SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2bid'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DVT_A_FLPA125_1
(TRANSTHYRETIN)		 2bid PROTEIN (BID)
(Homo
sapiens) 		4 / 8 LEU A 136
ALA A 132
LEU A 153
LEU A  22
 None
 0.96A 1dvtA-2bidA:
undetectable
1dvtB-2bidA:
undetectable		 1dvtA-2bidA:
19.70
1dvtB-2bidA:
19.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TT6_B_DESB128_1
(TRANSTHYRETIN)		 2bid PROTEIN (BID)
(Homo
sapiens) 		4 / 5 LEU A 115
ALA A 162
LEU A 168
SER A 167
 None
 1.07A 1tt6B-2bidA:
undetectable		 1tt6B-2bidA:
20.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QL8_A_BEZA143_0
(PUTATIVE REDOX
PROTEIN)		 2bid PROTEIN (BID)
(Homo
sapiens) 		4 / 7 ALA A 132
THR A 131
ALA A 130
ARG A 127
 None
 0.97A 2ql8A-2bidA:
undetectable
2ql8B-2bidA:
undetectable		 2ql8A-2bidA:
22.62
2ql8B-2bidA:
22.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IAA_A_RTZA401_1
(SERINE/THREONINE-PRO
TEIN KINASE PIM-1)		 2bid PROTEIN (BID)
(Homo
sapiens) 		6 / 11 VAL A  23
LEU A 155
VAL A 161
ASP A 171
GLU A 122
LEU A 115
 None
 1.29A 4iaaA-2bidA:
undetectable		 4iaaA-2bidA:
22.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IIZ_B_LURB201_1
(TRANSTHYRETIN)		 2bid PROTEIN (BID)
(Homo
sapiens) 		4 / 8 LEU A 191
THR A 175
LEU A  22
VAL A 172
 None
 0.90A 4iizB-2bidA:
undetectable		 4iizB-2bidA:
20.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4C_A_IPHA903_0
(PROTEIN ARGONAUTE-2)		 2bid PROTEIN (BID)
(Homo
sapiens) 		4 / 6 ILE A  84
GLN A  81
ILE A  18
ASP A  15
 None
 0.96A 4z4cA-2bidA:
undetectable		 4z4cA-2bidA:
13.89