SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2bf6'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4G_A_ZMRA466_1
(NEURAMINIDASE)		 2bf6 EXO-ALPHA-SIALIDASE
(Clostridium
perfringens) 		6 / 12 ARG A 266
ASP A 291
GLU A 539
ARG A 555
ARG A 615
TYR A 655
 SIA  A1692 (-2.7A)
SIA  A1692 (-2.8A)
SIA  A1692 ( 3.9A)
SIA  A1692 (-2.9A)
SIA  A1692 (-3.1A)
SIA  A1692 (-4.2A)
 0.47A 1a4gA-2bf6A:
25.0		 1a4gA-2bf6A:
22.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4G_B_ZMRB466_1
(NEURAMINIDASE)		 2bf6 EXO-ALPHA-SIALIDASE
(Clostridium
perfringens) 		5 / 12 ARG A 266
GLU A 539
ARG A 555
ARG A 615
TYR A 655
 SIA  A1692 (-2.7A)
SIA  A1692 ( 3.9A)
SIA  A1692 (-2.9A)
SIA  A1692 (-3.1A)
SIA  A1692 (-4.2A)
 0.37A 1a4gB-2bf6A:
24.9		 1a4gB-2bf6A:
22.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CLA_A_CLMA221_0
(TYPE III
CHLORAMPHENICOL
ACETYLTRANSFERASE)		 2bf6 EXO-ALPHA-SIALIDASE
(Clostridium
perfringens) 		5 / 10 ASN A 415
ALA A 421
LEU A 373
VAL A 383
ILE A 416
 None
 1.34A 1claA-2bf6A:
undetectable		 1claA-2bf6A:
19.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N49_D_RITD401_2
(PROTEASE)		 2bf6 EXO-ALPHA-SIALIDASE
(Clostridium
perfringens) 		4 / 6 ASP A 335
ILE A 593
PRO A 483
ILE A 332
 None
 0.92A 1n49D-2bf6A:
undetectable		 1n49D-2bf6A:
13.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NNC_A_ZMRA479_1
(NEURAMINIDASE N9)		 2bf6 EXO-ALPHA-SIALIDASE
(Clostridium
perfringens) 		5 / 12 ARG A 266
GLU A 539
ARG A 555
ARG A 615
TYR A 655
 SIA  A1692 (-2.7A)
SIA  A1692 ( 3.9A)
SIA  A1692 (-2.9A)
SIA  A1692 (-3.1A)
SIA  A1692 (-4.2A)
 0.51A 1nncA-2bf6A:
21.1		 1nncA-2bf6A:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ONI_A_BEZA502_0
(14.5 KDA
TRANSLATIONAL
INHIBITOR PROTEIN)		 2bf6 EXO-ALPHA-SIALIDASE
(Clostridium
perfringens) 		5 / 6 PHE A 407
ASN A 386
ASN A 401
ILE A 416
GLY A 404
 None
 1.49A 1oniA-2bf6A:
undetectable
1oniB-2bf6A:
undetectable		 1oniA-2bf6A:
15.18
1oniB-2bf6A:
15.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ONI_D_BEZD508_0
(14.5 KDA
TRANSLATIONAL
INHIBITOR PROTEIN)		 2bf6 EXO-ALPHA-SIALIDASE
(Clostridium
perfringens) 		5 / 6 PHE A 407
ASN A 386
ASN A 401
ILE A 416
GLY A 404
 None
 1.49A 1oniD-2bf6A:
undetectable
1oniF-2bf6A:
undetectable		 1oniD-2bf6A:
15.18
1oniF-2bf6A:
15.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P6K_A_MTLA870_0
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 2bf6 EXO-ALPHA-SIALIDASE
(Clostridium
perfringens) 		4 / 8 ARG A 517
ASN A 514
GLN A 493
ASN A 562
 None
None
SIA  A1692 (-3.0A)
None
 1.15A 1p6kA-2bf6A:
undetectable		 1p6kA-2bf6A:
22.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P6K_B_MTLB871_0
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 2bf6 EXO-ALPHA-SIALIDASE
(Clostridium
perfringens) 		4 / 8 ARG A 517
ASN A 514
GLN A 493
ASN A 562
 None
None
SIA  A1692 (-3.0A)
None
 1.08A 1p6kB-2bf6A:
undetectable		 1p6kB-2bf6A:
22.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_J_FUAJ711_1
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 2bf6 EXO-ALPHA-SIALIDASE
(Clostridium
perfringens) 		5 / 11 PHE A 341
PHE A 460
LEU A 461
VAL A 453
VAL A 484
 None
SIA  A1692 ( 4.9A)
None
None
None
 1.35A 1q23J-2bf6A:
undetectable		 1q23J-2bf6A:
16.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RS6_A_MTLA870_0
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 2bf6 EXO-ALPHA-SIALIDASE
(Clostridium
perfringens) 		4 / 8 ARG A 517
ASN A 514
GLN A 493
ASN A 562
 None
None
SIA  A1692 (-3.0A)
None
 1.20A 1rs6A-2bf6A:
undetectable		 1rs6A-2bf6A:
22.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RS6_B_MTLB871_0
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 2bf6 EXO-ALPHA-SIALIDASE
(Clostridium
perfringens) 		4 / 8 ARG A 517
ASN A 514
GLN A 493
ASN A 562
 None
None
SIA  A1692 (-3.0A)
None
 1.09A 1rs6B-2bf6A:
undetectable		 1rs6B-2bf6A:
22.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RS7_B_MTLB871_0
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 2bf6 EXO-ALPHA-SIALIDASE
(Clostridium
perfringens) 		4 / 8 ARG A 517
ASN A 514
GLN A 493
ASN A 562
 None
None
SIA  A1692 (-3.0A)
None
 1.05A 1rs7B-2bf6A:
undetectable		 1rs7B-2bf6A:
22.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V3E_B_ZMRB2200_1
(HEMAGGLUTININ-NEURAM
INIDASE GLYCOPROTEIN)		 2bf6 EXO-ALPHA-SIALIDASE
(Clostridium
perfringens) 		5 / 10 ARG A 266
TYR A 485
GLU A 539
ARG A 555
ARG A 615
 SIA  A1692 (-2.7A)
