SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2bkw'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EKJ_G_ACTG3009_0
(BETA-CARBONIC
ANHYDRASE)		 2bkw ALANINE-GLYOXYLATE
AMINOTRANSFERASE 1
(Saccharomyces
cerevisiae) 		4 / 5 GLY A 317
LEU A 318
THR A 319
VAL A 146
 None
 1.06A 1ekjF-2bkwA:
2.0
1ekjG-2bkwA:
2.0		 1ekjF-2bkwA:
23.68
1ekjG-2bkwA:
23.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1K6C_B_MK1B902_1
(POL POLYPROTEIN)		 2bkw ALANINE-GLYOXYLATE
AMINOTRANSFERASE 1
(Saccharomyces
cerevisiae) 		6 / 10 LEU A 297
VAL A 306
ILE A 348
GLY A 349
GLY A 343
THR A 319
 None
 1.08A 1k6cA-2bkwA:
undetectable		 1k6cA-2bkwA:
14.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KQW_A_RTLA135_0
(CELLULAR
RETINOL-BINDING
PROTEIN)		 2bkw ALANINE-GLYOXYLATE
AMINOTRANSFERASE 1
(Saccharomyces
cerevisiae) 		5 / 12 ILE A 344
THR A 142
THR A 144
VAL A  91
LEU A 196
 GLV  A1384 ( 4.3A)
None
PLP  A1201 (-4.3A)
None
None
 1.30A 1kqwA-2bkwA:
undetectable		 1kqwA-2bkwA:
15.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NH8_A_HISA289_0
(ATP
PHOSPHORIBOSYLTRANSF
ERASE)		 2bkw ALANINE-GLYOXYLATE
AMINOTRANSFERASE 1
(Saccharomyces
cerevisiae) 		4 / 5 ASP A 175
LEU A 156
ALA A 195
LEU A 196
 PLP  A1201 (-3.0A)
None
None
None
 1.11A 1nh8A-2bkwA:
undetectable		 1nh8A-2bkwA:
21.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TSN_A_C2FA266_0
(THYMIDYLATE SYNTHASE)		 2bkw ALANINE-GLYOXYLATE
AMINOTRANSFERASE 1
(Saccharomyces
cerevisiae) 		6 / 12 HIS A 145
SER A 179
ILE A 180
LEU A 267
LEU A 196
GLY A  68
 None
None
None
None
None
PLP  A1201 (-3.6A)
 1.47A 1tsnA-2bkwA:
undetectable		 1tsnA-2bkwA:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VPO_H_TESH1010_1
(ANTI-TESTOSTERONE
(HEAVY CHAIN)
ANTI-TESTOSTERONE
(LIGHT CHAIN))		 2bkw ALANINE-GLYOXYLATE
AMINOTRANSFERASE 1
(Saccharomyces
cerevisiae) 		5 / 12 SER A 307
ALA A 315
GLY A 317
LEU A 318
VAL A 298
 None
 1.29A 1vpoH-2bkwA:
undetectable
1vpoL-2bkwA:
undetectable		 1vpoH-2bkwA:
21.05
1vpoL-2bkwA:
19.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HDN_F_TACF3888_1
(ELONGATION FACTOR
EF-TU)		 2bkw ALANINE-GLYOXYLATE
AMINOTRANSFERASE 1
(Saccharomyces
cerevisiae) 		4 / 7 SER A  59
PRO A  61
SER A  57
LEU A 275
 None
 1.00A 2hdnE-2bkwA:
undetectable
2hdnF-2bkwA:
undetectable
2hdnH-2bkwA:
2.6		 2hdnE-2bkwA:
7.59
2hdnF-2bkwA:
22.11
2hdnH-2bkwA:
22.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HDN_H_TACH4888_1
(ELONGATION FACTOR
EF-TU)		 2bkw ALANINE-GLYOXYLATE
AMINOTRANSFERASE 1
(Saccharomyces
cerevisiae) 		4 / 7 SER A  57
LEU A 275
SER A  59
PRO A  61
 None
 1.00A 2hdnF-2bkwA:
undetectable
2hdnG-2bkwA:
undetectable
2hdnH-2bkwA:
2.6		 2hdnF-2bkwA:
22.11
2hdnG-2bkwA:
7.59
2hdnH-2bkwA:
22.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J2P_C_SC2C1289_1
(FICOLIN-2)		 2bkw ALANINE-GLYOXYLATE
AMINOTRANSFERASE 1
(Saccharomyces
cerevisiae) 		4 / 6 ASP A 175
