SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2bl2'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FBM_B_RTLB951_2
(PROTEIN (CARTILAGE
OLIGOMERIC MATRIX
PROTEIN))		 2bl2 V-TYPE SODIUM ATP
SYNTHASE SUBUNIT K
(Enterococcus
hirae) 		4 / 4 THR A 140
LEU A 144
VAL A 147
LEU A 151
 None
 0.58A 1fbmD-2bl2A:
undetectable		 1fbmD-2bl2A:
18.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FBM_B_RTLB951_3
(PROTEIN (CARTILAGE
OLIGOMERIC MATRIX
PROTEIN))		 2bl2 V-TYPE SODIUM ATP
SYNTHASE SUBUNIT K
(Enterococcus
hirae) 		4 / 5 THR A 140
LEU A 144
VAL A 147
LEU A 151
 None
 0.71A 1fbmE-2bl2A:
undetectable		 1fbmE-2bl2A:
18.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MZ9_D_VDYD1001_4
(CARTILAGE OLIGOMERIC
MATRIX PROTEIN)		 2bl2 V-TYPE SODIUM ATP
SYNTHASE SUBUNIT K
(Enterococcus
hirae) 		4 / 4 THR A 140
LEU A 144
VAL A 147
LEU A 151
 None
 0.79A 1mz9D-2bl2A:
undetectable		 1mz9D-2bl2A:
12.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SI7_A_ACTA5_0
(CYSTIC FIBROSIS
TRANSMEMBRANE
CONDUCTANCE
REGULATOR)		 2bl2 V-TYPE SODIUM ATP
SYNTHASE SUBUNIT K
(Enterococcus
hirae) 		3 / 3 LYS A 123
SER A  47
GLN A  48
 None
 1.26A 3si7A-2bl2A:
undetectable		 3si7A-2bl2A:
19.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_A_PCFA1807_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 2bl2 V-TYPE SODIUM ATP
SYNTHASE SUBUNIT K
(Enterococcus
hirae) 		5 / 7 GLY A  66
LEU A  17
ILE A  28
GLY A  29
LEU A 104
 None
LHG  A1159 ( 4.6A)
LHG  A1158 ( 4.8A)
None
LHG  A1158 ( 4.8A)
 1.26A 5vkqA-2bl2A:
3.1
5vkqB-2bl2A:
3.0		 5vkqA-2bl2A:
8.05
5vkqB-2bl2A:
8.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_B_PCFB1804_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 2bl2 V-TYPE SODIUM ATP
SYNTHASE SUBUNIT K
(Enterococcus
hirae) 		5 / 8 GLY A  66
LEU A  17
ILE A  28
GLY A  29
LEU A 104
 None
LHG  A1159 ( 4.6A)
LHG  A1158 ( 4.8A)
None
LHG  A1158 ( 4.8A)
 1.26A 5vkqB-2bl2A:
3.0
5vkqC-2bl2A:
3.1		 5vkqB-2bl2A:
8.05
5vkqC-2bl2A:
8.05