SIA  A1692 (-4.7A)
SIA  A1692 ( 3.9A)
SIA  A1692 (-2.9A)
SIA  A1692 (-3.1A)
 0.72A 1v3eB-2bf6A:
9.2		 1v3eB-2bf6A:
24.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V3E_B_ZMRB2200_1
(HEMAGGLUTININ-NEURAM
INIDASE GLYCOPROTEIN)		 2bf6 EXO-ALPHA-SIALIDASE
(Clostridium
perfringens) 		5 / 10 ARG A 266
TYR A 485
GLU A 539
ARG A 615
TYR A 655
 SIA  A1692 (-2.7A)
SIA  A1692 (-4.7A)
SIA  A1692 ( 3.9A)
SIA  A1692 (-3.1A)
SIA  A1692 (-4.2A)
 0.85A 1v3eB-2bf6A:
9.2		 1v3eB-2bf6A:
24.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZZQ_A_MTLA870_0
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 2bf6 EXO-ALPHA-SIALIDASE
(Clostridium
perfringens) 		4 / 8 ARG A 517
ASN A 514
GLN A 493
ASN A 562
 None
None
SIA  A1692 (-3.0A)
None
 1.17A 1zzqA-2bf6A:
undetectable		 1zzqA-2bf6A:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZZQ_B_MTLB871_0
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 2bf6 EXO-ALPHA-SIALIDASE
(Clostridium
perfringens) 		4 / 8 ARG A 517
ASN A 514
GLN A 493
ASN A 562
 None
None
SIA  A1692 (-3.0A)
None
 1.10A 1zzqB-2bf6A:
undetectable		 1zzqB-2bf6A:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZZU_B_MTLB871_0
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 2bf6 EXO-ALPHA-SIALIDASE
(Clostridium
perfringens) 		4 / 8 ARG A 517
ASN A 514
GLN A 493
ASN A 562
 None
None
SIA  A1692 (-3.0A)
None
 1.09A 1zzuB-2bf6A:
undetectable		 1zzuB-2bf6A:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A8T_B_ADNB252_1
(U8 SNORNA-BINDING
PROTEIN X29)		 2bf6 EXO-ALPHA-SIALIDASE
(Clostridium
perfringens) 		4 / 8 GLY A 504
PHE A 271
THR A 330
ILE A 480
 None
 0.96A 2a8tB-2bf6A:
undetectable		 2a8tB-2bf6A:
18.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CML_A_ZMRA1477_1
(NEURAMINIDASE)		 2bf6 EXO-ALPHA-SIALIDASE
(Clostridium
perfringens) 		6 / 12 ARG A 266
ASP A 291
GLU A 539
ARG A 555
ARG A 615
TYR A 655
 SIA  A1692 (-2.7A)
SIA  A1692 (-2.8A)
SIA  A1692 ( 3.9A)
SIA  A1692 (-2.9A)
SIA  A1692 (-3.1A)
SIA  A1692 (-4.2A)
 0.50A 2cmlA-2bf6A:
21.3		 2cmlA-2bf6A:
22.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CML_B_ZMRB2477_1
(NEURAMINIDASE)		 2bf6 EXO-ALPHA-SIALIDASE
(Clostridium
perfringens) 		6 / 12 ARG A 266
ASP A 291
GLU A 539
ARG A 555
ARG A 615
TYR A 655
 SIA  A1692 (-2.7A)
SIA  A1692 (-2.8A)
SIA  A1692 ( 3.9A)
SIA  A1692 (-2.9A)
SIA  A1692 (-3.1A)
SIA  A1692 (-4.2A)
 0.50A 2cmlB-2bf6A:
3.0		 2cmlB-2bf6A:
22.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CML_C_ZMRC3477_1
(NEURAMINIDASE)		 2bf6 EXO-ALPHA-SIALIDASE
(Clostridium
perfringens) 		6 / 12 ARG A 266
ASP A 291
GLU A 539
ARG A 555
ARG A 615
TYR A 655
 SIA  A1692 (-2.7A)
SIA  A1692 (-2.8A)
SIA  A1692 ( 3.9A)
SIA  A1692 (-2.9A)
SIA  A1692 (-3.1A)
SIA  A1692 (-4.2A)
 0.53A 2cmlC-2bf6A:
21.5		 2cmlC-2bf6A:
22.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CML_D_ZMRD4477_1
(NEURAMINIDASE)		 2bf6 EXO-ALPHA-SIALIDASE
(Clostridium
perfringens) 		6 / 12 ARG A 266
ASP A 291
GLU A 539
ARG A 555
ARG A 615
TYR A 655
 SIA  A1692 (-2.7A)
SIA  A1692 (-2.8A)
SIA  A1692 ( 3.9A)
SIA  A1692 (-2.9A)
SIA  A1692 (-3.1A)
SIA  A1692 (-4.2A)
 0.51A 2cmlD-2bf6A:
21.3		 2cmlD-2bf6A:
22.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DTJ_A_THRA401_0
(ASPARTOKINASE)		 2bf6 EXO-ALPHA-SIALIDASE
(Clostridium
perfringens) 		4 / 8 ASP A 574
GLY A 634
GLU A 635
THR A 565
 None
None
None
GOL  A1695 ( 4.8A)
 0.82A 2dtjA-2bf6A:
undetectable
2dtjB-2bf6A:
undetectable		 2dtjA-2bf6A:
16.48
2dtjB-2bf6A:
16.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F0Z_A_ZMRA381_1
(SIALIDASE 2)		 2bf6 EXO-ALPHA-SIALIDASE
(Clostridium
perfringens) 		6 / 12 ARG A 266
TYR A 485
GLU A 539
ARG A 555
ARG A 615
TYR A 655
 SIA  A1692 (-2.7A)
SIA  A1692 (-4.7A)
SIA  A1692 ( 3.9A)
SIA  A1692 (-2.9A)
SIA  A1692 (-3.1A)
SIA  A1692 (-4.2A)
 0.40A 2f0zA-2bf6A:
44.2		 2f0zA-2bf6A:
23.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F10_A_BCZA382_0
(SIALIDASE 2)		 2bf6 EXO-ALPHA-SIALIDASE
(Clostridium
perfringens) 		8 / 12 ARG A 266
ILE A 267
ARG A 285
TYR A 485
GLU A 539
ARG A 555
ARG A 615
TYR A 655
 SIA  A1692 (-2.7A)
SIA  A1692 (-4.5A)
SIA  A1692 (-3.6A)
SIA  A1692 (-4.7A)
SIA  A1692 ( 3.9A)
SIA  A1692 (-2.9A)
SIA  A1692 (-3.1A)
SIA  A1692 (-4.2A)
 0.57A 2f10A-2bf6A:
43.1		 2f10A-2bf6A:
23.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FUM_D_MIXD3539_2
(PROBABLE
SERINE/THREONINE-PRO
TEIN KINASE PKNB)		 2bf6 EXO-ALPHA-SIALIDASE
