SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2bkx'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YAJ_B_BEZB12_0
(CES1 PROTEIN)		 2bkx GLUCOSAMINE-6-PHOSPH
ATE DEAMINASE
(Bacillus
subtilis) 		4 / 4 GLY A  33
SER A 190
VAL A 120
LEU A  66
 None
None
None
F6R  A1243 (-4.0A)
 1.22A 1yajB-2bkxA:
undetectable		 1yajB-2bkxA:
18.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AZX_A_TRPA602_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 2bkx GLUCOSAMINE-6-PHOSPH
ATE DEAMINASE
(Bacillus
subtilis) 		4 / 8 ILE A  61
LEU A  47
ILE A  48
HIS A  51
 None
 0.51A 2azxA-2bkxA:
undetectable		 2azxA-2bkxA:
19.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIM_J_CHDJ60_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART)		 2bkx GLUCOSAMINE-6-PHOSPH
ATE DEAMINASE
(Bacillus
subtilis) 		4 / 5 TYR A 116
MET A 182
THR A 181
LEU A  66
 None
None
None
F6R  A1243 (-4.0A)
 1.39A 2eimJ-2bkxA:
undetectable		 2eimJ-2bkxA:
10.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIM_W_CHDW1060_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART)		 2bkx GLUCOSAMINE-6-PHOSPH
ATE DEAMINASE
(Bacillus
subtilis) 		4 / 5 TYR A 116
MET A 182
THR A 181
LEU A  66
 None
None
None
F6R  A1243 (-4.0A)
 1.41A 2eimW-2bkxA:
undetectable		 2eimW-2bkxA:
10.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HKK_A_ALEA300_1
(CARBONIC ANHYDRASE 2)		 2bkx GLUCOSAMINE-6-PHOSPH
ATE DEAMINASE
(Bacillus
subtilis) 		4 / 6 ASN A 158
ASN A 136
ILE A 133
THR A 146
 None
 1.23A 2hkkA-2bkxA:
undetectable		 2hkkA-2bkxA:
22.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2TSR_B_D16B409_1
(THYMIDYLATE SYNTHASE)		 2bkx GLUCOSAMINE-6-PHOSPH
ATE DEAMINASE
(Bacillus
subtilis) 		5 / 8 ARG A 192
ASP A  67
LEU A  66
GLY A 140
TYR A  80
 None
F6R  A1243 (-3.1A)
F6R  A1243 (-4.0A)
F6R  A1243 (-3.0A)
None
 1.46A 2tsrB-2bkxA:
undetectable		 2tsrB-2bkxA:
24.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2TSR_D_D16D609_1
(THYMIDYLATE SYNTHASE)		 2bkx GLUCOSAMINE-6-PHOSPH
ATE DEAMINASE
(Bacillus
subtilis) 		5 / 9 ASP A  67
LEU A  66
GLY A 140
TYR A  80
THR A 126
 F6R  A1243 (-3.1A)
F6R  A1243 (-4.0A)
F6R  A1243 (-3.0A)
None
None
 1.26A 2tsrD-2bkxA:
undetectable		 2tsrD-2bkxA:
24.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2N_D_X2ND1479_1
(LANOSTEROL
14-ALPHA-DEMETHYLASE)		 2bkx GLUCOSAMINE-6-PHOSPH
ATE DEAMINASE
(Bacillus
subtilis) 		5 / 12 ILE A 214
TYR A   9
ALA A  17
THR A  20
LEU A 130
 None
 0.91A 2x2nD-2bkxA:
undetectable		 2x2nD-2bkxA:
16.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XCT_X_CPFX1020_1
(DNA GYRASE SUBUNIT
B, DNA GYRASE
SUBUNIT A)		 2bkx GLUCOSAMINE-6-PHOSPH
ATE DEAMINASE
(Bacillus
subtilis) 		4 / 4 ARG A 151
GLY A 183
GLU A 117
SER A 221
 None
 1.28A 2xctS-2bkxA:
undetectable
2xctU-2bkxA:
undetectable		 2xctS-2bkxA:
17.88
2xctU-2bkxA:
17.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG2_J_CHDJ60_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1)		 2bkx GLUCOSAMINE-6-PHOSPH
ATE DEAMINASE
(Bacillus
subtilis) 		4 / 5 TYR A 116
MET A 182
THR A 181
LEU A  66
 None
None
None
F6R  A1243 (-4.0A)
 1.38A 3ag2J-2bkxA:
undetectable		 3ag2J-2bkxA:
10.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG4_J_CHDJ60_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1)		 2bkx GLUCOSAMINE-6-PHOSPH
ATE DEAMINASE
(Bacillus
subtilis) 		4 / 5 TYR A 116
MET A 182
THR A 181
LEU A  66
 None
None
None
F6R  A1243 (-4.0A)
 1.38A 3ag4J-2bkxA:
undetectable		 3ag4J-2bkxA:
10.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GWV_A_RFXA801_1
(TRANSPORTER)		 2bkx GLUCOSAMINE-6-PHOSPH
ATE DEAMINASE
(Bacillus
subtilis) 		5 / 12 LEU A  32
ILE A  24
PHE A  88
ALA A  17
LEU A  56
 None
 1.04A 3gwvA-2bkxA:
undetectable		 3gwvA-2bkxA:
19.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GWX_B_EPAB3_1
(PROTEIN (PEROXISOME
PROLIFERATOR
ACTIVATED RECEPTOR
(PPAR-DELTA)))		 2bkx GLUCOSAMINE-6-PHOSPH
ATE DEAMINASE
(Bacillus
subtilis) 		5 / 12 THR A  20
THR A  23
GLU A  26
LEU A  47
TYR A  44
 None
 1.20A 3gwxB-2bkxA:
undetectable		 3gwxB-2bkxA:
22.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3L4D_A_TPFA490_1
(STEROL 14-ALPHA
DEMETHYLASE)		 2bkx GLUCOSAMINE-6-PHOSPH
ATE DEAMINASE
(Bacillus
subtilis) 		4 / 8 TYR A   9
ALA A  17
THR A  20
LEU A 130
 None
 0.91A 3l4dA-2bkxA:
undetectable		 3l4dA-2bkxA:
22.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TBG_A_RTZA1_1
(CYTOCHROME P450 2D6)		 2bkx GLUCOSAMINE-6-PHOSPH
ATE DEAMINASE
(Bacillus
subtilis) 		5 / 12 PHE A 141
LEU A 157
GLY A  71
LEU A  72
PHE A 169
 None
 1.33A 3tbgA-2bkxA:
undetectable		 3tbgA-2bkxA:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DO3_B_0LAB602_1
(FATTY-ACID AMIDE
HYDROLASE 1)		 2bkx GLUCOSAMINE-6-PHOSPH
ATE DEAMINASE
(Bacillus
subtilis) 		4 / 6 LEU A 232
LEU A 194
ILE A 128
THR A  43
 None
 0.86A 4do3B-2bkxA:
undetectable		 4do3B-2bkxA:
18.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FGK_A_0TXA302_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 2bkx GLUCOSAMINE-6-PHOSPH
ATE DEAMINASE
(Bacillus
subtilis) 		4 / 7 GLY A  38
GLY A  37
TYR A 168
ASN A 165
 F6R  A1243 (-3.7A)
F6R  A1243 (-3.5A)
None
F6R  A1243 ( 4.8A)
 1.02A 4fgkB-2bkxA:
2.3		 4fgkB-2bkxA:
22.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PFJ_A_ADNA502_2
(ADENOSYLHOMOCYSTEINA
SE)		 2bkx GLUCOSAMINE-6-PHOSPH
ATE DEAMINASE
(Bacillus
subtilis) 		4 / 7 GLU A 159
THR A 161
THR A 146
HIS A 153
 None
 1.07A 4pfjA-2bkxA:
undetectable		 4pfjA-2bkxA:
19.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PFJ_B_ADNB502_2
