SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2bgs'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1S2A_A_IMNA2001_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C3)		 2bgs ALDOSE REDUCTASE
(Hordeum
vulgare) 		5 / 12 TRP A  90
HIS A 121
GLU A 190
TYR A 214
SER A 215
 None
BCT  A1322 ( 3.9A)
None
NDP  A1321 (-3.3A)
NDP  A1321 (-2.7A)
 0.26A 1s2aA-2bgsA:
39.7		 1s2aA-2bgsA:
33.97
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2INE_A_PACA317_0
(ALDOSE REDUCTASE)		 2bgs ALDOSE REDUCTASE
(Hordeum
vulgare) 		4 / 5 TRP A  32
TYR A  60
HIS A 121
TRP A 122
 BCT  A1322 ( 3.3A)
BCT  A1322 ( 4.4A)
BCT  A1322 ( 3.9A)
BCT  A1322 (-4.3A)
 0.25A 2ineA-2bgsA:
42.2		 2ineA-2bgsA:
38.39
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2ISF_A_PACA317_0
(ALDOSE REDUCTASE)		 2bgs ALDOSE REDUCTASE
(Hordeum
vulgare) 		4 / 5 TRP A  32
TYR A  60
HIS A 121
TRP A 122
 BCT  A1322 ( 3.3A)
BCT  A1322 ( 4.4A)
BCT  A1322 ( 3.9A)
BCT  A1322 (-4.3A)
 0.27A 2isfA-2bgsA:
42.0		 2isfA-2bgsA:
38.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EL4_A_ROCA100_2
(PROTEASE)		 2bgs ALDOSE REDUCTASE
(Hordeum
vulgare) 		5 / 9 ARG A 252
VAL A 272
ILE A 270
GLY A  28
ILE A 257
 None
None
None
None
NDP  A1321 (-4.4A)
 1.22A 3el4B-2bgsA:
undetectable		 3el4B-2bgsA:
15.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_B_TFPB201_1
(PROTEIN S100-A4)		 2bgs ALDOSE REDUCTASE
(Hordeum
vulgare) 		4 / 8 GLY A 146
ILE A  89
PHE A 301
PHE A 142
 None
 1.01A 3ko0B-2bgsA:
undetectable
3ko0J-2bgsA:
undetectable		 3ko0B-2bgsA:
14.50
3ko0J-2bgsA:
14.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3R43_A_ID8A332_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C3)		 2bgs ALDOSE REDUCTASE
(Hordeum
vulgare) 		5 / 12 TYR A  60
TRP A  90
HIS A 121
ASN A 167
TYR A 214
 BCT  A1322 ( 4.4A)
None
BCT  A1322 ( 3.9A)
NDP  A1321 (-3.3A)
NDP  A1321 (-3.3A)
 0.26A 3r43A-2bgsA:
39.9		 3r43A-2bgsA:
34.25
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3R6I_A_JMSA332_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C3)		 2bgs ALDOSE REDUCTASE
(Hordeum
vulgare) 		5 / 12 TYR A  60
TRP A  90
HIS A 121
ASN A 167
TYR A 214
 BCT  A1322 ( 4.4A)
None
BCT  A1322 ( 3.9A)
NDP  A1321 (-3.3A)
NDP  A1321 (-3.3A)
 0.23A 3r6iA-2bgsA:
39.8		 3r6iA-2bgsA:
34.25
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3RX3_A_SUZA317_1
(ALDOSE REDUCTASE)		 2bgs ALDOSE REDUCTASE
(Hordeum
vulgare) 		5 / 10 TRP A  32
TYR A  60
HIS A 121
TRP A 122
LEU A 300
 BCT  A1322 ( 3.3A)
BCT  A1322 ( 4.4A)
BCT  A1322 ( 3.9A)
BCT  A1322 (-4.3A)
None
 1.04A 3rx3A-2bgsA:
42.4		 3rx3A-2bgsA:
39.34
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3S3G_A_TLTA317_1
(ALDOSE REDUCTASE)		 2bgs ALDOSE REDUCTASE
(Hordeum
vulgare) 		4 / 7 TRP A  32
TYR A  60
HIS A 121
TRP A 122
 BCT  A1322 ( 3.3A)
BCT  A1322 ( 4.4A)
BCT  A1322 ( 3.9A)
BCT  A1322 (-4.3A)
 0.29A 3s3gA-2bgsA:
42.4		 3s3gA-2bgsA:
39.34
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3UG8_A_IMNA2001_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C3)		 2bgs ALDOSE REDUCTASE
(Hordeum
vulgare) 		5 / 12 TRP A  90
ASN A 167
TYR A 214
SER A 215
SER A 219
 None
