SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2bfr'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GM7_B_PNNB1577_0
(PENICILLIN G ACYLASE
ALPHA SUBUNIT
PENICILLIN G ACYLASE
BETA SUBUNIT)		 2bfr HYPOTHETICAL PROTEIN
AF1521
(Archaeoglobus
fulgidus) 		4 / 8 SER A 134
ALA A  28
PHE A  97
ILE A  93
 None
 1.12A 1gm7A-2bfrA:
undetectable
1gm7B-2bfrA:
undetectable		 1gm7A-2bfrA:
18.91
1gm7B-2bfrA:
15.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JFF_B_TA1B601_1
(TUBULIN BETA CHAIN)		 2bfr HYPOTHETICAL PROTEIN
AF1521
(Archaeoglobus
fulgidus) 		5 / 12 VAL A 168
LEU A 157
PHE A 137
THR A 155
PRO A 123
 None
 1.18A 1jffB-2bfrA:
undetectable		 1jffB-2bfrA:
16.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XP0_A_VDNA201_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		 2bfr HYPOTHETICAL PROTEIN
AF1521
(Archaeoglobus
fulgidus) 		5 / 10 LEU A 124
ALA A 127
ILE A 135
VAL A  80
PHE A 137
 None
 1.13A 1xp0A-2bfrA:
0.4		 1xp0A-2bfrA:
20.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AOF_C_FRDC305_1
(POL POLYPROTEIN
PEPTIDE INHIBITOR)		 2bfr HYPOTHETICAL PROTEIN
AF1521
(Archaeoglobus
fulgidus) 		4 / 5 GLY A  19
PRO A  25
ALA A  26
ILE A  29
 None
 0.94A 2aofA-2bfrA:
undetectable		 2aofA-2bfrA:
21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HXF_B_TA1B601_1
(TUBULIN BETA CHAIN)		 2bfr HYPOTHETICAL PROTEIN
AF1521
(Archaeoglobus
fulgidus) 		5 / 12 VAL A 168
LEU A 157
PHE A 137
THR A 155
PRO A 123
 None
 1.18A 2hxfB-2bfrA:
undetectable		 2hxfB-2bfrA:
16.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HXH_B_TA1B601_1
(TUBULIN BETA CHAIN)		 2bfr HYPOTHETICAL PROTEIN
AF1521
(Archaeoglobus
fulgidus) 		5 / 12 VAL A 168
LEU A 157
PHE A 137
THR A 155
PRO A 123
 None
 1.18A 2hxhB-2bfrA:
undetectable		 2hxhB-2bfrA:
16.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2P4N_B_TA1B601_1
(TUBULIN BETA CHAIN)		 2bfr HYPOTHETICAL PROTEIN
AF1521
(Archaeoglobus
fulgidus) 		5 / 12 VAL A 168
LEU A 157
PHE A 137
THR A 155
PRO A 123
 None
 1.18A 2p4nB-2bfrA:
undetectable		 2p4nB-2bfrA:
16.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WBE_B_TA1B1439_1
(TUBULIN BETA-2B
CHAIN)		 2bfr HYPOTHETICAL PROTEIN
AF1521
(Archaeoglobus
fulgidus) 		5 / 12 VAL A 168
LEU A 157
PHE A 137
THR A 155
PRO A 123
 None
 1.18A 2wbeB-2bfrA:
undetectable		 2wbeB-2bfrA:
16.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B2R_B_VDNB1_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		 2bfr HYPOTHETICAL PROTEIN
AF1521
(Archaeoglobus
fulgidus) 		5 / 11 LEU A 124
ALA A 127
ILE A 135
VAL A  80
PHE A 137
 None
 1.15A 3b2rB-2bfrA:
undetectable		 3b2rB-2bfrA:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DCO_B_TA1B601_1
(BOVINE BETA TUBULIN)		 2bfr HYPOTHETICAL PROTEIN
AF1521
(Archaeoglobus
fulgidus) 		5 / 12 VAL A 168
LEU A 157
PHE A 137
THR A 155
PRO A 123
 None
 1.18A 3dcoB-2bfrA:
undetectable		 3dcoB-2bfrA:
16.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EDL_B_TA1B601_1
(BETA TUBULIN)		 2bfr HYPOTHETICAL PROTEIN
AF1521
(Archaeoglobus
fulgidus) 		5 / 12 VAL A 168
LEU A 157
PHE A 137
THR A 155
PRO A 123
 None
 1.17A 3edlB-2bfrA:
undetectable		 3edlB-2bfrA:
16.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IZ0_B_TA1B820_1
(BETA TUBULIN, CHAIN
B FROM PDB 1JFF)		 2bfr HYPOTHETICAL PROTEIN
AF1521
(Archaeoglobus
fulgidus) 		5 / 12 VAL A 168
LEU A 157
PHE A 137
THR A 155
PRO A 123
 None
 1.17A 3iz0B-2bfrA:
undetectable		 3iz0B-2bfrA:
16.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3J6P_B_TA1B502_1
(TUBULIN BETA CHAIN)		 2bfr HYPOTHETICAL PROTEIN
AF1521
(Archaeoglobus
fulgidus) 		5 / 12 VAL A 168
LEU A 157
PHE A 137
THR A 155
PRO A 123
 None
 1.18A 3j6pB-2bfrA:
2.4		 3j6pB-2bfrA:
16.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LD6_A_KKKA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 2bfr HYPOTHETICAL PROTEIN
