SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2bkl'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HK2_A_T44A3002_1
(SERUM ALBUMIN)		 2bkl PROLYL ENDOPEPTIDASE
(Myxococcus
xanthus) 		4 / 8 LEU A 549
TYR A 422
LEU A 483
SER A 424
 None
 1.05A 1hk2A-2bklA:
undetectable		 1hk2A-2bklA:
22.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HXW_B_RITB301_1
(HIV-1 PROTEASE)		 2bkl PROLYL ENDOPEPTIDASE
(Myxococcus
xanthus) 		5 / 9 GLY A 497
ASP A 495
GLY A 487
PRO A 431
VAL A 430
 None
 1.03A 1hxwA-2bklA:
undetectable		 1hxwA-2bklA:
10.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MUI_B_AB1B100_2
(PROTEASE)		 2bkl PROLYL ENDOPEPTIDASE
(Myxococcus
xanthus) 		6 / 12 GLY A 497
ALA A 496
ASP A 495
GLY A 487
PRO A 431
VAL A 430
 None
 1.04A 1muiB-2bklA:
undetectable		 1muiB-2bklA:
10.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1S1X_A_NVPA999_1
(REVERSE
TRANSCRIPTASE)		 2bkl PROLYL ENDOPEPTIDASE
(Myxococcus
xanthus) 		4 / 8 LEU A 516
TYR A 478
GLY A 476
LEU A 450
 None
 1.00A 1s1xA-2bklA:
undetectable		 1s1xA-2bklA:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AQU_B_DR7B300_1
(HIV-1 PROTEASE)		 2bkl PROLYL ENDOPEPTIDASE
(Myxococcus
xanthus) 		6 / 10 GLY A 497
ALA A 496
ASP A 495
GLY A 487
PRO A 431
VAL A 430
 None
 1.06A 2aquA-2bklA:
undetectable		 2aquA-2bklA:
10.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AQU_B_DR7B300_2
(HIV-1 PROTEASE)		 2bkl PROLYL ENDOPEPTIDASE
(Myxococcus
xanthus) 		6 / 11 GLY A 497
ALA A 496
ASP A 495
GLY A 487
PRO A 431
VAL A 430
 None
 1.06A 2aquB-2bklA:
undetectable		 2aquB-2bklA:
10.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AVV_A_MK1A901_3
(POL POLYPROTEIN)		 2bkl PROLYL ENDOPEPTIDASE
(Myxococcus
xanthus) 		6 / 12 GLY A 497
ALA A 496
ASP A 495
GLY A 487
PRO A 431
VAL A 430
 None
 1.10A 2avvB-2bklA:
undetectable		 2avvB-2bklA:
10.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2B7Z_B_MK1B200_1
(HIV-1 PROTEASE)		 2bkl PROLYL ENDOPEPTIDASE
(Myxococcus
xanthus) 		5 / 12 GLY A 497
ALA A 496
ASP A 495
GLY A 487
PRO A 431
 None
 1.07A 2b7zA-2bklA:
undetectable		 2b7zA-2bklA:
10.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F8G_B_017B401_1
(POL POLYPROTEIN)		 2bkl PROLYL ENDOPEPTIDASE
(Myxococcus
xanthus) 		5 / 12 GLY A 497
ALA A 496
ASP A 495
GLY A 487
VAL A 430
 None
 0.96A 2f8gA-2bklA:
undetectable		 2f8gA-2bklA:
10.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FXE_A_DR7A102_1
(POL PROTEIN)		 2bkl PROLYL ENDOPEPTIDASE
(Myxococcus
xanthus) 		7 / 12 GLY A 497
ALA A 496
ASP A 495
GLY A 490
GLY A 487
PRO A 431
VAL A 430
 None
 1.15A 2fxeA-2bklA:
undetectable		 2fxeA-2bklA:
9.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FXE_A_DR7A102_2
(POL PROTEIN)		 2bkl PROLYL ENDOPEPTIDASE
(Myxococcus
xanthus) 		6 / 11 GLY A 497
ALA A 496
