SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2bma'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AVV_E_MK1E902_2
(POL POLYPROTEIN)		 2bma GLUTAMATE
DEHYDROGENASE
(NADP+)
(Plasmodium
falciparum) 		3 / 3 ASP A 261
ILE A 281
VAL A 256
 None
 0.60A 2avvD-2bmaA:
undetectable		 2avvD-2bmaA:
10.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QO5_A_CHDA131_0
(LIVER-BASIC FATTY
ACID BINDING PROTEIN)		 2bma GLUTAMATE
DEHYDROGENASE
(NADP+)
(Plasmodium
falciparum) 		5 / 12 ILE A 411
ILE A 226
LEU A 426
CYH A 367
PHE A 216
 None
 1.18A 2qo5A-2bmaA:
undetectable		 2qo5A-2bmaA:
16.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WD9_A_IBPA1570_1
(ACYL-COENZYME A
SYNTHETASE ACSM2A,
MITOCHONDRIAL)		 2bma GLUTAMATE
DEHYDROGENASE
(NADP+)
(Plasmodium
falciparum) 		4 / 7 LEU A 100
VAL A  79
GLY A 107
ARG A  93
 None
 0.73A 2wd9A-2bmaA:
3.7		 2wd9A-2bmaA:
22.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WD9_B_IBPB1570_1
(ACYL-COENZYME A
SYNTHETASE ACSM2A,
MITOCHONDRIAL)		 2bma GLUTAMATE
DEHYDROGENASE
(NADP+)
(Plasmodium
falciparum) 		4 / 8 LEU A 100
VAL A  79
GLY A 107
ARG A  93
 None
 0.71A 2wd9B-2bmaA:
2.8		 2wd9B-2bmaA:
22.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XFS_A_J01A500_1
(ORF12)		 2bma GLUTAMATE
DEHYDROGENASE
(NADP+)
(Plasmodium
falciparum) 		4 / 8 VAL A 220
LEU A 116
GLY A 429
ALA A 430
 None
 0.89A 2xfsA-2bmaA:
undetectable		 2xfsA-2bmaA:
21.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XH9_A_J01A1436_1
(ORF12)		 2bma GLUTAMATE
DEHYDROGENASE
(NADP+)
(Plasmodium
falciparum) 		4 / 8 VAL A 220
LEU A 116
GLY A 429
ALA A 430
 None
 0.89A 2xh9A-2bmaA:
undetectable		 2xh9A-2bmaA:
21.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BGR_A_T27A556_1
(REVERSE
TRANSCRIPTASE/RIBONU
CLEASE H
P51 RT)		 2bma GLUTAMATE
DEHYDROGENASE
(NADP+)
(Plasmodium
falciparum) 		5 / 11 LEU A 243
TYR A 294
PHE A 272
LEU A 277
GLU A 285
 None
 1.10A 3bgrA-2bmaA:
undetectable
3bgrB-2bmaA:
undetectable		 3bgrA-2bmaA:
21.27
3bgrB-2bmaA:
22.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IK3_A_0LIA1_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 2bma GLUTAMATE
DEHYDROGENASE
(NADP+)
(Plasmodium
falciparum) 		4 / 7 LEU A  85
VAL A 398
ILE A 405
ARG A 205
 None
 1.06A 3ik3A-2bmaA:
undetectable		 3ik3A-2bmaA:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IK3_B_0LIB2_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 2bma GLUTAMATE
DEHYDROGENASE
(NADP+)
(Plasmodium
falciparum) 		4 / 7 LEU A  85
VAL A 398
ILE A 405
ARG A 205
 None
 1.05A 3ik3B-2bmaA:
undetectable		 3ik3B-2bmaA:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C5L_C_UEGC300_1
(PHOSPHOMETHYLPYRIMID
INE KINASE)		 2bma GLUTAMATE
DEHYDROGENASE
(NADP+)
(Plasmodium
falciparum) 		5 / 10 GLY A 343
GLY A 345
VAL A 217
VAL A 235
CYH A 320
 None
 1.30A 4c5lC-2bmaA:
3.9		 4c5lC-2bmaA:
19.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C5L_D_UEGD300_1
(PHOSPHOMETHYLPYRIMID
INE KINASE)		 2bma GLUTAMATE
DEHYDROGENASE
(NADP+)
(Plasmodium
falciparum) 		5 / 10 GLY A 343
GLY A 345
VAL A 217
VAL A 235
CYH A 320
 None
 1.29A 4c5lD-2bmaA:
2.3		 4c5lD-2bmaA:
19.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C5N_B_PXLB300_1
(PHOSPHOMETHYLPYRIMID
INE KINASE)		 2bma GLUTAMATE
DEHYDROGENASE
(NADP+)
(Plasmodium
falciparum) 		5 / 10 GLY A 343
GLY A 345
VAL A 217
VAL A 235
CYH A 320
 None
 1.29A 4c5nB-2bmaA:
3.9		 4c5nB-2bmaA:
19.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KOU_A_C04A206_1
(UNCHARACTERIZED