(ADENOSYLHOMOCYSTEINA
SE)		 2bkx GLUCOSAMINE-6-PHOSPH
ATE DEAMINASE
(Bacillus
subtilis) 		4 / 6 GLU A 159
THR A 161
THR A 146
HIS A 153
 None
 1.03A 4pfjB-2bkxA:
undetectable		 4pfjB-2bkxA:
19.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TWJ_C_SAMC201_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE H)		 2bkx GLUCOSAMINE-6-PHOSPH
ATE DEAMINASE
(Bacillus
subtilis) 		5 / 12 ILE A 139
GLY A 140
LEU A  66
SER A 189
LEU A 188
 None
F6R  A1243 (-3.0A)
F6R  A1243 (-4.0A)
None
None
 0.67A 5twjC-2bkxA:
undetectable		 5twjC-2bkxA:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_A_PCFA1807_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 2bkx GLUCOSAMINE-6-PHOSPH
ATE DEAMINASE
(Bacillus
subtilis) 		5 / 7 GLY A 183
ILE A 139
GLY A 140
LEU A  66
ILE A 128
 None
None
F6R  A1243 (-3.0A)
F6R  A1243 (-4.0A)
None
 1.16A 5vkqA-2bkxA:
undetectable
5vkqB-2bkxA:
undetectable		 5vkqA-2bkxA:
9.78
5vkqB-2bkxA:
9.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_B_PCFB1804_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 2bkx GLUCOSAMINE-6-PHOSPH
ATE DEAMINASE
(Bacillus
subtilis) 		5 / 8 GLY A 183
ILE A 139
GLY A 140
LEU A  66
ILE A 128
 None
None
F6R  A1243 (-3.0A)
F6R  A1243 (-4.0A)
None
 1.13A 5vkqB-2bkxA:
undetectable
5vkqC-2bkxA:
undetectable		 5vkqB-2bkxA:
9.78
5vkqC-2bkxA:
9.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WAU_J_CHDJ101_1
(CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 2bkx GLUCOSAMINE-6-PHOSPH
ATE DEAMINASE
(Bacillus
subtilis) 		4 / 5 TYR A 116
MET A 182
THR A 181
LEU A  66
 None
None
None
F6R  A1243 (-4.0A)
 1.41A 5wauJ-2bkxA:
undetectable		 5wauJ-2bkxA:
10.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z86_J_CHDJ101_0
(CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 2bkx GLUCOSAMINE-6-PHOSPH
ATE DEAMINASE
(Bacillus
subtilis) 		4 / 5 TYR A 116
MET A 182
THR A 181
LEU A  66
 None
None
None
F6R  A1243 (-4.0A)
 1.40A 5z86J-2bkxA:
undetectable		 5z86J-2bkxA:
10.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AG0_A_ACRA605_0
(ALPHA-AMYLASE)		 2bkx GLUCOSAMINE-6-PHOSPH
ATE DEAMINASE
(Bacillus
subtilis) 		4 / 8 TYR A  80
GLY A 104
ASP A  75
PRO A  77
 None
 0.76A 6ag0A-2bkxA:
undetectable		 6ag0A-2bkxA:
17.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6C71_B_NCTB501_1
(AMINE OXIDASE)		 2bkx GLUCOSAMINE-6-PHOSPH
ATE DEAMINASE
(Bacillus
subtilis) 		4 / 8 LEU A  47
TYR A  44
THR A  20
ASN A  65
 None
 1.05A 6c71B-2bkxA:
undetectable		 6c71B-2bkxA:
17.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6D9K_F_ACTF802_0
(UNCHARACTERIZED
PROTEIN)		 2bkx GLUCOSAMINE-6-PHOSPH
ATE DEAMINASE
(Bacillus
subtilis) 		3 / 3 TYR A  44
ALA A  16
LEU A 130
 None
 0.73A 6d9kF-2bkxA:
undetectable		 6d9kF-2bkxA:
15.82