SER A 210
LEU A  70
GLY A  68
 PLP  A1201 (-3.0A)
None
None
PLP  A1201 (-3.6A)
 1.01A 2j2pA-2bkwA:
undetectable
2j2pC-2bkwA:
undetectable		 2j2pA-2bkwA:
19.13
2j2pC-2bkwA:
19.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NNH_A_9CRA501_1
(CYTOCHROME P450 2C8)		 2bkw ALANINE-GLYOXYLATE
AMINOTRANSFERASE 1
(Saccharomyces
cerevisiae) 		5 / 11 GLY A 191
ILE A 159
SER A 160
THR A  94
VAL A 174
 None
 1.11A 2nnhA-2bkwA:
undetectable		 2nnhA-2bkwA:
22.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RLC_A_CHDA332_0
(CHOLOYLGLYCINE
HYDROLASE)		 2bkw ALANINE-GLYOXYLATE
AMINOTRANSFERASE 1
(Saccharomyces
cerevisiae) 		5 / 12 PHE A 185
THR A 197
ALA A 195
ILE A 203
ILE A 274
 None
 0.89A 2rlcA-2bkwA:
undetectable		 2rlcA-2bkwA:
22.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W3A_B_TOPB1189_1
(DIHYDROFOLATE
REDUCTASE)		 2bkw ALANINE-GLYOXYLATE
AMINOTRANSFERASE 1
(Saccharomyces
cerevisiae) 		5 / 10 ALA A 140
PHE A 218
ILE A  74
LEU A 238
THR A 170
 None
 1.17A 2w3aB-2bkwA:
2.0		 2w3aB-2bkwA:
23.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CR5_X_PNTX95_0
(PROTEIN S100-B)		 2bkw ALANINE-GLYOXYLATE
AMINOTRANSFERASE 1
(Saccharomyces
cerevisiae) 		3 / 3 CYH A 373
PHE A 374
PHE A 293
 None
 1.05A 3cr5X-2bkwA:
undetectable		 3cr5X-2bkwA:
13.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EL5_B_1UNB201_1
(PROTEASE)		 2bkw ALANINE-GLYOXYLATE
AMINOTRANSFERASE 1
(Saccharomyces
cerevisiae) 		5 / 10 LEU A 297
VAL A 306
ILE A 348
GLY A 343
THR A 319
 None
 1.10A 3el5A-2bkwA:
undetectable		 3el5A-2bkwA:
14.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RD0_A_EDPA175_1
(FERRITIN LIGHT CHAIN)		 2bkw ALANINE-GLYOXYLATE
AMINOTRANSFERASE 1
(Saccharomyces
cerevisiae) 		4 / 6 LEU A 263
SER A 266
ALA A  23
LEU A 209
 None
 1.17A 3rd0A-2bkwA:
undetectable		 3rd0A-2bkwA:
17.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SPK_B_TPVB100_2
(HIV-1 PROTEASE)		 2bkw ALANINE-GLYOXYLATE
AMINOTRANSFERASE 1
(Saccharomyces
cerevisiae) 		5 / 12 LEU A 297
VAL A 306
ILE A 348
GLY A 343
THR A 319
 None
 0.98A 3spkB-2bkwA:
undetectable		 3spkB-2bkwA:
12.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DM8_B_REAB1501_1
(RETINOIC ACID
RECEPTOR BETA)		 2bkw ALANINE-GLYOXYLATE
AMINOTRANSFERASE 1
(Saccharomyces
cerevisiae) 		5 / 12 PHE A 218
ALA A 222
LEU A  81
ILE A  80
PHE A  75
 None
 1.13A 4dm8B-2bkwA:
undetectable		 4dm8B-2bkwA:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QYN_A_RTLA201_0
(RETINOL-BINDING
PROTEIN 2)		 2bkw ALANINE-GLYOXYLATE
AMINOTRANSFERASE 1
(Saccharomyces
cerevisiae) 		5 / 12 ILE A 344
THR A 142
THR A 144
VAL A  91
LEU A 196
 GLV  A1384 ( 4.3A)
None
PLP  A1201 (-4.3A)
None
None
 1.25A 4qynA-2bkwA:
undetectable		 4qynA-2bkwA:
15.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V20_A_ACTA1444_0
(CELLOBIOHYDROLASE)		 2bkw ALANINE-GLYOXYLATE
AMINOTRANSFERASE 1
(Saccharomyces
cerevisiae) 		4 / 5 GLY A 359
