THR A 478
 None
None
None
FAD  A 750 (-3.1A)
FAD  A 750 (-3.4A)
 0.95A 3dcsA-2bf4A:
undetectable		 3dcsA-2bf4A:
16.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FPJ_A_SAMA301_0
(PUTATIVE
UNCHARACTERIZED
PROTEIN)		 2bf4 NADPH-CYTOCHROME
P450 REDUCTASE
(Saccharomyces
cerevisiae) 		5 / 12 PHE A 632
ILE A 661
VAL A 631
ILE A 641
LEU A 676
 None
 0.97A 3fpjA-2bf4A:
3.1		 3fpjA-2bf4A:
17.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HCP_B_CHDB1_0
(FERROCHELATASE,
MITOCHONDRIAL)		 2bf4 NADPH-CYTOCHROME
P450 REDUCTASE
(Saccharomyces
cerevisiae) 		5 / 10 MET A 538
LEU A 576
ILE A 552
ARG A 553
GLY A 304
 None
 1.50A 3hcpB-2bf4A:
4.0		 3hcpB-2bf4A:
19.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HS4_A_AZMA701_1
(CARBONIC ANHYDRASE 2)		 2bf4 NADPH-CYTOCHROME
P450 REDUCTASE
(Saccharomyces
cerevisiae) 		5 / 11 VAL A 456
PHE A 292
LEU A 482
THR A 479
THR A 478
 None
None
None
FAD  A 750 (-3.1A)
FAD  A 750 (-3.4A)
 0.87A 3hs4A-2bf4A:
undetectable		 3hs4A-2bf4A:
18.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JQ7_C_DX2C270_1
(PTERIDINE REDUCTASE
1)		 2bf4 NADPH-CYTOCHROME
P450 REDUCTASE
(Saccharomyces
cerevisiae) 		4 / 8 SER A 373
PHE A 220
VAL A 430
PRO A 425
 None
 0.97A 3jq7C-2bf4A:
3.5		 3jq7C-2bf4A:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_R_TFPR201_1
(PROTEIN S100-A4)		 2bf4 NADPH-CYTOCHROME
P450 REDUCTASE
(Saccharomyces
cerevisiae) 		5 / 10 ILE A 539
MET A 538
PHE A 640
PHE A 526
PHE A 551
 None
 1.32A 3ko0R-2bf4A:
0.0
3ko0T-2bf4A:
undetectable		 3ko0R-2bf4A:
9.27
3ko0T-2bf4A:
9.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KWA_A_SPMA300_1
(CARBONIC ANHYDRASE 2)		 2bf4 NADPH-CYTOCHROME
P450 REDUCTASE
(Saccharomyces
cerevisiae) 		5 / 11 VAL A 456
PHE A 292
LEU A 482
THR A 479
THR A 478
 None
None
None
FAD  A 750 (-3.1A)
FAD  A 750 (-3.4A)
 0.95A 3kwaA-2bf4A:
undetectable		 3kwaA-2bf4A:
18.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ML5_A_AZMA264_1
(CARBONIC ANHYDRASE 7)		 2bf4 NADPH-CYTOCHROME
P450 REDUCTASE
(Saccharomyces
cerevisiae) 		5 / 11 VAL A 456
PHE A 292
LEU A 482
THR A 479
THR A 478
 None
None
None
FAD  A 750 (-3.1A)
FAD  A 750 (-3.4A)
 0.85A 3ml5A-2bf4A:
undetectable		 3ml5A-2bf4A:
17.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QPS_A_CHDA211_0
(CMER)		 2bf4 NADPH-CYTOCHROME
P450 REDUCTASE
(Saccharomyces
cerevisiae) 		5 / 10 LEU A 576
ALA A 546
PHE A 548
GLY A 550
ILE A 552
 None
FAD  A 750 ( 4.0A)
None
None
None
 0.98A 3qpsA-2bf4A:
undetectable		 3qpsA-2bf4A:
16.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SI7_D_ACTD5_0
(CYSTIC FIBROSIS
TRANSMEMBRANE
CONDUCTANCE
REGULATOR)		 2bf4 NADPH-CYTOCHROME
P450 REDUCTASE
(Saccharomyces
cerevisiae) 		4 / 6 LYS A  86
SER A 372
SER A 373
GLN A 369
 None
 1.19A 3si7C-2bf4A:
0.0
3si7D-2bf4A:
0.0		 3si7C-2bf4A:
17.44
3si7D-2bf4A:
17.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SI7_D_ACTD5_0
(CYSTIC FIBROSIS
TRANSMEMBRANE
CONDUCTANCE
REGULATOR)		 2bf4 NADPH-CYTOCHROME
P450 REDUCTASE
(Saccharomyces
cerevisiae) 		4 / 6 SER A 373
GLN A 369
LYS A  86
SER A 372
 None
 1.17A 3si7C-2bf4A:
0.0
3si7D-2bf4A:
0.0		 3si7C-2bf4A:
17.44
3si7D-2bf4A:
17.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9F_P_CLMP221_0
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 2bf4 NADPH-CYTOCHROME
P450 REDUCTASE
(Saccharomyces
cerevisiae) 		5 / 9 THR A 350
TYR A 226
LEU A 360
VAL A 433
PHE A 321
 None
 1.48A 3u9fP-2bf4A:
undetectable		 3u9fP-2bf4A:
15.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V2J_A_AZMA302_1
(CARBONIC ANHYDRASE 2)		 2bf4 NADPH-CYTOCHROME
P450 REDUCTASE
(Saccharomyces
cerevisiae) 		5 / 11 VAL A 456
PHE A 292
LEU A 482
THR A 479
THR A 478
 None
None
None
FAD  A 750 (-3.1A)
FAD  A 750 (-3.4A)
 0.91A 3v2jA-2bf4A:
undetectable		 3v2jA-2bf4A:
18.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V2M_A_AZMA303_1
(CARBONIC ANHYDRASE 2)		 2bf4 NADPH-CYTOCHROME
P450 REDUCTASE
(Saccharomyces
cerevisiae) 		5 / 10 VAL A 456
PHE A 292
LEU A 482
THR A 479
THR A 478
 None
None
None
FAD  A 750 (-3.1A)
FAD  A 750 (-3.4A)
 0.85A 3v2mA-2bf4A:
undetectable		 3v2mA-2bf4A:
18.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VYW_D_SAMD401_1
(MNMC2)		 2bf4 NADPH-CYTOCHROME
P450 REDUCTASE
(Saccharomyces
cerevisiae) 		4 / 5 GLU A 319
ASP A 328
ASP A 504
GLU A 330
 None
 1.38A 3vywD-2bf4A:
4.4		 3vywD-2bf4A:
19.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E3H_A_HQEA303_1
(CARBONIC ANHYDRASE 2)		 2bf4 NADPH-CYTOCHROME
P450 REDUCTASE
(Saccharomyces
cerevisiae) 		5 / 10 VAL A 456
PHE A 292
LEU A 482
THR A 479
THR A 478
 None
None
None
FAD  A 750 (-3.1A)
FAD  A 750 (-3.4A)
 1.01A 4e3hA-2bf4A:
undetectable		 4e3hA-2bf4A:
18.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FP9_A_SAMA401_0
(METHYLTRANSFERASE
NSUN4)		 2bf4 NADPH-CYTOCHROME
P450 REDUCTASE
(Saccharomyces
cerevisiae) 		5 / 12 ASN A 161
LEU A 152
GLY A 151
ASP A 122
PRO A 124
 None
FMN  A 751 (-4.1A)
None
None
None
 1.05A 4fp9A-2bf4A:
undetectable		 4fp9A-2bf4A:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FP9_C_SAMC401_0
(METHYLTRANSFERASE
NSUN4)		 2bf4 NADPH-CYTOCHROME
P450 REDUCTASE
(Saccharomyces
cerevisiae) 		5 / 12 ASN A 161
LEU A 152
GLY A 151
ASP A 122
PRO A 124
 None
FMN  A 751 (-4.1A)
None
None
None
 1.03A 4fp9C-2bf4A:
undetectable		 4fp9C-2bf4A:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FP9_F_SAMF401_0
(METHYLTRANSFERASE
NSUN4)		 2bf4 NADPH-CYTOCHROME
P450 REDUCTASE
(Saccharomyces
cerevisiae) 		5 / 12 ASN A 161
LEU A 152
GLY A 151
ASP A 122
PRO A 124
 None
FMN  A 751 (-4.1A)
None
None
None
 1.07A 4fp9F-2bf4A:
