SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2bku'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1H1D_A_SAMA301_0
(CATECHOL-O-METHYLTRA
NSFERASE)		 2bku IMPORTIN BETA-1
SUBUNIT
(Saccharomyces
cerevisiae) 		5 / 12 MET B 682
ASN B 683
VAL B 684
TYR B 720
MET B 725
 None
 1.40A 1h1dA-2bkuB:
undetectable		 1h1dA-2bkuB:
14.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LQT_B_ACTB1873_0
(FPRA)		 2bku IMPORTIN BETA-1
SUBUNIT
(Saccharomyces
cerevisiae) 		3 / 3 ASP B 343
ASP B 339
LYS B 468
 None
 1.17A 1lqtB-2bkuB:
undetectable		 1lqtB-2bkuB:
19.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LQU_B_ACTB1430_0
(FPRA)		 2bku IMPORTIN BETA-1
SUBUNIT
(Saccharomyces
cerevisiae) 		3 / 3 ASP B 343
ASP B 339
LYS B 468
 None
 1.16A 1lquB-2bkuB:
undetectable		 1lquB-2bkuB:
19.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VID_A_SAMA301_0
(CATECHOL
O-METHYLTRANSFERASE)		 2bku IMPORTIN BETA-1
SUBUNIT
(Saccharomyces
cerevisiae) 		5 / 12 MET B 682
ASN B 683
VAL B 684
TYR B 720
MET B 725
 None
 1.42A 1vidA-2bkuB:
undetectable		 1vidA-2bkuB:
14.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA3_C_STRC3001_1
(MINERALOCORTICOID
RECEPTOR)		 2bku IMPORTIN BETA-1
SUBUNIT
(Saccharomyces
cerevisiae) 		5 / 12 LEU B 199
LEU B 202
ASN B 203
LEU B 205
ALA B 206
 None
 0.62A 1ya3C-2bkuB:
undetectable		 1ya3C-2bkuB:
14.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ACL_C_REAC503_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 2bku IMPORTIN BETA-1
SUBUNIT
(Saccharomyces
cerevisiae) 		5 / 10 ILE B 119
ALA B 116
ALA B 115
ASN B  99
ALA B 154
 None
 1.11A 2aclC-2bkuB:
undetectable		 2aclC-2bkuB:
14.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CL5_B_SAMB1217_0
(CATECHOL
O-METHYLTRANSFERASE)		 2bku IMPORTIN BETA-1
SUBUNIT
(Saccharomyces
cerevisiae) 		5 / 12 MET B 682
ASN B 683
VAL B 684
TYR B 720
MET B 725
 None
 1.44A 2cl5B-2bkuB:
undetectable		 2cl5B-2bkuB:
14.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZVJ_A_SAMA301_0
(CATECHOL
O-METHYLTRANSFERASE)		 2bku IMPORTIN BETA-1
SUBUNIT
(Saccharomyces
cerevisiae) 		5 / 12 MET B 682
ASN B 683
VAL B 684
TYR B 720
MET B 725
 None
 1.41A 2zvjA-2bkuB:
undetectable		 2zvjA-2bkuB:
14.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D90_A_NOGA1001_1
(PROGESTERONE
RECEPTOR)		 2bku IMPORTIN BETA-1
SUBUNIT
(Saccharomyces
cerevisiae) 		5 / 12 LEU B 460
LEU B 452
LEU B 503
MET B 527
CYH B 473
 None
 1.46A 3d90A-2bkuB:
undetectable		 3d90A-2bkuB:
16.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D90_B_NOGB2001_1
(PROGESTERONE
RECEPTOR)		 2bku IMPORTIN BETA-1
SUBUNIT
(Saccharomyces
cerevisiae) 		5 / 12 LEU B   9
ASN B  12
LEU B  10
LEU B  43
MET B   1
 None
 1.25A 3d90B-2bkuB:
undetectable		 3d90B-2bkuB:
16.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D90_B_NOGB2001_1
(PROGESTERONE
RECEPTOR)		 2bku IMPORTIN BETA-1
SUBUNIT
(Saccharomyces
cerevisiae) 		5 / 12 LEU B 199
LEU B 202
ASN B 203
LEU B 205
LEU B 248
 None
 0.98A 3d90B-2bkuB:
undetectable		 3d90B-2bkuB:
16.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MDV_A_CL6A506_1
(CHOLESTEROL
24-HYDROXYLASE)		 2bku IMPORTIN BETA-1
SUBUNIT
(Saccharomyces
cerevisiae) 		5 / 9 LEU B  63
LEU B  55
ILE B 111
ALA B 112
GLU B 108
 None
 1.15A 3mdvA-2bkuB:
undetectable		 3mdvA-2bkuB:
