SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2bih'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4L_B_DCFB853_2
(ADENOSINE DEAMINASE)		 2bih NITRATE REDUCTASE
[NADPH]
(Ogataea
angusta) 		4 / 5 HIS A 233
LEU A  74
LEU A 301
GLY A 162
 MTV  A1479 (-3.7A)
None
None
None
 1.14A 1a4lB-2bihA:
undetectable		 1a4lB-2bihA:
22.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1D4Y_A_TPVA501_2
(PROTEIN (HIV-1
PROTEASE))		 2bih NITRATE REDUCTASE
[NADPH]
(Ogataea
angusta) 		4 / 8 LEU A 256
ALA A 180
VAL A 107
ILE A 109
 None
 0.63A 1d4yB-2bihA:
undetectable		 1d4yB-2bihA:
13.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MT1_G_AG2G7003_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE BETA
CHAIN
PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE ALPHA
CHAIN)		 2bih NITRATE REDUCTASE
[NADPH]
(Ogataea
angusta) 		4 / 6 ASP A 300
GLY A 243
ILE A 241
ARG A 216
 None
 0.83A 1mt1G-2bihA:
undetectable
1mt1J-2bihA:
undetectable		 1mt1G-2bihA:
8.31
1mt1J-2bihA:
12.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MT1_K_AG2K7002_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE ALPHA
CHAIN
PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE BETA
CHAIN)		 2bih NITRATE REDUCTASE
[NADPH]
(Ogataea
angusta) 		4 / 7 ILE A 241
ARG A 216
ASP A 300
GLY A 243
 None
 0.83A 1mt1H-2bihA:
undetectable
1mt1K-2bihA:
undetectable		 1mt1H-2bihA:
12.88
1mt1K-2bihA:
8.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N13_F_AG2F7016_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE BETA
CHAIN
PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE ALPHA
CHAIN)		 2bih NITRATE REDUCTASE
[NADPH]
(Ogataea
angusta) 		5 / 8 ASP A 300
LEU A 301
GLY A 243
ILE A 241
ARG A 216
 None
 1.08A 1n13A-2bihA:
undetectable
1n13F-2bihA:
undetectable		 1n13A-2bihA:
8.31
1n13F-2bihA:
12.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N49_D_RITD401_2
(PROTEASE)		 2bih NITRATE REDUCTASE
[NADPH]
(Ogataea
angusta) 		4 / 6 ASP A 129
GLY A 174
ILE A 177
ILE A 124
 None
 0.93A 1n49D-2bihA:
undetectable		 1n49D-2bihA:
11.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1S9Q_B_CHDB500_0
(ESTROGEN-RELATED
RECEPTOR GAMMA)		 2bih NITRATE REDUCTASE
[NADPH]
(Ogataea
angusta) 		4 / 4 LEU A 405
VAL A 342
ILE A 406
TRP A 474
 None
 1.47A 1s9qB-2bihA:
undetectable		 1s9qB-2bihA:
19.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T46_A_STIA3_2
(HOMO SAPIENS V-KIT
HARDY-ZUCKERMAN 4
FELINE SARCOMA VIRAL
ONCOGENE HOMOLOG)		 2bih NITRATE REDUCTASE
[NADPH]
(Ogataea
angusta) 		4 / 7 VAL A 244
VAL A 135
TYR A 222
ARG A 207
 None
 1.21A 1t46A-2bihA:
undetectable		 1t46A-2bihA:
18.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XOQ_A_ROFA502_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		 2bih NITRATE REDUCTASE
[NADPH]
(Ogataea
angusta) 		3 / 3 ASN A 429
TRP A 431
GLN A 304
 None
 1.34A 1xoqA-2bihA:
undetectable		 1xoqA-2bihA:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A15_A_NCAA1001_0
(HYPOTHETICAL PROTEIN
RV0760C)		 2bih NITRATE REDUCTASE
[NADPH]
(Ogataea
angusta) 		5 / 11 VAL A 176