(Clostridium
perfringens) 		3 / 3 VAL A 542
VAL A 482
ASP A 515
 None
 0.72A 2fumD-2bf6A:
undetectable		 2fumD-2bf6A:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HTQ_A_ZMRA472_1
(NEURAMINIDASE)		 2bf6 EXO-ALPHA-SIALIDASE
(Clostridium
perfringens) 		5 / 12 ARG A 266
GLU A 539
ARG A 555
ARG A 615
TYR A 655
 SIA  A1692 (-2.7A)
SIA  A1692 ( 3.9A)
SIA  A1692 (-2.9A)
SIA  A1692 (-3.1A)
SIA  A1692 (-4.2A)
 0.64A 2htqA-2bf6A:
12.8		 2htqA-2bf6A:
23.59
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2YA7_A_ZMRA1776_1
(NEURAMINIDASE A)		 2bf6 EXO-ALPHA-SIALIDASE
(Clostridium
perfringens) 		5 / 12 ARG A 266
ILE A 267
ASP A 283
ILE A 297
ARG A 615
 SIA  A1692 (-2.7A)
SIA  A1692 (-4.5A)
None
None
SIA  A1692 (-3.1A)
 1.40A 2ya7A-2bf6A:
57.0		 2ya7A-2bf6A:
43.11
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2YA7_A_ZMRA1776_1
(NEURAMINIDASE A)		 2bf6 EXO-ALPHA-SIALIDASE
(Clostridium
perfringens) 		10 / 12 ARG A 266
ILE A 267
ASP A 283
ILE A 327
ASP A 328
TYR A 485
GLN A 493
ARG A 555
ARG A 615
TYR A 655
 SIA  A1692 (-2.7A)
SIA  A1692 (-4.5A)
None
SIA  A1692 (-4.5A)
SIA  A1692 (-2.9A)
SIA  A1692 (-4.7A)
SIA  A1692 (-3.0A)
SIA  A1692 (-2.9A)
SIA  A1692 (-3.1A)
SIA  A1692 (-4.2A)
 0.35A 2ya7A-2bf6A:
57.0		 2ya7A-2bf6A:
43.11
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2YA7_A_ZMRA1776_1
(NEURAMINIDASE A)		 2bf6 EXO-ALPHA-SIALIDASE
(Clostridium
perfringens) 		5 / 12 ARG A 285
ILE A 267
ASP A 328
TYR A 485
GLN A 493
 SIA  A1692 (-3.6A)
SIA  A1692 (-4.5A)
SIA  A1692 (-2.9A)
SIA  A1692 (-4.7A)
SIA  A1692 (-3.0A)
 1.22A 2ya7A-2bf6A:
57.0		 2ya7A-2bf6A:
43.11
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2YA7_B_ZMRB1776_1
(NEURAMINIDASE A)		 2bf6 EXO-ALPHA-SIALIDASE
(Clostridium
perfringens) 		5 / 12 ARG A 266
ILE A 267
ASP A 283
ILE A 297
ARG A 615
 SIA  A1692 (-2.7A)
SIA  A1692 (-4.5A)
None
None
SIA  A1692 (-3.1A)
 1.38A 2ya7B-2bf6A:
56.7		 2ya7B-2bf6A:
43.11
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2YA7_B_ZMRB1776_1
(NEURAMINIDASE A)		 2bf6 EXO-ALPHA-SIALIDASE
(Clostridium
perfringens) 		10 / 12 ARG A 266
ILE A 267
ASP A 283
ILE A 327
ASP A 328
TYR A 485
GLN A 493
ARG A 555
ARG A 615
TYR A 655
 SIA  A1692 (-2.7A)
SIA  A1692 (-4.5A)
None
SIA  A1692 (-4.5A)
SIA  A1692 (-2.9A)
SIA  A1692 (-4.7A)
SIA  A1692 (-3.0A)
SIA  A1692 (-2.9A)
SIA  A1692 (-3.1A)
SIA  A1692 (-4.2A)
 0.36A 2ya7B-2bf6A:
56.7		 2ya7B-2bf6A:
43.11
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2YA7_B_ZMRB1776_1
(NEURAMINIDASE A)		 2bf6 EXO-ALPHA-SIALIDASE
(Clostridium
perfringens) 		5 / 12 ARG A 285
ILE A 267
ASP A 328
TYR A 485
GLN A 493
 SIA  A1692 (-3.6A)
SIA  A1692 (-4.5A)
SIA  A1692 (-2.9A)
SIA  A1692 (-4.7A)
SIA  A1692 (-3.0A)
 1.20A 2ya7B-2bf6A:
56.7		 2ya7B-2bf6A:
43.11
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2YA7_C_ZMRC1776_1
(NEURAMINIDASE A)		 2bf6 EXO-ALPHA-SIALIDASE
(Clostridium
perfringens) 		5 / 12 ARG A 266
ILE A 267
ASP A 283
ILE A 297
ARG A 615
 SIA  A1692 (-2.7A)
SIA  A1692 (-4.5A)
None
None
SIA  A1692 (-3.1A)
 1.36A 2ya7C-2bf6A:
52.3		 2ya7C-2bf6A:
43.11
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2YA7_C_ZMRC1776_1
(NEURAMINIDASE A)		 2bf6 EXO-ALPHA-SIALIDASE
(Clostridium
perfringens) 		9 / 12 ARG A 266
ILE A 267
ASP A 283
ILE A 327
ASP A 328
TYR A 485
ARG A 555
ARG A 615
TYR A 655
 SIA  A1692 (-2.7A)
SIA  A1692 (-4.5A)
None
SIA  A1692 (-4.5A)
SIA  A1692 (-2.9A)
SIA  A1692 (-4.7A)
SIA  A1692 (-2.9A)
SIA  A1692 (-3.1A)
SIA  A1692 (-4.2A)
 0.34A 2ya7C-2bf6A:
52.3		 2ya7C-2bf6A:
43.11
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2YA7_C_ZMRC1776_2
(NEURAMINIDASE A)		 2bf6 EXO-ALPHA-SIALIDASE
(Clostridium
perfringens) 		4 / 6 ASP A 291
GLN A 493
GLU A 539
TYR A 587
 SIA  A1692 (-2.8A)
SIA  A1692 (-3.0A)
SIA  A1692 ( 3.9A)
None
 0.28A 2ya7C-2bf6A:
52.3		 2ya7C-2bf6A:
43.11
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2YA7_D_ZMRD1776_1
(NEURAMINIDASE A)		 2bf6 EXO-ALPHA-SIALIDASE
(Clostridium
perfringens) 		5 / 12 ARG A 266
ILE A 267
ASP A 283
ILE A 297
ARG A 615
 SIA  A1692 (-2.7A)
SIA  A1692 (-4.5A)
None
None
SIA  A1692 (-3.1A)
 1.38A 2ya7D-2bf6A:
56.6		 2ya7D-2bf6A:
43.11
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2YA7_D_ZMRD1776_1
(NEURAMINIDASE A)		 2bf6 EXO-ALPHA-SIALIDASE
(Clostridium
perfringens) 		10 / 12 ARG A 266
ILE A 267
ASP A 283
ILE A 327
ASP A 328
TYR A 485
GLN A 493
ARG A 555
ARG A 615
TYR A 655