NDP  A1321 (-3.3A)
NDP  A1321 (-3.3A)
NDP  A1321 (-2.7A)
NDP  A1321 (-2.7A)
 0.74A 3ug8A-2bgsA:
39.8		 3ug8A-2bgsA:
34.25
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3UG8_A_IMNA2001_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C3)		 2bgs ALDOSE REDUCTASE
(Hordeum
vulgare) 		6 / 12 TYR A  60
TRP A  90
HIS A 121
ASN A 167
TYR A 214
SER A 215
 BCT  A1322 ( 4.4A)
None
BCT  A1322 ( 3.9A)
NDP  A1321 (-3.3A)
NDP  A1321 (-3.3A)
NDP  A1321 (-2.7A)
 0.36A 3ug8A-2bgsA:
39.8		 3ug8A-2bgsA:
34.25
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3UGR_A_IMNA2001_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C3)		 2bgs ALDOSE REDUCTASE
(Hordeum
vulgare) 		5 / 12 TRP A  90
HIS A 121
TYR A 214
SER A 215
PHE A 301
 None
BCT  A1322 ( 3.9A)
NDP  A1321 (-3.3A)
NDP  A1321 (-2.7A)
None
 1.07A 3ugrA-2bgsA:
39.6		 3ugrA-2bgsA:
34.25
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3UGR_A_IMNA2001_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C3)		 2bgs ALDOSE REDUCTASE
(Hordeum
vulgare) 		5 / 12 TRP A  90
HIS A 121
TYR A 214
SER A 215
SER A 219
 None
BCT  A1322 ( 3.9A)
NDP  A1321 (-3.3A)
NDP  A1321 (-2.7A)
NDP  A1321 (-2.7A)
 0.75A 3ugrA-2bgsA:
39.6		 3ugrA-2bgsA:
34.25
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3V35_A_NTIA317_1
(ALDOSE REDUCTASE)		 2bgs ALDOSE REDUCTASE
(Hordeum
vulgare) 		4 / 8 TRP A  32
TRP A  90
HIS A 121
TRP A 122
 BCT  A1322 ( 3.3A)
None
BCT  A1322 ( 3.9A)
BCT  A1322 (-4.3A)
 0.29A 3v35A-2bgsA:
42.7		 3v35A-2bgsA:
39.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AN2_A_EUIA1382_1
(DUAL SPECIFICITY
MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE 1)		 2bgs ALDOSE REDUCTASE
(Hordeum
vulgare) 		6 / 12 LEU A 173
LEU A 176
ASP A 162
GLY A 164
VAL A 165
GLY A  21
 None
 1.45A 4an2A-2bgsA:
undetectable		 4an2A-2bgsA:
21.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C9N_A_CAMA1419_0
(CYTOCHROME P450)		 2bgs ALDOSE REDUCTASE
(Hordeum
vulgare) 		4 / 8 THR A  56
LEU A 112
LEU A 110
GLY A  67
 None
 0.80A 4c9nA-2bgsA:
undetectable		 4c9nA-2bgsA:
22.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FIA_A_0U9A601_1
(CHOLESTEROL
24-HYDROXYLASE)		 2bgs ALDOSE REDUCTASE
(Hordeum
vulgare) 		5 / 12 LEU A  83
VAL A  54
ALA A  45
GLU A  75
ALA A  73
 None
 1.23A 4fiaA-2bgsA:
undetectable		 4fiaA-2bgsA:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FIA_A_198A602_1
(CHOLESTEROL
24-HYDROXYLASE)		 2bgs ALDOSE REDUCTASE
(Hordeum
vulgare) 		5 / 12 LEU A  83
VAL A  54
ALA A  45
GLU A  75
ALA A  73
 None
 1.23A 4fiaA-2bgsA:
undetectable		 4fiaA-2bgsA:
21.14
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4JQ4_B_IMNB401_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C2)		 2bgs ALDOSE REDUCTASE
(Hordeum
vulgare) 		5 / 10 TYR A  60
HIS A 121
ASN A 167
TYR A 214
LEU A 295
 BCT  A1322 ( 4.4A)
BCT  A1322 ( 3.9A)
NDP  A1321 (-3.3A)
NDP  A1321 (-3.3A)
NDP  A1321 (-4.8A)
 0.68A 4jq4B-2bgsA:
39.8		 4jq4B-2bgsA:
32.97
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4JTR_A_IBPA401_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C2)		 2bgs ALDOSE REDUCTASE
(Hordeum
vulgare) 		4 / 8 TYR A  60
TRP A  90
HIS A 121