ILE A 109
LEU A 256
LEU A 237
LEU A 253
 None
 1.16A 2a15A-2bihA:
undetectable		 2a15A-2bihA:
13.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BM9_A_SAMA301_1
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 2bih NITRATE REDUCTASE
[NADPH]
(Ogataea
angusta) 		3 / 3 LYS A 346
ASP A 468
ASN A 473
 None
 1.06A 2bm9A-2bihA:
undetectable		 2bm9A-2bihA:
20.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F8G_B_017B401_2
(POL POLYPROTEIN)		 2bih NITRATE REDUCTASE
[NADPH]
(Ogataea
angusta) 		5 / 12 LEU A 256
GLY A 178
ALA A 180
VAL A 107
ILE A 109
 None
 0.87A 2f8gB-2bihA:
undetectable		 2f8gB-2bihA:
12.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HC4_A_VDXA525_2
(VITAMIN D RECEPTOR)		 2bih NITRATE REDUCTASE
[NADPH]
(Ogataea
angusta) 		4 / 7 LEU A 256
ILE A 206
ARG A 248
SER A 249
 None
 1.14A 2hc4A-2bihA:
undetectable		 2hc4A-2bihA:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2O4L_A_TPVA403_2
(PROTEASE)		 2bih NITRATE REDUCTASE
[NADPH]
(Ogataea
angusta) 		5 / 12 LEU A 256
GLY A 178
ALA A 180
VAL A 107
ILE A 109
 None
 0.87A 2o4lB-2bihA:
undetectable		 2o4lB-2bihA:
11.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q63_A_1UNA1001_1
(PROTEASE RETROPEPSIN)		 2bih NITRATE REDUCTASE
[NADPH]
(Ogataea
angusta) 		5 / 12 LEU A 256
GLY A 178
ALA A 180
VAL A 107
ILE A 109
 None
 0.87A 2q63A-2bihA:
undetectable		 2q63A-2bihA:
11.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QQC_E_AG2E671_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE (EC
4.1.1.19) (PVLARGDC))		 2bih NITRATE REDUCTASE
[NADPH]
(Ogataea
angusta) 		4 / 7 ILE A 241
ARG A 216
ASP A 300
GLY A 243
 None
 0.82A 2qqcD-2bihA:
undetectable
2qqcE-2bihA:
undetectable		 2qqcD-2bihA:
13.19
2qqcE-2bihA:
9.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QQC_K_AG2K671_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE (EC
4.1.1.19) (PVLARGDC))		 2bih NITRATE REDUCTASE
[NADPH]
(Ogataea
angusta) 		4 / 8 ILE A 241
ARG A 216
ASP A 300
GLY A 243
 None
 0.85A 2qqcH-2bihA:
undetectable
2qqcK-2bihA:
undetectable		 2qqcH-2bihA:
13.19
2qqcK-2bihA:
9.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W8Y_A_486A1000_1
(PROGESTERONE
RECEPTOR)		 2bih NITRATE REDUCTASE
[NADPH]
(Ogataea
angusta) 		5 / 12 LEU A 391
GLY A 408
GLN A 416
ARG A 143
LEU A 344
 None
 1.43A 2w8yA-2bihA:
undetectable		 2w8yA-2bihA:
19.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YFB_B_ACTB501_0
(METHYL-ACCEPTING
CHEMOTAXIS
TRANSDUCER)		 2bih NITRATE REDUCTASE
[NADPH]
(Ogataea
angusta) 		4 / 6 ASP A 271
ARG A  89
ILE A 245
TYR A 202
 MTV  A1479 ( 4.5A)
MTV  A1479 (-4.8A)
MTV  A1479 (-3.6A)
MTV  A1479 (-3.7A)
 1.22A 2yfbB-2bihA:
undetectable		 2yfbB-2bihA:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AQI_A_CHDA3_0
(FERROCHELATASE)		 2bih NITRATE REDUCTASE
[NADPH]
(Ogataea
angusta) 		3 / 3 PRO A 134
LEU A 167
ARG A  30
 None
 0.78A 3aqiA-2bihA:
undetectable		 3aqiA-2bihA:
20.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CZV_A_AZMA263_1
(CARBONIC ANHYDRASE
13)		 2bih NITRATE REDUCTASE
[NADPH]
(Ogataea