 SIA  A1692 (-2.7A)
SIA  A1692 (-4.5A)
None
SIA  A1692 (-4.5A)
SIA  A1692 (-2.9A)
SIA  A1692 (-4.7A)
SIA  A1692 (-3.0A)
SIA  A1692 (-2.9A)
SIA  A1692 (-3.1A)
SIA  A1692 (-4.2A)
 0.35A 2ya7D-2bf6A:
56.6		 2ya7D-2bf6A:
43.11
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2YA7_D_ZMRD1776_1
(NEURAMINIDASE A)		 2bf6 EXO-ALPHA-SIALIDASE
(Clostridium
perfringens) 		5 / 12 ARG A 285
ILE A 267
ASP A 328
TYR A 485
GLN A 493
 SIA  A1692 (-3.6A)
SIA  A1692 (-4.5A)
SIA  A1692 (-2.9A)
SIA  A1692 (-4.7A)
SIA  A1692 (-3.0A)
 1.20A 2ya7D-2bf6A:
56.6		 2ya7D-2bf6A:
43.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YOE_C_FL7C1318_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 2bf6 EXO-ALPHA-SIALIDASE
(Clostridium
perfringens) 		4 / 8 ASN A 448
GLY A 361
ASN A 450
VAL A 344
 None
 0.90A 2yoeB-2bf6A:
undetectable
2yoeC-2bf6A:
undetectable		 2yoeB-2bf6A:
22.27
2yoeC-2bf6A:
22.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZIA_B_CL9B401_2
(DEOXYCYTIDINE KINASE)		 2bf6 EXO-ALPHA-SIALIDASE
(Clostridium
perfringens) 		4 / 4 ARG A 266
ASP A 283
LEU A 669
ARG A 555
 SIA  A1692 (-2.7A)
None
None
SIA  A1692 (-2.9A)
 1.36A 2ziaB-2bf6A:
undetectable		 2ziaB-2bf6A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B7E_A_ZMRA1001_1
(NEURAMINIDASE)		 2bf6 EXO-ALPHA-SIALIDASE
(Clostridium
perfringens) 		6 / 12 ARG A 266
ASP A 291
GLU A 539
ARG A 555
ARG A 615
TYR A 655
 SIA  A1692 (-2.7A)
SIA  A1692 (-2.8A)
SIA  A1692 ( 3.9A)
SIA  A1692 (-2.9A)
SIA  A1692 (-3.1A)
SIA  A1692 (-4.2A)
 0.58A 3b7eA-2bf6A:
21.3		 3b7eA-2bf6A:
19.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B7E_B_ZMRB1002_1
(NEURAMINIDASE)		 2bf6 EXO-ALPHA-SIALIDASE
(Clostridium
perfringens) 		6 / 12 ARG A 266
ASP A 291
GLU A 539
ARG A 555
ARG A 615
TYR A 655
 SIA  A1692 (-2.7A)
SIA  A1692 (-2.8A)
SIA  A1692 ( 3.9A)
SIA  A1692 (-2.9A)
SIA  A1692 (-3.1A)
SIA  A1692 (-4.2A)
 0.57A 3b7eB-2bf6A:
21.4		 3b7eB-2bf6A:
19.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CKZ_A_ZMRA469_1
(NEURAMINIDASE)		 2bf6 EXO-ALPHA-SIALIDASE
(Clostridium
perfringens) 		5 / 12 ARG A 266
GLU A 539
ARG A 555
ARG A 615
TYR A 655
 SIA  A1692 (-2.7A)
SIA  A1692 ( 3.9A)
SIA  A1692 (-2.9A)
SIA  A1692 (-3.1A)
SIA  A1692 (-4.2A)
 0.43A 3ckzA-2bf6A:
12.9		 3ckzA-2bf6A:
20.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FRQ_A_ERYA195_0
(REPRESSOR PROTEIN
MPHR(A))		 2bf6 EXO-ALPHA-SIALIDASE
(Clostridium
perfringens) 		5 / 12 VAL A 497
LEU A 550
SER A 566
VAL A 481
ILE A 471
 None
 1.38A 3frqA-2bf6A:
undetectable		 3frqA-2bf6A:
16.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GWX_B_EPAB3_2
(PROTEIN (PEROXISOME
PROLIFERATOR
ACTIVATED RECEPTOR
(PPAR-DELTA)))		 2bf6 EXO-ALPHA-SIALIDASE
(Clostridium
perfringens) 		5 / 12 ARG A 479
ILE A 449
VAL A 497
VAL A 542
ILE A 332
 None
 1.03A 3gwxB-2bf6A:
undetectable		 3gwxB-2bf6A:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K37_B_BCZB468_0
(NEURAMINIDASE)		 2bf6 EXO-ALPHA-SIALIDASE
(Clostridium
perfringens) 		5 / 12 ARG A 266
ASP A 291
GLU A 539
ARG A 555
ARG A 615
 SIA  A1692 (-2.7A)
SIA  A1692 (-2.8A)
SIA  A1692 ( 3.9A)
SIA  A1692 (-2.9A)
SIA  A1692 (-3.1A)
 0.54A 3k37B-2bf6A:
24.9		 3k37B-2bf6A:
22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K39_B_BCZB1001_0
(NEURAMINIDASE)		 2bf6 EXO-ALPHA-SIALIDASE
(Clostridium
perfringens) 		5 / 12 ARG A 266
ASP A 291
GLU A 539
ARG A 555
TYR A 655
 SIA  A1692 (-2.7A)
SIA  A1692 (-2.8A)
SIA  A1692 ( 3.9A)
SIA  A1692 (-2.9A)
SIA  A1692 (-4.2A)
 0.43A 3k39B-2bf6A:
24.9		 3k39B-2bf6A:
22.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KPD_B_SAMB1000_1
(UNCHARACTERIZED
PROTEIN MJ0100)		 2bf6 EXO-ALPHA-SIALIDASE
(Clostridium
perfringens) 		3 / 3 ASN A 514
ASN A 516
GLU A 511
 None
 0.91A 3kpdC-2bf6A:
undetectable		 3kpdC-2bf6A:
13.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OKX_B_SAMB201_0
(YAEB-LIKE PROTEIN
RPA0152)		 2bf6 EXO-ALPHA-SIALIDASE
(Clostridium
perfringens) 		3 / 3 LYS A 272
ARG A 467
LYS A 477
 None
 1.48A 3okxA-2bf6A:
undetectable		 3okxA-2bf6A:
18.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SAN_A_ZMRA901_1
(NEURAMINIDASE)		 2bf6 EXO-ALPHA-SIALIDASE
(Clostridium
perfringens) 		5 / 12 ARG A 266
GLU A 539
ARG A 555
ARG A 615
TYR A 655
 SIA  A1692 (-2.7A)
SIA  A1692 ( 3.9A)
SIA  A1692 (-2.9A)
SIA  A1692 (-3.1A)
SIA  A1692 (-4.2A)
 0.43A 3sanA-2bf6A:
4.4		 3sanA-2bf6A:
22.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SAN_B_ZMRB901_1