ASP A 495
GLY A 487
PRO A 431
VAL A 430
 None
 1.08A 2fxeB-2bklA:
undetectable		 2fxeB-2bklA:
9.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IEO_A_017A402_1
(PROTEASE)		 2bkl PROLYL ENDOPEPTIDASE
(Myxococcus
xanthus) 		6 / 12 GLY A 497
ALA A 496
ASP A 495
GLY A 487
PRO A 431
VAL A 430
 None
 1.06A 2ieoA-2bklA:
undetectable		 2ieoA-2bklA:
10.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JN3_A_JN3A130_2
(FATTY ACID-BINDING
PROTEIN, LIVER)		 2bkl PROLYL ENDOPEPTIDASE
(Myxococcus
xanthus) 		4 / 7 PHE A  83
LEU A 109
LEU A 110
PRO A 173
 None
 0.71A 2jn3A-2bklA:
undetectable		 2jn3A-2bklA:
11.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2O4K_A_DR7A301_2
(PROTEASE)		 2bkl PROLYL ENDOPEPTIDASE
(Myxococcus
xanthus) 		6 / 12 GLY A 497
ALA A 496
ASP A 495
GLY A 487
PRO A 431
VAL A 430
 None
 1.09A 2o4kB-2bklA:
undetectable		 2o4kB-2bklA:
10.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q5K_A_AB1A201_2
(PROTEASE)		 2bkl PROLYL ENDOPEPTIDASE
(Myxococcus
xanthus) 		6 / 12 GLY A 497
ALA A 496
ASP A 495
GLY A 487
PRO A 431
VAL A 430
 None
 1.10A 2q5kB-2bklA:
undetectable		 2q5kB-2bklA:
10.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2R5P_B_MK1B902_2
(PROTEASE)		 2bkl PROLYL ENDOPEPTIDASE
(Myxococcus
xanthus) 		6 / 12 GLY A 497
ALA A 496
ASP A 495
GLY A 487
PRO A 431
VAL A 430
 None
 1.11A 2r5pB-2bklA:
undetectable		 2r5pB-2bklA:
11.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2R5P_D_MK1D902_2
(PROTEASE)		 2bkl PROLYL ENDOPEPTIDASE
(Myxococcus
xanthus) 		6 / 12 GLY A 497
ALA A 496
ASP A 495
GLY A 487
PRO A 431
VAL A 430
 None
 1.11A 2r5pD-2bklA:
undetectable		 2r5pD-2bklA:
11.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X45_C_HSMC1161_1
(ALLERGEN ARG R 1)		 2bkl PROLYL ENDOPEPTIDASE
(Myxococcus
xanthus) 		4 / 5 VAL A 286
TYR A 275
VAL A 268
ASP A 253
 None
 1.30A 2x45C-2bklA:
undetectable		 2x45C-2bklA:
12.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Z54_A_AB1A200_2
(HIV-1 PROTEASE)		 2bkl PROLYL ENDOPEPTIDASE
(Myxococcus
xanthus) 		6 / 12 GLY A 497
ALA A 496
ASP A 495
GLY A 487
PRO A 431
VAL A 430
 None
 1.09A 2z54B-2bklA:
undetectable		 2z54B-2bklA:
9.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZIF_B_SAMB298_1
(PUTATIVE
MODIFICATION
METHYLASE)		 2bkl PROLYL ENDOPEPTIDASE
(Myxococcus
xanthus) 		3 / 3 ASP A 118
THR A  87
GLU A  92
 None
 0.81A 2zifB-2bklA:
undetectable		 2zifB-2bklA:
19.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EKT_D_017D200_2
(PROTEASE)		 2bkl PROLYL ENDOPEPTIDASE
(Myxococcus
xanthus) 		5 / 11 GLY A 497
ALA A 496
ASP A 495
GLY A 487
PRO A 431
 None
 1.14A 3ektD-2bklA:
undetectable		 3ektD-2bklA:
10.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EKY_A_DR7A100_1
(PROTEASE)		 2bkl PROLYL ENDOPEPTIDASE
(Myxococcus
xanthus) 		6 / 10 GLY A 497
