SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2bgk'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HXB_A_ROCA100_2
(HIV-1 PROTEASE)		 2bgk RHIZOME
SECOISOLARICIRESINOL
DEHYDROGENASE
(Podophyllum
peltatum) 		3 / 3 ARG A 138
THR A  86
VAL A  83
 None
 0.97A 1hxbA-2bgkA:
undetectable		 1hxbA-2bgkA:
14.45
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1UAY_A_ADNA1001_1
(TYPE II
3-HYDROXYACYL-COA
DEHYDROGENASE)		 2bgk RHIZOME
SECOISOLARICIRESINOL
DEHYDROGENASE
(Podophyllum
peltatum) 		6 / 11 GLY A  23
ALA A  25
ASP A  47
ASP A  72
VAL A  73
VAL A 102
 None
 0.54A 1uayA-2bgkA:
28.0		 1uayA-2bgkA:
30.10
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1UAY_B_ADNB1002_1
(TYPE II
3-HYDROXYACYL-COA
DEHYDROGENASE)		 2bgk RHIZOME
SECOISOLARICIRESINOL
DEHYDROGENASE
(Podophyllum
peltatum) 		6 / 10 GLY A  23
ALA A  25
ASP A  47
ASP A  72
VAL A  73
VAL A 102
 None
 0.50A 1uayB-2bgkA:
28.1		 1uayB-2bgkA:
30.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q64_B_1UNB1001_2
(PROTEASE RETROPEPSIN)		 2bgk RHIZOME
SECOISOLARICIRESINOL
DEHYDROGENASE
(Podophyllum
peltatum) 		3 / 3 ARG A 138
THR A  86
VAL A  83
 None
 0.92A 2q64A-2bgkA:
undetectable		 2q64A-2bgkA:
17.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QAK_A_1UNA1001_2
(PROTEASE RETROPEPSIN)		 2bgk RHIZOME
SECOISOLARICIRESINOL
DEHYDROGENASE
(Podophyllum
peltatum) 		3 / 3 ARG A 138
THR A  86
VAL A  83
 None
 0.94A 2qakA-2bgkA:
undetectable		 2qakA-2bgkA:
15.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YFX_A_VGHA9000_1
(TYROSINE-PROTEIN
KINASE RECEPTOR)		 2bgk RHIZOME
SECOISOLARICIRESINOL
DEHYDROGENASE
(Podophyllum
peltatum) 		5 / 8 ALA A  19
GLY A  40
LEU A  14
GLY A 245
ASP A 246
 None
 1.45A 2yfxA-2bgkA:
undetectable		 2yfxA-2bgkA:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AY0_A_ADNA401_1
(UNCHARACTERIZED
PROTEIN MJ0883)		 2bgk RHIZOME
SECOISOLARICIRESINOL
DEHYDROGENASE
(Podophyllum
peltatum) 		5 / 10 ASP A  47
ILE A  48
ALA A  25
ASP A  72
VAL A  73
 None
 1.02A 3ay0A-2bgkA:
6.9		 3ay0A-2bgkA:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AY0_B_ADNB402_1
(UNCHARACTERIZED
PROTEIN MJ0883)		 2bgk RHIZOME
SECOISOLARICIRESINOL
DEHYDROGENASE
(Podophyllum
peltatum) 		5 / 10 GLY A  24
ASP A  47
ILE A  48
ASP A  72
VAL A  73
 None
 1.03A 3ay0B-2bgkA:
7.0		 3ay0B-2bgkA:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3H0A_A_9RAA500_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 2bgk RHIZOME
SECOISOLARICIRESINOL
DEHYDROGENASE
(Podophyllum
peltatum) 		5 / 12 ALA A 136
ALA A 133
LEU A 181
ALA A 137
VAL A 240
 None
 0.99A 3h0aA-2bgkA:
undetectable		 3h0aA-2bgkA:
22.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QOW_A_SAMA417_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE)		 2bgk RHIZOME
SECOISOLARICIRESINOL