(NEURAMINIDASE)		 2bf6 EXO-ALPHA-SIALIDASE
(Clostridium
perfringens) 		5 / 12 ARG A 266
GLU A 539
ARG A 555
ARG A 615
TYR A 655
 SIA  A1692 (-2.7A)
SIA  A1692 ( 3.9A)
SIA  A1692 (-2.9A)
SIA  A1692 (-3.1A)
SIA  A1692 (-4.2A)
 0.43A 3sanB-2bf6A:
22.1		 3sanB-2bf6A:
22.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TI5_A_ZMRA1002_1
(NEURAMINIDASE)		 2bf6 EXO-ALPHA-SIALIDASE
(Clostridium
perfringens) 		6 / 12 ARG A 266
ASP A 291
GLU A 539
ARG A 555
ARG A 615
TYR A 655
 SIA  A1692 (-2.7A)
SIA  A1692 (-2.8A)
SIA  A1692 ( 3.9A)
SIA  A1692 (-2.9A)
SIA  A1692 (-3.1A)
SIA  A1692 (-4.2A)
 0.53A 3ti5A-2bf6A:
12.5		 3ti5A-2bf6A:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TI5_B_ZMRB1002_1
(NEURAMINIDASE)		 2bf6 EXO-ALPHA-SIALIDASE
(Clostridium
perfringens) 		6 / 12 ARG A 266
ASP A 291
GLU A 539
ARG A 555
ARG A 615
TYR A 655
 SIA  A1692 (-2.7A)
SIA  A1692 (-2.8A)
SIA  A1692 ( 3.9A)
SIA  A1692 (-2.9A)
SIA  A1692 (-3.1A)
SIA  A1692 (-4.2A)
 0.55A 3ti5B-2bf6A:
21.4		 3ti5B-2bf6A:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TIC_A_ZMRA1002_1
(NEURAMINIDASE)		 2bf6 EXO-ALPHA-SIALIDASE
(Clostridium
perfringens) 		6 / 12 ARG A 266
ASP A 291
GLU A 539
ARG A 555
ARG A 615
TYR A 655
 SIA  A1692 (-2.7A)
SIA  A1692 (-2.8A)
SIA  A1692 ( 3.9A)
SIA  A1692 (-2.9A)
SIA  A1692 (-3.1A)
SIA  A1692 (-4.2A)
 0.49A 3ticA-2bf6A:
8.6		 3ticA-2bf6A:
23.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TIC_B_ZMRB1002_1
(NEURAMINIDASE)		 2bf6 EXO-ALPHA-SIALIDASE
(Clostridium
perfringens) 		6 / 12 ARG A 266
ASP A 291
GLU A 539
ARG A 555
ARG A 615
TYR A 655
 SIA  A1692 (-2.7A)
SIA  A1692 (-2.8A)
SIA  A1692 ( 3.9A)
SIA  A1692 (-2.9A)
SIA  A1692 (-3.1A)
SIA  A1692 (-4.2A)
 0.53A 3ticB-2bf6A:
21.4		 3ticB-2bf6A:
23.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TIC_C_ZMRC1002_1
(NEURAMINIDASE)		 2bf6 EXO-ALPHA-SIALIDASE
(Clostridium
perfringens) 		6 / 12 ARG A 266
ASP A 291
GLU A 539
ARG A 555
ARG A 615
TYR A 655
 SIA  A1692 (-2.7A)
SIA  A1692 (-2.8A)
SIA  A1692 ( 3.9A)
SIA  A1692 (-2.9A)
SIA  A1692 (-3.1A)
SIA  A1692 (-4.2A)
 0.50A 3ticC-2bf6A:
8.9		 3ticC-2bf6A:
23.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TIC_D_ZMRD1002_1
(NEURAMINIDASE)		 2bf6 EXO-ALPHA-SIALIDASE
(Clostridium
perfringens) 		6 / 12 ARG A 266
ASP A 291
GLU A 539
ARG A 555
ARG A 615
TYR A 655
 SIA  A1692 (-2.7A)
SIA  A1692 (-2.8A)
SIA  A1692 ( 3.9A)
SIA  A1692 (-2.9A)
SIA  A1692 (-3.1A)
SIA  A1692 (-4.2A)
 0.50A 3ticD-2bf6A:
21.3		 3ticD-2bf6A:
23.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U5J_A_08HA1_1
(BROMODOMAIN-CONTAINI
NG PROTEIN 4)		 2bf6 EXO-ALPHA-SIALIDASE
(Clostridium
perfringens) 		4 / 7 PRO A 446
LEU A 371
ASN A 417
MET A 318
 None
 0.98A 3u5jA-2bf6A:
undetectable		 3u5jA-2bf6A:
15.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VLN_A_ASCA904_0
(GLUTATHIONE
S-TRANSFERASE
OMEGA-1)		 2bf6 EXO-ALPHA-SIALIDASE
(Clostridium
perfringens) 		4 / 6 ARG A 615
LEU A 590
PRO A 610
GLU A 585
 SIA  A1692 (-3.1A)
None
None
None
 1.19A 3vlnA-2bf6A:
undetectable		 3vlnA-2bf6A:
20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VNS_A_DVAA602_0
(NRPS ADENYLATION
PROTEIN CYTC1)		 2bf6 EXO-ALPHA-SIALIDASE
(Clostridium
perfringens) 		4 / 7 ASP A 580
PHE A 640
GLY A 623
PHE A 553
 GOL  A1696 (-3.7A)
None
None
None
 1.09A 3vnsA-2bf6A:
undetectable		 3vnsA-2bf6A:
21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4B7N_A_ZMRA601_1
(NEURAMINIDASE)		 2bf6 EXO-ALPHA-SIALIDASE
(Clostridium
perfringens) 		6 / 12 ARG A 266
ASP A 291
GLU A 539
ARG A 555
ARG A 615
TYR A 655
 SIA  A1692 (-2.7A)
SIA  A1692 (-2.8A)
SIA  A1692 ( 3.9A)
SIA  A1692 (-2.9A)
SIA  A1692 (-3.1A)
SIA  A1692 (-4.2A)
 0.57A 4b7nA-2bf6A:
21.3		 4b7nA-2bf6A:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4B7Q_A_ZMRA601_1
(NEURAMINIDASE)		 2bf6 EXO-ALPHA-SIALIDASE
(Clostridium
perfringens) 		6 / 12 ARG A 266
ASP A 291
GLU A 539
ARG A 555
ARG A 615
TYR A 655
 SIA  A1692 (-2.7A)
SIA  A1692 (-2.8A)
SIA  A1692 ( 3.9A)
SIA  A1692 (-2.9A)
SIA  A1692 (-3.1A)
SIA  A1692 (-4.2A)
 0.65A 4b7qA-2bf6A:
21.4		 4b7qA-2bf6A:
21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4B7Q_B_ZMRB601_1
(NEURAMINIDASE)		 2bf6 EXO-ALPHA-SIALIDASE
(Clostridium
perfringens) 		6 / 12 ARG A 266
ASP A 291
GLU A 539
ARG A 555
ARG A 615
TYR A 655
 SIA  A1692 (-2.7A)
SIA  A1692 (-2.8A)
SIA  A1692 ( 3.9A)
SIA  A1692 (-2.9A)
SIA  A1692 (-3.1A)
SIA  A1692 (-4.2A)
