SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2bkd'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JB0_B_PQNB2002_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A2)		 2bkd FRAGILE X MENTAL
RETARDATION 1
PROTEIN
(Homo
sapiens) 		5 / 11 PHE N  15
ILE N  94
ALA N  82
LEU N  81
ALA N  14
 None
 1.45A 1jb0B-2bkdN:
undetectable		 1jb0B-2bkdN:
11.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PCQ_B_PQNB842_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A2)		 2bkd FRAGILE X MENTAL
RETARDATION 1
PROTEIN
(Homo
sapiens) 		5 / 11 PHE N  15
ILE N  94
ALA N  82
LEU N  81
ALA N  14
 None
 1.45A 3pcqB-2bkdN:
undetectable		 3pcqB-2bkdN:
11.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HVC_B_HFGB1602_0
(BIFUNCTIONAL
GLUTAMATE/PROLINE--T
RNA LIGASE)		 2bkd FRAGILE X MENTAL
RETARDATION 1
PROTEIN
(Homo
sapiens) 		5 / 12 LEU N 112
GLU N  64
VAL N  84
PHE N  15
GLY N  13
 None
 1.21A 4hvcB-2bkdN:
undetectable		 4hvcB-2bkdN:
12.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q15_A_HFGA803_0
(PROLINE--TRNA LIGASE)		 2bkd FRAGILE X MENTAL
RETARDATION 1
PROTEIN
(Homo
sapiens) 		5 / 12 LEU N 112
GLU N  64
VAL N  84
PHE N  15
GLY N  13
 None
 1.23A 4q15A-2bkdN:
undetectable		 4q15A-2bkdN:
12.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y9Y_A_ACTA409_0
(UNCHARACTERIZED
PROTEIN KDOO)		 2bkd FRAGILE X MENTAL
RETARDATION 1
PROTEIN
(Homo
sapiens) 		3 / 3 LYS N 119
PRO N 120
LYS N 123
 None
 0.97A 5y9yA-2bkdN:
undetectable		 5y9yA-2bkdN:
17.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZW4_A_SAMA302_1
(PUTATIVE
O-METHYLTRANSFERASE
YRRM)		 2bkd FRAGILE X MENTAL
RETARDATION 1
PROTEIN
(Homo
sapiens) 		4 / 6 SER N  69
GLU N   7
ARG N   9
ASP N  46
 None
None
HSO  N  45 ( 3.9A)
HSO  N  45 ( 3.7A)
 1.30A 5zw4A-2bkdN:
undetectable		 5zw4A-2bkdN:
20.27