20.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NRR_A_D16A530_1
(DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 2bku IMPORTIN BETA-1
SUBUNIT
(Saccharomyces
cerevisiae) 		5 / 12 ALA B 412
ILE B 438
ASN B 479
GLY B 394
PHE B 393
 None
 1.23A 3nrrA-2bkuB:
undetectable		 3nrrA-2bkuB:
20.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NRR_B_D16B530_1
(DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 2bku IMPORTIN BETA-1
SUBUNIT
(Saccharomyces
cerevisiae) 		5 / 12 ALA B 412
ILE B 438
ASN B 479
GLY B 394
PHE B 393
 None
 1.21A 3nrrB-2bkuB:
undetectable		 3nrrB-2bkuB:
20.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OGP_B_017B200_1
(FIV PROTEASE)		 2bku IMPORTIN BETA-1
SUBUNIT
(Saccharomyces
cerevisiae) 		6 / 10 LEU B 645
ALA B 659
ILE B 657
ILE B 666
VAL B 684
LEU B 648
 None
 1.40A 3ogpA-2bkuB:
undetectable		 3ogpA-2bkuB:
8.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QXY_B_SAMB6735_0
(N-LYSINE
METHYLTRANSFERASE
SETD6
TRANSCRIPTION FACTOR
P65)		 2bku IMPORTIN BETA-1
SUBUNIT
(Saccharomyces
cerevisiae) 		5 / 11 VAL B 759
GLY B 804
ALA B 787
TYR B 830
PHE B 782
 None
 1.42A 3qxyB-2bkuB:
undetectable
3qxyQ-2bkuB:
undetectable		 3qxyB-2bkuB:
19.24
3qxyQ-2bkuB:
2.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FN9_A_STRA301_1
(STEROID RECEPTOR 2)		 2bku IMPORTIN BETA-1
SUBUNIT
(Saccharomyces
cerevisiae) 		5 / 12 LEU B 199
LEU B 202
ASN B 203
LEU B 205
ALA B 206
 None
 0.72A 4fn9A-2bkuB:
undetectable		 4fn9A-2bkuB:
15.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FN9_B_STRB301_1
(STEROID RECEPTOR 2)		 2bku IMPORTIN BETA-1
SUBUNIT
(Saccharomyces
cerevisiae) 		5 / 12 LEU B 199
LEU B 202
ASN B 203
LEU B 205
ALA B 206
 None
 0.77A 4fn9B-2bkuB:
undetectable		 4fn9B-2bkuB:
15.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FR8_A_TNGA601_1
(ALDEHYDE
DEHYDROGENASE,
MITOCHONDRIAL)		 2bku IMPORTIN BETA-1
SUBUNIT
(Saccharomyces
cerevisiae) 		5 / 11 LEU B 135
MET B 136
CYH B 163
SER B 165
ASP B 124
 None
 1.45A 4fr8A-2bkuB:
undetectable		 4fr8A-2bkuB:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LTW_A_STRA301_1
(ANCESTRAL STEROID
RECEPTOR 2)		 2bku IMPORTIN BETA-1
SUBUNIT
(Saccharomyces
cerevisiae) 		5 / 12 LEU B 199
LEU B 202
ASN B 203
LEU B 205
ALA B 206
 None
 0.70A 4ltwA-2bkuB:
undetectable		 4ltwA-2bkuB:
14.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKV_B_AERB601_1
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 2bku IMPORTIN BETA-1
SUBUNIT
(Saccharomyces
cerevisiae) 		5 / 12 ILE B 416
LEU B 417
GLY B 436
ALA B 439
VAL B 409
 None
 0.96A 4nkvB-2bkuB:
undetectable		 4nkvB-2bkuB:
20.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OK1_A_198A1001_2
(ANDROGEN RECEPTOR)		 2bku IMPORTIN BETA-1
SUBUNIT
(Saccharomyces
cerevisiae) 		4 / 8 MET B 162
MET B 139
LEU B 104
ILE B  59
 None
 0.97A 4ok1A-2bkuB:
undetectable		 4ok1A-2bkuB:
14.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4U15_B_0HKB1201_1
(MUSCARINIC
ACETYLCHOLINE
RECEPTOR
M3,LYSOZYME,MUSCARIN
IC ACETYLCHOLINE
RECEPTOR M3)		 2bku IMPORTIN BETA-1
SUBUNIT
(Saccharomyces
cerevisiae) 		5 / 12 TYR B 830
THR B 844
THR B 847
ALA B 848
ALA B 851
 None
 1.47A 4u15B-2bkuB:
2.7		 4u15B-2bkuB:
18.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WQ4_A_ACTA403_0
(TRNA N6-ADENOSINE
THREONYLCARBAMOYLTRA
NSFERASE)		 2bku IMPORTIN BETA-1
