SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2bfe'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1D8C_A_SORA4000_0
(MALATE SYNTHASE G)		 2bfe 2-OXOISOVALERATE
DEHYDROGENASE ALPHA
SUBUNIT
(Homo
sapiens) 		3 / 3 GLN A 145
HIS A 149
PRO A 147
 None
CL  A 504 (-4.4A)
None
 0.94A 1d8cA-2bfeA:
2.4		 1d8cA-2bfeA:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HA2_B_SCKB951_1
(ACETYLCHOLINESTERASE)		 2bfe 2-OXOISOVALERATE
DEHYDROGENASE ALPHA
SUBUNIT
(Homo
sapiens) 		4 / 8 TYR A  90
ASP A  71
TYR A 150
HIS A 149
 None
None
None
CL  A 504 (-4.4A)
 1.46A 2ha2B-2bfeA:
undetectable		 2ha2B-2bfeA:
23.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VQ5_B_LDPB1197_1
(S-NORCOCLAURINE
SYNTHASE)		 2bfe 2-OXOISOVALERATE
DEHYDROGENASE ALPHA
SUBUNIT
(Homo
sapiens) 		4 / 7 LEU A 382
LEU A 386
LEU A 363
PRO A 394
 None
 0.99A 2vq5B-2bfeA:
undetectable		 2vq5B-2bfeA:
19.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W98_A_P1ZA1352_1
(PROSTAGLANDIN
REDUCTASE 2)		 2bfe 2-OXOISOVALERATE
DEHYDROGENASE ALPHA
SUBUNIT
(Homo
sapiens) 		4 / 7 TYR A 121
TYR A 190
LEU A 103
ASN A 105
 None
 1.19A 2w98A-2bfeA:
2.5
2w98B-2bfeA:
2.4		 2w98A-2bfeA:
22.76
2w98B-2bfeA:
22.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XF3_A_J01A600_1
(ORF12)		 2bfe 2-OXOISOVALERATE
DEHYDROGENASE ALPHA
SUBUNIT
(Homo
sapiens) 		5 / 11 TYR A  86
ALA A 116
GLY A 117
MET A 120
PHE A 129
 None
 1.36A 2xf3A-2bfeA:
undetectable		 2xf3A-2bfeA:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XF3_B_J01B600_1
(ORF12)		 2bfe 2-OXOISOVALERATE
DEHYDROGENASE ALPHA
SUBUNIT
(Homo
sapiens) 		5 / 11 TYR A  86
ALA A 116
GLY A 117
MET A 120
PHE A 129
 None
 1.35A 2xf3B-2bfeA:
undetectable		 2xf3B-2bfeA:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XFS_A_J01A600_1
(ORF12)		 2bfe 2-OXOISOVALERATE
DEHYDROGENASE ALPHA
SUBUNIT
(Homo
sapiens) 		5 / 10 TYR A  86
ALA A 116
GLY A 117
MET A 120
PHE A 129
 None
 1.34A 2xfsA-2bfeA:
0.0		 2xfsA-2bfeA:
20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XFS_B_J01B600_1
(ORF12)		 2bfe 2-OXOISOVALERATE
DEHYDROGENASE ALPHA
SUBUNIT
(Homo
sapiens) 		5 / 11 TYR A  86
ALA A 116
GLY A 117
MET A 120
PHE A 129
 None
 1.35A 2xfsB-2bfeA:
0.0		 2xfsB-2bfeA:
20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XH9_A_J01A1437_1
(ORF12)		 2bfe 2-OXOISOVALERATE
DEHYDROGENASE ALPHA
SUBUNIT
(Homo
sapiens) 		5 / 11 TYR A  86
ALA A 116
GLY A 117
MET A 120
PHE A 129
 None
 1.36A 2xh9A-2bfeA:
undetectable		 2xh9A-2bfeA:
21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3J7Z_A_ERYA9000_0
(23S RRNA
50S RIBOSOMAL
PROTEIN L22
ERMCL NASCENT CHAIN)		 2bfe 2-OXOISOVALERATE
DEHYDROGENASE ALPHA
SUBUNIT
(Homo
sapiens) 		3 / 3 LYS A  56
ILE A 216
PHE A 279
 None
 0.77A 3j7zS-2bfeA:
undetectable
3j7za-2bfeA:
undetectable		 3j7zS-2bfeA:
13.72
3j7za-2bfeA:
4.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LD6_A_KKKA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 2bfe 2-OXOISOVALERATE
DEHYDROGENASE ALPHA
SUBUNIT
(Homo
sapiens) 		5 / 12 PHE A 205
GLY A 238
ALA A 240
ILE A 281
ILE A 188
 None
 1.39A 3ld6A-2bfeA:
undetectable		 3ld6A-2bfeA:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OCT_A_1N1A663_2
(TYROSINE-PROTEIN
KINASE BTK)		 2bfe 2-OXOISOVALERATE
DEHYDROGENASE ALPHA
SUBUNIT
(Homo
sapiens) 		4 / 5 PHE A 218
MET A 284
