SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2bkg'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJL_A_SAMA200_0
(METHIONINE REPRESSOR
PROTEIN METJ)		 2bkg SYNTHETIC CONSTRUCT
ANKYRIN REPEAT
PROTEIN E3_19
(synthetic
construct) 		5 / 11 ALA A  71
HIS A  52
LEU A  60
ALA A  55
LEU A  99
 None
 1.24A 1mjlA-2bkgA:
undetectable
1mjlB-2bkgA:
undetectable		 1mjlA-2bkgA:
21.82
1mjlB-2bkgA:
21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TZ8_C_DESC129_1
(TRANSTHYRETIN)		 2bkg SYNTHETIC CONSTRUCT
ANKYRIN REPEAT
PROTEIN E3_19
(synthetic
construct) 		4 / 6 LEU A  84
ALA A 108
SER A  81
SER A  79
 None
 0.99A 1tz8C-2bkgA:
undetectable
1tz8D-2bkgA:
undetectable		 1tz8C-2bkgA:
20.48
1tz8D-2bkgA:
20.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2G70_B_SAMB2002_0
(PHENYLETHANOLAMINE
N-METHYLTRANSFERASE)		 2bkg SYNTHETIC CONSTRUCT
ANKYRIN REPEAT
PROTEIN E3_19
(synthetic
construct) 		5 / 12 LEU A  60
ASP A  27
VAL A  30
VAL A  65
TYR A 102
 None
 1.39A 2g70B-2bkgA:
undetectable		 2g70B-2bkgA:
22.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LB0_A_ACTA401_0
(UNCHARACTERIZED
PROTEIN)		 2bkg SYNTHETIC CONSTRUCT
ANKYRIN REPEAT
PROTEIN E3_19
(synthetic
construct) 		5 / 9 SER A  81
GLY A  80
SER A  79
ASP A  48
THR A  82
 None
 1.25A 4lb0A-2bkgA:
0.0		 4lb0A-2bkgA:
18.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P65_I_IPHI101_0
(INSULIN)		 2bkg SYNTHETIC CONSTRUCT
ANKYRIN REPEAT
PROTEIN E3_19
(synthetic
construct) 		5 / 12 VAL A  96
LEU A  84
LEU A 117
ILE A 128
ALA A 137
 None
 1.00A 4p65B-2bkgA:
undetectable
4p65D-2bkgA:
undetectable
4p65I-2bkgA:
undetectable
4p65J-2bkgA:
undetectable		 4p65B-2bkgA:
12.00
4p65D-2bkgA:
12.00
4p65I-2bkgA:
10.91
4p65J-2bkgA:
12.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P65_K_IPHK101_0
(INSULIN)		 2bkg SYNTHETIC CONSTRUCT
ANKYRIN REPEAT
PROTEIN E3_19
(synthetic
construct) 		5 / 12 LEU A 117
VAL A  96
LEU A  84
ILE A 128
ALA A 137
 None
 1.04A 4p65F-2bkgA:
undetectable
4p65H-2bkgA:
undetectable
4p65K-2bkgA:
undetectable
4p65L-2bkgA:
undetectable		 4p65F-2bkgA:
12.00
4p65H-2bkgA:
12.00
4p65K-2bkgA:
10.91
4p65L-2bkgA:
12.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V5Z_A_1YNA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 2bkg SYNTHETIC CONSTRUCT
ANKYRIN REPEAT
PROTEIN E3_19
(synthetic
construct) 		5 / 12 ILE A  95
GLY A  91
THR A 123
LEU A 119
HIS A 118
 None
 1.38A 5v5zA-2bkgA:
undetectable		 5v5zA-2bkgA:
16.73