SUBUNIT
(Saccharomyces
cerevisiae) 		3 / 3 VAL B 427
LEU B 419
VAL B 390
 None
 0.48A 4wq4A-2bkuB:
undetectable		 4wq4A-2bkuB:
18.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X30_A_T44A401_1
(THYROXINE-BINDING
GLOBULIN)		 2bku IMPORTIN BETA-1
SUBUNIT
(Saccharomyces
cerevisiae) 		5 / 9 ALA B  41
GLN B 117
LEU B  69
ASN B  67
LEU B 118
 None
 1.48A 4x30A-2bkuB:
undetectable		 4x30A-2bkuB:
19.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XYZ_A_ACTA103_0
(POLYUBIQUITIN-C)		 2bku IMPORTIN BETA-1
SUBUNIT
(Saccharomyces
cerevisiae) 		4 / 4 LEU B 417
ILE B 446
HIS B 451
VAL B 455
 None
 1.05A 4xyzA-2bkuB:
undetectable		 4xyzA-2bkuB:
6.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YJI_A_TYLA502_1
(ARYL ACYLAMIDASE)		 2bku IMPORTIN BETA-1
SUBUNIT
(Saccharomyces
cerevisiae) 		4 / 7 LEU B 792
THR B 798
ALA B 802
ILE B 779
 None
 0.62A 4yjiA-2bkuB:
undetectable		 4yjiA-2bkuB:
20.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BMV_C_VLBC507_2
(TUBULIN ALPHA-1B
CHAIN)		 2bku IMPORTIN BETA-1
SUBUNIT
(Saccharomyces
cerevisiae) 		4 / 7 PRO B 497
VAL B 500
ILE B 504
PHE B 545
 None
 0.72A 5bmvC-2bkuB:
undetectable		 5bmvC-2bkuB:
18.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FHR_A_SAMA303_0
(CATECHOL
O-METHYLTRANSFERASE)		 2bku IMPORTIN BETA-1
SUBUNIT
(Saccharomyces
cerevisiae) 		5 / 12 MET B 682
ASN B 683
VAL B 684
TYR B 720
MET B 725
 None
 1.49A 5fhrA-2bkuB:
undetectable		 5fhrA-2bkuB:
14.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LSU_B_SAMB1304_1
(HISTONE-LYSINE
N-METHYLTRANSFERASE
NSD2)		 2bku IMPORTIN BETA-1
SUBUNIT
(Saccharomyces
cerevisiae) 		3 / 3 ASN B 722
TYR B 775
CYH B 728
 None
 1.01A 5lsuB-2bkuB:
undetectable		 5lsuB-2bkuB:
14.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BQG_A_ERMA1201_2
(5-HYDROXYTRYPTAMINE
RECEPTOR 2C,SOLUBLE
CYTOCHROME B562)		 2bku IMPORTIN BETA-1
SUBUNIT
(Saccharomyces
cerevisiae) 		4 / 5 VAL B 535
THR B 532
VAL B 456
LEU B 503
 None
 0.98A 6bqgA-2bkuB:
2.6		 6bqgA-2bkuB:
7.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DLZ_D_CYZD1302_0
(GLUTAMATE RECEPTOR
2,VOLTAGE-DEPENDENT
CALCIUM CHANNEL
GAMMA-2 SUBUNIT)		 2bku IMPORTIN BETA-1
SUBUNIT
(Saccharomyces
cerevisiae) 		5 / 11 ILE B 492
PRO B 491
PRO B 448
LEU B 480
LYS B 402
 None
 1.44A 6dlzA-2bkuB:
undetectable
6dlzD-2bkuB:
3.0		 6dlzA-2bkuB:
7.97
6dlzD-2bkuB:
7.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DM1_D_CYZD1302_0
(GLUTAMATE RECEPTOR
2,VOLTAGE-DEPENDENT
CALCIUM CHANNEL
GAMMA-2 SUBUNIT)		 2bku IMPORTIN BETA-1
SUBUNIT
(Saccharomyces
cerevisiae) 		5 / 11 ILE B 492
PRO B 491
PRO B 448
LEU B 480
LYS B 402
 None
 1.44A 6dm1A-2bkuB:
undetectable
6dm1D-2bkuB:
3.0		 6dm1A-2bkuB:
7.97
6dm1D-2bkuB:
7.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EFN_A_SAMA501_0
(SPORULATION KILLING
FACTOR MATURATION
PROTEIN SKFB)		 2bku IMPORTIN BETA-1
SUBUNIT
(Saccharomyces
cerevisiae) 		5 / 11 THR B   3
PHE B   6
THR B  64
LEU B 118
ALA B 114
 None
 1.12A 6efnA-2bkuB:
undetectable		 6efnA-2bkuB:
20.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6QGB_A_BEZA701_0
(MONO(2-HYDROXYETHYL)
TEREPHTHALATE
HYDROLASE)		 2bku IMPORTIN BETA-1
SUBUNIT
(Saccharomyces
cerevisiae) 		5 / 11 GLY B 661
SER B 623
LEU B 644
ALA B 647
PHE B 619
 None
 1.13A 6qgbA-2bkuB:
undetectable		 6qgbA-2bkuB:
22.36