ALA A 496
ASP A 495
GLY A 487
PRO A 431
VAL A 430
 None
 1.08A 3ekyA-2bklA:
undetectable		 3ekyA-2bklA:
10.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EL9_A_DR7A100_2
(PROTEASE)		 2bkl PROLYL ENDOPEPTIDASE
(Myxococcus
xanthus) 		5 / 10 GLY A 497
ALA A 496
ASP A 495
GLY A 487
PRO A 431
 None
 1.05A 3el9B-2bklA:
undetectable		 3el9B-2bklA:
9.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EM4_A_DR7A100_2
(PROTEASE)		 2bkl PROLYL ENDOPEPTIDASE
(Myxococcus
xanthus) 		5 / 9 ALA A 496
ASP A 495
GLY A 487
PRO A 431
VAL A 430
 None
 1.14A 3em4B-2bklA:
undetectable		 3em4B-2bklA:
10.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EM4_V_DR7V100_1
(PROTEASE)		 2bkl PROLYL ENDOPEPTIDASE
(Myxococcus
xanthus) 		6 / 11 GLY A 497
ALA A 496
ASP A 495
GLY A 487
PRO A 431
VAL A 430
 None
 1.09A 3em4U-2bklA:
undetectable		 3em4U-2bklA:
10.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EM6_A_017A200_1
(PROTEASE)		 2bkl PROLYL ENDOPEPTIDASE
(Myxococcus
xanthus) 		5 / 8 GLY A 497
ALA A 496
ASP A 495
GLY A 490
VAL A 430
 None
 1.43A 3em6A-2bklA:
undetectable		 3em6A-2bklA:
10.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3I5U_A_SAMA401_0
(O-METHYLTRANSFERASE)		 2bkl PROLYL ENDOPEPTIDASE
(Myxococcus
xanthus) 		5 / 12 PHE A 627
GLY A 535
GLY A 536
PRO A 558
ALA A 542
 None
 1.13A 3i5uA-2bklA:
undetectable		 3i5uA-2bklA:
22.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LZU_A_017A200_2
(HIV-1 PROTEASE)		 2bkl PROLYL ENDOPEPTIDASE
(Myxococcus
xanthus) 		6 / 12 GLY A 497
ALA A 496
ASP A 495
GLY A 487
PRO A 431
VAL A 430
 None
 1.12A 3lzuB-2bklA:
undetectable		 3lzuB-2bklA:
10.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OXW_B_017B200_1
(HIV-1 PROTEASE)		 2bkl PROLYL ENDOPEPTIDASE
(Myxococcus
xanthus) 		5 / 10 GLY A 497
ALA A 496
ASP A 495
GLY A 487
VAL A 430
 None
 0.95A 3oxwA-2bklA:
undetectable		 3oxwA-2bklA:
10.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OXW_D_017D200_1
(HIV-1 PROTEASE)		 2bkl PROLYL ENDOPEPTIDASE
(Myxococcus
xanthus) 		5 / 10 GLY A 497
ALA A 496
ASP A 495
GLY A 487
VAL A 430
 None
 0.98A 3oxwC-2bklA:
undetectable		 3oxwC-2bklA:
10.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OXX_A_DR7A100_2
(HIV-1 PROTEASE)		 2bkl PROLYL ENDOPEPTIDASE
(Myxococcus
xanthus) 		5 / 11 ALA A 496
ASP A 495
GLY A 487
PRO A 431
VAL A 430
 None
 1.11A 3oxxB-2bklA:
undetectable		 3oxxB-2bklA:
10.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OXX_C_DR7C100_1
(HIV-1 PROTEASE)		 2bkl PROLYL ENDOPEPTIDASE
(Myxococcus
xanthus) 		5 / 12 GLY A 497
ALA A 496
ASP A 495
GLY A 487
PRO A 431
 None
 1.06A 3oxxC-2bklA:
undetectable		 3oxxC-2bklA:
10.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UFN_A_ROCA401_1
(HIV-1 PROTEASE)		 2bkl PROLYL ENDOPEPTIDASE
(Myxococcus
xanthus) 		6 / 11 GLY A 497