THR A 361
HIS A 286
GLY A 317
 None
 1.01A 4v20A-2bkwA:
undetectable		 4v20A-2bkwA:
22.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZAU_A_YY3A1101_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 2bkw ALANINE-GLYOXYLATE
AMINOTRANSFERASE 1
(Saccharomyces
cerevisiae) 		5 / 8 LEU A  16
GLY A  18
VAL A  20
ALA A 205
GLY A 359
 None
 1.13A 4zauA-2bkwA:
undetectable		 4zauA-2bkwA:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ESL_A_1YNA701_2
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 2bkw ALANINE-GLYOXYLATE
AMINOTRANSFERASE 1
(Saccharomyces
cerevisiae) 		4 / 5 ALA A 250
PRO A  61
GLY A  68
LEU A 267
 None
None
PLP  A1201 (-3.6A)
None
 1.02A 5eslA-2bkwA:
undetectable		 5eslA-2bkwA:
23.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JCN_B_ASCB502_0
(OS09G0567300 PROTEIN)		 2bkw ALANINE-GLYOXYLATE
AMINOTRANSFERASE 1
(Saccharomyces
cerevisiae) 		4 / 6 GLY A 343
ARG A 354
PHE A  97
ARG A 100
 None
GLV  A1384 (-2.5A)
PLP  A1201 (-4.1A)
None
 1.14A 5jcnB-2bkwA:
undetectable		 5jcnB-2bkwA:
22.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MUO_D_PFLD402_1
(PROTON-GATED ION
CHANNEL)		 2bkw ALANINE-GLYOXYLATE
AMINOTRANSFERASE 1
(Saccharomyces
cerevisiae) 		5 / 9 THR A 150
SER A 149
ILE A 344
THR A  94
THR A 144
 None
None
GLV  A1384 ( 4.3A)
None
PLP  A1201 (-4.3A)
 1.50A 5muoA-2bkwA:
0.0
5muoB-2bkwA:
0.0
5muoC-2bkwA:
0.0
5muoD-2bkwA:
0.0
5muoE-2bkwA:
0.0		 5muoA-2bkwA:
12.57
5muoB-2bkwA:
12.57
5muoC-2bkwA:
12.57
5muoD-2bkwA:
12.57
5muoE-2bkwA:
12.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OY0_2_PQN2843_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A2)		 2bkw ALANINE-GLYOXYLATE
AMINOTRANSFERASE 1
(Saccharomyces
cerevisiae) 		5 / 12 ILE A  74
ARG A 106
ALA A 102
LEU A 105
ALA A 110
 None
 1.31A 5oy02-2bkwA:
undetectable		 5oy02-2bkwA:
14.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_A_PCFA1807_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 2bkw ALANINE-GLYOXYLATE
AMINOTRANSFERASE 1
(Saccharomyces
cerevisiae) 		5 / 7 GLY A  66
LEU A  64
ILE A  74
GLY A  71
LEU A 196
 None
 1.38A 5vkqA-2bkwA:
undetectable
5vkqB-2bkwA:
undetectable		 5vkqA-2bkwA:
12.82
5vkqB-2bkwA:
12.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZJI_A_PQNA844_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1
PHOTOSYSTEM I
REACTION CENTER
SUBUNIT IX)		 2bkw ALANINE-GLYOXYLATE
AMINOTRANSFERASE 1
(Saccharomyces
cerevisiae) 		5 / 10 SER A  17
GLY A  18
ALA A  23
LEU A  24
PHE A 235
 None
 1.17A 5zjiA-2bkwA:
undetectable
5zjiJ-2bkwA:
undetectable		 5zjiA-2bkwA:
13.25
5zjiJ-2bkwA:
8.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6JI6_A_ACTA305_0
(GLUTATHIONE
S-TRANSFERASE
CLASS-MU 26 KDA
ISOZYME)		 2bkw ALANINE-GLYOXYLATE
AMINOTRANSFERASE 1
(Saccharomyces
cerevisiae) 		4 / 5 GLY A  71
LEU A  70
SER A  77
TYR A 108
 None
 1.20A 6ji6A-2bkwA:
undetectable		 6ji6A-2bkwA:
19.74