LEU A 295
 BCT  A1322 ( 4.4A)
None
BCT  A1322 ( 3.9A)
NDP  A1321 (-4.8A)
 0.70A 4jtrA-2bgsA:
40.0		 4jtrA-2bgsA:
32.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NJV_D_RITD500_1
(PROTEASE)		 2bgs ALDOSE REDUCTASE
(Hordeum
vulgare) 		6 / 11 ARG A 252
ASP A  14
VAL A 272
ILE A 270
GLY A  28
ILE A 257
 None
None
None
None
None
NDP  A1321 (-4.4A)
 1.33A 4njvC-2bgsA:
undetectable		 4njvC-2bgsA:
15.61
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4YVP_B_GBMB402_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C1)		 2bgs ALDOSE REDUCTASE
(Hordeum
vulgare) 		5 / 12 TYR A  60
TRP A  90
HIS A 121
ASN A 167
LEU A 295
 BCT  A1322 ( 4.4A)
None
BCT  A1322 ( 3.9A)
NDP  A1321 (-3.3A)
NDP  A1321 (-4.8A)
 0.55A 4yvpB-2bgsA:
40.2		 4yvpB-2bgsA:
34.59
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4YVV_A_GBMA402_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C3)		 2bgs ALDOSE REDUCTASE
(Hordeum
vulgare) 		5 / 9 TYR A  60
TRP A  90
HIS A 121
ASN A 167
TYR A 214
 BCT  A1322 ( 4.4A)
None
BCT  A1322 ( 3.9A)
NDP  A1321 (-3.3A)
NDP  A1321 (-3.3A)
 0.21A 4yvvA-2bgsA:
39.7		 4yvvA-2bgsA:
34.44
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4YVX_A_GMRA401_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C3)		 2bgs ALDOSE REDUCTASE
(Hordeum
vulgare) 		5 / 12 TYR A  60
TRP A  90
HIS A 121
LEU A 126
ASN A 167
 BCT  A1322 ( 4.4A)
None
BCT  A1322 ( 3.9A)
None
NDP  A1321 (-3.3A)
 0.22A 4yvxA-2bgsA:
39.5		 4yvxA-2bgsA:
34.44
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4YVX_B_GMRB401_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C3)		 2bgs ALDOSE REDUCTASE
(Hordeum
vulgare) 		5 / 12 TYR A  60
TRP A  90
HIS A 121
LEU A 126
ASN A 167
 BCT  A1322 ( 4.4A)
None
BCT  A1322 ( 3.9A)
None
NDP  A1321 (-3.3A)
 0.19A 4yvxB-2bgsA:
39.3		 4yvxB-2bgsA:
34.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5W97_C_CHDC306_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 2bgs ALDOSE REDUCTASE
(Hordeum
vulgare) 		4 / 6 LYS A  19
LEU A  18
PHE A  16
LEU A 117
 None
 1.11A 5w97C-2bgsA:
undetectable
5w97J-2bgsA:
undetectable		 5w97C-2bgsA:
21.71
5w97J-2bgsA:
9.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZNI_A_YMZA302_0
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 2bgs ALDOSE REDUCTASE
(Hordeum
vulgare) 		5 / 9 VAL A 186
GLY A  28
VAL A  27
GLY A  30
PRO A 258
 None
None
None
NDP  A1321 (-3.3A)
NDP  A1321 (-4.6A)
 1.39A 5zniA-2bgsA:
undetectable		 5zniA-2bgsA:
15.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DYO_A_LDPA901_0
(EBONY)		 2bgs ALDOSE REDUCTASE
(Hordeum
vulgare) 		4 / 5 GLU A 221
VAL A 294
LEU A 295
HIS A 121
 None
None
NDP  A1321 (-4.8A)
BCT  A1322 ( 3.9A)
 1.19A 6dyoA-2bgsA:
undetectable		 6dyoA-2bgsA:
15.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HUP_B_DZPB502_0
(GAMMA-AMINOBUTYRIC
ACID RECEPTOR
SUBUNIT
ALPHA-1,GAMMA-AMINOB
UTYRIC ACID RECEPTOR
SUBUNIT ALPHA-1
GAMMA-AMINOBUTYRIC
ACID RECEPTOR
SUBUNIT BETA-3)		 2bgs ALDOSE REDUCTASE
(Hordeum
vulgare) 		5 / 11 ILE A 163
LEU A 117
THR A  56
THR A 106
LEU A 159
 None
 1.09A 6hupA-2bgsA:
undetectable
6hupB-2bgsA:
undetectable		 6hupA-2bgsA:
12.98
6hupB-2bgsA:
13.11