undetectable		 4fp9F-2bf4A:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G0C_A_AZMA302_1
(CARBONIC ANHYDRASE 2)		 2bf4 NADPH-CYTOCHROME
P450 REDUCTASE
(Saccharomyces
cerevisiae) 		5 / 11 VAL A 456
PHE A 292
LEU A 482
THR A 479
THR A 478
 None
None
None
FAD  A 750 (-3.1A)
FAD  A 750 (-3.4A)
 0.93A 4g0cA-2bf4A:
undetectable		 4g0cA-2bf4A:
18.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GKH_K_KANK301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 2bf4 NADPH-CYTOCHROME
P450 REDUCTASE
(Saccharomyces
cerevisiae) 		4 / 8 ASP A 193
ASP A 201
GLU A 194
GLU A  82
 FMN  A 752 (-3.8A)
None
None
None
 1.15A 4gkhC-2bf4A:
undetectable
4gkhK-2bf4A:
undetectable		 4gkhC-2bf4A:
15.96
4gkhK-2bf4A:
15.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GKI_G_KANG301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 2bf4 NADPH-CYTOCHROME
P450 REDUCTASE
(Saccharomyces
cerevisiae) 		4 / 8 ASP A 193
ASP A 201
GLU A 194
GLU A  82
 FMN  A 752 (-3.8A)
None
None
None
 1.08A 4gkiE-2bf4A:
undetectable
4gkiG-2bf4A:
undetectable		 4gkiE-2bf4A:
15.96
4gkiG-2bf4A:
15.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M2R_A_BZ1A302_1
(CARBONIC ANHYDRASE 2)		 2bf4 NADPH-CYTOCHROME
P450 REDUCTASE
(Saccharomyces
cerevisiae) 		5 / 12 VAL A 456
PHE A 292
LEU A 482
THR A 479
THR A 478
 None
None
None
FAD  A 750 (-3.1A)
FAD  A 750 (-3.4A)
 1.00A 4m2rA-2bf4A:
undetectable		 4m2rA-2bf4A:
18.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QZU_C_ACTC202_0
(RETINOL-BINDING
PROTEIN 2)		 2bf4 NADPH-CYTOCHROME
P450 REDUCTASE
(Saccharomyces
cerevisiae) 		4 / 6 TYR A 503
GLU A 361
THR A 363
LEU A 481
 None
FAD  A 750 ( 4.9A)
FAD  A 750 ( 4.5A)
None
 1.44A 4qzuC-2bf4A:
undetectable		 4qzuC-2bf4A:
11.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XTA_B_DIFB501_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 2bf4 NADPH-CYTOCHROME
P450 REDUCTASE
(Saccharomyces
cerevisiae) 		4 / 8 ILE A 408
SER A 416
LEU A 387
LEU A 390
 None
 0.98A 4xtaB-2bf4A:
undetectable		 4xtaB-2bf4A:
18.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M78_A_SALA304_1
(CARBONIC ANHYDRASE 2)		 2bf4 NADPH-CYTOCHROME
P450 REDUCTASE
(Saccharomyces
cerevisiae) 		5 / 7 VAL A 456
PHE A 292
LEU A 482
THR A 479
THR A 478
 None
None
None
FAD  A 750 (-3.1A)
FAD  A 750 (-3.4A)
 0.82A 5m78A-2bf4A:
undetectable		 5m78A-2bf4A:
8.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NU7_A_RTLA201_0
(RETINOL-BINDING
PROTEIN 4)		 2bf4 NADPH-CYTOCHROME
P450 REDUCTASE
(Saccharomyces
cerevisiae) 		4 / 8 LEU A 624
ALA A 639
VAL A 620
TYR A 686
 None
None
NAP  A 753 ( 4.8A)
None
 0.91A 5nu7A-2bf4A:
undetectable		 5nu7A-2bf4A:
13.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VW4_A_NCAA403_0
(FERREDOXIN--NADP
REDUCTASE)		 2bf4 NADPH-CYTOCHROME
P450 REDUCTASE