ALA A 496
ASP A 495
GLY A 490
GLY A 487
PRO A 431
 None
 1.15A 3ufnA-2bklA:
undetectable		 3ufnA-2bklA:
9.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C5L_A_UEGA300_1
(PHOSPHOMETHYLPYRIMID
INE KINASE)		 2bkl PROLYL ENDOPEPTIDASE
(Myxococcus
xanthus) 		5 / 11 GLY A 536
ALA A 542
GLY A 540
VAL A 553
HIS A 510
 None
 1.35A 4c5lA-2bklA:
undetectable		 4c5lA-2bklA:
18.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C5L_B_PXLB300_1
(PHOSPHOMETHYLPYRIMID
INE KINASE)		 2bkl PROLYL ENDOPEPTIDASE
(Myxococcus
xanthus) 		5 / 9 GLY A 536
ALA A 542
GLY A 540
VAL A 553
HIS A 510
 None
 1.40A 4c5lB-2bklA:
undetectable		 4c5lB-2bklA:
18.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C5L_C_UEGC300_1
(PHOSPHOMETHYLPYRIMID
INE KINASE)		 2bkl PROLYL ENDOPEPTIDASE
(Myxococcus
xanthus) 		5 / 10 GLY A 536
ALA A 542
GLY A 540
VAL A 553
HIS A 510
 None
 1.30A 4c5lC-2bklA:
undetectable		 4c5lC-2bklA:
18.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C5L_D_UEGD300_1
(PHOSPHOMETHYLPYRIMID
INE KINASE)		 2bkl PROLYL ENDOPEPTIDASE
(Myxococcus
xanthus) 		5 / 10 GLY A 536
ALA A 542
GLY A 540
VAL A 553
HIS A 510
 None
 1.40A 4c5lD-2bklA:
undetectable		 4c5lD-2bklA:
18.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C5N_D_UEGD300_1
(PHOSPHOMETHYLPYRIMID
INE KINASE)		 2bkl PROLYL ENDOPEPTIDASE
(Myxococcus
xanthus) 		5 / 10 GLY A 536
ALA A 542
GLY A 540
VAL A 553
HIS A 510
 None
 1.46A 4c5nD-2bklA:
2.2		 4c5nD-2bklA:
18.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D9H_A_ADNA301_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE
DEOD-TYPE)		 2bkl PROLYL ENDOPEPTIDASE
(Myxococcus
xanthus) 		5 / 11 ARG A 236
GLY A 329
VAL A 328
GLU A 372
VAL A 395
 None
 1.00A 4d9hA-2bklA:
undetectable		 4d9hA-2bklA:
17.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DA7_A_AC2A301_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE
DEOD-TYPE)		 2bkl PROLYL ENDOPEPTIDASE
(Myxococcus
xanthus) 		5 / 10 ARG A 236
GLY A 329
VAL A 328
GLU A 372
VAL A 395
 None
 0.95A 4da7A-2bklA:
2.6		 4da7A-2bklA:
17.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DAN_A_2FAA301_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE
DEOD-TYPE)		 2bkl PROLYL ENDOPEPTIDASE
(Myxococcus
xanthus) 		5 / 11 ARG A 236
GLY A 329
VAL A 328
GLU A 372
VAL A 395
 None
 1.00A 4danA-2bklA:
undetectable		 4danA-2bklA:
17.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DAN_B_2FAB301_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE
DEOD-TYPE)		 2bkl PROLYL ENDOPEPTIDASE
(Myxococcus
xanthus) 		5 / 12 ARG A 236
GLY A 329
VAL A 328
GLU A 372
VAL A 395
 None
 0.97A 4danA-2bklA:
undetectable
4danB-2bklA:
undetectable		 4danA-2bklA:
17.16
4danB-2bklA:
17.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DCM_A_SAMA401_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE G)		 2bkl PROLYL ENDOPEPTIDASE
