SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2bi0'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EKJ_A_ACTA3001_0
(BETA-CARBONIC
ANHYDRASE)		 2bi0 HYPOTHETICAL PROTEIN
RV0216
(Mycobacterium
tuberculosis) 		4 / 8 HIS A 237
GLY A 250
GLY A 251
TYR A  94
 None
 0.86A 1ekjA-2bi0A:
undetectable
1ekjB-2bi0A:
undetectable		 1ekjA-2bi0A:
22.29
1ekjB-2bi0A:
22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EKJ_E_ACTE3005_0
(BETA-CARBONIC
ANHYDRASE)		 2bi0 HYPOTHETICAL PROTEIN
RV0216
(Mycobacterium
tuberculosis) 		4 / 7 HIS A 237
GLY A 250
GLY A 251
TYR A  94
 None
 0.76A 1ekjE-2bi0A:
undetectable
1ekjF-2bi0A:
undetectable		 1ekjE-2bi0A:
22.29
1ekjF-2bi0A:
22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EKJ_G_ACTG3002_0
(BETA-CARBONIC
ANHYDRASE)		 2bi0 HYPOTHETICAL PROTEIN
RV0216
(Mycobacterium
tuberculosis) 		4 / 8 HIS A 237
GLY A 250
GLY A 251
TYR A  94
 None
 0.77A 1ekjG-2bi0A:
undetectable
1ekjH-2bi0A:
undetectable		 1ekjG-2bi0A:
22.29
1ekjH-2bi0A:
22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HBP_A_RTLA184_0
(RETINOL BINDING
PROTEIN)		 2bi0 HYPOTHETICAL PROTEIN
RV0216
(Mycobacterium
tuberculosis) 		5 / 11 ALA A  90
ALA A 154
VAL A 116
LEU A 172
HIS A 279
 None
 1.36A 1hbpA-2bi0A:
0.3		 1hbpA-2bi0A:
19.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JFF_B_TA1B601_1
(TUBULIN BETA CHAIN)		 2bi0 HYPOTHETICAL PROTEIN
RV0216
(Mycobacterium
tuberculosis) 		5 / 12 LEU A 109
LEU A  32
THR A  31
ARG A 142
PRO A  64
 None
 1.16A 1jffB-2bi0A:
undetectable		 1jffB-2bi0A:
20.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MX1_A_THAA1_1
(LIVER
CARBOXYLESTERASE I)		 2bi0 HYPOTHETICAL PROTEIN
RV0216
(Mycobacterium
tuberculosis) 		5 / 11 LEU A 226
GLY A 251
GLY A 250
VAL A 327
LEU A 328
 None
 1.14A 1mx1A-2bi0A:
undetectable		 1mx1A-2bi0A:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MZ9_D_VDYD1001_5
(CARTILAGE OLIGOMERIC
MATRIX PROTEIN)		 2bi0 HYPOTHETICAL PROTEIN
RV0216
(Mycobacterium
tuberculosis) 		3 / 3 THR A 270
LEU A 335
VAL A 306
 None
 0.46A 1mz9E-2bi0A:
undetectable		 1mz9E-2bi0A:
6.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RMT_C_ADNC1503_1
(CLASS B ACID
PHOSPHATASE)		 2bi0 HYPOTHETICAL PROTEIN
RV0216
(Mycobacterium
tuberculosis) 		4 / 8 PHE A 150
GLY A  79
ASP A  75
TYR A  94
 None
 0.87A 1rmtC-2bi0A:
undetectable		 1rmtC-2bi0A:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HXF_B_TA1B601_1
(TUBULIN BETA CHAIN)		 2bi0 HYPOTHETICAL PROTEIN
RV0216
(Mycobacterium
tuberculosis) 		5 / 12 LEU A 109
LEU A  32
THR A  31
ARG A 142
PRO A  64
 None
 1.16A 2hxfB-2bi0A:
undetectable		 2hxfB-2bi0A:
20.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HXH_B_TA1B601_1
(TUBULIN BETA CHAIN)		 2bi0 HYPOTHETICAL PROTEIN
RV0216
(Mycobacterium
tuberculosis) 		5 / 12 LEU A 109
LEU A  32
THR A  31
ARG A 142
PRO A  64
 None
 1.16A 2hxhB-2bi0A:
undetectable		 2hxhB-2bi0A:
20.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2P4N_B_TA1B601_1
(TUBULIN BETA CHAIN)		 2bi0 HYPOTHETICAL PROTEIN
RV0216
(Mycobacterium
tuberculosis) 		5 / 12 LEU A 109
LEU A  32
THR A  31
ARG A 142
PRO A  64
 None
 1.15A 2p4nB-2bi0A:
undetectable		 2p4nB-2bi0A:
20.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WBE_B_TA1B1439_1
(TUBULIN BETA-2B
CHAIN)		 2bi0 HYPOTHETICAL PROTEIN
RV0216
(Mycobacterium
tuberculosis) 		5 / 12 LEU A 109
LEU A  32
THR A  31
ARG A 142
PRO A  64
 None
 1.16A 2wbeB-2bi0A:
undetectable		 2wbeB-2bi0A:
