SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2bi3'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BTE_A_LEUA1894_0
(AMINOACYL-TRNA
SYNTHETASE)		 2bi3 PHOSPHOSERINE
AMINOTRANSFERASE
(Bacillus
alcalophilus) 		4 / 8 TYR A 158
SER A 103
TYR A 191
HIS A 146
 None
 1.12A 2bteA-2bi3A:
undetectable		 2bteA-2bi3A:
17.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NNI_A_MTKA501_2
(CYTOCHROME P450 2C8)		 2bi3 PHOSPHOSERINE
AMINOTRANSFERASE
(Bacillus
alcalophilus) 		5 / 8 ILE A 273
ILE A 274
ARG A 334
ILE A 343
VAL A 299
 None
None
CL  A1365 (-3.4A)
None
None
 1.41A 2nniA-2bi3A:
undetectable		 2nniA-2bi3A:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OIQ_A_STIA1001_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 2bi3 PHOSPHOSERINE
AMINOTRANSFERASE
(Bacillus
alcalophilus) 		4 / 5 LEU A  39
VAL A 205
LEU A 198
ARG A  58
 None
 1.12A 2oiqA-2bi3A:
undetectable		 2oiqA-2bi3A:
19.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VCV_F_ASDF1224_1
(GLUTATHIONE
S-TRANSFERASE A3)		 2bi3 PHOSPHOSERINE
AMINOTRANSFERASE
(Bacillus
alcalophilus) 		4 / 8 LEU A 198
ALA A 340
LEU A  14
ALA A  18
 None
 0.88A 2vcvF-2bi3A:
undetectable		 2vcvF-2bi3A:
23.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZB7_A_NCAA901_0
(PROSTAGLANDIN
REDUCTASE 2)		 2bi3 PHOSPHOSERINE
AMINOTRANSFERASE
(Bacillus
alcalophilus) 		4 / 5 TYR A 144
ILE A 170
LEU A 212
LEU A 213
 None
 1.12A 2zb7A-2bi3A:
undetectable		 2zb7A-2bi3A:
21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EEO_A_SAMA328_1
(MODIFICATION
METHYLASE HHAI)		 2bi3 PHOSPHOSERINE
AMINOTRANSFERASE
(Bacillus
alcalophilus) 		3 / 3 GLU A 104
SER A 329
VAL A 330
 PEG  A1368 (-3.5A)
None
None
 0.79A 3eeoA-2bi3A:
undetectable		 3eeoA-2bi3A:
21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3H52_A_486A3_1
(GLUCOCORTICOID
RECEPTOR)		 2bi3 PHOSPHOSERINE
AMINOTRANSFERASE
(Bacillus
alcalophilus) 		5 / 12 LEU A 324
ASN A 325
GLY A 326
VAL A 330
LEU A 303
 None
 1.40A 3h52A-2bi3A:
undetectable		 3h52A-2bi3A:
22.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KP6_A_SALA3005_1
(TRANSCRIPTIONAL
REGULATOR TCAR)		 2bi3 PHOSPHOSERINE
AMINOTRANSFERASE
(Bacillus
alcalophilus) 		4 / 8 ASN A  95
LEU A 169
ALA A 167
HIS A 166
 None
 1.02A 3kp6A-2bi3A:
undetectable		 3kp6A-2bi3A:
20.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MTE_B_SAMB220_0
(16S RRNA METHYLASE)		 2bi3 PHOSPHOSERINE
AMINOTRANSFERASE
(Bacillus
alcalophilus) 		5 / 12 GLY A 326
GLY A 331
ASN A 309
ALA A   9
THR A 152
 None
None
None
None
PLP  A1361 (-2.7A)
 1.05A 3mteB-2bi3A:
undetectable		 3mteB-2bi3A:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OKX_B_SAMB201_0
(YAEB-LIKE PROTEIN
RPA0152)		 2bi3 PHOSPHOSERINE
AMINOTRANSFERASE
(Bacillus
alcalophilus) 		3 / 3 LYS A 357
ARG A 304
LYS A 291
 None
None
1PE  A1366 ( 2.4A)
 1.39A 3okxA-2bi3A:
undetectable		 3okxA-2bi3A:
16.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P2K_A_SAMA6735_0
(16S RRNA METHYLASE)		 2bi3 PHOSPHOSERINE
AMINOTRANSFERASE
(Bacillus
alcalophilus) 		5 / 12 GLY A 326
GLY A 331
ASN A 309
