SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2bgh'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TT6_A_DESA129_1
(TRANSTHYRETIN)		 2bgh VINORINE SYNTHASE
(Rauvolfia
serpentina) 		4 / 4 LYS A 225
LEU A 229
LEU A 247
SER A 243
 None
 1.30A 1tt6A-2bghA:
undetectable		 1tt6A-2bghA:
16.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JST_A_HLTA101_1
(FOUR-ALPHA-HELIX
BUNDLE)		 2bgh VINORINE SYNTHASE
(Rauvolfia
serpentina) 		4 / 5 TRP A 253
ALA A 301
LEU A 348
ALA A 300
 None
 1.32A 2jstA-2bghA:
undetectable
2jstB-2bghA:
undetectable		 2jstA-2bghA:
11.65
2jstB-2bghA:
11.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VCV_D_ASDD1224_1
(GLUTATHIONE
S-TRANSFERASE A3)		 2bgh VINORINE SYNTHASE
(Rauvolfia
serpentina) 		5 / 9 PHE A 221
LEU A 348
LEU A 397
ALA A 395
PHE A 350
 None
 1.11A 2vcvD-2bghA:
undetectable		 2vcvD-2bghA:
20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VCV_E_ASDE1224_1
(GLUTATHIONE
S-TRANSFERASE A3)		 2bgh VINORINE SYNTHASE
(Rauvolfia
serpentina) 		5 / 9 PHE A 221
LEU A 348
LEU A 397
ALA A 395
PHE A 350
 None
 1.07A 2vcvE-2bghA:
undetectable		 2vcvE-2bghA:
20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VCV_F_ASDF1224_1
(GLUTATHIONE
S-TRANSFERASE A3)		 2bgh VINORINE SYNTHASE
(Rauvolfia
serpentina) 		4 / 8 PHE A 221
LEU A 397
ALA A 395
PHE A 350
 None
 0.90A 2vcvF-2bghA:
undetectable		 2vcvF-2bghA:
20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VCV_G_ASDG1224_1
(GLUTATHIONE
S-TRANSFERASE A3)		 2bgh VINORINE SYNTHASE
(Rauvolfia
serpentina) 		4 / 7 PHE A 221
LEU A 397
ALA A 395
PHE A 350
 None
 0.87A 2vcvG-2bghA:
undetectable		 2vcvG-2bghA:
20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X7H_A_PFNA1372_1
(ZINC-BINDING ALCOHOL
DEHYDROGENASE
DOMAIN-CONTAINING
PROTEIN 2)		 2bgh VINORINE SYNTHASE
(Rauvolfia
serpentina) 		5 / 11 LEU A  71
LEU A  67
LEU A  77
MET A 291
THR A 176
 None
 1.45A 2x7hA-2bghA:
0.0
2x7hB-2bghA:
0.0		 2x7hA-2bghA:
23.61
2x7hB-2bghA:
23.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CKZ_A_ZMRA469_2
(NEURAMINIDASE)		 2bgh VINORINE SYNTHASE
(Rauvolfia
serpentina) 		4 / 6 ARG A 195
ILE A 294
ARG A 279
SER A 167
 None
 1.39A 3ckzA-2bghA:
undetectable		 3ckzA-2bghA:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EIG_A_MTXA200_2
(DIHYDROFOLATE
REDUCTASE)		 2bgh VINORINE SYNTHASE
(Rauvolfia
serpentina) 		4 / 5 ASP A 303
ILE A 257
VAL A 272
THR A 319
 None
 1.21A 3eigA-2bghA:
undetectable		 3eigA-2bghA:
18.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OU7_B_SAMB300_1
(SAM-DEPENDENT
METHYLTRANSFERASE)		 2bgh VINORINE SYNTHASE
(Rauvolfia
serpentina) 		3 / 3 TYR A  75
ASP A  91
ASP A  88
 None
 0.95A 3ou7B-2bghA:
undetectable		 3ou7B-2bghA:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TGV_B_BEZB1_0
(HEME-BINDING PROTEIN
HUTZ)		 2bgh VINORINE SYNTHASE
(Rauvolfia
serpentina) 		4 / 6 GLN A 120
TYR A 121
PHE A  45
LEU A 105
 None
 1.26A 3tgvB-2bghA:
undetectable		 3tgvB-2bghA:
14.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TGV_D_BEZD1_0
(HEME-BINDING PROTEIN
HUTZ)		 2bgh VINORINE SYNTHASE
(Rauvolfia
serpentina) 		4 / 6 GLN A 120
TYR A 121
PHE A  45
LEU A 105
 None
 1.27A 3tgvD-2bghA:
undetectable		 3tgvD-2bghA:
14.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I3C_C_AC2C301_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE
DEOD-TYPE)		 2bgh VINORINE SYNTHASE
(Rauvolfia
serpentina) 		5 / 11 GLY A 392
ALA A 395
VAL A 393
GLU A 394
ILE A 226
 None
 1.15A 5i3cC-2bghA:
undetectable		 5i3cC-2bghA:
20.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TUD_D_ERMD1201_1
(5-HYDROXYTRYPTAMINE
RECEPTOR 2B,SOLUBLE
CYTOCHROME B562
CHIMERA)		 2bgh VINORINE SYNTHASE
(Rauvolfia
serpentina) 		5 / 12 ALA A 382
PHE A 219
VAL A 259
LEU A 412
VAL A 415
 None
 1.06A 5tudD-2bghA:
undetectable		 5tudD-2bghA:
22.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EXI_A_ADNA502_1
(ADENOSYLHOMOCYSTEINA
SE)		 2bgh VINORINE SYNTHASE
(Rauvolfia
serpentina) 		3 / 3 LEU A 332
ASN A 277
LEU A 298
 None
 0.64A 6exiA-2bghA:
undetectable		 6exiA-2bghA:
10.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6G9B_A_IXXA609_1
(ENVELOPE
GLYCOPROTEIN,ENVELOP
E GLYCOPROTEIN
ENVELOPE
GLYCOPROTEIN)		 2bgh VINORINE SYNTHASE
(Rauvolfia
serpentina) 		4 / 7 LEU A  71
VAL A 156
LEU A 140
LEU A 172
 None
 0.74A 6g9bA-2bghA:
undetectable
6g9bB-2bghA:
undetectable		 6g9bA-2bghA:
12.50
6g9bB-2bghA:
11.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6R2E_F_FFOF403_0
(THYMIDYLATE SYNTHASE)		 2bgh VINORINE SYNTHASE
(Rauvolfia
serpentina) 		5 / 11 ILE A  81
ASN A 135
GLY A  79
ASN A  90
ALA A 141
 None
 1.29A 6r2eF-2bghA:
undetectable		 6r2eF-2bghA:
19.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6R2E_H_FFOH403_0
(THYMIDYLATE SYNTHASE)		 2bgh VINORINE SYNTHASE
(Rauvolfia
serpentina) 		5 / 12 ILE A  81
ASN A 135
GLY A  79
ASN A  90
ALA A 141
 None
 1.30A 6r2eH-2bghA:
undetectable		 6r2eH-2bghA:
19.19