AF1521
(Archaeoglobus
fulgidus) 		5 / 12 GLY A  42
ALA A  46
THR A  22
ILE A  29
ILE A 135
 ADP  A1193 (-3.1A)
ADP  A1193 (-3.4A)
ADP  A1193 ( 4.9A)
None
None
 1.34A 3ld6A-2bfrA:
undetectable		 3ld6A-2bfrA:
17.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AWU_A_4CHA502_0
(OXIDOREDUCTASE,
FMN-BINDING)		 2bfr HYPOTHETICAL PROTEIN
AF1521
(Archaeoglobus
fulgidus) 		4 / 7 THR A 155
TRP A 108
LEU A 149
PHE A 120
 None
 1.01A 4awuA-2bfrA:
undetectable		 4awuA-2bfrA:
22.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EVR_A_BEZA401_0
(PUTATIVE ABC
TRANSPORTER SUBUNIT,
SUBSTRATE-BINDING
COMPONENT)		 2bfr HYPOTHETICAL PROTEIN
AF1521
(Archaeoglobus
fulgidus) 		5 / 11 LEU A 124
VAL A 168
SER A 134
ALA A  26
PHE A  97
 None
 1.34A 4evrA-2bfrA:
4.6		 4evrA-2bfrA:
23.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YJI_A_TYLA502_1
(ARYL ACYLAMIDASE)		 2bfr HYPOTHETICAL PROTEIN
AF1521
(Archaeoglobus
fulgidus) 		4 / 7 GLY A  40
GLY A  41
ALA A  44
ILE A 144
 None
None
None
ADP  A1193 (-3.7A)
 0.54A 4yjiA-2bfrA:
undetectable		 4yjiA-2bfrA:
17.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EQB_A_1YNA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 2bfr HYPOTHETICAL PROTEIN
AF1521
(Archaeoglobus
fulgidus) 		5 / 12 GLY A  71
ILE A 144
TYR A 145
GLY A  42
GLY A  40
 None
ADP  A1193 (-3.7A)
ADP  A1193 (-3.4A)
ADP  A1193 (-3.1A)
None
 1.10A 5eqbA-2bfrA:
undetectable		 5eqbA-2bfrA:
17.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ESH_A_1YNA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 2bfr HYPOTHETICAL PROTEIN
AF1521
(Archaeoglobus
fulgidus) 		5 / 12 ALA A 127
ILE A 144
TYR A 145
GLY A  40
THR A  59
 None
ADP  A1193 (-3.7A)
ADP  A1193 (-3.4A)
None
None
 1.10A 5eshA-2bfrA:
undetectable		 5eshA-2bfrA:
17.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HNW_B_TA1B902_1
(TUBULIN BETA-2B
CHAIN)		 2bfr HYPOTHETICAL PROTEIN
AF1521
(Archaeoglobus
fulgidus) 		5 / 12 VAL A 168
LEU A 157
PHE A 137
THR A 155
PRO A 123
 None
 1.13A 5hnwB-2bfrA:
undetectable		 5hnwB-2bfrA:
17.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HNY_B_TA1B601_1
(TUBULIN BETA-2B
CHAIN)		 2bfr HYPOTHETICAL PROTEIN
AF1521
(Archaeoglobus
fulgidus) 		5 / 12 VAL A 168
LEU A 157
PHE A 137
THR A 155
PRO A 123
 None
 1.15A 5hnyB-2bfrA:
undetectable		 5hnyB-2bfrA:
18.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HNZ_B_TA1B902_1
(TUBULIN BETA-2B
CHAIN)		 2bfr HYPOTHETICAL PROTEIN
AF1521
(Archaeoglobus
fulgidus) 		5 / 12 VAL A 168
LEU A 157
PHE A 137
THR A 155
PRO A 123
 None
 1.19A 5hnzB-2bfrA:
undetectable		 5hnzB-2bfrA:
16.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HWA_A_GCSA302_1
(CHITOSANASE)		 2bfr HYPOTHETICAL PROTEIN
AF1521
(Archaeoglobus
fulgidus) 		4 / 7 THR A  22
ASP A  20
TYR A 176
TYR A  45
 ADP  A1193 ( 4.9A)
ADP  A1193 (-3.5A)
ADP  A1193 (-4.0A)
None
 1.02A 5hwaA-2bfrA:
undetectable		 5hwaA-2bfrA:
19.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JLC_A_1YNA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 2bfr HYPOTHETICAL PROTEIN
AF1521
(Archaeoglobus
fulgidus) 		5 / 12 ALA A 127
ILE A 144
TYR A 145
GLY A  40
THR A  59
 None
ADP  A1193 (-3.7A)
ADP  A1193 (-3.4A)
None
None
 0.98A 5jlcA-2bfrA:
undetectable		 5jlcA-2bfrA:
18.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JNC_A_ACTA305_0
(CARBONIC ANHYDRASE 4)		 2bfr HYPOTHETICAL PROTEIN
AF1521
(Archaeoglobus
fulgidus) 		4 / 4 GLN A  69
VAL A  81
GLU A  79
ILE A  75
 None
 1.32A 5jncA-2bfrA:
0.0		 5jncA-2bfrA:
22.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OGC_B_TA1B601_1
(TUBULIN BETA CHAIN)		 2bfr HYPOTHETICAL PROTEIN
AF1521
(Archaeoglobus
fulgidus) 		5 / 12 VAL A 168
LEU A 157
PHE A 137
THR A 155
PRO A 123
 None
 1.17A 5ogcB-2bfrA:
undetectable		 5ogcB-2bfrA:
16.59