SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2bht'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C4D_C_DVAC6_0
(GRAMICIDIN A)		 2bht CYSTEINE SYNTHASE B
(Escherichia
coli) 		3 / 3 ALA A 267
VAL A 274
TRP A  28
 None
 0.96A 1c4dC-2bhtA:
undetectable
1c4dD-2bhtA:
undetectable		 1c4dC-2bhtA:
3.10
1c4dD-2bhtA:
3.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q8J_B_C2FB802_0
(5-METHYLTETRAHYDROFO
LATE S-HOMOCYSTEINE
METHYLTRANSFERASE)		 2bht CYSTEINE SYNTHASE B
(Escherichia
coli) 		5 / 12 GLY A 253
ASP A  42
ILE A  79
GLY A  73
SER A  69
 None
None
None
None
PLP  A 320 ( 4.5A)
 1.01A 1q8jB-2bhtA:
undetectable		 1q8jB-2bhtA:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QCA_A_FUAA221_1
(TYPE III
CHLORAMPHENICOL
ACETYLTRANSFERASE)		 2bht CYSTEINE SYNTHASE B
(Escherichia
coli) 		4 / 7 THR A 175
PHE A 141
SER A 172
LEU A  76
 PLP  A 320 (-3.5A)
None
None
None
 0.86A 1qcaA-2bhtA:
undetectable		 1qcaA-2bhtA:
19.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SBR_A_VIBA502_1
(YKOF)		 2bht CYSTEINE SYNTHASE B
(Escherichia
coli) 		4 / 6 PHE A 169
ALA A 277
SER A 171
CYH A 252
 None
 1.03A 1sbrA-2bhtA:
undetectable
1sbrB-2bhtA:
undetectable		 1sbrA-2bhtA:
20.58
1sbrB-2bhtA:
20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
209D_C_DVAC8_0
(N8-ACTINOMYCIN D)		 2bht CYSTEINE SYNTHASE B
(Escherichia
coli) 		3 / 3 THR A 180
THR A 178
PRO A 147
 None
PLP  A 320 (-4.1A)
None
 0.88A 209dC-2bhtA:
undetectable		 209dC-2bhtA:
3.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DU8_A_BEZA352_0
(D-AMINO-ACID OXIDASE)		 2bht CYSTEINE SYNTHASE B
(Escherichia
coli) 		4 / 6 LEU A  64
TYR A  85
ILE A  49
GLY A  56
 None
 0.94A 2du8A-2bhtA:
undetectable		 2du8A-2bhtA:
23.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QD3_A_CHDA502_0
(FERROCHELATASE)		 2bht CYSTEINE SYNTHASE B
(Escherichia
coli) 		4 / 8 MET A  95
SER A 288
VAL A 254
GLY A 253
 None
 0.86A 2qd3A-2bhtA:
undetectable		 2qd3A-2bhtA:
22.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A50_B_VD3B2001_1
(VITAMIN D
HYDROXYLASE)		 2bht CYSTEINE SYNTHASE B
(Escherichia
coli) 		5 / 11 ILE A   8
LEU A  76
LEU A  46
ILE A  79
PRO A  36
 None
 1.22A 3a50B-2bhtA:
undetectable		 3a50B-2bhtA:
22.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUD_D_SUED1201_1
(NS3 PROTEASE, NS4A
PROTEIN)		 2bht CYSTEINE SYNTHASE B
(Escherichia
coli) 		5 / 12 GLY A  73
VAL A  40
ALA A 102
SER A 288
ASP A 284
 None
 1.01A 3sudD-2bhtA:
undetectable		 3sudD-2bhtA:
20.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T7V_A_SAMA992_0
(METHYLORNITHINE
SYNTHASE PYLB)		 2bht CYSTEINE SYNTHASE B
(Escherichia
coli) 		5 / 12 THR A 152
GLY A 181
GLY A 155
GLU A  32
ALA A  45
 None
 1.23A 3t7vA-2bhtA:
undetectable		 3t7vA-2bhtA:
22.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TKA_A_SAMA400_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE H)		 2bht CYSTEINE SYNTHASE B
(Escherichia
coli) 		5 / 12 THR A 153
GLY A 155
GLY A 181
HIS A 150
GLN A 161
 None
 1.35A 3tkaA-2bhtA:
2.5		 3tkaA-2bhtA:
23.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UAY_A_ADNA236_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE
DEOD-TYPE)		 2bht CYSTEINE SYNTHASE B
(Escherichia
coli) 		5 / 10 THR A 152
GLY A 155
VAL A 182
GLU A 184
ILE A 158
 None
 1.17A 3uayA-2bhtA:
undetectable		 3uayA-2bhtA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BB2_B_STRB1384_1
(CORTICOSTEROID-BINDI
NG GLOBULIN)		 2bht CYSTEINE SYNTHASE B
(Escherichia
coli) 		5 / 11 SER A 224
PHE A 169
ILE A 195
SER A 171
HIS A 150
 None
 1.44A 4bb2A-2bhtA:
0.9
4bb2B-2bhtA:
0.0		 4bb2A-2bhtA:
24.12
4bb2B-2bhtA:
8.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KIC_B_SAMB401_0
(METHYLTRANSFERASE
MPPJ)		 2bht CYSTEINE SYNTHASE B
(Escherichia
coli) 		5 / 12 ILE A 195
GLY A 177
ALA A  44
ARG A  43
MET A 173
 None
PLP  A 320 (-4.1A)
None
None
None
 1.13A 4kicB-2bhtA:
undetectable		 4kicB-2bhtA:
23.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M11_D_MXMD606_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 2bht CYSTEINE SYNTHASE B
(Escherichia
coli) 		5 / 12 MET A  19
ILE A 250
LEU A 244
VAL A 170
ALA A 277
 None
 1.46A 4m11D-2bhtA:
undetectable		 4m11D-2bhtA:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MK4_A_CHDA504_0
(FERROCHELATASE,
MITOCHONDRIAL)		 2bht CYSTEINE SYNTHASE B
(Escherichia
coli) 		4 / 8 MET A  95
SER A 288
VAL A 254
GLY A 253
 None
 0.90A 4mk4A-2bhtA:
undetectable		 4mk4A-2bhtA:
22.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RET_A_DGXA1107_2
(SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT ALPHA-1)		 2bht CYSTEINE SYNTHASE B
(Escherichia
coli) 		4 / 4 ASN A 270
VAL A 196
THR A 167
ILE A 166
 None
 1.27A 4retA-2bhtA:
2.0		 4retA-2bhtA:
15.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RET_C_DGXC2005_2
(SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT ALPHA-1)		 2bht CYSTEINE SYNTHASE B
(Escherichia
coli) 		4 / 4 ASN A 270
VAL A 196
THR A 167
ILE A 166
 None
 1.27A 4retC-2bhtA:
2.1		 4retC-2bhtA:
15.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V0V_A_8QPA613_1
(SERUM ALBUMIN)		 2bht CYSTEINE SYNTHASE B
(Escherichia
coli) 		4 / 8 ALA A 277
VAL A 170
THR A 167
GLY A 262
 None
 0.84A 5v0vA-2bhtA:
undetectable		 5v0vA-2bhtA:
19.46