SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2bhv'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DRE_A_MTXA161_1
(DIHYDROFOLATE
REDUCTASE)		 2bhv COMB10
(Helicobacter
pylori) 		5 / 12 ALA A 204
PHE A 362
SER A 216
ILE A 240
LEU A 250
 None
 1.28A 1dreA-2bhvA:
undetectable		 1dreA-2bhvA:
20.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E7A_B_PFLB4001_1
(SERUM ALBUMIN)		 2bhv COMB10
(Helicobacter
pylori) 		5 / 9 ILE A 354
LEU A 233
VAL A 194
GLY A 220
LEU A 182
 None
 1.19A 1e7aB-2bhvA:
undetectable		 1e7aB-2bhvA:
18.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E7B_A_HLTA4003_1
(SERUM ALBUMIN)		 2bhv COMB10
(Helicobacter
pylori) 		5 / 9 LEU A 233
VAL A 194
GLY A 220
ALA A 196
LEU A 182
 None
 0.89A 1e7bA-2bhvA:
undetectable		 1e7bA-2bhvA:
18.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Z9H_A_IMNA379_1
(MEMBRANE-ASSOCIATED
PROSTAGLANDIN E
SYNTHASE-2)		 2bhv COMB10
(Helicobacter
pylori) 		5 / 12 THR A 284
PRO A 356
VAL A 194
ILE A 354
LEU A 182
 None
 1.30A 1z9hA-2bhvA:
undetectable		 1z9hA-2bhvA:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Z9H_B_IMNB381_1
(MEMBRANE-ASSOCIATED
PROSTAGLANDIN E
SYNTHASE-2)		 2bhv COMB10
(Helicobacter
pylori) 		5 / 12 THR A 284
PRO A 356
VAL A 194
ILE A 354
LEU A 182
 None
 1.30A 1z9hB-2bhvA:
undetectable		 1z9hB-2bhvA:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Z9H_C_IMNC379_1
(MEMBRANE-ASSOCIATED
PROSTAGLANDIN E
SYNTHASE-2)		 2bhv COMB10
(Helicobacter
pylori) 		5 / 12 THR A 284
PRO A 356
VAL A 194
ILE A 354
LEU A 182
 None
 1.31A 1z9hC-2bhvA:
undetectable		 1z9hC-2bhvA:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ASN_W_CHDW1059_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1)		 2bhv COMB10
(Helicobacter
pylori) 		4 / 8 ILE A 212
PHE A 362
ARG A 239
LEU A 282
 None
 0.94A 3asnN-2bhvA:
undetectable
3asnW-2bhvA:
undetectable		 3asnN-2bhvA:
19.84
3asnW-2bhvA:
12.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ASO_W_CHDW1059_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1)		 2bhv COMB10
(Helicobacter
pylori) 		4 / 8 ILE A 212
PHE A 362
ARG A 239
LEU A 282
 None
 0.91A 3asoN-2bhvA:
undetectable
3asoW-2bhvA:
undetectable		 3asoN-2bhvA:
19.84
3asoW-2bhvA:
12.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E1V_C_URFC1301_1
(URIDINE
PHOSPHORYLASE)		 2bhv COMB10
(Helicobacter
pylori) 		4 / 8 THR A 242
ARG A 170
VAL A 370
PRO A 365
 None
 0.97A 4e1vC-2bhvA:
undetectable		 4e1vC-2bhvA:
22.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E1V_D_URFD1301_1
(URIDINE
PHOSPHORYLASE)		 2bhv COMB10
(Helicobacter
pylori) 		4 / 8 THR A 242
ARG A 170
VAL A 370
PRO A 365
 None
 0.95A 4e1vD-2bhvA:
undetectable		 4e1vD-2bhvA:
22.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E1V_G_URFG1301_1
(URIDINE
PHOSPHORYLASE)		 2bhv COMB10
(Helicobacter
pylori) 		4 / 8 THR A 242
ARG A 170
VAL A 370
PRO A 365
 None
 1.00A 4e1vG-2bhvA:
undetectable		 4e1vG-2bhvA:
22.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E1V_H_URFH1301_1
(URIDINE
PHOSPHORYLASE)		 2bhv COMB10
(Helicobacter
pylori) 		4 / 8 THR A 242
ARG A 170
VAL A 370
PRO A 365
 None
 0.95A 4e1vH-2bhvA:
undetectable		 4e1vH-2bhvA:
22.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IY5_W_CHDW101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 2bhv COMB10
(Helicobacter
pylori) 		4 / 7 ILE A 212
PHE A 362
ARG A 239
LEU A 282
 None
 0.90A 5iy5N-2bhvA:
undetectable
5iy5W-2bhvA:
undetectable		 5iy5N-2bhvA:
19.84
5iy5W-2bhvA:
12.20