(Myxococcus
xanthus) 		5 / 11 ALA A 542
GLY A 452
GLY A 535
ILE A 529
ASN A 459
 None
 1.14A 4dcmA-2bklA:
undetectable		 4dcmA-2bklA:
20.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DQB_B_017B101_2
(ASPARTYL PROTEASE)		 2bkl PROLYL ENDOPEPTIDASE
(Myxococcus
xanthus) 		5 / 10 GLY A 497
ALA A 496
ASP A 495
GLY A 487
VAL A 430
 None
 0.93A 4dqbB-2bklA:
undetectable		 4dqbB-2bklA:
9.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DQE_B_017B101_2
(ASPARTYL PROTEASE)		 2bkl PROLYL ENDOPEPTIDASE
(Myxococcus
xanthus) 		5 / 10 GLY A 497
ALA A 496
ASP A 495
GLY A 487
VAL A 430
 None
 0.92A 4dqeB-2bklA:
undetectable		 4dqeB-2bklA:
11.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DQH_B_017B101_2
(WILD-TYPE HIV-1
PROTEASE DIMER)		 2bkl PROLYL ENDOPEPTIDASE
(Myxococcus
xanthus) 		5 / 10 GLY A 497
ALA A 496
ASP A 495
GLY A 487
VAL A 430
 None
 0.94A 4dqhB-2bklA:
undetectable		 4dqhB-2bklA:
9.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E7C_D_ACTD504_0
(UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE)		 2bkl PROLYL ENDOPEPTIDASE
(Myxococcus
xanthus) 		3 / 3 GLY A 569
SER A 570
TRP A 574
 None
None
ZAH  A1533 (-3.7A)
 0.61A 4e7cD-2bklA:
undetectable		 4e7cD-2bklA:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EYS_A_ACTA402_0
(MCCC FAMILY PROTEIN)		 2bkl PROLYL ENDOPEPTIDASE
(Myxococcus
xanthus) 		4 / 6 SER A 424
ASP A 507
ARG A 546
GLU A 514
 None
 1.22A 4eysA-2bklA:
undetectable		 4eysA-2bklA:
18.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FFW_A_715A801_2
(DIPEPTIDYL PEPTIDASE
4)		 2bkl PROLYL ENDOPEPTIDASE
(Myxococcus
xanthus) 		3 / 3 PHE A 384
TYR A 451
TYR A 478
 None
 0.96A 4ffwA-2bklA:
26.3		 4ffwA-2bklA:
22.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FFW_B_715B801_1
(DIPEPTIDYL PEPTIDASE
4)		 2bkl PROLYL ENDOPEPTIDASE
(Myxococcus
xanthus) 		5 / 12 GLY A 248
TYR A 453
SER A 533
TYR A 578
VAL A 619
 None
ZAH  A1533 (-4.5A)
ZAH  A1533 (-1.4A)
None
None
 1.16A 4ffwB-2bklA:
23.7		 4ffwB-2bklA:
22.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FU8_A_ACTA302_0
(UROKINASE-TYPE
PLASMINOGEN
ACTIVATOR)		 2bkl PROLYL ENDOPEPTIDASE
(Myxococcus
xanthus) 		4 / 5 HIS A 651
TYR A 530
GLY A 532
SER A 533
 ZAH  A1533 (-4.7A)
None
None
ZAH  A1533 (-1.4A)
 1.16A 4fu8A-2bklA:
undetectable		 4fu8A-2bklA:
16.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HLA_A_017A200_1
(PROTEASE)		 2bkl PROLYL ENDOPEPTIDASE
(Myxococcus
xanthus) 		6 / 12 GLY A 497
ALA A 496
ASP A 495
GLY A 487
PRO A 431
VAL A 430
 None
 1.10A 4hlaA-2bklA:
undetectable		 4hlaA-2bklA:
10.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HLA_A_017A200_2
(PROTEASE)		 2bkl PROLYL ENDOPEPTIDASE
(Myxococcus
xanthus) 		6 / 11 GLY A 497
ALA A 496
ASP A 495