20.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AQI_A_CHDA3_0
(FERROCHELATASE)		 2bi0 HYPOTHETICAL PROTEIN
RV0216
(Mycobacterium
tuberculosis) 		3 / 3 PRO A 282
LEU A 247
ARG A 246
 None
 0.63A 3aqiA-2bi0A:
undetectable		 3aqiA-2bi0A:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DCO_B_TA1B601_1
(BOVINE BETA TUBULIN)		 2bi0 HYPOTHETICAL PROTEIN
RV0216
(Mycobacterium
tuberculosis) 		5 / 12 LEU A 109
LEU A  32
THR A  31
ARG A 142
PRO A  64
 None
 1.16A 3dcoB-2bi0A:
undetectable		 3dcoB-2bi0A:
20.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EDL_B_TA1B601_1
(BETA TUBULIN)		 2bi0 HYPOTHETICAL PROTEIN
RV0216
(Mycobacterium
tuberculosis) 		5 / 12 LEU A 109
LEU A  32
THR A  31
ARG A 142
PRO A  64
 None
 1.17A 3edlB-2bi0A:
undetectable		 3edlB-2bi0A:
20.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G4L_A_ROFA901_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		 2bi0 HYPOTHETICAL PROTEIN
RV0216
(Mycobacterium
tuberculosis) 		3 / 3 ASP A 329
LEU A 328
GLN A 260
 None
 0.80A 3g4lA-2bi0A:
undetectable		 3g4lA-2bi0A:
21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GP0_A_NILA1_2
(MITOGEN-ACTIVATED
PROTEIN KINASE 11)		 2bi0 HYPOTHETICAL PROTEIN
RV0216
(Mycobacterium
tuberculosis) 		4 / 7 ARG A 152
VAL A  44
LEU A 328
ILE A  43
 None
 0.86A 3gp0A-2bi0A:
undetectable		 3gp0A-2bi0A:
22.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IZ0_B_TA1B820_1
(BETA TUBULIN, CHAIN
B FROM PDB 1JFF)		 2bi0 HYPOTHETICAL PROTEIN
RV0216
(Mycobacterium
tuberculosis) 		5 / 12 LEU A 109
LEU A  32
THR A  31
ARG A 142
PRO A  64
 None
 1.11A 3iz0B-2bi0A:
undetectable		 3iz0B-2bi0A:
20.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3Q1E_D_T44D328_1
(5-HYDROXYISOURATE
HYDROLASE)		 2bi0 HYPOTHETICAL PROTEIN
RV0216
(Mycobacterium
tuberculosis) 		5 / 9 LEU A  67
LEU A  50
THR A 187
LEU A 272
LEU A 335
 None
 1.34A 3q1eB-2bi0A:
undetectable
3q1eD-2bi0A:
undetectable		 3q1eB-2bi0A:
15.02
3q1eD-2bi0A:
15.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ROX_A_TEPA266_1
(APOLIPOPROTEIN
A-I-BINDING PROTEIN)		 2bi0 HYPOTHETICAL PROTEIN
RV0216
(Mycobacterium
tuberculosis) 		5 / 8 ALA A  77
VAL A  73
ASP A  75
LEU A  72
LEU A 231
 None
 1.48A 3roxA-2bi0A:
undetectable		 3roxA-2bi0A:
22.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FN9_B_STRB301_1
(STEROID RECEPTOR 2)		 2bi0 HYPOTHETICAL PROTEIN
RV0216
(Mycobacterium
tuberculosis) 		5 / 12 LEU A  52
LEU A  48
LEU A 268
ALA A 269
TRP A 190
 None
 1.28A 4fn9B-2bi0A:
undetectable		 4fn9B-2bi0A:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z2E_F_TR6F101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
SYMMETRIZED E-SITE
DNA)		 2bi0 HYPOTHETICAL PROTEIN
RV0216
(Mycobacterium
tuberculosis) 		4 / 5 GLY A 176
ARG A  95
GLY A  96
GLU A 275
 None
 1.00A 4z2eB-2bi0A:
undetectable
4z2eC-2bi0A:
undetectable		 4z2eB-2bi0A:
22.00
4z2eC-2bi0A:
21.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4F_A_IPHA903_0
(PROTEIN ARGONAUTE-2)		 2bi0 HYPOTHETICAL PROTEIN
RV0216
(Mycobacterium
tuberculosis) 		4 / 4 VAL A 271
ALA A 269
PHE A 102
THR A 187
 None
 1.19A 4z4fA-2bi0A:
0.0		 4z4fA-2bi0A:
18.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4H_A_IPHA903_0
(PROTEIN ARGONAUTE-2)		 2bi0 HYPOTHETICAL PROTEIN
RV0216
(Mycobacterium
tuberculosis) 		4 / 4 VAL A 271
ALA A 269
PHE A 102
THR A 187
 None
 1.18A 4z4hA-2bi0A:
undetectable		 4z4hA-2bi0A:
