SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2bg5'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VPT_A_SAMA400_0
(VP39)		 2bg5 PHOSPHOENOLPYRUVATE-
PROTEIN KINASE
(Caldanaerobacter
subterraneus) 		5 / 12 LEU A 406
TYR A 390
ILE A 428
GLY A 427
VAL A 446
 None
 0.96A 1vptA-2bg5A:
undetectable		 1vptA-2bg5A:
24.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZGY_A_BRLA503_2
(PEROXISOME
PROLIFERATOR
ACTIVATED RECEPTOR
GAMMA)		 2bg5 PHOSPHOENOLPYRUVATE-
PROTEIN KINASE
(Caldanaerobacter
subterraneus) 		4 / 5 ILE A 336
ILE A 377
ILE A 369
LEU A 294
 None
 0.88A 1zgyA-2bg5A:
undetectable		 1zgyA-2bg5A:
20.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZGY_A_BRLA503_2
(PEROXISOME
PROLIFERATOR
ACTIVATED RECEPTOR
GAMMA)		 2bg5 PHOSPHOENOLPYRUVATE-
PROTEIN KINASE
(Caldanaerobacter
subterraneus) 		4 / 5 ILE A 428
ILE A 481
ILE A 432
LEU A 520
 None
 0.89A 1zgyA-2bg5A:
undetectable		 1zgyA-2bg5A:
20.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QHF_A_ACTA503_0
(CHORISMATE SYNTHASE)		 2bg5 PHOSPHOENOLPYRUVATE-
PROTEIN KINASE
(Caldanaerobacter
subterraneus) 		4 / 5 THR A 372
ARG A 375
ALA A 376
ARG A 379
 None
 1.44A 2qhfA-2bg5A:
undetectable		 2qhfA-2bg5A:
24.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2R2V_C_ACTC36_0
(GCN4 LEUCINE ZIPPER)		 2bg5 PHOSPHOENOLPYRUVATE-
PROTEIN KINASE
(Caldanaerobacter
subterraneus) 		5 / 10 SER A 283
ALA A 527
ASN A 287
ALA A 289
ALA A 273
 None
 1.00A 2r2vC-2bg5A:
undetectable
2r2vF-2bg5A:
undetectable
2r2vG-2bg5A:
undetectable		 2r2vC-2bg5A:
9.00
2r2vF-2bg5A:
9.00
2r2vG-2bg5A:
9.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VUF_B_FUAB2002_1
(SERUM ALBUMIN)		 2bg5 PHOSPHOENOLPYRUVATE-
PROTEIN KINASE
(Caldanaerobacter
subterraneus) 		4 / 9 ILE A 428
ALA A 443
VAL A 446
LYS A 425
 None
 0.95A 2vufB-2bg5A:
undetectable		 2vufB-2bg5A:
21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S79_A_ASDA601_1
(CYTOCHROME P450 19A1)		 2bg5 PHOSPHOENOLPYRUVATE-
PROTEIN KINASE
(Caldanaerobacter
subterraneus) 		5 / 12 ILE A 377
ALA A 376
THR A 372
LEU A 345
LEU A 334
 None
 1.21A 3s79A-2bg5A:
undetectable		 3s79A-2bg5A:
21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUE_B_SUEB1201_1
(NS3 PROTEASE, NS4A
PROTEIN)		 2bg5 PHOSPHOENOLPYRUVATE-
PROTEIN KINASE
(Caldanaerobacter
subterraneus) 		5 / 12 GLY A 503
GLY A 293
SER A 524
ALA A 527
ALA A 284
 None
 1.12A 3sueB-2bg5A:
undetectable		 3sueB-2bg5A:
19.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QA0_A_SHHA404_2
(HISTONE DEACETYLASE
8)		 2bg5 PHOSPHOENOLPYRUVATE-
PROTEIN KINASE
(Caldanaerobacter
subterraneus) 		3 / 3 PRO A 348
MET A 347
TYR A 357
 None
 1.07A 4qa0B-2bg5A:
undetectable		 4qa0B-2bg5A:
22.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QA0_B_SHHB404_1
(HISTONE DEACETYLASE
8)		 2bg5 PHOSPHOENOLPYRUVATE-
PROTEIN KINASE
(Caldanaerobacter
subterraneus) 		3 / 3 PRO A 348
MET A 347
TYR A 357
 None
 1.07A 4qa0A-2bg5A:
undetectable		 4qa0A-2bg5A:
22.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JKV_A_ASDA602_1
(AROMATASE)		 2bg5 PHOSPHOENOLPYRUVATE-
PROTEIN KINASE
(Caldanaerobacter
subterraneus) 		5 / 12 ILE A 377
ALA A 376
THR A 372
LEU A 345
LEU A 334
 None
 1.20A 5jkvA-2bg5A:
undetectable		 5jkvA-2bg5A:
21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JSD_B_1GNB603_1
(PHIAB6 TAILSPIKE)		 2bg5 PHOSPHOENOLPYRUVATE-
PROTEIN KINASE
(Caldanaerobacter
subterraneus) 		3 / 3 VAL A 418
GLU A 315
GLU A 311
 None
 0.84A 5jsdB-2bg5A:
0.5
5jsdC-2bg5A:
undetectable		 5jsdB-2bg5A:
17.63
5jsdC-2bg5A:
17.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A5Z_D_9CRD501_0
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 2bg5 PHOSPHOENOLPYRUVATE-
PROTEIN KINASE
(Caldanaerobacter
subterraneus) 		5 / 12 ALA A 491
ILE A 451
ALA A 443
ILE A 481
LEU A 518
 None
 1.15A 6a5zD-2bg5A:
undetectable		 6a5zD-2bg5A:
14.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BXN_B_SAMB901_0
(DIPHTHAMIDE
BIOSYNTHESIS ENZYME
DPH2)		 2bg5 PHOSPHOENOLPYRUVATE-
PROTEIN KINASE
(Caldanaerobacter
subterraneus) 		5 / 12 LEU A 355
GLY A 356
SER A 395
ARG A 358
ILE A 360
 None
 1.38A 6bxnB-2bg5A:
undetectable		 6bxnB-2bg5A:
23.69