(Saccharomyces
cerevisiae) 		6 / 9 SER A 442
THR A 543
GLY A 544
ALA A 546
CYH A 644
GLY A 645
 FAD  A 750 (-3.1A)
NAP  A 753 (-3.7A)
None
FAD  A 750 ( 4.0A)
None
None
 0.35A 5vw4A-2bf4A:
27.7		 5vw4A-2bf4A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VW5_A_NCAA403_0
(FERREDOXIN--NADP
REDUCTASE)		 2bf4 NADPH-CYTOCHROME
P450 REDUCTASE
(Saccharomyces
cerevisiae) 		5 / 8 SER A 442
THR A 543
GLY A 544
CYH A 644
GLY A 645
 FAD  A 750 (-3.1A)
NAP  A 753 (-3.7A)
None
None
None
 0.36A 5vw5A-2bf4A:
27.5		 5vw5A-2bf4A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VW9_A_NCAA403_0
(FERREDOXIN--NADP
REDUCTASE)		 2bf4 NADPH-CYTOCHROME
P450 REDUCTASE
(Saccharomyces
cerevisiae) 		6 / 8 SER A 442
THR A 543
GLY A 544
ALA A 546
CYH A 644
GLY A 645
 FAD  A 750 (-3.1A)
NAP  A 753 (-3.7A)
None
FAD  A 750 ( 4.0A)
None
None
 0.35A 5vw9A-2bf4A:
27.7		 5vw9A-2bf4A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XXI_A_LSNA501_2
(CYTOCHROME P450 2C9)		 2bf4 NADPH-CYTOCHROME
P450 REDUCTASE
(Saccharomyces
cerevisiae) 		4 / 4 PHE A 133
LEU A  62
LEU A 145
VAL A  96
 None
 1.29A 5xxiA-2bf4A:
undetectable		 5xxiA-2bf4A:
22.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B3A_A_SAMA701_0
(APRA
METHYLTRANSFERASE 1)		 2bf4 NADPH-CYTOCHROME
P450 REDUCTASE
(Saccharomyces
cerevisiae) 		5 / 12 GLY A 653
GLY A 649
TYR A 619
ALA A 647
ASP A 622
 None
NAP  A 753 (-3.9A)
NAP  A 753 (-3.5A)
None
None
 1.10A 6b3aA-2bf4A:
2.1		 6b3aA-2bf4A:
22.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BCC_A_EZLA302_1
(CARBONIC ANHYDRASE 2)		 2bf4 NADPH-CYTOCHROME
P450 REDUCTASE
(Saccharomyces
cerevisiae) 		5 / 12 VAL A 456
PHE A 292
LEU A 482
THR A 479
THR A 478
 None
None
None
FAD  A 750 (-3.1A)
FAD  A 750 (-3.4A)
 0.94A 6bccA-2bf4A:
undetectable		 6bccA-2bf4A:
8.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DWN_A_AQ4A602_1
(CYTOCHROME P450 1A1)		 2bf4 NADPH-CYTOCHROME
P450 REDUCTASE
(Saccharomyces
cerevisiae) 		4 / 5 ILE A 288
SER A 290
ALA A 488
LEU A 499
 None
 0.99A 6dwnA-2bf4A:
undetectable		 6dwnA-2bf4A:
6.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MN5_A_LLLA301_0
(AMINOGLYCOSIDE
N(3)-ACETYLTRANSFERA
SE, AAC(3)-IVA)		 2bf4 NADPH-CYTOCHROME
P450 REDUCTASE
(Saccharomyces
cerevisiae) 		4 / 6 ASP A 187
TYR A 157
ASP A 646
GLU A 461
 FMN  A 752 (-3.1A)
FMN  A 751 (-3.5A)
NAP  A 753 (-2.7A)
NAP  A 753 ( 3.0A)
 1.26A 6mn5A-2bf4A:
undetectable		 6mn5A-2bf4A:
8.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MN5_C_LLLC301_0
(AMINOGLYCOSIDE
N(3)-ACETYLTRANSFERA
SE, AAC(3)-IVA)		 2bf4 NADPH-CYTOCHROME
P450 REDUCTASE
(Saccharomyces
cerevisiae) 		4 / 6 ASP A 187
TYR A 157
ASP A 646
GLU A 461
 FMN  A 752 (-3.1A)
FMN  A 751 (-3.5A)
NAP  A 753 (-2.7A)
NAP  A 753 ( 3.0A)
 1.35A 6mn5C-2bf4A:
undetectable		 6mn5C-2bf4A:
8.98