18.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BTI_E_LFXE101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
DNA SUBSTRATE 24-MER
GGTCATGAATGACTATGCAC
GTAA)		 2bi0 HYPOTHETICAL PROTEIN
RV0216
(Mycobacterium
tuberculosis) 		4 / 5 SER A  81
ARG A  95
GLY A  96
GLU A 275
 None
 1.21A 5btiA-2bi0A:
undetectable
5btiB-2bi0A:
undetectable		 5btiA-2bi0A:
21.12
5btiB-2bi0A:
21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5G48_B_1FLB1375_1
(DNA POLYMERASE III
SUBUNIT BETA)		 2bi0 HYPOTHETICAL PROTEIN
RV0216
(Mycobacterium
tuberculosis) 		5 / 9 LEU A 109
THR A 139
LEU A 148
PRO A 103
LEU A  97
 None
 1.34A 5g48B-2bi0A:
undetectable		 5g48B-2bi0A:
20.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5GWY_E_010E6_0
(N-[(5-METHYLISOXAZOL
-3-YL)CARBONYL]ALANY
L-L-VALYL-N~1~-((1R,
2Z)-4-(BENZYLOXY)-4-
OXO-1-{[(3R)-2-OXOPY
RROLIDIN-3-YL]METHYL
}BUT-2-ENYL)-L-LEUCI
NAMIDE
MAIN PROTEASE)		 2bi0 HYPOTHETICAL PROTEIN
RV0216
(Mycobacterium
tuberculosis) 		4 / 4 THR A 262
LEU A 258
HIS A  69
GLY A 255
 None
 1.28A 5gwyA-2bi0A:
undetectable		 5gwyA-2bi0A:
22.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HNW_B_TA1B902_1
(TUBULIN BETA-2B
CHAIN)		 2bi0 HYPOTHETICAL PROTEIN
RV0216
(Mycobacterium
tuberculosis) 		5 / 12 LEU A 109
LEU A  32
THR A  31
ARG A 142
PRO A  64
 None
 1.17A 5hnwB-2bi0A:
undetectable		 5hnwB-2bi0A:
20.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HNY_B_TA1B601_1
(TUBULIN BETA-2B
CHAIN)		 2bi0 HYPOTHETICAL PROTEIN
RV0216
(Mycobacterium
tuberculosis) 		5 / 12 LEU A 109
LEU A  32
THR A  31
ARG A 142
PRO A  64
 None
 1.11A 5hnyB-2bi0A:
undetectable		 5hnyB-2bi0A:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KKZ_E_ASCE1004_0
(CYTOCHROME B
UBIQUINOL-CYTOCHROME
C REDUCTASE
IRON-SULFUR SUBUNIT)		 2bi0 HYPOTHETICAL PROTEIN
RV0216
(Mycobacterium
tuberculosis) 		4 / 7 HIS A 279
HIS A 252
ILE A 254
TYR A  94
 None
 1.26A 5kkzC-2bi0A:
undetectable
5kkzE-2bi0A:
undetectable		 5kkzC-2bi0A:
20.32
5kkzE-2bi0A:
22.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KKZ_K_ASCK1004_0
(CYTOCHROME B
UBIQUINOL-CYTOCHROME
C REDUCTASE
IRON-SULFUR SUBUNIT)		 2bi0 HYPOTHETICAL PROTEIN
RV0216
(Mycobacterium
tuberculosis) 		4 / 7 HIS A 252
ILE A 254
TYR A  94
HIS A 279
 None
 1.24A 5kkzK-2bi0A:
undetectable
5kkzQ-2bi0A:
undetectable		 5kkzK-2bi0A:
22.80
5kkzQ-2bi0A:
20.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5T7B_A_IPHA901_0
(PROTEIN ARGONAUTE-2)		 2bi0 HYPOTHETICAL PROTEIN
RV0216
(Mycobacterium
tuberculosis) 		4 / 6 VAL A 271
ALA A 269
PHE A 102
THR A 187
 None
 1.14A 5t7bA-2bi0A:
undetectable		 5t7bA-2bi0A:
18.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UHG_C_RFPC1201_1
(DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA)		 2bi0 HYPOTHETICAL PROTEIN
RV0216
(Mycobacterium
tuberculosis) 		5 / 12 ASP A 149
ARG A 174
ILE A 175
ARG A 136
HIS A 100
 None
 1.13A 5uhgC-2bi0A:
0.6		 5uhgC-2bi0A:
15.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VYH_A_FOLA409_0
(S PROTEIN)		 2bi0 HYPOTHETICAL PROTEIN
RV0216
(Mycobacterium
tuberculosis) 		5 / 10 PRO A 282
HIS A 284
GLY A  79
THR A 230
ILE A  78
 None
 1.12A 5vyhA-2bi0A:
undetectable		 5vyhA-2bi0A:
23.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DJZ_B_GMJB301_0
(SIGMA NON-OPIOID
INTRACELLULAR
RECEPTOR 1)		 2bi0 HYPOTHETICAL PROTEIN
RV0216
(Mycobacterium
tuberculosis) 		5 / 12 ILE A  78
THR A  85
VAL A  88
THR A 230
LEU A 229
 None
 1.34A 6djzB-2bi0A:
undetectable		 6djzB-2bi0A:
21.69