GLY A 487
PRO A 431
VAL A 430
 None
 1.11A 4hlaB-2bklA:
undetectable		 4hlaB-2bklA:
10.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K50_I_ACTI504_0
(RNA POLYMERASE
3D-POL)		 2bkl PROLYL ENDOPEPTIDASE
(Myxococcus
xanthus) 		3 / 3 VAL A 148
GLY A 167
LYS A 169
 None
 0.77A 4k50I-2bklA:
undetectable		 4k50I-2bklA:
21.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M2X_A_TMQA202_2
(DIHYDROFOLATE
REDUCTASE)		 2bkl PROLYL ENDOPEPTIDASE
(Myxococcus
xanthus) 		3 / 3 TRP A 186
GLN A 231
THR A 202
 None
 0.97A 4m2xA-2bklA:
undetectable		 4m2xA-2bklA:
12.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NJV_A_RITA500_1
(PROTEASE)		 2bkl PROLYL ENDOPEPTIDASE
(Myxococcus
xanthus) 		5 / 12 GLY A 497
ALA A 496
ASP A 495
GLY A 487
PRO A 431
 None
 1.10A 4njvA-2bklA:
undetectable		 4njvA-2bklA:
10.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OR0_B_NPSB601_1
(SERUM ALBUMIN)		 2bkl PROLYL ENDOPEPTIDASE
(Myxococcus
xanthus) 		5 / 10 ARG A 465
TYR A 478
VAL A 554
LEU A 667
SER A 467
 None
 1.50A 4or0B-2bklA:
0.0		 4or0B-2bklA:
22.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XDT_A_ACTA409_0
(FAD:PROTEIN FMN
TRANSFERASE)		 2bkl PROLYL ENDOPEPTIDASE
(Myxococcus
xanthus) 		4 / 5 ILE A 204
VAL A 243
ILE A 245
THR A 223
 None
 0.73A 4xdtA-2bklA:
undetectable		 4xdtA-2bklA:
20.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XLD_A_BRLA502_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 2bkl PROLYL ENDOPEPTIDASE
(Myxococcus
xanthus) 		5 / 12 PHE A 509
GLY A 531
LEU A 608
MET A 543
LEU A 449
 None
 1.39A 4xldA-2bklA:
0.0		 4xldA-2bklA:
17.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YMG_B_SAMB1001_1
(PUTATIVE
SAM-DEPENDENT
O-METHYLTRANFERASE)		 2bkl PROLYL ENDOPEPTIDASE
(Myxococcus
xanthus) 		3 / 3 SER A  71
GLU A  92
GLU A 646
 None
 0.77A 4ymgB-2bklA:
undetectable		 4ymgB-2bklA:
16.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z3O_F_MFXF101_1
(DNA TOPOISOMERASE 4
SUBUNIT
B,PARE30-PARC55
FUSED TOPO IV FROM
S. PNEUMONIAE
E-SITE DNA)		 2bkl PROLYL ENDOPEPTIDASE
(Myxococcus
xanthus) 		4 / 5 ARG A 498
GLY A 485
GLU A 577
SER A 321
 None
 1.27A 4z3oA-2bklA:
2.4
4z3oB-2bklA:
2.0		 4z3oA-2bklA:
22.75
4z3oB-2bklA:
22.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4I_A_IPHA904_0
(PROTEIN ARGONAUTE-2)		 2bkl PROLYL ENDOPEPTIDASE
(Myxococcus
xanthus) 		4 / 6 ALA A 513
THR A 448
THR A 522
TYR A 521
 None
 1.32A 4z4iA-2bklA:
3.4		 4z4iA-2bklA:
22.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CDQ_F_MFXF2101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT
B,DNA GYRASE SUBUNIT
B)		 2bkl PROLYL ENDOPEPTIDASE
(Myxococcus
xanthus) 		4 / 6 SER A 321
ASP A 495
ARG A 498
GLY A 485
 None
 0.88A 5cdqA-2bklA:
undetectable
5cdqC-2bklA:
undetectable
5cdqD-2bklA:
2.9		 5cdqA-2bklA:
20.43
5cdqC-2bklA:
20.43
5cdqD-2bklA:
14.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E5J_A_017A201_3
(PROTEASE)		 2bkl PROLYL ENDOPEPTIDASE
(Myxococcus
xanthus) 		3 / 3 ASP A  22
VAL A 563
LEU A  15
 None
 0.60A 5e5jB-2bklA:
undetectable		 5e5jB-2bklA:
10.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FCT_B_C2FB402_0
(THYMIDYLATE SYNTHASE)		 2bkl PROLYL ENDOPEPTIDASE
(Myxococcus
xanthus) 		5 / 12 VAL A 434
PHE A 384
ILE A 468
LEU A  59
LEU A 449
 None
 1.46A 5fctB-2bklA:
undetectable		 5fctB-2bklA:
18.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FVO_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2bkl PROLYL ENDOPEPTIDASE
(Myxococcus
xanthus) 		3 / 3 ARG A 526
VAL A 477
TRP A 471
 None
 1.26A 5fvoA-2bklA:
1.8		 5fvoA-2bklA:
19.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M5K_B_ADNB502_2
(ADENOSYLHOMOCYSTEINA
SE)		 2bkl PROLYL ENDOPEPTIDASE
(Myxococcus
xanthus) 		4 / 4 GLN A 523
THR A 522
LEU A 671
LEU A 675
 None
 1.32A 5m5kB-2bklA:
2.7		 5m5kB-2bklA:
21.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5T2Z_B_017B201_1
(PROTEASE)		 2bkl PROLYL ENDOPEPTIDASE
(Myxococcus
xanthus) 		5 / 12 GLY A 497
ALA A 496
ASP A 495
GLY A 487
PRO A 431
 None
 1.03A 5t2zA-2bklA:
undetectable		 5t2zA-2bklA:
9.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TL8_A_X2NA502_1
(PROTEIN CYP51)		 2bkl PROLYL ENDOPEPTIDASE
(Myxococcus
xanthus) 		5 / 12 ALA A 641
ALA A 481
ALA A 479
THR A 448
LEU A 527
 None
 1.25A 5tl8A-2bklA:
undetectable		 5tl8A-2bklA:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X7P_A_ACRA1421_1
(GLYCOSIDE HYDROLASE
FAMILY 31
ALPHA-GLUCOSIDASE)		 2bkl PROLYL ENDOPEPTIDASE
(Myxococcus
xanthus) 		4 / 5 MET A 543
TYR A 530
GLY A 531
GLY A 532
 None
 1.08A 5x7pA-2bklA:
undetectable		 5x7pA-2bklA:
20.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AYC_A_1YNA502_1
(PROTEIN CYP51)		 2bkl PROLYL ENDOPEPTIDASE
(Myxococcus
xanthus) 		5 / 12 ALA A 641
ALA A 481
ALA A 479
THR A 448
LEU A 527
 None
 1.31A 6aycA-2bklA:
undetectable		 6aycA-2bklA:
8.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DH0_A_017A101_1
(PROTEASE)		 2bkl PROLYL ENDOPEPTIDASE
(Myxococcus
xanthus) 		5 / 12 GLY A 497
ALA A 496
GLY A 487
PRO A 431
VAL A 430
 None
 0.96A 6dh0B-2bklA:
undetectable		 6dh0B-2bklA:
10.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DJ1_B_AB1B201_1
(HIV-1 PROTEASE)		 2bkl PROLYL ENDOPEPTIDASE
(Myxococcus
xanthus) 		6 / 12 GLY A 497
ALA A 496
ASP A 495
GLY A 487
PRO A 431
VAL A 430
 None
 1.10A 6dj1B-2bklA:
undetectable		 6dj1B-2bklA:
10.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DJ2_B_AB1B201_1
(HIV-1 PROTEASE)		 2bkl PROLYL ENDOPEPTIDASE
(Myxococcus
xanthus) 		6 / 12 GLY A 497
ALA A 496
ASP A 495
GLY A 487
PRO A 431
VAL A 430
 None
 1.09A 6dj2B-2bklA:
undetectable		 6dj2B-2bklA:
10.16