 0.61A 4b7qB-2bf6A:
21.3		 4b7qB-2bf6A:
21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4B7Q_C_ZMRC601_1
(NEURAMINIDASE)		 2bf6 EXO-ALPHA-SIALIDASE
(Clostridium
perfringens) 		6 / 12 ARG A 266
ASP A 291
GLU A 539
ARG A 555
ARG A 615
TYR A 655
 SIA  A1692 (-2.7A)
SIA  A1692 (-2.8A)
SIA  A1692 ( 3.9A)
SIA  A1692 (-2.9A)
SIA  A1692 (-3.1A)
SIA  A1692 (-4.2A)
 0.57A 4b7qC-2bf6A:
21.2		 4b7qC-2bf6A:
21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4B7Q_D_ZMRD601_1
(NEURAMINIDASE)		 2bf6 EXO-ALPHA-SIALIDASE
(Clostridium
perfringens) 		6 / 12 ARG A 266
ASP A 291
GLU A 539
ARG A 555
ARG A 615
TYR A 655
 SIA  A1692 (-2.7A)
SIA  A1692 (-2.8A)
SIA  A1692 ( 3.9A)
SIA  A1692 (-2.9A)
SIA  A1692 (-3.1A)
SIA  A1692 (-4.2A)
 0.64A 4b7qD-2bf6A:
12.5		 4b7qD-2bf6A:
21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CPN_A_ZMRA700_1
(NEURAMINIDASE)		 2bf6 EXO-ALPHA-SIALIDASE
(Clostridium
perfringens) 		6 / 12 ARG A 266
ASP A 291
GLU A 539
ARG A 555
ARG A 615
TYR A 655
 SIA  A1692 (-2.7A)
SIA  A1692 (-2.8A)
SIA  A1692 ( 3.9A)
SIA  A1692 (-2.9A)
SIA  A1692 (-3.1A)
SIA  A1692 (-4.2A)
 0.54A 4cpnA-2bf6A:
24.9		 4cpnA-2bf6A:
23.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CPN_B_ZMRB700_1
(NEURAMINIDASE)		 2bf6 EXO-ALPHA-SIALIDASE
(Clostridium
perfringens) 		6 / 12 ARG A 266
ASP A 291
GLU A 539
ARG A 555
ARG A 615
TYR A 655
 SIA  A1692 (-2.7A)
SIA  A1692 (-2.8A)
SIA  A1692 ( 3.9A)
SIA  A1692 (-2.9A)
SIA  A1692 (-3.1A)
SIA  A1692 (-4.2A)
 0.54A 4cpnB-2bf6A:
25.1		 4cpnB-2bf6A:
23.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CPZ_A_ZMRA1471_1
(NEURAMINIDASE)		 2bf6 EXO-ALPHA-SIALIDASE
(Clostridium
perfringens) 		5 / 12 ARG A 266
GLU A 539
ARG A 555
ARG A 615
TYR A 655
 SIA  A1692 (-2.7A)
SIA  A1692 ( 3.9A)
SIA  A1692 (-2.9A)
SIA  A1692 (-3.1A)
SIA  A1692 (-4.2A)
 0.39A 4cpzA-2bf6A:
25.0		 4cpzA-2bf6A:
23.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CPZ_B_ZMRB1471_1
(NEURAMINIDASE)		 2bf6 EXO-ALPHA-SIALIDASE
(Clostridium
perfringens) 		5 / 12 ARG A 266
GLU A 539
ARG A 555
ARG A 615
TYR A 655
 SIA  A1692 (-2.7A)
SIA  A1692 ( 3.9A)
SIA  A1692 (-2.9A)
SIA  A1692 (-3.1A)
SIA  A1692 (-4.2A)
 0.36A 4cpzB-2bf6A:
25.0		 4cpzB-2bf6A:
23.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CPZ_C_ZMRC1470_1
(NEURAMINIDASE)		 2bf6 EXO-ALPHA-SIALIDASE
(Clostridium
perfringens) 		6 / 12 ARG A 266
ASP A 291
GLU A 539
ARG A 555
ARG A 615
TYR A 655
 SIA  A1692 (-2.7A)
SIA  A1692 (-2.8A)
SIA  A1692 ( 3.9A)
SIA  A1692 (-2.9A)
SIA  A1692 (-3.1A)
SIA  A1692 (-4.2A)
 0.55A 4cpzC-2bf6A:
5.8		 4cpzC-2bf6A:
23.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CPZ_D_ZMRD1471_1
(NEURAMINIDASE)		 2bf6 EXO-ALPHA-SIALIDASE
(Clostridium
perfringens) 		5 / 12 ARG A 266
GLU A 539
ARG A 555
ARG A 615
TYR A 655
 SIA  A1692 (-2.7A)
SIA  A1692 ( 3.9A)
SIA  A1692 (-2.9A)
SIA  A1692 (-3.1A)
SIA  A1692 (-4.2A)
 0.33A 4cpzD-2bf6A:
25.0		 4cpzD-2bf6A:
23.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CPZ_E_ZMRE1471_1
(NEURAMINIDASE)		 2bf6 EXO-ALPHA-SIALIDASE
(Clostridium
perfringens) 		6 / 12 ARG A 266
ASP A 291
GLU A 539
ARG A 555
ARG A 615
TYR A 655
 SIA  A1692 (-2.7A)
SIA  A1692 (-2.8A)
SIA  A1692 ( 3.9A)
SIA  A1692 (-2.9A)
SIA  A1692 (-3.1A)
SIA  A1692 (-4.2A)
 0.58A 4cpzE-2bf6A:
25.0		 4cpzE-2bf6A:
23.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CPZ_F_ZMRF1470_1
(NEURAMINIDASE)		 2bf6 EXO-ALPHA-SIALIDASE
(Clostridium
perfringens) 		6 / 12 ARG A 266
ASP A 291
GLU A 539
ARG A 555
ARG A 615
TYR A 655
 SIA  A1692 (-2.7A)
SIA  A1692 (-2.8A)
SIA  A1692 ( 3.9A)
SIA  A1692 (-2.9A)
SIA  A1692 (-3.1A)
SIA  A1692 (-4.2A)
 0.56A 4cpzF-2bf6A:
24.9		 4cpzF-2bf6A:
23.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CPZ_G_ZMRG1471_1
(NEURAMINIDASE)		 2bf6 EXO-ALPHA-SIALIDASE
(Clostridium
perfringens) 		6 / 12 ARG A 266
ASP A 291
GLU A 539
ARG A 555
ARG A 615
TYR A 655
 SIA  A1692 (-2.7A)
SIA  A1692 (-2.8A)
SIA  A1692 ( 3.9A)
SIA  A1692 (-2.9A)
SIA  A1692 (-3.1A)
SIA  A1692 (-4.2A)
 0.50A 4cpzG-2bf6A:
25.1		 4cpzG-2bf6A:
23.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CPZ_H_ZMRH1470_1
(NEURAMINIDASE)		 2bf6 EXO-ALPHA-SIALIDASE
(Clostridium
perfringens) 		6 / 12 ARG A 266
ASP A 291
GLU A 539
ARG A 555
ARG A 615
TYR A 655
 SIA  A1692 (-2.7A)
SIA  A1692 (-2.8A)
SIA  A1692 ( 3.9A)
SIA  A1692 (-2.9A)
SIA  A1692 (-3.1A)
SIA  A1692 (-4.2A)
 0.57A 4cpzH-2bf6A:
24.9		 4cpzH-2bf6A:
23.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EMA_A_BRLA601_2
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 2bf6 EXO-ALPHA-SIALIDASE
(Clostridium
perfringens) 		3 / 3 PHE A 567
VAL A 481
ILE A 471
 None
 0.64A 4emaA-2bf6A:
undetectable		 4emaA-2bf6A:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FU8_A_ACTA304_0
(UROKINASE-TYPE
PLASMINOGEN
ACTIVATOR)		 2bf6 EXO-ALPHA-SIALIDASE
(Clostridium
perfringens) 		3 / 3 ARG A 479
HIS A 476
TYR A 499
 None
 0.90A 4fu8A-2bf6A:
undetectable		 4fu8A-2bf6A:
21.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FU9_A_ACTA312_0
(UROKINASE-TYPE
PLASMINOGEN
ACTIVATOR)		 2bf6 EXO-ALPHA-SIALIDASE
(Clostridium
perfringens) 		3 / 3 ARG A 479
HIS A 476
TYR A 499
 None
 0.94A 4fu9A-2bf6A:
undetectable		 4fu9A-2bf6A:
21.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4I00_A_ZMRA509_1
(NEURAMINIDASE)		 2bf6 EXO-ALPHA-SIALIDASE
(Clostridium
perfringens) 		6 / 12 ARG A 266
ASP A 291
GLU A 539
ARG A 555
ARG A 615
TYR A 655
 SIA  A1692 (-2.7A)
SIA  A1692 (-2.8A)
SIA  A1692 ( 3.9A)
SIA  A1692 (-2.9A)
SIA  A1692 (-3.1A)
SIA  A1692 (-4.2A)
 0.49A 4i00A-2bf6A:
21.7		 4i00A-2bf6A:
21.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IV0_A_SAMA302_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE,
PUTATIVE)		 2bf6 EXO-ALPHA-SIALIDASE
(Clostridium
perfringens) 		5 / 12 VAL A 453
ILE A 332
GLY A 504
ILE A 449
SER A 500
 None
 1.04A 4iv0A-2bf6A:
undetectable		 4iv0A-2bf6A:
20.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KOT_A_CE3A205_1
(UNCHARACTERIZED
PROTEIN)		 2bf6 EXO-ALPHA-SIALIDASE
(Clostridium
perfringens) 		5 / 12 CYH A 657
GLY A 667
ILE A 681
ARG A 302
LEU A 254
 None
 1.29A 4kotA-2bf6A:
undetectable		 4kotA-2bf6A:
15.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LV9_A_20JA602_1
(NICOTINAMIDE
PHOSPHORIBOSYLTRANSF
ERASE)		 2bf6 EXO-ALPHA-SIALIDASE
(Clostridium
perfringens) 		4 / 7 TYR A 485
ILE A 498
ILE A 509
ALA A 496
 SIA  A1692 (-4.7A)
None
None
None
 0.87A 4lv9A-2bf6A:
undetectable		 4lv9A-2bf6A:
22.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MWR_A_ZMRA513_1
(NEURAMINIDASE)		 2bf6 EXO-ALPHA-SIALIDASE
(Clostridium
perfringens) 		5 / 12 ARG A 266
GLU A 539
ARG A 555
ARG A 615
TYR A 655
 SIA  A1692 (-2.7A)
SIA  A1692 ( 3.9A)
SIA  A1692 (-2.9A)
SIA  A1692 (-3.1A)
SIA  A1692 (-4.2A)
 0.44A 4mwrA-2bf6A:
21.2		 4mwrA-2bf6A:
22.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MWX_A_ZMRA513_1
(NEURAMINIDASE)		 2bf6 EXO-ALPHA-SIALIDASE
(Clostridium
perfringens) 		5 / 12 ARG A 266
ASP A 291
GLU A 539
ARG A 615
TYR A 655
 SIA  A1692 (-2.7A)
SIA  A1692 (-2.8A)
SIA  A1692 ( 3.9A)
SIA  A1692 (-3.1A)
SIA  A1692 (-4.2A)
 0.53A 4mwxA-2bf6A:
21.3		 4mwxA-2bf6A:
22.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MWZ_B_SAMB301_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE,
PUTATIVE)		 2bf6 EXO-ALPHA-SIALIDASE
(Clostridium
perfringens) 		5 / 12 VAL A 453
ILE A 332
GLY A 504
ILE A 449
SER A 500
 None
 1.05A 4mwzB-2bf6A:
undetectable		 4mwzB-2bf6A:
20.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MX0_A_BCZA513_1
(NEURAMINIDASE)		 2bf6 EXO-ALPHA-SIALIDASE
(Clostridium
perfringens) 		3 / 3 ARG A 266
ASP A 291
ARG A 615
 SIA  A1692 (-2.7A)
SIA  A1692 (-2.8A)
SIA  A1692 (-3.1A)
 0.47A 4mx0A-2bf6A:
9.2		 4mx0A-2bf6A:
22.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OTW_A_DB8A1101_2
(RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-3)		 2bf6 EXO-ALPHA-SIALIDASE
(Clostridium
perfringens) 		3 / 3 LEU A 537
LEU A 461
ASN A 488
 None
 0.62A 4otwA-2bf6A:
0.9		 4otwA-2bf6A:
22.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WA5_A_ZMRA501_1
(NEURAMINIDASE)		 2bf6 EXO-ALPHA-SIALIDASE
(Clostridium
perfringens) 		6 / 12 ARG A 266
ASP A 291
GLU A 539
ARG A 555
ARG A 615
TYR A 655
 SIA  A1692 (-2.7A)
SIA  A1692 (-2.8A)
SIA  A1692 ( 3.9A)
SIA  A1692 (-2.9A)
SIA  A1692 (-3.1A)
SIA  A1692 (-4.2A)
 0.68A 4wa5A-2bf6A:
10.2		 4wa5A-2bf6A:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WNU_C_QDNC602_1
(CYTOCHROME P450 2D6)		 2bf6 EXO-ALPHA-SIALIDASE
(Clostridium
perfringens) 		5 / 11 GLY A 462
GLU A 539
PHE A 347
ALA A 292
ASP A 291
 None
SIA  A1692 ( 3.9A)
None
None
SIA  A1692 (-2.8A)
 1.37A 4wnuC-2bf6A:
undetectable		 4wnuC-2bf6A:
21.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_3_BEZ3801_0
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 1
BEZ-LEU-LEU)		 2bf6 EXO-ALPHA-SIALIDASE
(Clostridium
perfringens) 		4 / 4 LEU A 278