ASN A 256
PHE A 217
 None
 1.32A 3octA-2bfeA:
undetectable		 3octA-2bfeA:
19.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TGV_B_BEZB1_0
(HEME-BINDING PROTEIN
HUTZ)		 2bfe 2-OXOISOVALERATE
DEHYDROGENASE ALPHA
SUBUNIT
(Homo
sapiens) 		4 / 6 GLN A 326
TYR A 322
PHE A 259
LEU A  52
 None
 1.33A 3tgvB-2bfeA:
undetectable		 3tgvB-2bfeA:
15.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TGV_D_BEZD1_0
(HEME-BINDING PROTEIN
HUTZ)		 2bfe 2-OXOISOVALERATE
DEHYDROGENASE ALPHA
SUBUNIT
(Homo
sapiens) 		4 / 6 GLN A 326
TYR A 322
PHE A 259
LEU A  52
 None
 1.39A 3tgvD-2bfeA:
undetectable		 3tgvD-2bfeA:
15.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AC9_C_DXCC1476_0
(MJ0495-LIKE PROTEIN)		 2bfe 2-OXOISOVALERATE
DEHYDROGENASE ALPHA
SUBUNIT
(Homo
sapiens) 		4 / 5 ILE A 168
ALA A 195
HIS A 202
ARG A 242
 None
TDP  A 601 (-3.5A)
None
None
 1.21A 4ac9B-2bfeA:
3.3
4ac9C-2bfeA:
2.8		 4ac9B-2bfeA:
21.70
4ac9C-2bfeA:
21.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ACA_C_DXCC1476_0
(TRANSLATION
ELONGATION FACTOR
SELB)		 2bfe 2-OXOISOVALERATE
DEHYDROGENASE ALPHA
SUBUNIT
(Homo
sapiens) 		4 / 5 ILE A 168
ALA A 195
HIS A 202
ARG A 242
 None
TDP  A 601 (-3.5A)
None
None
 1.25A 4acaB-2bfeA:
2.1
4acaC-2bfeA:
3.5		 4acaB-2bfeA:
21.70
4acaC-2bfeA:
21.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4B7Q_C_ZMRC601_2
(NEURAMINIDASE)		 2bfe 2-OXOISOVALERATE
DEHYDROGENASE ALPHA
SUBUNIT
(Homo
sapiens) 		3 / 3 ARG A  35
ARG A  39
ILE A  44
 None
 0.91A 4b7qC-2bfeA:
undetectable		 4b7qC-2bfeA:
22.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E1G_A_LNLA701_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 2bfe 2-OXOISOVALERATE
DEHYDROGENASE ALPHA
SUBUNIT
(Homo
sapiens) 		5 / 12 TYR A  86
ILE A 188
GLY A 117
ALA A 116
GLY A 111
 None
 0.91A 4e1gA-2bfeA:
undetectable		 4e1gA-2bfeA:
20.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E1G_B_LNLB701_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 2bfe 2-OXOISOVALERATE
DEHYDROGENASE ALPHA
SUBUNIT
(Homo
sapiens) 		5 / 12 TYR A  86
ILE A 188
GLY A 117
ALA A 116
GLY A 111
 None
 0.87A 4e1gB-2bfeA:
undetectable		 4e1gB-2bfeA:
20.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J6C_A_STRA501_1
(CYTOCHROME P450
MONOOXYGENASE)		 2bfe 2-OXOISOVALERATE
DEHYDROGENASE ALPHA
SUBUNIT
(Homo
sapiens) 		5 / 11 GLN A 170
ALA A 171
ALA A 174
ALA A 175
LEU A 103
 None
 0.89A 4j6cA-2bfeA:
undetectable		 4j6cA-2bfeA:
22.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L6V_1_PQN12001_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1
FUSION PROTEIN OF
PHOTOSYSTEM I
SUBUNIT III AND
SUBUNIT IX)		 2bfe 2-OXOISOVALERATE
DEHYDROGENASE ALPHA
SUBUNIT
(Homo
sapiens) 		5 / 11 PHE A 205
GLY A 199
ALA A 165
GLY A 204
ALA A 102
 None
 0.98A 4l6v1-2bfeA:
undetectable
4l6v6-2bfeA:
0.7		 4l6v1-2bfeA:
19.39
4l6v6-2bfeA:
15.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LG1_C_SAMC301_0
(PROTEIN-LYSINE
METHYLTRANSFERASE
METTL21D)		 2bfe 2-OXOISOVALERATE
DEHYDROGENASE ALPHA
SUBUNIT
(Homo
sapiens) 		5 / 12 CYH A 219
ALA A 201
GLY A 194
GLY A 192
TYR A 234
 None
None
TDP  A 601 (-3.5A)
TDP  A 601 (-3.4A)
None
 1.06A 4lg1C-2bfeA:
undetectable		 4lg1C-2bfeA:
21.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OAE_A_CLMA208_0
(GNAT SUPERFAMILY
ACETYLTRANSFERASE
PA4794)		 2bfe 2-OXOISOVALERATE
