SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2bfw'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A29_A_TFPA153_1
(CALMODULIN)		 2bfw GLGA GLYCOGEN
SYNTHASE
(Pyrococcus
abyssi) 		5 / 8 GLU A 283
ILE A 354
LEU A 398
GLU A 392
ALA A 390
 None
 1.22A 1a29A-2bfwA:
undetectable		 1a29A-2bfwA:
22.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1D4S_A_TPVA201_2
(PROTEIN (HIV-1
PROTEASE))		 2bfw GLGA GLYCOGEN
SYNTHASE
(Pyrococcus
abyssi) 		4 / 8 LEU A 363
ALA A 377
GLY A 261
VAL A 360
 None
None
SO4  A1414 (-3.5A)
None
 0.73A 1d4sB-2bfwA:
undetectable		 1d4sB-2bfwA:
20.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_H_FUAH709_1
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 2bfw GLGA GLYCOGEN
SYNTHASE
(Pyrococcus
abyssi) 		5 / 12 PHE A 286
LEU A 303
PHE A 281
VAL A 310
ALA A 271
 None
 1.09A 1q23H-2bfwA:
undetectable
1q23I-2bfwA:
undetectable		 1q23H-2bfwA:
19.21
1q23I-2bfwA:
19.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_B_TFPB201_1
(PROTEIN S100-A4)		 2bfw GLGA GLYCOGEN
SYNTHASE
(Pyrococcus
abyssi) 		4 / 8 GLY A 308
ILE A 288
MET A 253
PHE A 331
 None
 0.95A 3ko0B-2bfwA:
undetectable
3ko0J-2bfwA:
undetectable		 3ko0B-2bfwA:
19.00
3ko0J-2bfwA:
19.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_K_TFPK201_1
(PROTEIN S100-A4)		 2bfw GLGA GLYCOGEN
SYNTHASE
(Pyrococcus
abyssi) 		4 / 8 GLY A 308
ILE A 288
MET A 253
PHE A 331
 None
 0.94A 3ko0K-2bfwA:
0.9
3ko0S-2bfwA:
undetectable		 3ko0K-2bfwA:
19.00
3ko0S-2bfwA:
19.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UA5_A_06XA501_1
(CYTOCHROME P450 2B6)		 2bfw GLGA GLYCOGEN
SYNTHASE
(Pyrococcus
abyssi) 		4 / 8 ILE A 255
ILE A 313
LEU A 240
VAL A 329
 None
 0.87A 3ua5A-2bfwA:
undetectable		 3ua5A-2bfwA:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A79_A_P1BA601_1
(AMINE OXIDASE
[FLAVIN-CONTAINING]
B)		 2bfw GLGA GLYCOGEN
SYNTHASE
(Pyrococcus
abyssi) 		5 / 12 LEU A 275
LEU A 268
ILE A 387
PHE A 254
TYR A 337
 None
 1.44A 4a79A-2bfwA:
undetectable		 4a79A-2bfwA:
16.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A79_B_P1BB601_1
(AMINE OXIDASE
[FLAVIN-CONTAINING]
B)		 2bfw GLGA GLYCOGEN
SYNTHASE
(Pyrococcus
abyssi) 		5 / 12 LEU A 275
LEU A 268
ILE A 387
PHE A 254
TYR A 337
 None
 1.38A 4a79B-2bfwA:
undetectable		 4a79B-2bfwA:
16.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A7A_A_RGZA601_1
(AMINE OXIDASE
[FLAVIN-CONTAINING]
B)		 2bfw GLGA GLYCOGEN
SYNTHASE
(Pyrococcus
abyssi) 		5 / 11 LEU A 275
LEU A 268
ILE A 387
PHE A 254
TYR A 337
 None
 1.43A 4a7aA-2bfwA:
undetectable		 4a7aA-2bfwA:
16.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XQE_A_AG2A506_1
(HOMOSPERMIDINE
SYNTHASE)		 2bfw GLGA GLYCOGEN
SYNTHASE
(Pyrococcus
abyssi) 		4 / 6 ARG A 395
ARG A 402
ASP A 234
ASP A 330
 None
 1.30A 4xqeA-2bfwA:
7.5		 4xqeA-2bfwA:
19.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XQE_A_AG2A506_1
(HOMOSPERMIDINE
SYNTHASE)		 2bfw GLGA GLYCOGEN
SYNTHASE
(Pyrococcus
abyssi) 		4 / 6 ARG A 402
ARG A 395
ASP A 330
ASP A 234
 None
 1.23A 4xqeA-2bfwA:
7.5		 4xqeA-2bfwA:
19.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XQE_B_AG2B505_1
(HOMOSPERMIDINE
SYNTHASE)		 2bfw GLGA GLYCOGEN
SYNTHASE
(Pyrococcus
abyssi) 		4 / 6 ARG A 395
ARG A 402
ASP A 234
ASP A 330
 None
 1.28A 4xqeB-2bfwA:
7.6		 4xqeB-2bfwA:
19.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XQE_B_AG2B505_1
(HOMOSPERMIDINE
SYNTHASE)		 2bfw GLGA GLYCOGEN
SYNTHASE
(Pyrococcus
abyssi) 		4 / 6 ARG A 402
ARG A 395
ASP A 330
ASP A 234
 None
 1.21A 4xqeB-2bfwA:
7.6		 4xqeB-2bfwA:
19.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XV2_B_P06B801_2
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 2bfw GLGA GLYCOGEN
SYNTHASE
(Pyrococcus
abyssi) 		4 / 4 GLY A 256
VAL A 265
PHE A 252
ILE A 333
 SO4  A1417 ( 2.6A)
None
None
None
 1.15A 4xv2B-2bfwA:
undetectable		 4xv2B-2bfwA:
24.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VYH_A_FOLA409_0
(S PROTEIN)		 2bfw GLGA GLYCOGEN
SYNTHASE
(Pyrococcus
abyssi) 		5 / 10 PRO A 340
ALA A 357
GLY A 372
THR A 371
ALA A 345
 None
 1.37A 5vyhA-2bfwA:
undetectable		 5vyhA-2bfwA:
18.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VYH_A_FOLA409_0
(S PROTEIN)		 2bfw GLGA GLYCOGEN
SYNTHASE
(Pyrococcus
abyssi) 		5 / 10 PRO A 380
ALA A 357
GLY A 372
ILE A 367
ALA A 359
 None
 1.34A 5vyhA-2bfwA:
undetectable		 5vyhA-2bfwA:
18.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y7P_E_CHDE401_0
(BILE SALT HYDROLASE)		 2bfw GLGA GLYCOGEN
SYNTHASE
(Pyrococcus
abyssi) 		4 / 8 ILE A 289
LEU A 325
LEU A 351
ALA A 353
 None
 0.86A 5y7pE-2bfwA:
undetectable		 5y7pE-2bfwA:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B89_B_NOVB403_1
(LIPOPOLYSACCHARIDE
EXPORT SYSTEM
ATP-BINDING PROTEIN
LPTB)		 2bfw GLGA GLYCOGEN
SYNTHASE
(Pyrococcus
abyssi) 		4 / 7 PHE A 258
ARG A 257
LEU A 296
ALA A 300
 None
ACT  A1500 ( 4.2A)
None
None
 1.29A 6b89A-2bfwA:
undetectable		 6b89A-2bfwA:
17.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FGD_A_ACTA819_0
(GEPHYRIN)		 2bfw GLGA GLYCOGEN
SYNTHASE
(Pyrococcus
abyssi) 		3 / 3 ARG A 285
GLY A 249
GLU A 248
 None
 0.57A 6fgdA-2bfwA:
2.0		 6fgdA-2bfwA:
19.28