SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2bkr'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XVA_A_ACTA294_0
(GLYCINE
N-METHYLTRANSFERASE)		 2bkr SENTRIN-SPECIFIC
PROTEASE 8
(Homo
sapiens) 		4 / 5 ILE A 168
LEU A 190
ALA A 173
GLU A 172
 None
 1.32A 1xvaA-2bkrA:
undetectable
1xvaB-2bkrA:
undetectable		 1xvaA-2bkrA:
19.87
1xvaB-2bkrA:
19.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2I2Z_A_SALA1100_1
(SERUM ALBUMIN)		 2bkr SENTRIN-SPECIFIC
PROTEASE 8
(Homo
sapiens) 		4 / 5 LEU A 136
ILE A  62
ILE A  71
ALA A  72
 None
 0.59A 2i2zA-2bkrA:
undetectable		 2i2zA-2bkrA:
15.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J2P_F_SC2F1291_1
(FICOLIN-2)		 2bkr SENTRIN-SPECIFIC
PROTEASE 8
(Homo
sapiens) 		4 / 6 LEU A 106
SER A 104
ASP A 119
GLU A 151
 None
 1.16A 2j2pE-2bkrA:
undetectable
2j2pF-2bkrA:
undetectable		 2j2pE-2bkrA:
24.50
2j2pF-2bkrA:
24.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CR5_X_PNTX95_0
(PROTEIN S100-B)		 2bkr SENTRIN-SPECIFIC
PROTEASE 8
(Homo
sapiens) 		3 / 3 CYH A 175
PHE A 178
PHE A 179
 None
 1.07A 3cr5X-2bkrA:
0.4		 3cr5X-2bkrA:
16.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PTH_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 2bkr SENTRIN-SPECIFIC
PROTEASE 8
(Homo
sapiens) 		5 / 12 ILE A  32
ILE A 206
LEU A  13
ILE A  31
THR A 171
 None
 1.09A 4pthA-2bkrA:
undetectable		 4pthA-2bkrA:
18.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DSG_A_0HKA1201_2
(MUSCARINIC
ACETYLCHOLINE
RECEPTOR
M4,ENDOLYSIN,ENDOLYS
IN,MUSCARINIC
ACETYLCHOLINE
RECEPTOR M4)		 2bkr SENTRIN-SPECIFIC
PROTEASE 8
(Homo
sapiens) 		3 / 3 ASN A  41
LEU A 205
PHE A  36
 None
 0.82A 5dsgA-2bkrA:
undetectable		 5dsgA-2bkrA:
20.15