PROTEIN)		 2bma GLUTAMATE
DEHYDROGENASE
(NADP+)
(Plasmodium
falciparum) 		5 / 10 PHE A 143
TYR A 175
GLY A 170
PHE A  94
LEU A  92
 None
 1.39A 4kouA-2bmaA:
0.0		 4kouA-2bmaA:
15.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QWP_A_GCSA301_1
(CHITOSANASE)		 2bma GLUTAMATE
DEHYDROGENASE
(NADP+)
(Plasmodium
falciparum) 		3 / 3 TYR A 180
GLY A 156
PRO A 157
 None
 0.66A 4qwpA-2bmaA:
0.7		 4qwpA-2bmaA:
20.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M0O_C_EPAC502_1
(TERMINAL
OLEFIN-FORMING FATTY
ACID DECARBOXYLASE)		 2bma GLUTAMATE
DEHYDROGENASE
(NADP+)
(Plasmodium
falciparum) 		4 / 8 LEU A  32
ILE A  48
PHE A 108
PRO A 368
 None
 0.89A 5m0oC-2bmaA:
undetectable		 5m0oC-2bmaA:
21.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0O_B_SAMB501_0
(PEPTIDE
N-METHYLTRANSFERASE)		 2bma GLUTAMATE
DEHYDROGENASE
(NADP+)
(Plasmodium
falciparum) 		5 / 12 ILE A 111
TYR A  81
GLY A 124
PHE A 105
VAL A 103
 None
 1.12A 5n0oB-2bmaA:
undetectable		 5n0oB-2bmaA:
22.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0X_A_SAMA501_0
(PEPTIDE
N-METHYLTRANSFERASE)		 2bma GLUTAMATE
DEHYDROGENASE
(NADP+)
(Plasmodium
falciparum) 		5 / 12 ILE A 111
TYR A  81
PHE A 105
VAL A 103
ILE A  48
 None
 1.08A 5n0xA-2bmaA:
undetectable		 5n0xA-2bmaA:
19.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QGJ_A_ACTA301_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 2bma GLUTAMATE
DEHYDROGENASE
(NADP+)
(Plasmodium
falciparum) 		3 / 3 VAL A 214
VAL A 217
GLN A 231
 None
 0.66A 5qgjA-2bmaA:
undetectable		 5qgjA-2bmaA:
18.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QGL_A_ACTA301_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 2bma GLUTAMATE
DEHYDROGENASE
(NADP+)
(Plasmodium
falciparum) 		3 / 3 VAL A 214
VAL A 217
GLN A 231
 None
 0.65A 5qglA-2bmaA:
undetectable		 5qglA-2bmaA:
18.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QGU_A_ACTA301_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 2bma GLUTAMATE
DEHYDROGENASE
(NADP+)
(Plasmodium
falciparum) 		3 / 3 VAL A 214
VAL A 217
GLN A 231
 None
 0.68A 5qguA-2bmaA:
undetectable		 5qguA-2bmaA:
18.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QGV_A_ACTA301_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 2bma GLUTAMATE
DEHYDROGENASE
(NADP+)
(Plasmodium
falciparum) 		3 / 3 VAL A 214
VAL A 217
GLN A 231
 None
 0.72A 5qgvA-2bmaA:
undetectable		 5qgvA-2bmaA:
18.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QHE_A_ACTA301_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 2bma GLUTAMATE
DEHYDROGENASE
(NADP+)
(Plasmodium
falciparum) 		3 / 3 VAL A 214
VAL A 217
GLN A 231
 None
 0.71A 5qheA-2bmaA:
undetectable		 5qheA-2bmaA:
18.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QHF_A_ACTA301_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 2bma GLUTAMATE
DEHYDROGENASE
(NADP+)
(Plasmodium
falciparum) 		3 / 3 VAL A 214
VAL A 217
GLN A 231
 None
 0.71A 5qhfA-2bmaA:
undetectable		 5qhfA-2bmaA:
18.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UBB_A_SAMA301_1
(ALPHA N-TERMINAL
PROTEIN
METHYLTRANSFERASE 1B)		 2bma GLUTAMATE
DEHYDROGENASE
(NADP+)
(Plasmodium
falciparum) 		4 / 5 GLY A 164
ARG A 205
ASP A 165
GLN A 323
 None
 1.36A 5ubbA-2bmaA:
undetectable		 5ubbA-2bmaA:
19.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CB4_A_BEZA501_0
(CANAVALIN)		 2bma GLUTAMATE
DEHYDROGENASE
(NADP+)
(Plasmodium
falciparum) 		4 / 8 LEU A 277
VAL A 266
LEU A 259
ILE A 291
 None
 0.92A 6cb4A-2bmaA:
undetectable		 6cb4A-2bmaA:
23.11