ILE A 279
GLY A 276
ILE A 340
 None
 0.86A 5dzk3-2bf6A:
undetectable
5dzkm-2bf6A:
undetectable		 5dzk3-2bf6A:
1.98
5dzkm-2bf6A:
17.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L17_A_ZMRA512_1
(NEURAMINIDASE)		 2bf6 EXO-ALPHA-SIALIDASE
(Clostridium
perfringens) 		6 / 12 ARG A 266
ASP A 291
GLU A 539
ARG A 555
ARG A 615
TYR A 655
 SIA  A1692 (-2.7A)
SIA  A1692 (-2.8A)
SIA  A1692 ( 3.9A)
SIA  A1692 (-2.9A)
SIA  A1692 (-3.1A)
SIA  A1692 (-4.2A)
 0.49A 5l17A-2bf6A:
21.1		 5l17A-2bf6A:
23.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NUJ_A_Z80A201_1
(BETA-LACTOGLOBULIN)		 2bf6 EXO-ALPHA-SIALIDASE
(Clostridium
perfringens) 		4 / 8 VAL A 583
PHE A 553
LEU A 561
VAL A 605
 None
 0.75A 5nujA-2bf6A:
undetectable		 5nujA-2bf6A:
10.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X7P_A_ACRA1401_2
(GLYCOSIDE HYDROLASE
FAMILY 31
ALPHA-GLUCOSIDASE)		 2bf6 EXO-ALPHA-SIALIDASE
(Clostridium
perfringens) 		5 / 9 GLN A 536
GLN A 493
ILE A 267
GLY A 559
SER A 558
 None
SIA  A1692 (-3.0A)
SIA  A1692 (-4.5A)
None
None
 1.31A 5x7pB-2bf6A:
0.9		 5x7pB-2bf6A:
16.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X7P_B_ACRB1401_1
(GLYCOSIDE HYDROLASE
FAMILY 31
ALPHA-GLUCOSIDASE)		 2bf6 EXO-ALPHA-SIALIDASE
(Clostridium
perfringens) 		5 / 9 GLN A 536
GLN A 493
ILE A 267
GLY A 559
SER A 558
 None
SIA  A1692 (-3.0A)
SIA  A1692 (-4.5A)
None
None
 1.38A 5x7pA-2bf6A:
1.4		 5x7pA-2bf6A:
16.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AG0_A_ACRA608_0
(ALPHA-AMYLASE)		 2bf6 EXO-ALPHA-SIALIDASE
(Clostridium
perfringens) 		4 / 6 GLY A 634
THR A 630
GLN A 627
TYR A 638
 None
 1.15A 6ag0A-2bf6A:
undetectable		 6ag0A-2bf6A:
11.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AG0_C_ACRC606_0
(ALPHA-AMYLASE)		 2bf6 EXO-ALPHA-SIALIDASE
(Clostridium
perfringens) 		4 / 6 GLY A 634
THR A 630
GLN A 627
TYR A 638
 None
 1.19A 6ag0C-2bf6A:
undetectable		 6ag0C-2bf6A:
11.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BXM_A_SAMA402_0
(DIPHTHAMIDE
BIOSYNTHESIS ENZYME
DPH2)		 2bf6 EXO-ALPHA-SIALIDASE
(Clostridium
perfringens) 		5 / 12 GLY A 569
LEU A 343
ARG A 479
ILE A 480
ASP A 501
 None
 1.22A 6bxmA-2bf6A:
undetectable		 6bxmA-2bf6A:
23.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DWN_A_AQ4A602_0
(CYTOCHROME P450 1A1)		 2bf6 EXO-ALPHA-SIALIDASE
(Clostridium
perfringens) 		5 / 12 ASN A 448
ASN A 432
ASN A 417
GLY A 361
PHE A 362
 None
 1.30A 6dwnA-2bf6A:
undetectable		 6dwnA-2bf6A:
11.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EKU_A_ZMRA901_1
(SIALIDASE)		 2bf6 EXO-ALPHA-SIALIDASE
(Clostridium
perfringens) 		7 / 12 ARG A 266
ILE A 267
ARG A 285
GLU A 539
ARG A 555
ARG A 615
TYR A 655
 SIA  A1692 (-2.7A)
SIA  A1692 (-4.5A)
SIA  A1692 (-3.6A)
SIA  A1692 ( 3.9A)
SIA  A1692 (-2.9A)
SIA  A1692 (-3.1A)
SIA  A1692 (-4.2A)
 0.39A 6ekuA-2bf6A:
44.2		 6ekuA-2bf6A:
23.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EKU_A_ZMRA901_1
(SIALIDASE)		 2bf6 EXO-ALPHA-SIALIDASE
(Clostridium
perfringens) 		7 / 12 ARG A 266
ILE A 267
ASP A 328
GLU A 539
ARG A 555
ARG A 615
TYR A 655
 SIA  A1692 (-2.7A)
SIA  A1692 (-4.5A)
SIA  A1692 (-2.9A)
SIA  A1692 ( 3.9A)
SIA  A1692 (-2.9A)
SIA  A1692 (-3.1A)
SIA  A1692 (-4.2A)
 0.67A 6ekuA-2bf6A:
44.2		 6ekuA-2bf6A:
23.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FDY_U_DB8U302_1
(-)		 2bf6 EXO-ALPHA-SIALIDASE
(Clostridium
perfringens) 		5 / 9 VAL A 599
SER A 690
LEU A 688
GLU A 689
ILE A 622
 None
 1.25A 6fdyU-2bf6A:
0.7		 6fdyU-2bf6A:
19.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HCX_A_ZMRA519_0
(NEURAMINIDASE)		 2bf6 EXO-ALPHA-SIALIDASE
(Clostridium
perfringens) 		5 / 12 ARG A 266
ASP A 291
ARG A 555
ARG A 615
TYR A 655
 SIA  A1692 (-2.7A)
SIA  A1692 (-2.8A)
SIA  A1692 (-2.9A)
SIA  A1692 (-3.1A)
SIA  A1692 (-4.2A)
 0.53A 6hcxA-2bf6A:
21.2		 6hcxA-2bf6A:
10.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6JMJ_A_ASCA201_0
(PHOSPHOPANTETHEINE
ADENYLYLTRANSFERASE)		 2bf6 EXO-ALPHA-SIALIDASE
(Clostridium
perfringens) 		4 / 5 GLY A 404
HIS A 346
SER A 349
SER A 324
 None
 1.10A 6jmjA-2bf6A:
undetectable		 6jmjA-2bf6A:
16.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MHT_D_SAMD328_0
(CYTOSINE-SPECIFIC
METHYLTRANSFERASE
HHAI)		 2bf6 EXO-ALPHA-SIALIDASE
(Clostridium
perfringens) 		5 / 12 GLY A 466
ASP A 328
ILE A 498
SER A 591
VAL A 592
 None
SIA  A1692 (-2.9A)
None
None
None
 1.11A 6mhtA-2bf6A:
undetectable		 6mhtA-2bf6A:
22.78