DEHYDROGENASE
(Podophyllum
peltatum) 		5 / 12 GLY A  27
GLU A  30
GLY A  23
ALA A  49
ASP A  72
 None
 1.30A 3qowA-2bgkA:
4.2		 3qowA-2bgkA:
21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T7V_A_SAMA992_0
(METHYLORNITHINE
SYNTHASE PYLB)		 2bgk RHIZOME
SECOISOLARICIRESINOL
DEHYDROGENASE
(Podophyllum
peltatum) 		5 / 12 THR A 151
GLY A  98
GLY A  23
VAL A 240
ALA A 241
 None
 1.12A 3t7vA-2bgkA:
3.3		 3t7vA-2bgkA:
21.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LBG_A_ADNA402_1
(PROBABLE SUGAR
KINASE PROTEIN)		 2bgk RHIZOME
SECOISOLARICIRESINOL
DEHYDROGENASE
(Podophyllum
peltatum) 		6 / 10 GLU A 184
ILE A 190
VAL A 192
ALA A 133
ALA A 136
ILE A 148
 None
 1.41A 4lbgA-2bgkA:
6.9		 4lbgA-2bgkA:
23.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LBG_B_ADNB402_1
(PROBABLE SUGAR
KINASE PROTEIN)		 2bgk RHIZOME
SECOISOLARICIRESINOL
DEHYDROGENASE
(Podophyllum
peltatum) 		6 / 9 GLU A 184
ILE A 190
VAL A 192
ALA A 133
ALA A 136
ILE A 148
 None
 1.41A 4lbgB-2bgkA:
7.1		 4lbgB-2bgkA:
23.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PGH_A_SAMA401_0
(CAFFEIC ACID
O-METHYLTRANSFERASE)		 2bgk RHIZOME
SECOISOLARICIRESINOL
DEHYDROGENASE
(Podophyllum
peltatum) 		5 / 11 GLY A  23
GLY A  24
THR A  32
ASP A  47
ASP A  72
 None
 1.10A 4pghA-2bgkA:
6.7		 4pghA-2bgkA:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RZV_A_032A801_2
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 2bgk RHIZOME
SECOISOLARICIRESINOL
DEHYDROGENASE
(Podophyllum
peltatum) 		4 / 5 ILE A  87
VAL A 139
PHE A 130
HIS A  90
 None
 1.35A 4rzvA-2bgkA:
undetectable		 4rzvA-2bgkA:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KC4_A_RBFA201_2
(RIBOFLAVIN
TRANSPORTER RIBU)		 2bgk RHIZOME
SECOISOLARICIRESINOL
DEHYDROGENASE
(Podophyllum
peltatum) 		3 / 3 LYS A 144
LEU A  93
ILE A 148
 None
 0.80A 5kc4A-2bgkA:
undetectable		 5kc4A-2bgkA:
23.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VLM_F_CVIF301_1
(REGULATORY PROTEIN
TETR)		 2bgk RHIZOME
SECOISOLARICIRESINOL
DEHYDROGENASE
(Podophyllum
peltatum) 		4 / 8 ILE A  28
TYR A 167
VAL A 195
ASP A 238
 None
 1.17A 5vlmF-2bgkA:
undetectable		 5vlmF-2bgkA:
22.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B6A_C_9F2C302_1
(BETA-LACTAMASE)		 2bgk RHIZOME
SECOISOLARICIRESINOL
DEHYDROGENASE
(Podophyllum
peltatum) 		5 / 9 THR A 170
ILE A 124
THR A 106
THR A 105
ASP A  47
 None
 1.21A 6b6aC-2bgkA:
undetectable
6b6aD-2bgkA:
undetectable		 6b6aC-2bgkA:
19.81
6b6aD-2bgkA:
19.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NJ9_K_SAMK500_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-79
SPECIFIC)		 2bgk RHIZOME
SECOISOLARICIRESINOL
DEHYDROGENASE
(Podophyllum
peltatum) 		5 / 12 GLY A  27
GLY A  24
ALA A  49
ASP A  72
PHE A  97
 None
 0.85A 6nj9K-2bgkA:
4.8		 6nj9K-2bgkA:
21.86