angusta) 		5 / 12 VAL A 239
VAL A 250
LEU A 256
VAL A 189
VAL A 176
 None
MTV  A1479 (-3.8A)
None
None
None
 1.24A 3czvA-2bihA:
undetectable
3czvB-2bihA:
undetectable		 3czvA-2bihA:
20.73
3czvB-2bihA:
20.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HS4_A_AZMA702_1
(CARBONIC ANHYDRASE 2)		 2bih NITRATE REDUCTASE
[NADPH]
(Ogataea
angusta) 		4 / 7 VAL A 176
LYS A 179
TYR A 117
GLU A 106
 None
 1.27A 3hs4A-2bihA:
undetectable		 3hs4A-2bihA:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3J6G_B_TA1B502_1
(TUBULIN BETA CHAIN)		 2bih NITRATE REDUCTASE
[NADPH]
(Ogataea
angusta) 		5 / 10 ASP A  53
HIS A 233
SER A  67
THR A 136
LEU A  74
 None
MTV  A1479 (-3.7A)
None
None
None
 1.19A 3j6gB-2bihA:
undetectable		 3j6gB-2bihA:
22.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3J6G_D_TA1D502_1
(TUBULIN BETA CHAIN)		 2bih NITRATE REDUCTASE
[NADPH]
(Ogataea
angusta) 		5 / 10 ASP A  53
HIS A 233
SER A  67
THR A 136
LEU A  74
 None
MTV  A1479 (-3.7A)
None
None
None
 1.19A 3j6gD-2bihA:
undetectable		 3j6gD-2bihA:
22.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3J6G_F_TA1F502_1
(TUBULIN BETA CHAIN)		 2bih NITRATE REDUCTASE
[NADPH]
(Ogataea
angusta) 		5 / 10 ASP A  53
HIS A 233
SER A  67
THR A 136
LEU A  74
 None
MTV  A1479 (-3.7A)
None
None
None
 1.19A 3j6gF-2bihA:
undetectable		 3j6gF-2bihA:
22.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3J6G_H_TA1H502_1
(TUBULIN BETA CHAIN)		 2bih NITRATE REDUCTASE
[NADPH]
(Ogataea
angusta) 		5 / 10 ASP A  53
HIS A 233
SER A  67
THR A 136
LEU A  74
 None
MTV  A1479 (-3.7A)
None
None
None
 1.19A 3j6gH-2bihA:
undetectable		 3j6gH-2bihA:
22.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3J6G_J_TA1J502_1
(TUBULIN BETA CHAIN)		 2bih NITRATE REDUCTASE
[NADPH]
(Ogataea
angusta) 		5 / 10 ASP A  53
HIS A 233
SER A  67
THR A 136
LEU A  74
 None
MTV  A1479 (-3.7A)
None
None
None
 1.19A 3j6gJ-2bihA:
undetectable		 3j6gJ-2bihA:
22.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3J6G_L_TA1L502_1
(TUBULIN BETA CHAIN)		 2bih NITRATE REDUCTASE
[NADPH]
(Ogataea
angusta) 		5 / 10 ASP A  53
HIS A 233
SER A  67
THR A 136
LEU A  74
 None
MTV  A1479 (-3.7A)
None
None
None
 1.19A 3j6gL-2bihA:
undetectable		 3j6gL-2bihA:
22.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3J6G_N_TA1N502_1
(TUBULIN BETA CHAIN)		 2bih NITRATE REDUCTASE
[NADPH]
(Ogataea
angusta) 		5 / 10 ASP A  53
HIS A 233
SER A  67
THR A 136
LEU A  74
 None
MTV  A1479 (-3.7A)
None
None
None
 1.19A 3j6gN-2bihA:
undetectable		 3j6gN-2bihA:
22.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3J6G_P_TA1P502_1
(TUBULIN BETA CHAIN)		 2bih NITRATE REDUCTASE
[NADPH]
(Ogataea
angusta) 		5 / 10 ASP A  53
HIS A 233
SER A  67
THR A 136
LEU A  74
 None
MTV  A1479 (-3.7A)
None
None
None
 1.19A 3j6gP-2bihA:
undetectable		 3j6gP-2bihA:
22.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3J6G_R_TA1R502_1
(TUBULIN BETA CHAIN)		 2bih NITRATE REDUCTASE
[NADPH]
(Ogataea
angusta) 		5 / 10 ASP A  53
HIS A 233
SER A  67
THR A 136
LEU A  74
 None
MTV  A1479 (-3.7A)
None
None
None
 1.19A 3j6gR-2bihA:
undetectable		 3j6gR-2bihA:
22.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3J6P_B_TA1B502_1
(TUBULIN BETA CHAIN)		 2bih NITRATE REDUCTASE
[NADPH]
(Ogataea
angusta) 		5 / 12 ASP A  53
HIS A 233
SER A  67
THR A 136
LEU A  74
 None
MTV  A1479 (-3.7A)
None
None
None
 1.18A 3j6pB-2bihA:
undetectable		 3j6pB-2bihA:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3J6P_B_TA1B502_1
(TUBULIN BETA CHAIN)		 2bih NITRATE REDUCTASE
[NADPH]
(Ogataea
angusta) 		5 / 12 HIS A 233
SER A  67
THR A 136
PRO A  69
LEU A  74
 MTV  A1479 (-3.7A)
None
None
None
None
 1.26A 3j6pB-2bihA:
undetectable		 3j6pB-2bihA:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JW2_A_017A401_1
(GAG-POL POLYPROTEIN)		 2bih NITRATE REDUCTASE
[NADPH]
(Ogataea
angusta) 		5 / 12 LEU A 256
GLY A 178
ALA A 180
VAL A 107
ILE A 109
 None
 0.83A 3jw2A-2bihA:
undetectable		 3jw2A-2bihA:
12.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LZU_A_017A200_2
(HIV-1 PROTEASE)		 2bih NITRATE REDUCTASE
[NADPH]
(Ogataea
angusta) 		5 / 12 LEU A 256
GLY A 178
ALA A 180
VAL A 107
ILE A 109
 None
 0.84A 3lzuB-2bihA:
undetectable		 3lzuB-2bihA:
13.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NDT_A_ROCA101_1
(PROTEASE)		 2bih NITRATE REDUCTASE
[NADPH]
(Ogataea
angusta) 		5 / 12 LEU A 256
GLY A 178
ALA A 180
VAL A 107
ILE A 109
 None
 0.86A 3ndtA-2bihA:
undetectable		 3ndtA-2bihA:
13.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NDT_A_ROCA101_3
(PROTEASE)		 2bih NITRATE REDUCTASE
[NADPH]
(Ogataea
angusta) 		5 / 12 LEU A 256
GLY A 178
ALA A 180
VAL A 107
ILE A 109
 None
 0.84A 3ndtB-2bihA:
undetectable		 3ndtB-2bihA:
13.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OWX_B_XRAB233_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 2bih NITRATE REDUCTASE
[NADPH]
(Ogataea
angusta) 		5 / 11 PHE A  87
TRP A 158
GLY A 247
TYR A 202
ILE A 241
 MTV  A1479 (-3.5A)
None
MTV  A1479 (-3.4A)
MTV  A1479 (-3.7A)
None
 1.39A 3owxA-2bihA:
undetectable
3owxB-2bihA:
undetectable		 3owxA-2bihA:
17.82
3owxB-2bihA:
17.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OXV_B_478B200_1
(HIV-1 PROTEASE)		 2bih NITRATE REDUCTASE
[NADPH]
(Ogataea
angusta) 		5 / 9 LEU A 256
GLY A 178
ALA A 180
VAL A 107
ILE A 109
 None
 0.91A 3oxvA-2bihA:
undetectable		 3oxvA-2bihA:
10.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P2K_C_SAMC6735_0
(16S RRNA METHYLASE)		 2bih NITRATE REDUCTASE
[NADPH]
(Ogataea
angusta) 		5 / 12 GLY A 329
ALA A 160
ALA A 161
PHE A  79
LEU A  74
 None
 1.03A 3p2kC-2bihA:
undetectable		 3p2kC-2bihA:
17.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QG2_B_CP6B709_1
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 2bih NITRATE REDUCTASE
[NADPH]
(Ogataea
angusta) 		5 / 11 ILE A 404
ALA A 436
PHE A 446
ILE A 318
LEU A 398
 None
 1.26A 3qg2B-2bihA:
undetectable		 3qg2B-2bihA:
20.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TKW_B_017B401_2
(PROTEASE)		 2bih NITRATE REDUCTASE
[NADPH]
(Ogataea
angusta) 		5 / 12 LEU A 256
GLY A 178
ALA A 180
VAL A 107
ILE A 109
 None
 0.85A 3tkwB-2bihA:
undetectable		 3tkwB-2bihA:
13.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TL9_A_ROCA401_3
(PROTEASE)		 2bih NITRATE REDUCTASE
[NADPH]
(Ogataea
angusta) 		5 / 12 LEU A 256
GLY A 178
ALA A 180
VAL A 107
ILE A 109
 None
 0.86A 3tl9B-2bihA:
undetectable		 3tl9B-2bihA:
13.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A7A_B_RGZB601_1
(AMINE OXIDASE
[FLAVIN-CONTAINING]
B)		 2bih NITRATE REDUCTASE
[NADPH]
(Ogataea
angusta) 		5 / 12 LEU A 237
LEU A 253
LEU A 256
ILE A 119
ILE A 220
 None
 1.13A 4a7aB-2bihA:
undetectable		 4a7aB-2bihA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D33_A_MTLA870_0
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 2bih NITRATE REDUCTASE
[NADPH]
(Ogataea
angusta) 		4 / 8 SER A 426
ASN A 148
GLU A 146
ASN A 423
 None
 1.13A 4d33A-2bihA:
undetectable		 4d33A-2bihA:
19.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MUR_B_PFLB407_1
(PROTON-GATED ION
CHANNEL)		 2bih NITRATE REDUCTASE
[NADPH]
(Ogataea
angusta) 		4 / 7 PRO A 449
TYR A 433
MET A 420
ILE A 469
 None
 0.89A 5murB-2bihA:
undetectable		 5murB-2bihA:
12.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N8J_E_DVAE7_0
(GLY-DTY-GLY-DLE-DAL-
DSG-DVA-DAS-DGL-DSN-
DSN-GLY
STREPTAVIDIN)		 2bih NITRATE REDUCTASE
[NADPH]
(Ogataea
angusta) 		3 / 3 TYR A 222
SER A 122
TRP A 228
 None
 0.61A 5n8jB-2bihA:
undetectable		 5n8jB-2bihA:
18.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N8J_O_DVAO7_0
(GLY-DTY-GLY-DLE-DAL-
DSG-DVA-DAS-DGL-DSN-
DSN-GLY
STREPTAVIDIN)		 2bih NITRATE REDUCTASE
[NADPH]
(Ogataea
angusta) 		3 / 3 TYR A 222
SER A 122
TRP A 228
 None
 0.61A 5n8jA-2bihA:
undetectable		 5n8jA-2bihA:
18.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N8J_P_DVAP5_0
(GLY-DTY-GLY-DLE-DAL-
DSG-DVA-DAS-DGL-DSN-
DSN-GLY
STREPTAVIDIN)		 2bih NITRATE REDUCTASE
[NADPH]
(Ogataea
angusta) 		3 / 3 TYR A 222
SER A 122
TRP A 228
 None
 0.59A 5n8jD-2bihA:
undetectable		 5n8jD-2bihA:
18.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OGC_B_TA1B601_1
(TUBULIN BETA CHAIN)		 2bih NITRATE REDUCTASE
[NADPH]
(Ogataea
angusta) 		5 / 12 ASP A  53
HIS A 233
SER A  67
THR A 136
LEU A  74
 None
MTV  A1479 (-3.7A)
None
None
None
 1.14A 5ogcB-2bihA:
undetectable		 5ogcB-2bihA:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OGC_B_TA1B601_1
(TUBULIN BETA CHAIN)		 2bih NITRATE REDUCTASE
[NADPH]
(Ogataea
angusta) 		5 / 12 HIS A 233
SER A  67
THR A 136
PRO A  69
LEU A  74
 MTV  A1479 (-3.7A)
None
None
None
None
 1.15A 5ogcB-2bihA:
undetectable		 5ogcB-2bihA:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UOC_B_H4BB502_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 2bih NITRATE REDUCTASE
[NADPH]
(Ogataea
angusta) 		4 / 6 TRP A 386
PHE A 328
VAL A 138
ARG A 143
 None
 1.50A 5uocA-2bihA:
0.0
5uocB-2bihA:
0.0		 5uocA-2bihA:
20.55
5uocB-2bihA:
20.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DWN_B_AQ4B602_1
(CYTOCHROME P450 1A1)		 2bih NITRATE REDUCTASE
[NADPH]
(Ogataea
angusta) 		4 / 7 PHE A  65
GLY A 162
ALA A 161
LEU A  57
 None
 0.81A 6dwnB-2bihA:
undetectable		 6dwnB-2bihA:
13.99