ALA A   9
THR A 152
 None
None
None
None
PLP  A1361 (-2.7A)
 1.03A 3p2kA-2bi3A:
undetectable		 3p2kA-2bi3A:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P2K_B_SAMB6735_0
(16S RRNA METHYLASE)		 2bi3 PHOSPHOSERINE
AMINOTRANSFERASE
(Bacillus
alcalophilus) 		5 / 12 GLY A 326
GLY A 331
ASN A 309
ALA A   9
THR A 152
 None
None
None
None
PLP  A1361 (-2.7A)
 1.04A 3p2kB-2bi3A:
undetectable		 3p2kB-2bi3A:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S8P_B_SAMB500_1
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SUV420H1)		 2bi3 PHOSPHOSERINE
AMINOTRANSFERASE
(Bacillus
alcalophilus) 		3 / 3 HIS A 146
SER A 121
ASN A 151
 None
 0.77A 3s8pB-2bi3A:
undetectable		 3s8pB-2bi3A:
20.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TWP_D_SALD404_1
(ANTHRANILATE
PHOSPHORIBOSYLTRANSF
ERASE)		 2bi3 PHOSPHOSERINE
AMINOTRANSFERASE
(Bacillus
alcalophilus) 		4 / 5 ASN A   6
ALA A  13
TYR A 338
ALA A   9
 None
 1.37A 3twpD-2bi3A:
undetectable		 3twpD-2bi3A:
21.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ARC_A_LEUA1001_0
(LEUCINE--TRNA LIGASE)		 2bi3 PHOSPHOSERINE
AMINOTRANSFERASE
(Bacillus
alcalophilus) 		4 / 7 TYR A 158
SER A 103
TYR A 191
HIS A 146
 None
 1.11A 4arcA-2bi3A:
undetectable		 4arcA-2bi3A:
17.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PST_A_FOLA201_1
(DIHYDROFOLATE
REDUCTASE)		 2bi3 PHOSPHOSERINE
AMINOTRANSFERASE
(Bacillus
alcalophilus) 		3 / 3 ILE A 177
ASP A 172
ARG A 180
 None
PLP  A1361 (-2.9A)
None
 0.77A 4pstA-2bi3A:
undetectable		 4pstA-2bi3A:
17.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CPR_B_SAMB402_1
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SUV420H1)		 2bi3 PHOSPHOSERINE
AMINOTRANSFERASE
(Bacillus
alcalophilus) 		3 / 3 HIS A 146
SER A 121
ASN A 151
 None
 0.79A 5cprB-2bi3A:
undetectable		 5cprB-2bi3A:
20.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_2_BEZ2801_0
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 1
BEZ-LEU-LEU)		 2bi3 PHOSPHOSERINE
AMINOTRANSFERASE
(Bacillus
alcalophilus) 		4 / 4 LEU A  70
ARG A  58
ILE A  69
ILE A  63
 None
 0.84A 5dzk2-2bi3A:
undetectable
5dzkM-2bi3A:
undetectable
5dzkN-2bi3A:
undetectable		 5dzk2-2bi3A:
7.41
5dzkM-2bi3A:
20.27
5dzkN-2bi3A:
20.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_4_BEZ4801_0
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 1
ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 2
BEZ-LEU-LEU)		 2bi3 PHOSPHOSERINE
AMINOTRANSFERASE
(Bacillus
alcalophilus) 		4 / 5 LEU A  70
ARG A  58
ILE A  69
ILE A  63
 None
 0.96A 5dzk4-2bi3A:
undetectable
5dzkg-2bi3A:
undetectable
5dzkm-2bi3A:
undetectable
5dzkn-2bi3A:
undetectable		 5dzk4-2bi3A:
7.41
5dzkg-2bi3A:
21.43
5dzkm-2bi3A:
20.27
5dzkn-2bi3A:
20.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_V_BEZV801_0
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 1
BEZ-LEU-LEU)		 2bi3 PHOSPHOSERINE
AMINOTRANSFERASE
(Bacillus
alcalophilus) 		4 / 4 ILE A  69
ILE A  63
ARG A  58
LEU A  70
 None
 0.98A 5dzkh-2bi3A:
undetectable
5dzkn-2bi3A:
undetectable
5dzkv-2bi3A:
undetectable		 5dzkh-2bi3A:
20.27
5dzkn-2bi3A:
20.27
5dzkv-2bi3A:
7.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ERG_B_SAMB401_0
(TRNA
(ADENINE(58)-N(1))-M
ETHYLTRANSFERASE
CATALYTIC SUBUNIT
TRM61)		 2bi3 PHOSPHOSERINE
AMINOTRANSFERASE
(Bacillus
alcalophilus) 		5 / 12 GLN A  68
ILE A 207
VAL A 206
GLY A 188
VAL A 217
 None
 1.18A 5ergB-2bi3A:
2.5		 5ergB-2bi3A:
22.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X6Y_A_SAMA901_0
(MRNA CAPPING ENZYME
P5)		 2bi3 PHOSPHOSERINE
AMINOTRANSFERASE
(Bacillus
alcalophilus) 		5 / 11 VAL A 203
GLY A 202
ALA A 194
SER A 243
LEU A 247
 None
 1.11A 5x6yA-2bi3A:
undetectable		 5x6yA-2bi3A:
17.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X6Y_A_SAMA902_0
(MRNA CAPPING ENZYME
P5)		 2bi3 PHOSPHOSERINE
AMINOTRANSFERASE
(Bacillus
alcalophilus) 		5 / 12 GLY A  94
ALA A 167
HIS A 166
PRO A  84
THR A 116
 None
 1.27A 5x6yA-2bi3A:
1.2		 5x6yA-2bi3A:
17.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X6Y_A_SAMA902_0
(MRNA CAPPING ENZYME
P5)		 2bi3 PHOSPHOSERINE
AMINOTRANSFERASE
(Bacillus
alcalophilus) 		5 / 12 LEU A 138
GLY A  94
ALA A 167
HIS A 166
PRO A  84
 None
 1.19A 5x6yA-2bi3A:
1.2		 5x6yA-2bi3A:
17.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X6Y_B_SAMB901_0
(MRNA CAPPING ENZYME
P5)		 2bi3 PHOSPHOSERINE
AMINOTRANSFERASE
(Bacillus
alcalophilus) 		5 / 10 VAL A 203
GLY A 202
ALA A 194
SER A 243
LEU A 247
 None
 1.15A 5x6yB-2bi3A:
undetectable		 5x6yB-2bi3A:
17.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X6Y_C_SAMC902_0
(MRNA CAPPING ENZYME
P5)		 2bi3 PHOSPHOSERINE
AMINOTRANSFERASE
(Bacillus
alcalophilus) 		5 / 12 GLY A  94
ALA A 167
HIS A 166
PRO A  84
THR A 116
 None
 1.22A 5x6yC-2bi3A:
undetectable		 5x6yC-2bi3A:
17.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X6Y_C_SAMC902_0
(MRNA CAPPING ENZYME
P5)		 2bi3 PHOSPHOSERINE
AMINOTRANSFERASE
(Bacillus
alcalophilus) 		5 / 12 LEU A 138
GLY A  94
ALA A 167
HIS A 166
PRO A  84
 None
 1.18A 5x6yC-2bi3A:
undetectable		 5x6yC-2bi3A:
17.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y7P_B_CHDB401_0
(BILE SALT HYDROLASE)		 2bi3 PHOSPHOSERINE
AMINOTRANSFERASE
(Bacillus
alcalophilus) 		5 / 10 ILE A 170
LEU A 169
ASN A 139
ALA A 119
LEU A 138
 None
 1.24A 5y7pB-2bi3A:
undetectable		 5y7pB-2bi3A:
22.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y7P_H_CHDH401_0
(BILE SALT HYDROLASE)		 2bi3 PHOSPHOSERINE
AMINOTRANSFERASE
(Bacillus
alcalophilus) 		5 / 10 ILE A 170
LEU A 169
ASN A 139
ALA A 119
LEU A 138
 None
 1.26A 5y7pH-2bi3A:
undetectable		 5y7pH-2bi3A:
22.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YN6_A_SAMA401_0
(NSP16 PROTEIN)		 2bi3 PHOSPHOSERINE
AMINOTRANSFERASE
(Bacillus
alcalophilus) 		5 / 12 GLY A 323
PRO A  11
GLY A  10
ASN A 325
PHE A 321
 None
 1.19A 5yn6A-2bi3A:
undetectable		 5yn6A-2bi3A:
23.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F88_A_STRA502_1
(CYTOCHROME P450
CYP260A1)		 2bi3 PHOSPHOSERINE
AMINOTRANSFERASE
(Bacillus
alcalophilus) 		4 / 6 PHE A 321
LEU A 324
ALA A 316
THR A 277
 None
 0.97A 6f88A-2bi3A:
undetectable		 6f88A-2bi3A:
13.13