DEHYDROGENASE ALPHA
SUBUNIT
(Homo
sapiens) 		4 / 4 ALA A 174
ALA A 177
ALA A 178
ALA A 181
 None
 0.13A 4oaeA-2bfeA:
0.0		 4oaeA-2bfeA:
18.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R29_A_SAMA301_0
(UNCHARACTERIZED
PROTEIN)		 2bfe 2-OXOISOVALERATE
DEHYDROGENASE ALPHA
SUBUNIT
(Homo
sapiens) 		5 / 12 ALA A 208
GLY A 204
ALA A 240
GLY A 243
PHE A 205
 None
 1.13A 4r29A-2bfeA:
undetectable		 4r29A-2bfeA:
23.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R29_B_SAMB301_0
(UNCHARACTERIZED
PROTEIN)		 2bfe 2-OXOISOVALERATE
DEHYDROGENASE ALPHA
SUBUNIT
(Homo
sapiens) 		5 / 12 ALA A 208
GLY A 204
ALA A 240
GLY A 243
PHE A 205
 None
 1.15A 4r29B-2bfeA:
undetectable		 4r29B-2bfeA:
23.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R29_B_SAMB301_0
(UNCHARACTERIZED
PROTEIN)		 2bfe 2-OXOISOVALERATE
DEHYDROGENASE ALPHA
SUBUNIT
(Homo
sapiens) 		5 / 12 GLY A 204
GLU A 282
ALA A 240
GLY A 243
PHE A 205
 None
 1.18A 4r29B-2bfeA:
undetectable		 4r29B-2bfeA:
23.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R29_C_SAMC301_0
(UNCHARACTERIZED
PROTEIN)		 2bfe 2-OXOISOVALERATE
DEHYDROGENASE ALPHA
SUBUNIT
(Homo
sapiens) 		5 / 12 ALA A 208
GLY A 204
ALA A 240
GLY A 243
PHE A 205
 None
 1.14A 4r29C-2bfeA:
undetectable		 4r29C-2bfeA:
23.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_A_PCFA1805_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 2bfe 2-OXOISOVALERATE
DEHYDROGENASE ALPHA
SUBUNIT
(Homo
sapiens) 		4 / 7 HIS A 314
PRO A 315
ILE A 316
THR A 285
 None
 0.76A 5vkqA-2bfeA:
undetectable
5vkqD-2bfeA:
undetectable		 5vkqA-2bfeA:
13.26
5vkqD-2bfeA:
13.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_B_PCFB1802_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 2bfe 2-OXOISOVALERATE
DEHYDROGENASE ALPHA
SUBUNIT
(Homo
sapiens) 		4 / 7 THR A 285
HIS A 314
PRO A 315
ILE A 316
 None
 0.80A 5vkqA-2bfeA:
undetectable
5vkqB-2bfeA:
undetectable		 5vkqA-2bfeA:
13.26
5vkqB-2bfeA:
13.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_C_PCFC1803_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 2bfe 2-OXOISOVALERATE
DEHYDROGENASE ALPHA
SUBUNIT
(Homo
sapiens) 		4 / 8 THR A 285
HIS A 314
PRO A 315
ILE A 316
 None
 0.75A 5vkqB-2bfeA:
undetectable
5vkqC-2bfeA:
undetectable		 5vkqB-2bfeA:
13.26
5vkqC-2bfeA:
13.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_D_PCFD1803_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 2bfe 2-OXOISOVALERATE
DEHYDROGENASE ALPHA
SUBUNIT
(Homo
sapiens) 		4 / 7 THR A  95
HIS A 314
PRO A 315
ILE A 316
 None
 1.23A 5vkqC-2bfeA:
undetectable
5vkqD-2bfeA:
undetectable		 5vkqC-2bfeA:
13.26
5vkqD-2bfeA:
13.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_D_PCFD1803_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 2bfe 2-OXOISOVALERATE
DEHYDROGENASE ALPHA
SUBUNIT
(Homo
sapiens) 		4 / 7 THR A 285
HIS A 314
PRO A 315
ILE A 316
 None
 0.76A 5vkqC-2bfeA:
undetectable
5vkqD-2bfeA:
undetectable		 5vkqC-2bfeA:
13.26
5vkqD-2bfeA:
13.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NMF_W_CHDW101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 2bfe 2-OXOISOVALERATE
DEHYDROGENASE ALPHA
SUBUNIT
(Homo
sapiens) 		4 / 6 ILE A  73
LEU A  74
ARG A 338
THR A  65
 None
 1.07A 6nmfN-2bfeA:
undetectable
6nmfW-2bfeA:
undetectable		 6nmfN-2bfeA:
19.01
6nmfW-2bfeA:
9.18